Articles tagged with Metastasis
The Harvard Medical School Cancer Biology and Therapeutics Training Program will provide specialized education and training in cancer research and treatment. The one-year, nonclinical blended-learning certificate program is designed to promote a deeper understanding of cancer biology, diagnosis, and personalized treatments.
A study by researchers at Lund University found that high levels of ALK1 protein in blood vessels increase the risk of metastases. The drug Dalantercept can prevent this spread by blocking ALK1, offering new hope for breast cancer patients.
Researchers found that high levels of ALK1 protein in breast tumor vasculature correlate with increased risk of metastatic disease. An investigational drug targeting ALK1 prevented disease spread in preclinical studies, offering a potential new therapeutic approach for treating metastatic breast cancer.
Min Yu, a USC stem cell researcher, has been named a Pew-Stewart scholar for her work on metastatic breast cancer. She aims to identify molecular adaptations and genetic mutations that allow circulating tumor cells to establish new tumors throughout the body.
Researchers unveiled innovative approaches to cancer treatment and malaria vaccination at the 2015 AAPS National Biotechnology Conference. Dual antibody-coated nanomaterials show promise in capturing circulating tumor cells, while penfluridol suppresses pancreatic tumor growth through autophagy-mediated apoptosis.
A team of researchers from the University of South Florida doubled survival time in an aggressive metastatic cancer model using a novel combination of ketogenic diet and supplements with hyperbaric oxygen therapy. The study shows beneficial effects of ketone supplements in conjunction with non-toxic therapeutic regimens.
Researchers used PET/CT with Ga-68 DOTATOC to detect primary tumors in patients with metastatic neuroendocrine cancer. The study found that 28% of patients underwent a major change in cancer management due to the imaging technique.
Researchers at Arizona State University identify five foundations of multicellularity that cancer cells bypass to fulfill their selfish needs, leading to disastrous outcomes for the organism. The study provides clues about how to diagnose and treat cancer, a disease with rapid evolution capabilities.
Researchers from Mount Sinai Health System will present updates on a lymphoma vaccine clinical trial and new treatment strategies in relapsed multiple myeloma. Preliminary results show patients achieving partial or complete clinical remissions, including those with advanced stage disease.
A large study has found that whole brain radiation therapy (WBRT) significantly worsens cognitive function compared to radiosurgery, and should no longer be used in the adjuvant setting after radiosurgery. WBRT's side effects include hair loss, fatigue, and significant interruptions in systemic therapy.
The PALOMA-3 study found that palbociclib significantly extended progression-free survival for women with hormone-receptor-positive metastatic breast cancer, reducing cancer recurrence by 25% compared to chemotherapy alone. The treatment was well-tolerated and improved quality of life, offering a new hope for women with advanced disease.
Genetically programmed probiotics can detect liver cancer metastases early-on by producing signals easily detectable in urine. The approach may be useful for detecting the disease earlier, increasing chances of survival.
A phase I/II clinical trial found that brigatinib responded to treatment in 58 of 78 ALK+ patients, with a 13.4-month progression-free survival rate for those previously treated with crizotinib. Brigatinib also showed promise in treating brain metastases, with a 30% decrease in tumor size and controlled disease for 15.6 months.
Researchers have identified a molecule, PMEPA1, that promotes metastasis of advanced prostate cancer to the bone, which can lead to incurable conditions. The discovery may offer new targets for diagnosing and treating prostate cancer.
A phase 3 international trial found that ipilimumab improved recurrence-free survival in advanced stage melanoma patients who underwent surgical resection. The study showed that patients with microscopic metastatic disease responded best to ipilimumab treatment.
Researchers developed a new micro-device that separates and analyzes highly mobile cancer cells, which are believed to be the more aggressive cells responsible for metastasis. The study aims to gain an understanding of what makes some cancer cells able to spread to other areas of the body.
Researchers studied 293 patients with brain metastases and blood clots to determine if administering blood-thinning medication was safe. The study found no significant difference in bleeding risk between patients who received a widely used blood thinner and those who did not.
A new blood test has been developed to detect breast cancer metastasis significantly earlier than current methods, according to researchers at Lund University. The test uses circulating tumor DNA in the blood to identify genetic mutations specific to each tumor.
A study published in Nature Cell Biology reveals that exosomes secreted by pancreatic cancer cells contain MIF, which educates liver cells to produce a protein leading to fibrosis and tumor growth. This discovery could lead to targeted treatments and biomarkers for early detection.
Researchers developed a microfluidic chip to capture CTC clusters from whole blood, revealing their prevalence and potential role in metastasis. The Cluster-Chip captured 30-40% of patients' CTC clusters, offering new insights into cancer biology and potentially leading to breakthroughs in cancer research.
