Articles tagged with Infectious Diseases
Researchers at Karolinska Institutet have conducted a Phase 2 UNITY clinical trial involving pregnant women with a history of very severe HDFN. Nipocalimab was found to prevent and mitigate the disease without causing serious side effects in the mother or fetus.
A clinical study in Birmingham has found that nipocalimab can improve the survival rate of unborn babies with rare fetal anaemia. The majority of pregnant patients who received nipocalimab gave birth at or after 32 weeks without needing an intrauterine transfusion, resulting in a perinatal survival rate of 92%.
Researchers have trained dogs to sniff out Chronic Wasting Disease (CWD) in the droppings of farmed and wild deer. This method offers a promising non-invasive approach for detecting CWD.
A team of researchers from Stanford University and Brazil has developed models to predict the impact of environmental changes on schistosomiasis, a disease affecting over 200 million people worldwide. The collaboration has helped epidemiologists prioritize public health interventions and identify new transmission hotspots.
A comprehensive meta-analysis found that interventions increasing access to vaccines and providing transportation assistance tripled vaccination odds, particularly in low-income countries. Financial incentives also showed a moderate effect, but were less impactful.
A new study reveals that blowflies in southern Japan are carrying the bird flu virus, which could lead to transmission through contaminated surfaces, food sources, and water. This finding highlights the need for effective countermeasures to prevent and control the disease in poultry farms.
Researchers find significant association between illicit fentanyl use and HCV transmission, highlighting need for point-of-care testing and treatment access. The study suggests that fentanyl's short half-life may lead to increased risk of HCV transmission through frequent dosing and sharing.
A preclinical study led by Weill Cornell Medicine researchers found that the iron-chelating drug deferiprone can selectively target and kill ovarian cancer cells. By starving cancer cells of iron, deferiprone triggers a cellular stress response, prompting the immune system to attack them.
A Madrid study found a significant decrease in active hepatitis C infection among people who use drugs (PWUD) from 23% to 6% between 2017 and 2023. The study attributed this decline to improved access to testing and treatment, as well as public health campaigns.
The study tested wearable sensors and associated alerts to guide people's behavior, finding that personalized timing and symptom-based notifications led to higher self-test rates. The researchers also emphasized the importance of designing and clinically implementing new wearable sensors that track various health parameters.
A study by Dr. Takanori Sekito and colleagues reveals a strong association between vaginal pathogenic Escherichia coli and recurrent cystitis in postmenopausal women, suggesting that targeting both the urinary bladder and vagina is crucial for effective treatment.
A Cleveland Clinic-led study found that maternal Zika virus infections can reprogram fetal immune development, leading to long-term consequences in children's immunity. The changes occur even in children born without physical or neurological symptoms of congenital Zika syndrome, suggesting a broader impact.
The new guidelines from the Surgical Infection Society offer updated recommendations for antimicrobial agent selection, source control, and treatment of specific pathogens. These evidence-based guidelines aim to improve clinical outcomes and reduce mortality rates from intra-abdominal infections globally.
Researchers found that certain flu viruses can use a second entry pathway, MHC class II protein complexes, to infect human and animal cells. This ability helps the viruses infect different species and potentially jump between animals and humans.
Pamela J. Bjorkman, K. Christopher Garcia, and Ian A. Wilson receive inaugural prize for their groundbreaking research in structural immunology, which has paved the way for novel disease treatments and revealed new insights into the immune system.
Researchers developed a strategy to identify new antimicrobial drugs with therapeutic promise from bacterial datasets. PHAb10 and PHAb11 showed robust antibacterial activity against various bacterial species, including those resistant to traditional antibiotics.
Researchers identified six priority pathogens for WWS during the Paris 2024 Games, including poliovirus, influenza A virus, and SARS-CoV-2. The study offers a model framework for context-specific WWS targets in mass gatherings.
A team of researchers has discovered a mechanism by which the liver's immune cells are suppressed in chronic hepatitis B, leading to organ damage. The 'sleep timer' function allows immune cells to weaken their activity over time, preventing them from proliferating excessively and causing further damage.
Researchers discovered Pradimicin A's molecular basis for binding to viral N-glycan, showing promise as an anti-SARS-CoV-2 drug. The compound inhibits SARS-CoV-2 infectivity by interacting with branched oligomannose-containing glycans.
Scientists have developed a new immunotherapy that can identify and fight cancer cells in patients with Merkel cell carcinoma. The treatment involves stimulating the immune system's T cells against specific elements of the virus involved in cancer formation.
