Articles tagged with Coronary Artery Disease
A new study reveals delayed diagnosis of HoFH leads to premature cardiovascular disease, highlighting the need for increased lipid screening and aggressive treatment. Despite available therapies, most patients require further lipid-lowering treatments.
A study found that young women are more likely to experience adverse outcomes and rehospitalization after a heart attack, with non-cardiac hospitalizations showing the most significant disparity. Researchers highlight the need for public awareness and sex-specific post-heart attack care.
Researchers have developed a non-invasive technique using laser speckle imaging to visualize microvasculature in donor hearts and detect abnormal blood flow. The method enables precise visualization of blood circulation, potentially identifying hearts suitable for transplantation.
A study published in Circulation Research identifies the FHL5 gene as a key regulator of vascular disease, including heart attacks and aneurysms. The discovery advances our understanding of the underlying causes of vascular disease and provides new insights into genetic risk factors.
A new study from the University of Eastern Finland identified 12 cell types involved in CAD pathogenesis. The genetic risk factors for CAD take effect via smooth vascular muscle cells, which change their phenotype as the disease progresses.
A machine learning model has been developed to predict a patient's risk for a sleep disorder using demographic, lifestyle, physical exam results, and laboratory values. The model identified depression, weight, age, and waist circumference as the greatest predictors of a sleep disorder diagnosis.
A cohort study of over 9,000 persons found that asymptomatic middle-aged individuals with subclinical coronary atherosclerosis are at an 8-fold increased risk for myocardial infarction. The study highlights the importance of identifying and addressing obstructive coronary artery disease in patients without known cardiovascular disease.
The Lp(a) Discovery Project will develop clinical standards for optimal patient care through a new screening measure and quality improvement interventions. The three-year project aims to fill knowledge gaps around Lp(a) and encourage better treatments to reduce cardiovascular risk.
Researchers from Kyushu University found that the single mechanosensitive protein VGLL3 induces fibrosis, thickening and scarring tissue. The study suggests targeting this protein could lead to new treatments against fibrosis.
The VALOR-QI program will provide a blueprint for quality care improvement, focusing on high-risk patients and addressing health equity gaps. It will offer education, staff training, monitoring, and other steps to achieve better compliance with cholesterol management.
A real-world analysis found that high-risk Americans who fail to reach guideline-recommended LDL-C levels experience a 44% higher rate of cardiovascular events. The study, presented at the AMCP Conference, used data from over 300 million Americans and compared those who met and maintained recommended targets with those who did not.
Women have a roughly 30-40% higher risk of dying following coronary artery bypass surgery, with female patients having a 2.8% rate of death during or soon after surgery compared to 1.7% for male patients.
A study of over 1.2 million patients found women remain at higher risk for adverse outcomes after coronary artery bypass grafting. No significant improvement in outcomes has been observed over the past decade.
Researchers created a novel pre-clinical model of non-ST elevation myocardial infarction (NSTEMI), which closely resembles clinical cases in humans. The model can aid in developing targeted pharmacological solutions to correct tissue changes associated with NSTEMI.
Researchers have found a significant link between frequent marijuana use and an increased risk of coronary artery disease (CAD), with daily cannabis users being about one-third more likely to develop the condition. The study used data from 175,000 people and suggested that cannabis use disorder is associated with a higher risk of CAD.
A recent study finds a strong association between hypertensive disorders of pregnancy and an increased risk of coronary artery disease and stroke. The study suggests that hypertensive disorders in pregnancy can be classified as risk factors for cardiovascular disease, highlighting the importance of prenatal care.
Scientists have identified genes that play key roles in the development of coronary artery disease (CAD), a leading cause of death worldwide. The study found notable differences in gene activity between males and females, as well as between cells that were multiplying and those that were not.
Researchers identified a panel of novel blood biomarkers associated with sudden cardiac arrest, which have the potential to enhance clinical prediction. Additionally, an AI-powered ultrasound technology can accurately identify coronary artery calcium buildup, potentially replacing CT scans as a diagnostic tool.
A new American Heart Association scientific statement emphasizes the importance of rapid evaluation for TIA, which can lead to full-blown stroke. The statement offers a standardized approach to evaluating people with suspected TIA, including guidance for hospitals in rural areas with limited resources.
Muscle mass and blood pressure are key factors in maintaining healthy arteries, with higher muscle mass and lower blood pressure linked to reduced arterial stiffness. The study found that these associations remain significant even after accounting for age.
