Articles tagged with Arginine
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A new study published in JDR Clinical & Translational Research found that arginine dentifrices can significantly reduce childhood caries. The 8.0% arginine-containing dentifrice demonstrated a 26.0% reduction in DMFS scores compared to the control group.
Research suggests that consuming high levels of sucralose can make cancer treatment less effective by disrupting the gut microbiome and altering T cell function. However, adding arginine or citrulline supplements to the diet may restore immunotherapy effectiveness in patients with melanoma and non-small cell lung cancer.
A new study reveals that breast cancer cells exploit the amino acid arginine to drive aggressive tumor behavior and resistance to immunotherapies. Cancer cells act as 'arginine factories,' saturating the tumor microenvironment with this nutrient, which is then used by immune cells to suppress cancer-fighting CD8+ T cells.
A new Cleveland Clinic study reveals that diet-derived molecules called metabolites are the main drivers of young-onset colorectal cancer risk, particularly those associated with red and processed meat. The research suggests that addressing diet with doctors can help prevent colon cancer in younger adults.
A new treatment combining a novel drug with traditional chemotherapy has been shown to increase the survival of patients with malignant mesothelioma, a rare and aggressive cancer. The ATOMIC-meso trial found that this treatment quadrupled the survival at 36 months compared to placebo-chemotherapy.
A University of Basel study reveals that high levels of arginine drive metabolic reprogramming to promote tumor growth. The findings suggest targeting the specific arginine-binding factor for effective liver cancer treatment.
A study by Michigan Medicine researchers reveals that modifications to amino acids in sperm may be linked to infertility. The team analyzed the molecular sequence composition of protamines, finding non-arginine amino acids with unexpected post-translational modifications that affect sperm shape and function.
Researchers use cryo-electron microscopy to visualize a sirtuin enzyme bound to a nucleosome, clarifying how it accesses DNA and histone proteins to modulate gene expression. The study provides insight into the function of SIRT6 in humans and other animals.
Researchers found that arginine levels are limited in human cancers, prompting cancer cells to manipulate proteins to take up the amino acid. Starving cancer cells of arginine may lead to mutations that make them more recognizable to the immune system.
A new study by CHOP researchers found that antibiotic-resistant Enterococcus enhances C. difficile virulence by modulating the gut environment, increasing toxin production and nutrient supply. This interaction supports increased colonization and persistence of C. difficile in the gut.
A new chemoproteomic method has been developed to globally profile arginine dimethylation, which plays a crucial role in regulating protein phase separation and membraneless organelle dynamics.
A team of researchers from Ritsumeikan University in Japan has elucidated the mechanism behind the liquid-solid phase transition of FUS protein that leads to ALS. They discovered a new therapeutic target, arginine, which suppresses FUS aggregation and could delay ALS progression.
Researchers at IBiS have developed a new treatment that completely eliminated glioblastoma tumors in animal models, offering a new therapeutic option against this aggressive disease. The therapy combines the use of ADI-PEG20 with focal brain radiotherapy and has shown promising results without side effects.
A Texas A&M research team is using dietary supplements of arginine and creatine to improve the overall litter weight and health of individual pig babies. The study's findings also have implications for human fetal development, as arginine plays a key role in pregnancy by promoting blood vessel growth and supporting fetal-placental growth.
A comprehensive review of watermelon consumption has found evidence that eating watermelon regularly may promote cardiovascular and metabolic health. The fruit contains essential vitamins, minerals, antioxidants, and amino acids that support blood pressure regulation, lipid reduction, and glucose control.
A study found that arginine treatment improved outcomes in cancer patients with brain metastases, showing a complete or partial response in nearly 78% of patients. The amino acid may be useful as an anticancer therapy when combined with radiotherapy or other treatments.
Researchers discovered that Streptococcus pyogenes can use arginine to survive on the skin surface. This knowledge could lead to new treatment strategies by blocking arginine metabolism in the bacteria.
Research suggests that cesarean delivery leads to lower levels of key 'birth signaling hormones', which may influence long-term neurodevelopmental outcomes. The study's findings have significant implications for understanding the potential effects of cesarean delivery on autism and obesity rates.
Researchers at CUNY's ASRC discovered that amino acids arginine and lysine regulate liquid-liquid phase separation, creating multi-phase droplets with unique properties. The study provides insights into cellular dysfunction and disease mechanisms, paving the way for potential therapies.
