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Compound derived from Brazilian plant exhibits action against parasite that causes visceral leishmaniasis

Researchers have synthesized a molecule inspired by Nectandra leucantha and found it to be four times more potent than the prototype, killing Leishmania infantum selectively. The compound's bioavailability was improved, allowing it to circulate in the rat's organism for longer periods.

SourceFundação de Amparo à Pesquisa do Estado de São Paulo·JournalAntimicrobial Agents and Chemotherapy·DateJan 7, 2025

Brazilian study identifies potential targets for treatment of visceral leishmaniasis

Researchers have characterized a novel class of proteins in the parasite Leishmania infantum involved in regulating its cell cycle, which could lead to the development of more effective drugs against visceral leishmaniasis. The discovery highlights six F-box proteins essential for L. infantum growth and development, providing potential...

Test detects co-infection by novel species of parasite in severe cases of visceral leishmaniasis

Researchers developed a PCR test that accurately identifies the causative agent of visceral leishmaniasis, a neglected disease affecting Brazil and Latin America. The test can detect co-infection by both Leishmania infantum and Crithidia, with infection by Crithidia more frequent than previously thought.

SourceFundação de Amparo à Pesquisa do Estado de São Paulo·JournalTropical Medicine and Infectious Disease·DateNov 1, 2023

Co-infection by novel species of parasite is confirmed in visceral leishmaniasis patient

A child patient was co-infected with Leishmania infantum and an unnamed Crithidia parasite species, revealing a rare case of non-ulcerated cutaneous leishmaniasis. Genome sequencing confirmed the presence of both parasites, sparking new research questions on disease transmission and host susceptibility.

SourceFundação de Amparo à Pesquisa do Estado de São Paulo·JournalInternational Journal of Infectious Diseases·DateAug 8, 2023

Leishmania parasite manipulates organism’s defense system to continue replicating, study shows

Researchers at USP in Brazil discovered that Leishmania parasites manipulate the protein gasdermin-D to prevent the immune system from killing them. This allows the parasite to continue replicating and causing disease. The findings offer hope for developing novel treatments for leishmaniasis, a disease affecting 30,000 people annually.

Troubling news about sea otter deaths

A new UC Davis analysis reveals that adult sea otters in California are dying at an alarming rate due to diseases and parasites. The study found that nearly two-thirds of the otters died from disease, with parasitic infections being a major cause, including thorny-headed worms and protozoa.

SourceUniversity of California - Davis·JournalJournal of Wildlife Diseases·DateMay 6, 2003