Articles tagged with Hypertension
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Researchers developed an experimental rat model that mimics the plexiform lesion in pulmonary arterial hypertension (PAH), a life-threatening problem. The model is expected to reveal detailed cellular and molecular mechanisms of severe PAH.
Researchers found that anti-inflammatory drugs can preserve kidney function in hypertensive rats by regulating blood pressure on tiny filters called glomeruli. The study aims to understand how kidneys autoregulate pressure and explore the role of inflammatory factors in arteriole dysregulation.
A clinical panel recommends that patients' blood pressure should be closely monitored and controlled before starting angiogenesis inhibitors for cancer treatment. Treating a patient's hypertension before treatment begins and maintaining blood pressure below 140/90 mmHg can help control this side effect.
A study found that individuals with fluctuating blood pressure, in addition to high blood pressure, are at a higher risk of cerebrovascular disease. Fluctuations in blood pressure were associated with an increased risk of cerebrovascular disease, even among those with normal blood pressure.
A study of 2,500 patient records found that medical staff fails to check a child's blood pressure nearly half the time and often misses elevated readings. The consequences are missed development of hypertension and its serious consequences.
Patients with hypertension who excrete slightly increased amounts of protein in the urine, known as microalbuminuria, have an elevated risk of developing heart and kidney problems. Microalbuminuria is associated with a higher risk of chronic kidney disease and cardiovascular complications in non-diabetic patients with hypertension.
Scientists sequenced the genome of the spontaneously hypertensive rat to understand causes of human hypertension. The study identified 788 genes mutated in SHR, including those related to ion transport and immunological processes, which may be causally associated with the disease.
Researchers found that African American boys have higher levels of angiotensin II, a hormone that contributes to high blood pressure, while African American girls have lower levels of protective angiotensin (1-7). These findings suggest that changes in hormone metabolism may occur before blood pressure changes, potentially leading to p...
Researchers investigated the role of Heat Shock Protein-90 (HSP-90) in neural vasoregulation and portal hypertension. They found that HSP-90 is essential for nNOS-mediated vasodilation, a significant finding with potential implications for clinical trials targeting portal hypertension.
Researchers found that dark chocolate reduced damage to blood vessels in cirrhotic patients and lowered blood pressure. In contrast, white chocolate had no beneficial effects on portal hypertension.
A recent NIH study found that vitamin C and E supplements starting in early pregnancy do not reduce the risk of hypertensive disorders and their complications. The supplements did not show any significant difference in preeclampsia or other pregnancy-related hypertension complications, contradicting earlier small studies.
Researchers found an inverse association between high systolic blood pressure and mortality risk, with those having high BP having a favorable prognosis. Patients with higher systolic BP had lower mortality rates compared to those with lower BP levels.
A new study found a direct link between chronic loneliness and increased blood pressure over four years, independent of age and other factors. Even modest levels of loneliness can lead to significant increases in blood pressure.
LCZ696, a new dual-action drug, has been shown to provide significantly greater reductions in blood pressure than the established ARB valsartan. The drug's dual mechanism of action, blocking both angiotensin II and neprilysin, may offer superior benefits for treating hypertension and heart failure.
Researchers at Georgetown University Medical Center found that female sex chromosomes, not just hormones, help regulate blood pressure. Male mice with female sex chromosomes experience hypertension seen in postmenopausal women.
Researchers found that lowering systolic blood pressure below 115 can increase cardiovascular risk for patients with diabetes and coronary artery disease. This new data challenges traditional guidelines recommending lower blood pressure levels as better.
A research team at Oregon Health & Science University has discovered that nitric oxide is a powerful regulator of brain-derived neurotrophic factor (BDNF), a molecule involved in the development and function of the nervous system. This finding could play a significant role in preventing and treating high blood pressure.
A study suggests that variability in blood pressure can be a strong predictor of stroke and other cardiovascular events, independent of mean blood pressure. The researchers found that patients with the most variation in systolic blood pressure were six times more likely to have a stroke.
Early treatment reduces glaucoma risk in high-risk individuals, but delaying treatment may not offer significant benefits for those at low risk. An individualized assessment can aid patients and clinicians in making informed treatment decisions.
A study published in the Journal of Cardiovascular Pharmacology and Therapeutics reveals Pycnogenol lowers urinary proteins and improves blood flow to the kidneys. Pycnogenol also reduced systolic and diastolic blood pressure, as well as inflammatory markers.