Genital herpes infections have a significant global impact, with estimated health care expenditures and productivity losses totaling $13 billion annually. The study highlights the need for increased investment in preventing herpes transmission, including the development of effective vaccines.
Researchers found that H5N1 virus particles in unpasteurized milk can remain stable on metal and rubber components of commercial milking equipment for over an hour. This increases the potential for bird flu exposure among dairy farm workers and animal-to-animal transmission.
A new mathematical model suggests that waiting two days after symptoms arise for rapid COVID tests can increase accuracy by reducing false negatives. The model also recommends a 'test-to-exit' strategy to prevent infections and minimize inconvenience, which may be more effective than the five-day isolation policy.
Researchers at Georgia Tech have developed a method to improve adoptive T-cell therapy using nanowires to deliver therapeutic miRNA to naïve T-cells. This approach retains the cells' naïve state, making them more effective disease fighters when infused back into patients.
Researchers found a consistent positive relation between social media use and vaccination across all major political parties. For Democrats, social media exposure predicted greater vaccine uptake due to increased information about new pathogens. For Republicans, believing others were vaccinated was the key factor.
Researchers have identified a new tuberculosis vaccine candidate recombinant protein MDP1 with additional post-translational modifications occurring in Mycobacterium tuberculosis cells. When expressed in M. smegmatis, MDP1 triggered notably higher levels of IFN-gamma production compared to E. coli-expressed variant.
A recent study by Tokyo Medical and Dental University researchers suggests that a specific variant of the CARD9 gene prevalent across northern China, Korea, and Japan may have originated from a common ancestor. The c.820dup variant was found to be relatively common in China and has been estimated to be between 2,000 and 4,000 years old...
Researchers discovered that Klebsiella oxytoca bacteria compete with salmonella for nutrients, employing multiple strategies to combat the spread of the infection. The bacteria also produce a toxin that has anti-salmonella effects, which may be harnessed to develop new treatments.
A new molecular test WID-qCIN detects significantly more cancers and precancerous stages than current methods, identifying 100% of invasive cervical cancer and 93% of serious precancerous lesions. The test reduces the need for colposcopy examinations by 40%, improving the effectiveness of screening programs.
Researchers identified two groups of follicular helper lymphocytes that produce different types of antibodies in response to virus infections and allergies. This discovery could lead to new treatments for allergy diseases without affecting immune responses to infections.
The ACCELERATE program aims to enhance educational experiences of HCC students, providing access to resources and opportunities for biomedical research training. Students will participate in extracurricular laboratory modules, immersive research training, and mentorship programs.
Researchers have identified genetic changes that can leave children born with little to no immune defense against infection. The study links mutations in the NUDCD3 gene to Severe Combined Immunodeficiency and Omenn syndrome, rare and life-threatening immunodeficiency disorders.
A novel real-time PCR method has been developed to detect and identify the emerging zoonotic foodborne pathogen E. albertii, which is often misidentified as E. coli. The study found that E. albertii can survive in the human intestinal tract for approximately four weeks.
A new Cochrane review suggests that taking zinc may reduce the duration of common cold symptoms by around two days, but the evidence is not conclusive. Common side-effects include bowel problems, nausea, and unpleasant taste.
A new study suggests that countries should prioritize tuberculosis treatment for exposed individuals with evidence of TB infection, regardless of age—except in high-burden settings, where all exposed individuals should be considered for treatment. Preventive treatment can stop latent TB infections from developing into deadly TB disease.
Researchers created panoramic view of infection pathways in human placenta, highlighting potential drug targets for severe pregnancy complications. The study used 'mini placenta' models to map placental response to infections in early development, revealing secondary inflammation as a cause of complications.
The disease has devastated susceptible coral species, allowing fast-growing organisms like algae to thrive. This shift in ecosystem balance poses long-term threats to marine biodiversity and coastal communities, with potential benefits including reduced competition for herbivores.
Researchers at George Mason University have developed a urine test for Lyme disease that detects the bacteria causing the infection, leading to earlier treatment and prevention of long-term debilitating effects. The test has shown high sensitivity and specificity, and will be made available through telehealth to increase accessibility.
A new ultraviolet light technology called far-UVC has been shown to be effective in killing viruses and bacteria without the safety concerns of conventional UV light. This technology could help reduce the risk of healthcare infections and even the next pandemic by continuously decontaminating occupied spaces.
The Campos Lab will investigate how human papillomavirus moves from lower epithelial cells to the upper layers and into the nucleus, where it hijacks the cell to make copies of itself. By understanding this process, researchers hope to shed light on cell division and viral transmission.
