Articles tagged with Metastasis
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Researchers at UC San Diego School of Medicine discovered G proteins signaling on membranes inside cells, controlling Golgi trafficking and enzyme secretion. Inhibition of protein GIV was shown to delay enzyme secretion and inhibit key cancer-driving signals.
Researchers developed a microfluidic chip that uses sound waves to separate circulating tumor cells from white blood cells, achieving a throughput rate up to 20 times faster than prior attempts. The device preserves the integrity of separated CTCs and offers a label-free approach without chemically altering the cells.
A new study found that cells within metastases from prostate tumors can migrate to other body parts and form new sites of spread on their own. This challenges the long-held belief that cells with metastatic potential originate solely from the original tumor site.
Breast tumors trick immune cells to produce neutrophils that block T-cell action, allowing cancer to spread. Anti-IL17 drugs already exist for inflammatory diseases, offering potential treatment for metastatic breast cancer.
Cancer cells with high stress granule levels are more likely to metastasize. Removing YB-1 reduces stress granule formation and decreases metastatic spread in animal models.
Researchers at Children's Hospital Los Angeles have identified a new role for VEGFA in the metastasis of neuroblastoma. The study found that an increase in bone deposition occurs when NB cells metastasize to the bone, driven by VEGFA, leading to increased bone resorption and severe bone loss.
Scientists at MD Anderson Cancer Center discovered a vital connection between the Hippo pathway and glucose metabolism, which can be manipulated to regulate tumor growth. The study found that regulating blood sugar levels impacts the nutrient source of tumors, ultimately leading to cancer suppression.
Researchers from Boston University School of Medicine shed new light on tumor metastasis, proposing a hypothesis that reversible epigenetic events regulate different types of metastatic cancers. Epigenetics enables cancer progenitor cells to differentiate into metastatic tumors.
A genome-scale CRISPR-Cas9 screen in a mouse model of non-small cell lung cancer reveals genes involved in tumor evolution and metastasis. The study highlights well-known tumor suppressor genes and identifies several microRNAs that promote tumor growth.
Researchers found that a secreted immune protein called interleukin(IL)-17B promotes pancreatic cancer growth and metastasis. Treating tumor-bearing mice with an IL-17B inhibitor halted tumor growth and spread, resulting in increased survival.
Researchers at the Montreal Neurological Institute and Hospital have discovered a new mechanism driving cancer cell metastasis, focusing attention on the biological role of DENND2B protein. The study highlights Rab13 as an enzyme promoting cell migration in cancer cells.
A study found that both fruit flies and mice exhibit similar cellular and genetic features during ovulation, including the degradation of follicle cells and the role of Matrix metalloproteinase (Mmp) enzymes. These similarities suggest a conserved basic mechanism in ovulation across animals.
A study by Menashe Bar-Eli and colleagues found that a lack of RNA editing contributes to melanoma tumor growth and metastasis by manipulating proteins. The researchers identified a previously unknown target for CREB, a transcription factor involved in melanoma development.
Researchers found that certain HPV+ oropharyngeal cancer patients can survive for over two years without further disease after intensive treatment. The study identified key factors contributing to the survival advantage, including cancer sensitivity to radiotherapy and chemotherapy.
Researchers found that collagen cross-links play a crucial role in regulating stromal stiffness and determining tumor cell metastatic fate. The study identified two types of collagen cross-links, HLCC and LCC, which are associated with different levels of tumor growth and spread.
Researchers at the University of Chicago Medical Center have created a new screening tool for ovarian cancer that can rapidly test compounds to block metastasis. The three-dimensional cell-culture system mimics human tissue and has identified small molecules that inhibit adhesion and invasion.
A new study explains how a protein that suppresses tumors can also promote metastasis in breast cancer cells. Researchers found that 14-3-3 zeta destabilizes key proteins p53 and GLi2, switching off TGF-β's tumor-suppressing abilities while promoting cancer spread.
Researchers discovered that cells with low levels of profilin 1 protein in breast tumors have increased capacity to metastasize and invade other tissues. The protein regulates the formation of invasive structures called invadopodia, which play a critical role in tumor invasion and metastasis.
Researchers Weissman and Massagué win prestigious prize for their groundbreaking work on cancer stem cells and metastatic spread. Their research aims to develop targeted treatments by understanding the connection between cancer stem cells and immune system control.
Researchers suggest inhibition of Sirtuin1 protein as a future treatment option for metastatic Ewing sarcoma. The study found overexpression of sirtuin 1 significantly correlated with metastasis in patient samples, opening the door to treatment of aggressive tumors.