The ACCOMPLISH study shows that initial treatment with benazepril plus amlodipine reduces CKD progression more effectively than benazepril plus hydrochlorothiazide. This benefit was seen in patients at high risk for cardiovascular events.
A Mediterranean-like diet was found to be associated with a lower risk of brain infarcts and areas of dead tissue linked to thinking problems. Researchers assessed the diets of 712 people and found those who closely followed the diet were 36% less likely to have brain damage.
A study of 990 older adults found that hypertension predicts dementia progression in those with executive function deficits, but not in those with memory dysfunction. Control of hypertension may decrease the projected rate of dementia progression by half.
Researchers found that new immigrants to Ontario, Canada had a 30% lower rate of strokes at age 16-65 compared to long-term residents. The study controlled for factors such as income level, smoking, and history of diseases like high blood pressure and diabetes.
A large-scale research project at the University of Copenhagen found that soccer is an effective form of exercise for improving cardiovascular risk factors, including maximal oxygen uptake and blood pressure. Small-sided games also showed significant gains in terms of cardio and strength training.
A survey by the University of Michigan Medical School found that 28% of doctors and their diabetic patients do not agree on the most important health conditions to manage. Diabetics were more likely to prioritize symptoms such as pain and depression, while doctors focused on diabetes and hypertension.
A new study found that childhood obesity can increase the risk of future heart disease and stroke as early as age 7, regardless of other health factors. Obese children had abnormal blood markers, including inflammation and clotting, compared to their lean counterparts.
A systematic review found that combining beta-blockers with certain anti-hypertensive drugs significantly lowers blood pressure in patients. The combination therapy resulted in a 30% greater reduction in blood pressure compared to single drug therapy.
A new study reveals that Caribbean-origin Hispanics have a higher prevalence of hypertension, while Mexicans are more susceptible to diabetes. The research highlights the importance of considering crucial distinctions among Hispanic ethnic subgroups to prevent adverse cardiovascular events.
A study by the University of Gothenburg found that young Swedish men are consuming at least double the recommended daily amount of salt. The high salt intake may lead to high blood pressure, a major risk factor for heart problems and stroke, although no direct connection was detected in the study.
Research from the Women's Health Initiative Memory Study finds elevated blood pressure increases white matter lesions, a known risk factor for dementia. Maintaining normal blood pressure may help prevent brain damage and associated cognitive decline.
Research from the University of Pittsburgh Graduate School of Public Health found that high blood pressure is associated with white matter abnormalities in the brain, which can lead to dementia. Women who had hypertension at age 65 were more likely to develop dementia eight years later.
The National Salt Reduction Initiative proposes targets to reduce sodium levels in packaged and restaurant foods by 25% over five years. The initiative aims to decrease the nation's salt intake by 20% and prevent thousands of premature deaths.
Research suggests that low vitamin D levels are an independent risk factor for cardiovascular disease and may contribute to higher cardiovascular risk among blacks. The study found that accounting for vitamin D levels reduced the race-based risk of cardiovascular mortality by 60 percent.
A new therapeutic approach to treating hypertension may be possible using an enzyme called ACE2, which breaks down angiotensin II in the system. This approach could provide a more complete and effective suppression of the renin-angiotensin system, treating not just hypertension but also other medical conditions.
A study found that patients with a specific gene variant are twice as likely to develop congestive heart failure, suggesting a genetic link between vitamin D action and heart disease. The research analyzed the genetic profiles of 617 subjects and identified a critical enzyme associated with the development of congestive heart failure.
Researchers have identified a novel gene, phosducin, that modulates high blood pressure in response to stress. The studies found that mice lacking the gene developed high blood pressure under stress, while certain DNA variants serve as markers for increased blood pressure risk in humans.
Researchers identify phosducin's role in modulating blood pressure in response to stress, finding increased baseline and stress-dependent blood pressure in mice and humans. The study suggests phosducin as a promising target for developing drugs to alleviate stress-induced hypertension.
Patients treated with team-based care involving pharmacists achieved lower blood pressure levels and were more likely to reach blood pressure control goals compared to those without this approach. The study found significant improvements in mean blood pressure and overall blood pressure control rates.
A study found that nearly 40% of children with chronic kidney disease have masked hypertension, which increases the risk of heart problems. Children with masked hypertension are four times more likely to develop left ventricular hypertrophy, a common consequence of untreated hypertension.