Researchers from Osaka University found that tricaprin supplementation leads to remarkable regression of coronary artery plaque and resolution of symptoms in patients with triglyceride deposit cardiomyovasculopathy. The study's findings provide a novel treatment concept for coronary atherosclerosis.
Researchers at Mount Sinai developed a digital marker for coronary artery disease using machine learning and electronic health records. The model accurately measures CAD on a spectrum, revealing distinct gradations of disease risk and survival, which may otherwise be missed with conventional binary frameworks.
Dr. Urbut's award-winning research explores a new framework to predict coronary artery disease throughout an individual's lifespan, incorporating genomic and nongenomic risk factors. The American Heart Association recognized her innovative work in improving cardiovascular disease prevention.
A new PET imaging method is more effective than angiograms in determining the need for coronary stents or bypass surgery, according to UTHealth Houston researchers. The study confirms that PET threshold of severity at which stents and bypass surgery improve survival compared to medical treatment alone.
Scientists at Medical College of Georgia discover a new target to intervene in coronary artery disease, the most common type of heart disease. The target is ATIC, a gene essential for purine production, which increases in response to arterial disease.
Dr. Matt Budoff will investigate the effects of Colchicine in people with coronary artery disease, comparing it to placebo. The goal is to determine if this anti-inflammatory medication can reduce plaque volume and improve patient outcomes.
The American Heart Association statement highlights telehealth's benefits in managing cardiovascular disease, including cost-effectiveness and improved rehabilitation. However, challenges like access to broadband internet and privacy security concerns hinder widespread adoption.
A new study found that a personalized 'precision' testing approach for people with stable chest pain led to more efficient evaluations and improved diagnosis of coronary artery disease. The approach involved assessing cardiovascular risk factors to identify low-risk individuals who may not benefit from further testing.
Neighborhood walkability is associated with lower cardiovascular disease burden and risk, according to two preliminary studies. The analysis found that even after considering other factors, walkability alone was linked to a 0.1% decrease in cardiovascular disease for each one-point increase in walkability score.
A new study found that soluble urokinase plasminogen activator receptor (suPAR) levels are significantly higher in patients with heart failure, predicting both heart failure and death. When combined with traditional measures like BNP, suPAR's predictive ability increases.
Researchers have identified a new way to treat young children with Kawasaki Disease by using mTOR inhibitors to prevent coronary artery damage and aneurysms. The treatment has shown promise in preclinical studies and could potentially be trialled rapidly in the clinic for children with KD.
A new American Heart Association scientific statement emphasizes the importance of managing PAD based on a person's experience of symptoms, rather than relying solely on clinical measures. This approach aims to improve patient-centered care and outcomes, particularly for individuals with severe limb ischemia or comorbidities.
A national study found that patients with cardiovascular disease had a higher mortality rate than those without, but this association was largely due to shared risk factors. Myocardial injury was common among critically ill COVID-19 patients and associated with poor outcomes.
Children with homozygous familial hypercholesterolemia are diagnosed earlier and have higher untreated LDL-C levels than adults, while those not identified early miss out on decades of life-saving treatment. This study emphasizes the need for universal screening to identify children with HoFH or heterozygous familial hypercholesterolemia.
Researchers developed an AI algorithm to assess retinal vasculature, predicting cardiovascular disease and death. The model captured half to two-thirds of circulatory disease deaths in those most at risk, outperforming traditional risk frameworks.
Women with a history of gestational diabetes are at substantially higher risk of cardiovascular and cerebrovascular diseases, including coronary artery disease, heart attack, and stroke. Continuous monitoring is crucial to mitigate these risks.
A prospective study in the Canadian Journal of Cardiology found that dedicated women's heart centers can significantly improve clinical and psychological outcomes for women with myocardial ischemia. The study, which followed 154 patients, showed a significant decrease in chest pain frequency and improved quality of life after attending...
The study found that the probability of surviving cardiac arrest outside hospital has more than doubled in 30 years, from approximately 5% to 11%. The improvement is attributed to increased CPR training and better healthcare resources. However, ambulance delays and an increase in difficult-to-treat cases are hindering further progress.
Researchers developed a polygenic risk score to predict sudden cardiac death in coronary artery disease patients. The study found that patients with high genetic risk scores had a 77% increased risk of sudden cardiac death.
TCT 2022 will feature late-breaking clinical science presenting the safety and effectiveness of minimally invasive techniques, pharmaceuticals, technologies, and devices for treating or preventing cardiovascular disease. The event takes place September 16-19 in Boston at the Boston Convention and Exhibition Center.
