Articles tagged with Prostate Cancer
Researchers developed Tripath to analyze 3D tissue samples, predicting clinical outcomes based on 3D morphological features. This approach outperformed traditional methods, providing promising potential for guiding critical treatment decisions.
Researchers developed a Pix-2-Pix GAN model to correct PSMA PET/CT images, improving image quality and quantitative markers. The AI-generated images show high correlation with original images and potential for reducing CT scans without compromising image quality.
A new study found that experienced firefighters have different epigenetic modifications linked to prostate cancer risk compared to new firefighters. Chemical exposure to PFAS is associated with these changes. The research team investigated fire department data and found a link between PFAS exposure and increased prostate cancer risk.
The PSMAfore study found that 177Lu-PSMA-617 prolonged radiographic progression-free survival and improved PSA response rate compared to a change in ARPI. Treatment with 177Lu-PSMA-617 also increased objective response rate, regardless of prior treatment.
A plant-based diet after prostate cancer diagnosis was associated with lower cancer progression risk. Higher intake of plant foods was linked to reduced disease progression in men with prostate cancer.
Men with prostate cancer who listened to mindfulness audio recordings during radiation therapy experienced significant reductions in fatigue, sleep problems, anxiety, and depressive symptoms. The study found that the mindfulness intervention was more effective than listening to relaxing music during treatment.
A study of 4,253 newly diagnosed prostate cancer patients in China found that 27.0% had concurrent cardiovascular disease and 7.2% suffered from two or more conditions. The Framingham Risk Score revealed an increased risk associated with advancing age and metabolic disorders.
Researchers at the University of Notre Dame found that adding a pre-ketone supplement to an immunotherapy treatment significantly reduced prostate cancer in laboratory settings. The combination therapy made tumors sensitive to immunotherapy, leading to 23% tumor cure rates and dramatic shrinking.
Research shows breast cancer survivors are at increased risk of developing second cancers, including endometrial and ovarian cancer for women, and prostate cancer for men. Socioeconomic deprivation is linked to a greater risk of second cancers among breast cancer survivors.
The ECOG-ACRIN Cancer Research Group will present late-breaking findings on prostate cancer, breast cancer, and pancreas cancer at ASCO 2024. These studies include optimal chemotherapy for Black women with breast cancer and results from the first randomized national trial in older adults with pancreas cancer.
A new urine test, MyProstateScore 2.0 (MPS2), measures 18 genes associated with prostate cancer and offers higher diagnostic accuracy than existing tests. The test reduces unnecessary prostate biopsies by up to 51% in men with a history of previous negative biopsy.
Researchers have developed a new urine-based test that identifies high-grade prostate cancer by analyzing 18 genes linked to the disease. The test, called MyProstateScore2.0, was shown to be nearly 100% correct at ruling out aggressive cancers and helped avoid up to 41% of unnecessary biopsies.
A new study supports the use of neoadjuvant chemohormonal therapy for patients with locally advanced prostate cancer, showing improved biochemical progression-free survival and treatment-free survival rates. The treatment combination offers significant benefits in controlling PSA levels and potentially improving patient outcomes.
A novel SPECT/CT acquisition method utilizing lead-212 (212Pb) can accurately detect radiopharmaceutical biodistribution in a convenient manner. This technique has the potential to change practice and increase access for patients around the world by providing more precise treatment options.
A new study found that PET/MRI can accurately classify prostate cancer patients and help avoid unnecessary biopsies. The PRIMARY scoring system showed that over 80% of unnecessary biopsies could be avoided while missing only 12.5% of clinically significant prostate cancer cases.
Researchers at the University of Eastern Finland have identified coregulator proteins as an alternative target to prevent drug resistance in prostate cancer. By inhibiting these proteins, the growth of drug-resistant cancer cells can be inhibited, and the activity of the glucocorticoid receptor can be limited.
A new three-step prostate cancer screening method can detect aggressive cancers while minimizing the detection of insignificant ones. The study found that this approach reduces unnecessary diagnoses and may lead to improved mortality rates.
A study found that proteogenomic signatures in prostate cancer tissue from patients with African and European ancestries were associated with a higher risk of metastasis and/or recurrence. The study identified mutation signatures and recurrent copy number alterations that correlated with disease progression.
A culturally sensitive video addresses prostate cancer screening disparities in the Black community. The video increased knowledge and reduced uncertainty about screenings among over 600 men, leading to a 93% intent to undergo PSA screening.
A biologic drug-device combination therapy has shown promising results in treating metastatic prostate cancer, with 60% of patients experiencing an objective response. The treatment, SYNC-T, uses a cold-temperature probe to kill tumor cells and release immune-stimulating neoantigens, leading to a high response rate without severe toxic...