Researchers developed a microfluidic device called the Cluster-Chip to capture clusters of two or more cells, which are significantly more likely to cause metastases. The device proved 40-50% better at finding clusters with targeted markers and 1000% better at capturing cells without them.
Researchers have developed nanoparticles carrying siRNA to silence the β3 integrin gene, which regulates cancer cell spread. The treatment significantly inhibited metastasis in mouse models, including five mice with human triple-negative breast cancer.
Researchers at Karolinska Institutet have discovered how cancer cells can infiltrate the lymphatic system by mimicking immune cells. This finding may lead to the development of new treatments targeting metastasis via the lymphatic system.
A study published in the Journal of Leukocyte Biology suggests that pre-existing inflammation can promote the spread of cancer by raising levels of chitinase-3-like-1, a known biomarker of cancer. This increase in CHI3L1 leads to faster cancer growth and increased metastasis.
Researchers at Harvard Medical School have developed an imageable mouse model of brain-metastatic breast cancer and shown the potential of a stem-cell-based therapy to eliminate metastatic cells from the brain and prolong survival. The study also describes a strategy to prevent negative consequences of stem cell therapy.
Researchers developed an imageable mouse model of brain-metastatic breast cancer and tested a stem-cell-based therapy that eliminates metastatic cells from the brain, prolonging survival. The treatment also prevents negative consequences by targeting tumor-specific molecules.
Breast cancer cells can survive detachment from the extracellular matrix by forming multicellular aggregates, stabilizing EGFR protein. Elevated Bim-EL protein in inflammatory breast cancer cells blocks anoikis through complex with Beclin-1 and LC8.
Researchers discovered a molecular mechanism connecting breast tissue stiffness to tumor metastasis and poor prognosis. High stiffness causes TWIST1 protein to lose its anchor, enabling cancer cells to invade surrounding tissue and metastasize.
Researchers have linked a new protein, megalin, to aggressive malignant melanoma cells that are more likely to spread. The protein's presence can improve cancer cell division and survival, making it a potential marker for early detection and targeted treatment options.
Researchers at Houston Methodist have developed a new, ex vivo lung cancer model that mimics the process of tumor progression. The '4-D' model allows for the study of cancer metastasis, including the growth of primary tumors and formation of circulating tumor cells, providing insights into tumor progression and potential new therapies.
Researchers at UC San Diego School of Medicine discovered G proteins signaling on membranes inside cells, controlling Golgi trafficking and enzyme secretion. Inhibition of protein GIV was shown to delay enzyme secretion and inhibit key cancer-driving signals.
Researchers developed a microfluidic chip that uses sound waves to separate circulating tumor cells from white blood cells, achieving a throughput rate up to 20 times faster than prior attempts. The device preserves the integrity of separated CTCs and offers a label-free approach without chemically altering the cells.
A new study found that cells within metastases from prostate tumors can migrate to other body parts and form new sites of spread on their own. This challenges the long-held belief that cells with metastatic potential originate solely from the original tumor site.
Breast tumors trick immune cells to produce neutrophils that block T-cell action, allowing cancer to spread. Anti-IL17 drugs already exist for inflammatory diseases, offering potential treatment for metastatic breast cancer.
Cancer cells with high stress granule levels are more likely to metastasize. Removing YB-1 reduces stress granule formation and decreases metastatic spread in animal models.
Researchers at Children's Hospital Los Angeles have identified a new role for VEGFA in the metastasis of neuroblastoma. The study found that an increase in bone deposition occurs when NB cells metastasize to the bone, driven by VEGFA, leading to increased bone resorption and severe bone loss.
Scientists at MD Anderson Cancer Center discovered a vital connection between the Hippo pathway and glucose metabolism, which can be manipulated to regulate tumor growth. The study found that regulating blood sugar levels impacts the nutrient source of tumors, ultimately leading to cancer suppression.
Researchers from Boston University School of Medicine shed new light on tumor metastasis, proposing a hypothesis that reversible epigenetic events regulate different types of metastatic cancers. Epigenetics enables cancer progenitor cells to differentiate into metastatic tumors.
A genome-scale CRISPR-Cas9 screen in a mouse model of non-small cell lung cancer reveals genes involved in tumor evolution and metastasis. The study highlights well-known tumor suppressor genes and identifies several microRNAs that promote tumor growth.
Researchers found that a secreted immune protein called interleukin(IL)-17B promotes pancreatic cancer growth and metastasis. Treating tumor-bearing mice with an IL-17B inhibitor halted tumor growth and spread, resulting in increased survival.