A VA study found nearly identical genetic variations contributing to coronary heart disease risk across major racial and ethnic backgrounds. The findings suggest that other factors like access to healthcare contribute to higher heart disease rates in certain populations.
The Women's Preventive Services Initiative issues guidelines for preventing obesity in midlife women, recommending counseling on healthy eating and physical activity. The guideline aims to mitigate concerns about weight stigma by normalizing counseling among all midlife women, regardless of BMI status.
A new analysis from the Family Heart Foundation shows that only 31.3% of individuals with familial hypercholesterolemia (FH) in its database had been diagnosed as of June 2020. This represents a significant increase since 2016, but highlights the ongoing challenge of diagnosing and managing the condition.
Researchers have created a new DNA atlas that provides insights into how genes in specific cells contribute to coronary artery disease. The atlas identifies over 200 independent genetic markers associated with disease risk, offering a potential roadmap for interpreting non-coding variants.
The Heart and Lung Research Institute (HLRI) at the University of Cambridge will bring together over 380 researchers and clinicians to tackle cardiovascular and respiratory diseases. The institute aims to deliver high-impact research to drive breakthroughs in prevention, early diagnosis, and treatment of these diseases, which represent...
A new study published in Behavior Genetics found that natural selection favors characteristics associated with lower earnings and poorer education, such as having more children. The research, led by UEA, analyzed data from over 300,000 people in the UK and suggests that this may be contributing to increasing income inequality.
A long-term study of 3,926 adults with CKD found that higher levels of physical activity reduced the risk of atherosclerotic events, new-onset heart failure, and death. The association was strongest for incident peripheral arterial disease and reinforces current guideline recommendations.
Researchers developed an AI method to automatically detect plaque erosion in heart arteries using OCT images. The new technique uses neural networks and post-processing algorithms to predict regions of possible plaque erosion and refine the initial prediction based on clinically interpretable features.
A novel study published in the Canadian Journal of Cardiology demonstrates that Nordic walking provides greater long-term improvements in functional capacity compared to high-intensity interval training and moderate-to-vigorous intensity continuous training. Nordic walking engages core, upper, and lower body muscles, resulting in a sig...
Researchers found a potential association between COVID-19 vaccines and an increased risk of coagulation disorders and coronary artery disease events. The study analyzed data from Norway, Finland, and Denmark to investigate this connection.
A study using PET imaging found that severe obstructive sleep apnea is associated with abnormal heart blood flow reserve, increasing the risk of heart disease. The findings suggest that cardiac PET imaging can identify high-risk OSA patients.
A long-term study found that cigarette smoking significantly increases the risk of developing both reduced ejection fraction and preserved ejection fraction heart failure. Former smokers retained a higher risk of heart failure for decades after quitting, with the risk decreasing only after 30 years without smoking.
Researchers from NTU and NUS found a link between NAFLD and blood vessel damage, leading to increased risks of cardiovascular diseases. High levels of chemokines attract immune cells into blood vessels, causing inflammation and damage.
A new analysis of the PROGRESS-CTO registry shows a significant increase in successful CTO PCI procedures, with higher efficiency and lower risk of complications. The findings demonstrate improved operator training and real-world experience leading to better patient outcomes.
A nationwide study reveals lower rates of cardiac catheterization and revascularization among non-Hispanic Black patients with a history of cocaine use compared to white patients. The findings suggest implicit bias in treatment, emphasizing the need for health equity.
Researchers at UC San Diego School of Medicine found that COVID-19, MIS-C and Kawasaki disease share similar underlying molecular patterns. The study reveals that MIS-C is a more severe version of the immune response than KD, with potential implications for improved disease diagnosis and treatment.
A new study reveals that allergic asthma is a significant risk factor for human cardiovascular diseases, with certain medications affecting heart health. Researchers found that inflammatory cells play a crucial role in both conditions and that targeting them may lead to better treatment options.
Scientists use advanced measurement methods to study carotid artery stenosis, discovering significant gaps between their findings and clinical methods. They propose improvements for surgical treatment technology and future medical devices.
A new study from Norway found that COPD patients have a higher degree of coronary artery calcification and narrower coronary arteries. The researchers discovered an increased risk of coronary disease in COPD patients, independent of disease severity, emphasizing the importance of early detection.
A study by Kobe University researchers has illuminated the characteristics of Myeloid immune cells in coronary plaque, a major contributor to acute coronary syndrome. The findings suggest that macrophages and monocytes accumulate in the plaques of patients with acute coronary syndrome, leading to increased inflammation.