Moffitt researchers identify a key protein pathway involved in the spread of lung cancer, including beta-arrestin-1 and E2F1. Blocking this pathway may offer new therapeutic strategies to combat lung cancer metastasis.
A new study by Rice University researchers shows how cancer cells use 'jagged' proteins to hijack cell-signaling process and promote metastasis. The mechanism plays a crucial role in embryonic development and wound healing.
A team of researchers identified a key epigenetic factor EZH2 that plays a central role in controlling tumor growth and metastasis in melanoma. The study found that suppressing EZH2 activity can prevent the growth and spread of cancer cells, offering new hope for cancer treatment.
A team led by Dr. Andrew Craig is developing inhibitory antibodies targeting key signals that cancer cells require for metastasis. The goal is to identify lead antibodies and test their potency in pre-clinical models to develop new immunotherapies for clinical trials.
A recent study published in JAMA Surgery found that patients with metastatic colorectal cancer are experiencing a decrease in primary tumor resection rates. Despite this decrease, overall survival rates for these patients have improved, indicating potential overutilization of surgery in certain patient populations.
A study of nearly 375,000 US women with invasive breast cancer found that racial and ethnic groups had different rates of early-stage diagnosis and survival. Biological factors, such as tumor aggressiveness and metastatic potential, played a significant role in determining stage at diagnosis.
A new study supports the hypothesis that lung cancer can travel through airways to adjacent lung tissue. This finding has significant implications for diagnosis and management of primary lung adenocarcinoma.
Researchers found that decreasing CHI3L1 levels slows the spread of two different kinds of cancer to the lungs of mice. This suggests addressing dysregulation is key in fighting metastasis and may lead to new treatments, such as preventing or delaying cancer spread after surgery.
Breast cancer cells can spread throughout the body when they overexpress the gene SNAIL, which helps them break free from the primary tumor and become more mobile. This unique blend of microarray analysis and characterization of physical changes in breast cancer cells could aid the search for ways to block or slow metastasis.
A University of Colorado Cancer Center study reveals that triple-negative breast cancer cells process tryptophan to promote survival while detached, allowing them to metastasize. The kynurenine pathway, specifically the enzyme TDO2, plays a key role in degrading tryptophan and evading anoikis.
A study at Dana-Farber Cancer Institute found that a narrow subset of myeloma cells is responsible for metastasis. The researchers identified 11 genes with functional roles in metastasis and proposed these as potential targets for therapies.
Hepatitis B virus (HBV) infection is associated with a complex tumor microenvironment in hepatocellular carcinoma (HCC), leading to carcinogenic progression. Targeted therapies targeting the microenvironment offer promise for treating this disease.
Researchers have found that blocking the CCR5 receptor with an HIV drug can significantly reduce metastasis to the bone in prostate cancer. This breakthrough suggests a potential new treatment approach for patients with advanced prostate cancer.
Researchers have found that specific cells are required for the spread of breast cancer, which could lead to new anti-cancer therapies and improve predictive tests. The study combined tumor cells from patients with breast cancer with laboratory models and found a correlation between high MenaINV levels and metastasis.
Researchers found high-dose interleukin-2 to be effective in metastatic renal cell cancer patients pre-treated with VEGF-targeted agents, achieving durable complete responses in a selected population. The therapy's efficacy and safety were confirmed, offering an alternative treatment option for carefully selected patients.
Research shows that brain metastases have dense concentrations of tumour infiltrating lymphocytes, providing an immunoactive environment. High expression of PDL1 is common in both glioblastoma and brain metastases, making immune checkpoint inhibitors a promising treatment option.
Researchers at MD Anderson Cancer Center have identified a protein complex called CSN and its subunit CSN6 as a key factor in cancer development. The study found that inhibiting CSN6 can quickly destabilize the master cancer gene Myc, greatly impairing tumor growth and metastasis.
Researchers found that cirmtuzumab induces senescence in cancer stem cells, degrading their ability to grow and metastasize. Ovarian cancer patients with high levels of ROR1 experienced more aggressive forms of the disease, highlighting the potential of this antibody therapy as a targeted treatment.
Researchers at NUS and their collaborators developed a novel scoring scheme that predicts the ability of cancer cells to spread. The system monitors epithelial-mesenchymal transition (EMT) mechanism, a key process in metastasis, and has shown good correlation with previously published EMT signatures.
Researchers identified a cellular culprit in metastasis, finding that an overabundance of Frizzled-2 and its activator Wnt5 triggers EMT in cancer cells. This discovery informs the design of new treatments to prevent or delay metastasis.
