A retrospective study found that PITX2, PHOX2B, and HAND2 do not offer diagnostic utility in fine-needle aspiration biopsies of primary and secondary medullary thyroid carcinomas. The markers were expressed in some samples but did not improve diagnosis accuracy.
SourceXia & He Publishing Inc.·JournalJournal of Clinical and Translational Pathology·DateJun 29, 2026
Combined hepatocellular-cholangiocarcinoma is a rare and aggressive form of primary liver cancer that poses significant diagnostic and therapeutic challenges. The absence of standardized treatment guidelines limits effective management, emphasizing the need for thorough pathological evaluation and multidisciplinary management.
SourceImpact Journals LLC·JournalOncoscience·TypeCase study·DateJun 24, 2026
Apple Watch Series 11 (GPS, 46mm)
Apple Watch Series 11 (GPS, 46mm) tracks health metrics and safety alerts during long observing sessions, fieldwork, and remote expeditions.
Researchers at Salk Institute uncover an unexpected role for HDAC enzymes in controlling critical genes involved in DNA repair, making pancreatic cells more vulnerable to therapies that induce DNA damage. This finding paves the way for new treatment strategies combining entinostat with DNA-damaging therapies.
SourceSalk Institute·JournalProceedings of the National Academy of Sciences·DateJun 22, 2026
Mr. Takenobu Nakagawa receives prestigious MEXT Minister’s Award for excellence in research support, recognizing his work on histological specimen preparation and standardization of immunohistochemistry protocols. The award highlights the vital role of technical specialists in driving innovation through specialized expertise.
A rare case of high-grade laryngeal leiomyosarcoma was successfully treated with extended laryngectomy, left neck dissection, and adjuvant chemotherapy. Complete surgical excision remains the cornerstone of therapy, while multidisciplinary-guided adjuvant treatment may benefit selected high-grade or high-risk patients.
SourceImpact Journals LLC·JournalOncotarget·TypeCase study·DateMay 13, 2026
A retrospective study of 40 immunocompromised ICU patients found associations between low CD4+T-cell counts and specific lung pathogens. Patients with severe CD4 depletion had higher proportions of fungal infections, while moderate immunosuppression was linked to Streptococcus pneumoniae.
SourceJournal of Intensive Medicine·JournalJournal of Intensive Medicine·TypeObservational study·DateApr 2, 2026
Researchers created a novel approach for simultaneous ERG, PanCK, and H&E image generation from label-free tissue sections, enhancing vascular invasion assessment accuracy and efficiency. The virtual multiplexed immunostaining method overcomes traditional IHC limitations, such as section-to-section variability and tissue loss.
SourceBMEF (BME Frontiers)·TypeExperimental study·DateMar 6, 2026
SAMSUNG T9 Portable SSD 2TB
SAMSUNG T9 Portable SSD 2TB transfers large imagery and model outputs quickly between field laptops, lab workstations, and secure archives.
A new case report describes a large, calcified solid pseudopapillary neoplasm of the pancreatic head, emphasizing the importance of multidisciplinary evaluation and long-term follow-up for monitoring recurrence. The case underscores the diagnostic value of integrating imaging, histopathology, and immunohistochemistry.
SourceImpact Journals LLC·JournalOncoscience·TypeCase study·DateMar 6, 2026
A study published in Microbiome found that gut microbiome-derived butyrate activates immune cells to enhance vaccine efficacy by promoting T follicular helper (Tfh) cell activity and mucosal antibody production. This discovery highlights the crucial role of gut environment regulation in controlling infections and enhancing vaccine resp...
SourcePohang University of Science & Technology (POSTECH)·JournalMicrobiome·DateFeb 4, 2026
Epithelioid hemangioendothelioma is a rare and potentially malignant vascular tumor that can be mistaken for benign conditions. A new case report highlights the diagnostic challenges raised by rare tumors and emphasizes the need for vigilant evaluation of slow-growing swellings.
SourceImpact Journals LLC·JournalOncoscience·TypeCase study·DateOct 16, 2025
Researchers developed a novel technology to attach 'fake targets' to tumor cells, enabling immune cells to attack regardless of antigen presence. The Univody platform showed promising results in animal models, suppressing tumor growth and triggering broader immune activation.
SourcePohang University of Science & Technology (POSTECH)·JournalACS Nano·DateOct 16, 2025
Researchers found that DMT reduces infarct volume and edema formation in rat stroke models by restoring blood-brain barrier function and reducing inflammatory cytokines. The compound's dual action may complement existing treatments, offering a novel approach to stroke therapy.