The CAP trial found that PSA test screening led to a small reduction in prostate cancer deaths, but also resulted in overdiagnosis of 1 in 6 cancers. The study suggests that the benefits of screening do not outweigh the potential harms.
In a preliminary report from an ongoing clinical trial, prostate cancer screenings using PSA, Kallikrein Panel, and MRI detected higher rates of cancer compared to no screening. The study found one additional high-grade cancer per 196 men and one low-grade cancer per 909 men were detected in the screened group.
A randomized clinical trial found that PSA screening compared to no routine screening resulted in a small reduction in prostate cancer deaths after 15 years. The absolute reduction in deaths was modest, but the finding suggests potential benefits of PSA screening.
A simple blood test every five years is sufficient to screen low-risk men for prostate cancer, according to new research. Researchers found that only 0.13% of men with low PSA levels developed cancer after a decade.
Integrating magnetic resonance imaging (MRI) in prostate cancer screening pathways is associated with reduced unnecessary biopsies and overdiagnosis. MRI maintains clinically significant prostate cancer detection, reducing harm from overtreatment.
Global prostate cancer cases are projected to double from 1.4 million in 2020 to 2.9 million by 2040, with low- and middle-income countries seeing the highest increases. The number of annual deaths is predicted to rise by 85%, mainly in LMICs due to under-diagnosis.
A global plan to combat the projected surge in prostate cancer cases worldwide by 2040 highlights the need for increased screening among high-risk populations. The report emphasizes the importance of targeted community outreach, including mobile vans, to provide earlier diagnoses and improve treatment outcomes.
Researchers from Penn Medicine will share data on the latest advances in cancer science and medicine, including novel targets in the tumor microenvironment and the influence of the microbiome on cancer therapy. The presentation is part of the American Association for Cancer Research (AACR) Annual Meeting 2024.
Researchers found that doctors can confidently skip 50% of biopsies by combining MRI-based prostate imaging reporting and data system scores with prostate-specific antigen density testing. The study suggests that this approach can decrease patient harm and healthcare costs associated with unnecessary biopsies.
A study published in International Journal of Cancer found that men with advanced degrees and higher incomes are more likely to receive comprehensive care for prostate cancer, including MRI scans and curative treatment. This leads to lower mortality rates from the disease compared to those with lower education and income.
Patients from socially vulnerable areas show increased treatment adherence when treated at 340B-participating hospitals compared to non-participating hospitals. The study found no difference in use between 340B and non-340B hospitals but noted improved adherence among patients from disadvantaged areas.
A new study found that the COVID-19 pandemic could have led to 20,000 prostate cancer diagnoses being missed in England. The study used data from OpenSAFELY and found a significant drop in diagnosis rates during the pandemic, with a decline of 31% in 2020 and 18% in 2021.
A new acceptable practice standard for hypofractionated post-prostatectomy radiotherapy has been established based on the NRG Oncology trial findings. The study showed that HYPORT was non-inferior to COPORT in terms of late GI or GU toxicity, with greater short-term GI toxicity associated with HYPORT but resolving at 6 months following...
A combination of short-course hormonal therapy and stereotactic body radiation therapy has been shown to be safe and effective in treating metastatic prostate cancer. In a preliminary study, 50% of patients remained recurrence-free six months after treatment, with less than a quarter experiencing severe side effects.
Researchers developed a machine-learning model to assess prostate cancer biopsy samples, overcoming limitations of traditional methods. The new model, nnU-Net, provides accurate 3D segmentation of glandular tissue structures, leading to better prognostic analyses and potential improvements in patient outcomes.
New research reveals that radioguided surgery can effectively detect and remove metastatic pelvic lymph nodes in newly diagnosed prostate cancer patients. The procedure targets the prostate-specific membrane antigen, improving nodal staging to guide treatment recommendations.
A new study found that a widely used prostate cancer test may leave black men at increased risk of overdiagnosis due to naturally higher PSA levels. The study analyzed patient records of 730,000 men and found that black men were more likely to receive a diagnosis of prostate cancer after a raised PSA test result.
A Cancer Research UK-funded study uses AI to identify two distinct subtypes of prostate cancer, termed evotypes, which could lead to personalized treatments. The discovery has the potential to improve diagnosis and treatment outcomes, saving thousands of lives in the future.
Researchers found GZ17-6.02 alone and in combination with standard-of-care agents was effective in killing MF cells, activating key pathways including ATM, AMPK, NFκB, and macroautophagy. The compound's unique multi-factorial mechanism suggests potential for treating mycosis fungoides.
A study of over 3,500 men with prostate cancer found that a plant-based diet significantly improved measures of sexual function, urinary health, and vitality scores. The research suggests that adding more fruits and vegetables to the diet while reducing meat and dairy can have a positive impact on quality of life.