A phase 2 clinical trial found that adding sargramostim to ipilimumab improved overall survival in patients with metastatic melanoma. The combination treatment also had lower toxicity compared to ipilimumab alone.
Cancer cells use genetic circuits as a three-way switch to form both cancer stem cells and circulating tumor cells, leading to metastasis. Researchers found significant correspondence between the operation of these two switches, suggesting a mechanism that would confer 'stemness' on hybrid cancer cells.
A new lab device developed by Johns Hopkins engineers provides a clear view of how tumor cells spread through the body, causing over 90% of cancer-related deaths. By studying the movement of individual cancer cells, researchers aim to uncover new ways to keep cancer in check and develop effective treatment strategies.
Ludwig researchers find ASPP2 acts as a molecular switch to regulate EMT and MET, crucial processes in cancer progression. Poor ASPP2 expression correlates with lower patient survival rates in liver and breast tumors.
Research at Beth Israel Deaconess Medical Center identified an unexpected link between the transcription factor FOXP2 and metastatic colonization of breast cancer. Silencing FOXP2 enables breast cancer cells to acquire malignant traits, facilitating their survival and proliferation.
Researchers discovered that high levels of the inhibitor TIMP-1 induce local inflammation in liver tissue, allowing tumor cells to form metastases. By understanding this mechanism, scientists can develop new treatments to prevent cancer progression and metastasis formation.
Researchers created a novel method for cell migration by mimicking the connective tissue environment, allowing cells to move in a controlled direction. This breakthrough could lead to new approaches in combating cancer metastasis and inflammation.
Weian Zhao, a UCI stem cell scientist, has been awarded the prestigious NIH New Innovator Award to create stem cell-based detection methods for cancer. His project aims to engineer smart stem cell systems to target cancer cells and improve treatment outcomes.
A study published in the Journal of the National Cancer Institute finds that osteoporosis treatment may also benefit breast cancer patients by slowing skeletal metastasis. Women who took oral bisphosphonates had a reduced risk of bone metastases, with longer medication use resulting in greater reduction.
The CLEOPATRA study demonstrated a significant survival benefit of 15.7 months with the combination therapy, outperforming previous studies. The long-term safety profile and cardiac safety were also maintained.
Researchers at Dana-Farber Cancer Institute have developed a novel compound that impedes the spread of multiple myeloma to bones in mice. By targeting the microenvironment, the compound alters the bone marrow environment, making it less hospitable to cancer cells, and slows disease progression and prolongs survival.
A study found that postpartum mice develop metastatic disease due to dying tumor cells triggering anti-inflammatory cytokines that promote wound healing. Mice lacking a receptor for macrophage clearance of dying cells did not develop metastasis, highlighting potential targets for limiting postpartum breast cancer severity.
A Massachusetts General Hospital study analyzed circulating tumor cells and found increased expression of extracellular matrix genes, which could be a novel therapeutic target for pancreatic cancer. The study also identified distinct classes of pancreatic CTCs with unique gene expression patterns.
A team of Stanford researchers has developed a protein therapy that disrupts the process of metastasis, which causes cancer cells to break away and spread. The treatment uses a harmless version of Axl protein that acts like a decoy to prevent Gas6 proteins from linking with it.
A new study by MD Anderson Cancer Center researchers found that cancer cells traveling to other sites have different energy needs from their original tumor site counterparts. The study suggests that targeting the protein PGC-1 may be a potential therapeutic approach for breast cancer patients.
The European Society for Medical Oncology calls for high-quality research and clinical trials for advanced breast cancer. Key areas of focus include treatment strategies for patients with liver or lung metastases, HER2-positive disease, and men receiving aromatase inhibitors.
Scientists at VCU Massey Cancer Center have developed a new molecular imaging approach that can image bone metastases from prostate cancer with greater accuracy than existing methods. The new method detects the gene AEG-1, which is expressed in most cancers but not in healthy cells.
A meta-analysis of 757 Stage IV NSCLC patients found that factors such as timing of metastases and lymph node involvement impact overall survival. The study identified three risk groups with different five-year OS rates, and highlighted the importance of identifying patients who are most likely to benefit from aggressive treatments.
A study found that single fraction radiation therapy (SFRT) is equally effective as multiple fraction radiation therapy (MFRT) in improving patients' pain, function, and quality of life, including for those with excluded characteristics. The results support the generalizability of prior randomized controlled trials to real-world practice.
A UK study has identified a novel molecule called Arylquin 1 that induces Par-4 secretion from normal cells, killing cancer cells while leaving normal cells unharmed. The researchers found that Arylquin 1 binds to vimentin, displacing the Par-4 for secretion and may be useful in inhibiting tumor metastasis.