Researchers at the Montreal Neurological Institute and Hospital have discovered a new mechanism driving cancer cell metastasis, focusing attention on the biological role of DENND2B protein. The study highlights Rab13 as an enzyme promoting cell migration in cancer cells.
A study found that both fruit flies and mice exhibit similar cellular and genetic features during ovulation, including the degradation of follicle cells and the role of Matrix metalloproteinase (Mmp) enzymes. These similarities suggest a conserved basic mechanism in ovulation across animals.
A study by Menashe Bar-Eli and colleagues found that a lack of RNA editing contributes to melanoma tumor growth and metastasis by manipulating proteins. The researchers identified a previously unknown target for CREB, a transcription factor involved in melanoma development.
Researchers found that certain HPV+ oropharyngeal cancer patients can survive for over two years without further disease after intensive treatment. The study identified key factors contributing to the survival advantage, including cancer sensitivity to radiotherapy and chemotherapy.
Researchers at the University of Chicago Medical Center have created a new screening tool for ovarian cancer that can rapidly test compounds to block metastasis. The three-dimensional cell-culture system mimics human tissue and has identified small molecules that inhibit adhesion and invasion.
A new study explains how a protein that suppresses tumors can also promote metastasis in breast cancer cells. Researchers found that 14-3-3 zeta destabilizes key proteins p53 and GLi2, switching off TGF-β's tumor-suppressing abilities while promoting cancer spread.
Researchers found that collagen cross-links play a crucial role in regulating stromal stiffness and determining tumor cell metastatic fate. The study identified two types of collagen cross-links, HLCC and LCC, which are associated with different levels of tumor growth and spread.
Researchers discovered that cells with low levels of profilin 1 protein in breast tumors have increased capacity to metastasize and invade other tissues. The protein regulates the formation of invasive structures called invadopodia, which play a critical role in tumor invasion and metastasis.
Researchers Weissman and Massagué win prestigious prize for their groundbreaking work on cancer stem cells and metastatic spread. Their research aims to develop targeted treatments by understanding the connection between cancer stem cells and immune system control.
Researchers suggest inhibition of Sirtuin1 protein as a future treatment option for metastatic Ewing sarcoma. The study found overexpression of sirtuin 1 significantly correlated with metastasis in patient samples, opening the door to treatment of aggressive tumors.
Moffitt researchers identify a key protein pathway involved in the spread of lung cancer, including beta-arrestin-1 and E2F1. Blocking this pathway may offer new therapeutic strategies to combat lung cancer metastasis.
A new study by Rice University researchers shows how cancer cells use 'jagged' proteins to hijack cell-signaling process and promote metastasis. The mechanism plays a crucial role in embryonic development and wound healing.
A team of researchers identified a key epigenetic factor EZH2 that plays a central role in controlling tumor growth and metastasis in melanoma. The study found that suppressing EZH2 activity can prevent the growth and spread of cancer cells, offering new hope for cancer treatment.
A team led by Dr. Andrew Craig is developing inhibitory antibodies targeting key signals that cancer cells require for metastasis. The goal is to identify lead antibodies and test their potency in pre-clinical models to develop new immunotherapies for clinical trials.
A recent study published in JAMA Surgery found that patients with metastatic colorectal cancer are experiencing a decrease in primary tumor resection rates. Despite this decrease, overall survival rates for these patients have improved, indicating potential overutilization of surgery in certain patient populations.
A study of nearly 375,000 US women with invasive breast cancer found that racial and ethnic groups had different rates of early-stage diagnosis and survival. Biological factors, such as tumor aggressiveness and metastatic potential, played a significant role in determining stage at diagnosis.
A new study supports the hypothesis that lung cancer can travel through airways to adjacent lung tissue. This finding has significant implications for diagnosis and management of primary lung adenocarcinoma.
Researchers found that decreasing CHI3L1 levels slows the spread of two different kinds of cancer to the lungs of mice. This suggests addressing dysregulation is key in fighting metastasis and may lead to new treatments, such as preventing or delaying cancer spread after surgery.
Breast cancer cells can spread throughout the body when they overexpress the gene SNAIL, which helps them break free from the primary tumor and become more mobile. This unique blend of microarray analysis and characterization of physical changes in breast cancer cells could aid the search for ways to block or slow metastasis.
A University of Colorado Cancer Center study reveals that triple-negative breast cancer cells process tryptophan to promote survival while detached, allowing them to metastasize. The kynurenine pathway, specifically the enzyme TDO2, plays a key role in degrading tryptophan and evading anoikis.