SourceHUN-REN Szegedi Biológiai Kutatóközpont·JournalScience Advances·TypeExperimental study·DateSep 26, 2025
Apple iPhone 17 Pro
Apple iPhone 17 Pro delivers top performance and advanced cameras for field documentation, data collection, and secure research communications.
Mesonephric carcinoma and mesonephric-like adenocarcinoma are rare aggressive neoplasms with overlapping morphological and immunophenotypic features. MC arises from mesonephric remnants, while MLA likely originates from Müllerian epithelium undergoing mesonephric differentiation.
SourceXia & He Publishing Inc.·JournalJournal of Clinical and Translational Pathology·DateSep 9, 2025
The WHO Reporting System for Soft Tissue Cytopathology provides a standardized classification system to improve diagnostic accuracy and guide clinical decision-making. The system aligns with the WHO Classification of Soft Tissue and Bone Tumours and incorporates cytomorphologic features, ancillary studies, and clinical correlation.
SourceXia & He Publishing Inc.·JournalJournal of Clinical and Translational Pathology·DateJul 17, 2025
Researchers have developed a new 3D-IHC technique that improves the speed, depth, and sensitivity of immunolabeling in thick tissue samples using nanobodies fused with peroxidase. The method enables ultra-fast and high-resolution mapping of neurons and glia in 1-mm-thick brain tissues.
SourceJuntendo University Research Promotion Center·JournalCommunications Biology·TypeExperimental study·DateJun 19, 2025
Researchers from Osaka University discovered that the GPR31 receptor in gut surveillance cells detects bacterial metabolites and triggers immune responses, which could lead to new drug developments and probiotic treatments. The study also found that these receptors play a key role in the immune response to gut infections in humans.
SourceImmunology Frontier Research Center (IFReC) - Osaka University·JournalProceedings of the National Academy of Sciences·TypeExperimental study·DateOct 22, 2024
CalDigit TS4 Thunderbolt 4 Dock
CalDigit TS4 Thunderbolt 4 Dock simplifies serious desks with 18 ports for high-speed storage, monitors, and instruments across Mac and PC setups.
Researchers discuss HER2 in breast cancer, highlighting the prognostic and predictive factors. They found an independent positive prognostic effect of HER2-low compared to HER2-zero in early breast cancer, challenging the long-held view that HER2-negative tumors do not benefit from trastuzumab-based therapy.
SourceImpact Journals LLC·JournalOncotarget·TypeObservational study·DateJul 16, 2024
Researchers found that MMTV-NeuT/ATTAC mice treated with anti-PD-1 therapy developed increased tumor-associated macrophages, EMT, fibroblast proliferation, and enhanced extracellular matrix. These findings suggest potential therapeutic avenues to enhance PD-1 immune checkpoint sensitivity.
SourceImpact Journals LLC·JournalOncotarget·TypeExperimental study·DateJan 5, 2023
Researchers analyzed COX-2 levels and segmental chromosome aberrations in pediatric neuroblastoma tumor samples. Positive correlations between pre-CT Ch 7q gain and COX-2 expression were found, as well as negative correlations between Ch 7q gain and Ch 11q deletion.
SourceImpact Journals LLC·JournalGenes & Cancer·TypeData/statistical analysis·DateDec 16, 2022
Sony Alpha a7 IV (Body Only)
Sony Alpha a7 IV (Body Only) delivers reliable low-light performance and rugged build for astrophotography, lab documentation, and field expeditions.
Researchers found that P2-HNF4α expression is associated with p-STAT3 and c-Myc expression in NAFLD patients, suggesting potential biomarkers for hepatocellular carcinoma (HCC) risk. Additionally, p-STAT3 expression was linked to hypertension, while c-Myc expression was associated with advanced fibrosis.
SourceImpact Journals LLC·JournalOncotarget·TypeObservational study·DateDec 6, 2022
A study by Okayama University researchers found that neuromedin U (NMU) is involved in metabolic processes but its 'anti-hunger' function may not be crucial for rats. Unlike mice, NMU expression is restricted in the rat brain and does not suppress feeding behavior.
SourceOkayama University·JournalScientific Reports·TypeExperimental study·DateNov 11, 2022
Researchers found that Merkel cell carcinoma (MCC) Glypican-3 (GPC3) is expressed in nearly 70% of MCC tumors and up to 90% of MCPyV-negative cases. GPC3 expression is associated with worse prognosis, including increased risk of death from MCC. This makes GPC3 a promising target for chimeric antigen receptor T cell therapy.