A new study published in the American Journal of Hypertension found that Transcendental Meditation significantly reduces blood pressure, anxiety and depression in young adults at risk for hypertension. The three-month intervention program showed a 52% lower risk of developing hypertension in later years.
A protein long thought secondary to stressors like hypertension is actually a primary regulator according to researchers. Knocking out GSK-3alpha causes significant hypertrophy in mice models. The findings also suggest GSK-3alpha as a positive regulator of the beta-adrenergic system, potentially helping failing hearts pump better.
A new study from Johns Hopkins Medicine suggests that young athletes should undergo both EKG and echocardiogram screenings to detect early signs of life-threatening heart defects. Abnormal findings were discovered in 36 athletes, highlighting the importance of comprehensive screening programs.
A study found that one-third of children with CKD have masked hypertension, which increases the risk of left ventricular hypertrophy and heart disease. Children with masked hypertension are four times more likely to develop LVH, highlighting the need for regular blood pressure monitoring outside the clinic.
A prospective study found obesity and hypertension to be independent predictors of left atrial enlargement, increasing the risk of atrial fibrillation, stroke, and death. Obesity was associated with greater increases in left atrial volume and incidence of LAE compared to hypertension.
A special issue of a medical journal examines Latino health disparities, including chronic diseases like hypertension and diabetes. It also highlights the lack of access to primary care services and patient-centered medical homes among Latinos.
Researchers at Thomas Jefferson University have received $3.9 million in Challenge grant funds to tackle specific scientific and health research challenges in biomedical and behavioral sciences. Drs. Flemming Forsberg, Laura N. Gitlin, Maurizio Pacifici, and Scott Waldman will study portal venous pressure, depression treatment, Heredit...
Research suggests that high blood pressure and inflammatory markers are more prevalent in middle age among individuals with a family history of Alzheimer's disease. The study also found that these risk factors cluster within families, highlighting the potential for early interventions to prevent late-onset Alzheimer's disease.
Researchers at the University of Warwick have identified central obesity, high blood pressure, and high blood sugar as the most dangerous combination of health factors for developing metabolic syndrome. This combination can increase the risk of heart attack by doubling it and mortality rates by three times.
A diet high in fructose increases the risk of developing high blood pressure. Studies found that consuming more than 74 grams per day of fructose led to a higher risk of hypertension, with significant associations seen across various blood pressure levels.
The Systolic Blood Pressure Intervention Trial (SPRINT) aims to determine whether maintaining blood pressure levels below current recommendations reduces cardiovascular and kidney disease risk. The nine-year trial will enroll over 7,500 participants aged 55+ with high systolic blood pressure.
A study by University of Rochester Medical Center evaluates the cost effectiveness of an experimental blood pressure device called Rheos. The research suggests that Rheos can be a cost-effective treatment for individuals with drug-resistant hypertension, especially those with extremely high blood pressure or diabetes.
Research found a higher incidence of chronic rhinosinusitis among patients with other chronic diseases, particularly asthma. The study suggests that some chronic diseases may share common mechanisms of how they arise or progress, highlighting the need for further investigation into the relationship between CRS and other conditions.
Research found that premenopausal women with vitamin D deficiency were three times more likely to develop systolic hypertension 15 years later. Vitamin D has a well-established role in bone health, and deficiency may also increase cancer risk and immune function problems.
A five-year study at Penn State will analyze hypertension in humans and laboratory conditions, shedding light on potential therapeutic strategies for people with essential hypertension. The study aims to understand how hypertension affects the body's cardiovascular system and its impact on individuals.
Excessive sodium consumption linked to high blood pressure, cardiovascular disease, and various cancers. A population-wide reduction in sodium intake could prevent significant cardiovascular events.
A new endothelin type A antagonist, darusentan, provides significant reduction in blood pressure for patients with treatment-resistant hypertension. The study shows that darusentan is generally well-tolerated, but fluid retention is a main adverse effect.
A new study estimates that reducing Americans' average intake of sodium to recommended levels could save the nation $18 billion annually in avoided health care costs. Meeting national sodium guidelines could also eliminate 11 million cases of high blood pressure nationally and extend thousands of lives each year.
Research suggests that living close to noisy roads increases the risk of developing hypertension and cardiovascular diseases. The study found modest exposure effects at lower noise levels, but more marked effects among younger and middle-aged populations.
A new study by the University of Florida combines socio-cultural and genetic data to reveal health disparities between different groups. The research suggests that social classification is a better predictor of disease status than genetic ancestry.