Researchers discovered a new link between arginine metabolism and plant shape formation, using the moss Physcomitrium patens as a model organism. The study identified a core pathway involving transcriptional co-activators ANGUSTIFOLIA3/GRF-INTERACTING FACTOR1 (AN3/GIF1) family signaling.
Researchers at the Weizmann Institute of Science and Hebrew University of Jerusalem reconstructed ancient protein sequences that may resemble those of early life forms. They discovered a way these primitive proteins could have progressed to form living cells, with positively-charged amino acids playing a crucial role.
A natural amino acid called arginine has been identified as a potential new treatment for polyglutamine diseases. The study found that arginine improved neurological symptoms in mice with polyQ diseases before and after symptom onset, suggesting its therapeutic potential.
This article reviews the state-of-the-art analytical strategies for studying protein arginine methylation using mass spectrometry. The authors discuss the latest studies on profiling protein-methylation events, implementing biochemical methods, computational analysis tools, and the heavy methyl SILAC strategy.
The study reveals arginine vasotocin increases aggression, while isotocin boosts egg care, offering insight into vertebrate behavior. The findings have implications for understanding parental care and behavior across the animal kingdom.
Researchers found that the influenza NS1 protein can bind to the cell's RIG-I protein, quelling the alarm that activates the cellular innate immunity defense against infection. This newly described mechanism increases viral survival and highlights the need for better vaccines and antivirals.
Researchers at RUDN University have found that adding arginine to fish food reduces mortality from ammonia exposure in common carp. The additive activates detoxification, suppressing oxidative stress and increasing urea production, which helps excrete excess ammonia from the body.
Researchers found that patients with low arginine levels had lower blood platelet counts and impaired immune function. Supplementing arginine in SFTS patients increased platelet production and cleared the virus faster, providing hope for potential treatment targeting this amino acid.
A retrospective study found that intravenous arginine treatment led to clinical improvements and no adverse effects in children with mitochondrial disease after acute metabolic strokes. The treatment resulted in partial or complete reversal of symptoms such as seizures, paralysis, and low muscle tone in 47% of patients.
A new study from the University of Eastern Finland found that people with major depressive disorder have reduced arginine levels, which can affect nitric oxide production and vascular regulation. The study also suggests that depression may be linked to lower arginine bioavailability, but further research is needed
Researchers at UC Santa Barbara found evidence that the amino acid arginine was essential for protein-aptamer interactions, potentially altering our understanding of the origin of life. This discovery provides new insights into the ideal conditions for life to emerge, with implications for various hypotheses and experiments.
Scientists discovered a new binding motif that enables positively charged amino acids to bind with negatively charged terminal groups in peptides or proteins. This discovery may help rationalize why certain peptides easily pass through cell membranes and aid in designing efficient transport of drug molecules.
Methylation and S-nitrosylation are conserved protein modifications that regulate abiotic stress responses in plants. NO positively regulates PRMT5 activity through S-nitrosylation, leading to proper splicing-specific pre-mRNA processing and enhanced tolerance to stress.
Aarhus researchers identified the mechanism behind the acid pump, which pumps acid into the stomach. Replacing a key amino acid with arginine enables the pump to function like an electroneutral pump.
A new study published in The American Journal of Pathology found that over 90% of bladder cancers lack the enzyme argininosuccinate synthetase 1, making them susceptible to arginine-degrading therapy. This approach has shown promising results in treating bladder cancer with low ASS1 expression.
The researchers used spectroscopy to visualize the arginine finger bonded to the GTP molecule at high precision, revealing how its snap affects geometry and charge distribution. This discovery has implications for understanding switch processes in the body and developing treatments for cancer and genetic diseases.
Researchers found that ibuprofen arginate is better tolerated, released more rapidly into the bloodstream, and provides faster pain relief compared to current formulations. This new formulation may negate cardiovascular side effects associated with high doses of ibuprofen.
Research found that high arginine levels support metabolic pathways that reduce airway inflammation in asthma. Elevated arginine metabolism in human cells and mice improved mitochondrial function to offset inflammation.
Researchers studying a mutant worm found that the absence of a gene altered dopamine signaling, leading to changes in how nerve cells respond to stimuli. This discovery may open new treatment avenues for diseases such as Parkinson's and schizophrenia.
A recent study has identified the enzyme responsible for obesity-related hypertension, which breaks down a molecule necessary for relaxing blood vessels. The research suggests that targeting this enzyme may lead to new treatment options for obese patients with high blood pressure.