Researchers from Florida Atlantic University found that alpha-santalol, a compound in sandalwood oil, decreases cell proliferation and induces apoptosis to prevent prostate cancer development. The study showed a 53% increase in normal tissue area in treated mice, indicating protection against prostate cancer progression.
A study published in The Journal of Urology reports that racial representation matters to Black patients seeking prostate cancer information online. This lack of representation can lead to mistrust and discourage screening among Black men, who have higher rates of prostate cancer compared to White or Hispanic men.
A study reveals that Rucaparib and its metabolite M324 have differentiated activities, with M324 reducing α-synuclein accumulation in neurons from Parkinson's patients. This synergy could lead to new opportunities for treating prostate cancer and potentially developing treatments for Parkinson's.
Researchers at Northwestern University found a significant decrease in screenings for prostate cancer and urinary tract infections after implementing point-of-care alerts. The study showed a 9% reduction in PSA screenings and a 5.5% reduction in urine testing, with minimal changes in overtreatment of blood sugar.
A team of researchers from Wayne State University received a $1.4 million grant to investigate the role of cytochrome c in prostate cancer aggressiveness and the Warburg effect. The study aims to establish novel therapeutic targets to overcome treatment resistance.
Researchers at Germans Trias i Pujol Research Institute have identified a combination of drugs that could change the treatment of patients with prostate cancer resistant to docetaxel. The study proposes a new treatment based on a combination of kinase inhibitors in patients who inevitably stop responding to docetaxel.
Researchers discovered that depletion of the protein DPYSL5 can restore drug-responsive neuroendocrine prostate cancer cells, promoting cell transformation and lineage plasticity. This finding could lead to the development of new cancer drugs.
Research found a strong association between annual improvements in cardiorespiratory fitness and reduced risk of developing prostate cancer. Men with higher levels of fitness were 35% less likely to develop the disease than those with declining fitness. The study suggests encouraging physical activity may help lower prostate cancer risk.
Researchers have identified UCHL1, a protein found in highly aggressive neuroendocrine carcinomas and neuroblastoma, as a potential molecular biomarker for diagnosing these cancers and predicting responses to therapy. Targeting UCHL1 with inhibitors has been shown to delay the growth and spread of these tumors in pre-clinical models.
Researchers at São Paulo State University found a link between a protein-poor diet during pregnancy and an increased risk of prostate cancer in offspring. The study detected changes in the expression of over 700 genes in offspring, including the gene ABCG1, which is associated with prostate cancer.
A recent study published in Cell Reports reveals that cancer cells can prevent the immune system from attacking them by inhibiting key checkpoints. Researchers found that monotherapy agents targeting these checkpoints may not be effective without an inflammatory trigger, explaining why some immunotherapies work while others fail.
A 10-year follow-up study of nearly 2,500 U.S. men who received prostate cancer treatment found that adverse effects of treatments on sexual function may be deemphasized in decision making for some men. The study suggests that active surveillance can be a beneficial option for patients with favorable-prognosis prostate cancer.
A Phase 3 clinical trial found that combining testosterone-blocking drugs prevents cancer spread and extends treatment time in patients with relapsed prostate cancer. The approach is more effective than single-drug treatment in delaying cancer progression.
A new study by Northwestern University found that lab-trained AI models are easily misled by tissue contaminants, resulting in errors in diagnoses and vessel damage detection. The researchers suggest improving the problem of quantifying and addressing biological impurities in AI models to enhance accuracy.
Researchers developed computational algorithms to analyze patient data and discovered a protein, NME2, that works closely with MYC in advanced prostate cancer cells resistant to enzalutamide. Reducing NME2 levels restored the drug's efficacy, offering new hope for patients who initially respond poorly.
Researchers at Washington State University have discovered a key protein in prostate cancer cells' resistance to docetaxel. Blocking this protein, CHRM1, with dicyclomine restored the effectiveness of docetaxel and reduced tumor growth.
A new study found that Black patients were more likely to choose active surveillance, while those with a strong desire for a cure or expecting longer life with treatment were less likely. Education and urologist interventions can increase active surveillance adoption among low-risk prostate cancer patients.
This study explores the perspectives of primary care physicians (PCPs) and urologists on active surveillance (AS) care for men with low-risk prostate cancer. Key findings include the importance of patient education and clear communication among care team members to prevent loss to follow-up.
A study found rectal examinations offer no advantages over PSA blood tests for detecting prostate cancer. The research analyzed data from 85,738 participants and concluded digital rectal examination alone or with PSA is not more effective than the PSA test.
Researchers developed a blood test, NEMO, to detect neuroendocrine prostate cancer (NEPC) and differentiate it from CRPC-adenocarcinoma. The test uses cell-free DNA methylation changes to quantify tumor burden and identify subtypes.