Researchers at Tulane University identified a promising new approach to treating persistent neurological symptoms associated with Lyme disease. Fibroblast growth factor receptor inhibitors showed promise in reducing inflammation and cell death in brain and nerve tissue samples infected with Borrelia burgdorferi.
A new study found that younger people from high-income areas accessed vaccines ahead of schedule, particularly in New York City. This led to lower coverage rates in low-income areas with high proportions of older residents, resulting in higher mortality rates over the year.
A Danish study found that PrEP use was associated with a more than twofold increase in chlamydia, gonorrhea, and syphilis diagnoses. The researchers suggest that changes in sexual risk-taking may lead people to seek PrEP rather than increased risks.
Researchers found that a simple pre-surgical infection prevention protocol involving povidone-iodine and skin antisepsis significantly reduced severe surgical site infections. The protocol eradicated Staphylococcus aureus in nearly 40% of patients, with a three-fold risk of developing an SSI associated with its presence within a day af...
Researchers have identified a combination of medications that may improve blood flow within granulomas, benefiting drug delivery and reducing bacterial burden in tuberculosis-infected rabbits. The study leverages decades of cancer research to study tuberculosis-affected lung tissue and improves treatment.
Researchers found that humans transfer viruses to domestic and wild animals at a rate twice that of animal-to-human transmission, highlighting the importance of monitoring viral exchange between species. This study's findings have significant implications for understanding zoonotic diseases and conservation efforts.
A newly developed compound is showing promise as a more effective treatment for human schistosomiasis, an understudied tropical disease caused by parasitic worms. The compound overcomes the limitations of current treatment praziquantel by being effective against the larval stage and resistant strains.
A systematic review by Gogichadze et al. suggests that active pulmonary TB screening programs targeting vulnerable populations in low-TB-incidence countries are cost-effective. The authors conclude that screening immigrants and other high-risk groups is a viable approach to detecting latent infections.
A study of two large European patient cohorts found that increased abundance of butyrate-producing gut bacteria is associated with reduced risk of hospitalization for infections. Each 10% increase in these bacteria resulted in a 14-25% lower risk of hospitalization, regardless of demographics or comorbidities.
Researchers support increased genomic sequencing of dengue for better understanding of genetic diversity, transmission dynamics, and virulence. This could lead to the development of vaccines that don't require pre-screening for serotypes, enabling more efficient vaccination campaigns against this global disease.
Researchers found that genetic variants in the Fore population made them resistant to kuru, while a large influx of females migrated into the region due to flexible kinship systems. The study suggests an alternative theory on how Fore communities interacted with neighboring communities despite fears of kuru.
The American Society for Biochemistry and Molecular Biology's annual meeting features exciting research findings on antibacterial compounds, whooping cough infection, nicotine addiction, and more. Complementary on-site press passes will be issued to a limited number of attendees.
The uOttawa Faculty of Medicine is encouraging its counterparts to replicate its leadership in planetary health by creating a Director of Planetary Health position. This move aims to prioritize the health of the planet and address the escalating urgency of the climate crisis.
A competition among researchers predicted B. pertussis vaccine responses based on a simple correlation between calendar age and antibody responses. The result highlights the need for further research to understand variability in vaccination outcomes.
A new study finds that the high burden of typhoid fever in sub-Saharan African countries calls for stronger prevention strategies, including the use and implementation of typhoid conjugate vaccines. The study estimates that there are 12.5 to 16.3 million cases of typhoid every year with 140,000 deaths.
European Centre for Disease Prevention and Control reports significant increase in STI cases across Europe, with gonorrhoea cases rising by 48%, syphilis cases by 34%, and chlamydia cases by 16%. The surge highlights the need for enhanced prevention, access to testing, and effective treatment to address this public health challenge.
A novel antibody constant region variant (REW) extends plasma half-life and improves biodistribution, allowing for both invasive and non-invasive delivery. The REW technology also enhances the complement system, providing enhanced ability to kill cancer cells and bacteria.
ISB researchers identify NKG2A-biased immune responses as protective against decreased inflammation and increased survival rates in various disease contexts. The study suggests potential therapeutic targets for modifying immune responses across diseases.
A study of 372 veterans found that COVID-19 infection negatively impacted everyday functioning via multiple pathways. The negative effects on functioning persisted even without a documented COVID-19 infection.
A UC Riverside-led study has devised a way to make large quantities of the Membrane protein, which plays a crucial role in how SARS-CoV-2 acquires its spherical structure. The researchers found that when the M protein interacts with the membrane, it coaxes the membrane to curve, leading to the virus's characteristic shape.