A new Duke University study in mice found that immune cells consuming an important amino acid called arginine may contribute to the development of Alzheimer's disease. Blocking this process with a small-molecule drug prevented characteristic brain plaques and memory loss in mouse models, suggesting a potential new treatment strategy.
Researchers identify SLC38A9 as a protein that senses amino acid arginine, activating mTORC1 signaling even in the absence of nutrients. This discovery sheds light on the mechanistic target of rapamycin complex 1 (mTORC1) pathway and its role in regulating cellular growth.
Research reveals that consuming non-native algae 'superweeds' rich in arginine promotes the deadly virus causing tumors in endangered sea turtles. The disease is considered the leading cause of death for green sea turtles, with over 60% of Kāne'ohe Bay turtles bearing tumors.
A new study published in PeerJ found that pollution in urban and farm runoff in Hawaii causes tumors in endangered sea turtles. The researchers discovered that high levels of nitrogen in the runoff promote the formation of tumors on the animals' eyes, flippers, and internal organs.
University of Miami researchers found that an amino acid transporter regulates glutamine supply to symbiotic bacteria in pea aphids, enabling the exchange of essential nutrients. This simple mechanism allows the insect-bacteria partnership to adapt to changing demand for nutrients.
A recent clinical study found that arginine therapy significantly reduces the need for pain medication and lowers pain scores in children with sickle cell disease. The treatment also shows promise as a potential cure for acute pain episodes, with no safety concerns reported.
Researchers have demonstrated that the amino acid arginine significantly improves glucose metabolism in both lean and obese mice. The study found that arginine increases the body's production of glucagon-like peptide-1 (GLP-1), an intestinal hormone that plays a key role in regulating appetite and glucose metabolism.
Researchers found that diabetic rats on a high protein diet with arginine and proline showed better wound healing compared to those without supplementation. The study suggests that arginine and proline enrichment could offer new hope for effective treatment in diabetic patients with chronic wounds.
Anthony R. Richardson has been honored with the Merck Irving S. Sigal Memorial Award for his pioneering work on the metabolic adaptations of Staphylococcus aureus to host immunity. His research has profound implications for understanding the evolution and emergence of highly virulent pathogens.
A team of researchers led by Dr. Brendan Lee discovered a treatment that bypasses the enzyme deficiency causing argininosuccinic aciduria, allowing patients to receive nitric oxide through medication. This breakthrough has shown promise for treating similar conditions in hypertensive teens and individuals with organ damage.
Researchers are working to improve lung function in babies with heart defects by boosting the recycling system that enables blood vessels to handle excess blood volume. They've found that a key enzyme is insufficiently energized, and PPAR agonists may provide the necessary boost.
Researchers at the University of Alberta have discovered a crucial mechanism for fighting infections, revealing that an amino acid called arginine is essential for immune function. The study's findings could have significant implications for people in third world countries with limited access to nutrition.
Researchers found that arginine supplements improved the cycling ability of older cyclists by increasing their anaerobic threshold. The study, published in Journal of the International Society of Sports Nutrition, showed a significant increase in exercise capacity after just one week of supplementation.
A team of researchers found that the malaria parasite breaks down essential amino acid arginine to trigger a more deadly phase of the disease. By depleting this substance, the parasite may be able to 'switch off' human immune functions that threaten its survival.
Researchers have discovered that arginine, an amino acid, reduces fat mass in diet-induced obese rats and promotes skeletal-muscle gain. Arginine supplementation shifts nutrient partitioning to increase lean tissue growth and reduce insulin resistance.
UC Davis Cancer Center researchers have discovered a metabolic deficiency in pancreatic cancer cells that can be used to slow the progress of the deadliest form of cancer. By depleting arginine levels, they were able to significantly reduce pancreatic cancer-cell proliferation and inhibit tumor growth by 50 percent.
Researchers at Stanford University have developed a method to get around one of the most common forms of resistance, thereby opening up some resistant diseases to the reinvigorated fury of medications. The method uses an arginine-rich transporter to deliver potent medication inside a resistant cell.
A multidisciplinary team from the University of Illinois has solved the mystery of how the HIV virus's TAT protein crosses cell membranes. The findings reveal that the protein creates a 'saddle splay curvature' in the membrane, making it porous and allowing molecules to pass through.
A four-year study published in JAMA found that patients with sickle cell disease who had low arginine levels were at a higher risk of death from pulmonary hypertension. The researchers hope to develop new treatments using nutritional supplements or drug therapies to increase arginine availability.