Articles tagged with Pharmacology
Researchers found that silencing synapses in the nucleus accumbens can prevent intensification of cocaine craving. They discovered a chemical receptor known as CP-AMPAR essential for maturation of silent synapses, which revert to silence when removed.
Dr. R. Clinton Webb, a leading expert in hypertension research, is honored with the American Heart Association Council on High Blood Pressure Research's Lifetime Achievement Award. He is recognized for his groundbreaking contributions to the field of hypertension and his dedication to mentoring and service.
Autophagy is triggered when cells are starved for nutrients, infected, or damaged. The study reveals that AMPK regulates Vps34 kinase complexes in different ways, inhibiting non-autophagy enzymes and activating autophagic ones.
Researchers at Western University have made a breakthrough in understanding diffuse idiopathic skeletal hyperostosis (DISH), a common form of arthritis affecting six to 12 percent of North Americans. The team discovered a mouse model that resembles DISH, pointing to the role of adenosine in causing abnormal mineralization.
Researchers discover fibroblast growth factor-21 (FGF21) increases insulin sensitivity and blocks the growth hormone/insulin-like growth factor-1 signaling pathway, leading to a 30-40% increase in average life span in mice. FGF21 overproduction also results in lean mice with no ill effects from reduced bone density.
A new study published in Drug Testing and Analysis found that DMAA, a stimulant in many pre-workout supplements, does not originate from natural substances but is comprised of synthetic compounds. The FDA should regulate and/or ban products with significant amounts of synthetic pharmacological compounds added.
Researchers have identified a key gene, TAK1, in KRAS mutant colon cancers that promotes disease progression. Pharmacological inhibition of TAK1 shows strong killing of tumor cells with minimal effects on normal cells.
Researchers have discovered that the protein p97/VCP aids DNA repair by unwinding proteins at damaged sites. This mechanism holds potential for improving radio- and chemotherapy effects on cancer cells.
The American Society for Nutrition will present a symposium on responsive feeding and how to promote healthy growth and development for infants and toddlers. Meanwhile, the American Physiological Society will discuss personalized, 'systems' medicine, integrating biologic and informational sciences to address complex biomedical problems.
Researchers discovered that neutrophils, a type of white blood cell, lose their direction when the protein p55 is absent. This leads to impaired healing and slower response times to infections.
A new study published in the International Journal of Obesity found that biotransformed blueberry juice has strong anti-obesity and anti-diabetic effects. The juice was tested on mice prone to obesity, insulin resistance, diabetes, and hypertension, and showed a significant reduction in food intake and body weight.
Dr. Huijing Xia, a postdoc at LSU Health Sciences Center New Orleans, has been awarded the American Physiological Society's Postdoctoral Fellowship in Physiological Genomics for her research on ACE2, an enzyme that regulates blood pressure. The two-year fellowship will cover $37,000/year in stipend and trainee allowance.
Dr. Rama Ranganathan received the Edith and Peter O'Donnell Award for his groundbreaking work on understanding how networks of interactions produce complex biological systems. His research aims to develop tailor-made proteins with specific functions, which could lead to new treatments for diseases.
Researchers found that patients with bipolar disorder have a poorer quality of life than the general population, with factors such as early onset, long-term illness, and tobacco dependence contributing to this effect. In contrast, social support from family can improve quality of life.
John van den Anker, MD, PhD, director of Pediatric Clinical Pharmacology at Children's National Medical Center, has received the American College of Clinical Pharmacology (ACCP) Distinguished Investigator Award. The award recognizes his sustained and prolific contributions to pediatric clinical pharmacology.
Researchers have reviewed literature on stress tests to determine the most effective strategies for physicians. The study highlights the importance of choosing the right stress test to accurately detect coronary artery disease, emphasizing the role of pharmacologic agents and exercise EKGs in maximizing sensitivity and specificity.
A recent study by UCLA researchers found that at least 100 of the 599 documented cigarette additives have pharmacological effects, including enhancing or maintaining nicotine delivery. The study highlights a need for regulation of these additives to address concerns over addictiveness and environmental impact.
Medical schools are adopting problem-based learning to improve personal drug selection. Students learn to choose medications based on efficacy, safety, cost, and convenience. This approach leads to better medicine use worldwide.
Dr. Elliot V. Hersh has been recognized for his research on non-steroidal anti-inflammatory drugs and local anaesthetics used in dentistry, including the approval of articaine by the US FDA. He is a prominent figure in the IADR Pharmacology, Therapeutics & Toxicology Group, having served in leadership roles and organized symposia.
Researchers have discovered that spinal cord neurons show irregular firing patterns during network activity, similar to the cerebral cortex. This finding enables exploration of how spinal cords generate movements, shedding light on the complex system controlling human motion.
A study by University of North Carolina researchers found that the protein CIB1 plays a critical role in proper sperm formation in mice. Mice missing both copies of the gene are infertile, while those with only one copy are fertile. This discovery sheds light on fertility genes and their potential impact on human infertility.
Dr. Meechan has received the IADR Pharmacology, Therapeutics, & Toxicology Research Award for his contributions to dental care management and medically compromised patients. The award recognizes his research interests in local anesthesia and pain control.
Renowned clinicians call for collaborative effort to revive clinical pharmacology in the UK. The Lancet experts advocate for joint action by medical schools, government bodies, and industry partners to bolster this crucial field.
A UK study found that BBC Panorama programmes airing in 2002-04 led to a marked increase in reported adverse drug reactions for paroxetine, an SSRI used to treat depression. This effect was short-lived and less pronounced after regulatory announcements.
A four-year study found a sharp decline in HRT prescribing after the Million Women Study's publication, whereas an earlier study had little effect. Widespread media coverage is believed to have played a significant role in this change.
A study found that alcohol's reinforcing properties in rodent infants are due to its pharmacological effects, independent of smell or taste. This suggests that animals and people may find alcohol rewarding for the same reasons throughout their development, with implications for human brain development and behavior.
Researchers at Johns Hopkins Medicine found that focusing on step-by-step goals for patients during daily rounds improves patient safety and satisfaction. The study involved 112 patients in the ICU and showed a significant decrease in hospital stays and an increase in staff understanding of recovery goals.
The new center will focus on developing hormonal methods for effective and reversible male contraception, with potential health benefits such as preventing prostate disease. The program supports interactive research projects aiming to develop clinically useful products for people of different backgrounds and ages.
The AAAS jobs survey shows a 7% increase in median salaries for U.S. life scientists between May 2000 and May 2001, with real average weekly earnings outperforming raises for many other jobs. However, women earn nearly one-third less than men, with significant gaps in non-academic settings.