SourceImpact Journals LLC·JournalOncotarget·TypeExperimental study·DateAug 11, 2022
Researchers at UBC and BC Cancer developed a new test to distinguish between high-risk medulloblastoma cases requiring radiation therapy and lower-risk cases. This test has the potential to improve diagnosis and future treatment of childhood brain tumours worldwide, reducing unnecessary side effects and increasing cure rates.
SourceUniversity of British Columbia·JournalClinical Cancer Research·TypeExperimental study·DateNov 1, 2021
A new study reveals that high-grade gliomas in dogs contain more immune cells associated with suppressing immune response than low-grade gliomas. The findings suggest that these brain tumors may recruit cells to aid in immunosuppression, which could lead to improved immunotherapies for both humans and dogs.
SourceNorth Carolina State University·JournalVeterinary Pathology·DateAug 19, 2021
Meta Quest 3 512GB
Meta Quest 3 512GB enables immersive mission planning, terrain rehearsal, and interactive STEM demos with high-resolution mixed-reality experiences.
Researchers assessed CEACAM5 expression in breast cancer subtypes using immunohistochemistry, finding a high correlation between primary tumor and lymph node status. Expression of CEACAM5 also predicted different clinical outcomes depending on molecular subtypes, suggesting its potential role as a clinically relevant marker.
SourceImpact Journals LLC·JournalOncotarget·DateNov 3, 2020
A new machine learning-based model evaluates immunohistochemical characteristics in patients with suspected thyroid nodules, achieving excellent performance for individualized noninvasive prediction. The model improves thyroid nodule diagnoses and helps identify papillary thyroid cancers earlier.
SourceAmerican Roentgen Ray Society·JournalAmerican Journal of Roentgenology·DateAug 30, 2019
Researchers evaluate immunohistochemistry for detecting ALK rearrangement in lung adenocarcinoma, finding it a reliable and cost-effective method. The study suggests that IHC can effectively detect ALK rearrangement and identify suitable candidates for targeted therapy.
SourceInternational Association for the Study of Lung Cancer·JournalJournal of Thoracic Oncology·DateJun 25, 2013
The FASEB MARC Program conferred 11 travel awards totaling $20,350 to promote underrepresented minority students and scientists in immunohistochemistry and microscopy. The awards aim to increase diversity in biomedical research and encourage young scientists' participation.
SourceFederation of American Societies for Experimental Biology·DateMar 7, 2013
A recent study found immunohistochemistry to be a reliable and accurate method for detecting ALK rearrangement in non-small cell lung cancer. The technique outperformed fluorescence in situ hybridization, which is currently the standard but time-consuming method.
SourceInternational Association for the Study of Lung Cancer·JournalJournal of Thoracic Oncology·DateDec 15, 2012
GoPro HERO13 Black
GoPro HERO13 Black records stabilized 5.3K video for instrument deployments, field notes, and outreach, even in harsh weather and underwater conditions.
A new test identifying aggressive lung cancer sub-type in never-smokers may help doctors select the most appropriate therapies. The study found that tumors expressing a protein product called anaplastic lymphoma kinase (ALK) are more common in this group, increasing disease progression risk.
SourceEuropean Society for Medical Oncology·JournalLung Cancer·DateFeb 25, 2011
A review of phase I clinical trial designs and the association between lymphovascular invasion and breast cancer recurrence, highlighting the need for new methods to expedite drug development and improve patient outcomes.
SourceJournal of the National Cancer Institute·JournalJNCI Journal of the National Cancer Institute·DateMay 12, 2009
The study found that GST-pi was highly expressed in neoplastic tissues and exhibited a significant increase in intensity with the grade of dysplasia. In addition, the research revealed unique ultrastructural changes in some cases characterized as mild-grade dysplasia.
SourceWorld Journal of Gastroenterology·JournalWorld Journal of Gastroenterology·DateSep 23, 2008
Fluke 87V Industrial Digital Multimeter
Fluke 87V Industrial Digital Multimeter is a trusted meter for precise measurements during instrument integration, repairs, and field diagnostics.
Studies found that statins and fibrates have uncertain impact on melanoma prevention, while a new virus kills brain cancer cells in mice. An antibody combination shows efficacy in ovarian cancer, while immunohistochemical assays predict breast cancer treatment response better than older methods
SourceJournal of the National Cancer Institute·JournalJNCI Journal of the National Cancer Institute·DateOct 31, 2006