Articles tagged with Mesenchymal Stem Cells
Researchers at McGill University Health Centre discover a new pathway that controls bone remodelling with interferon gamma. Interferon gamma may become an efficient drug-target for treating osteoporosis.
Researchers at Columbia University Medical Center have designed a new way to grow bone and other tissues by co-transplanting hematopoietic and mesenchymal stem cells. This approach results in faster regeneration of vascularized tissues compared to previous methods.
Eben Alsberg, a biomedical engineering professor at Case Western Reserve University, has received the Ellison Medical Foundation New Scholar in Aging award. The award provides funding for his project to develop novel microenvironmental technology to rescue chondrogenic potential of mesenchymal stem cells from aged individuals.
Researchers found adult stem cells can improve fracture healing by increasing bone and cartilage formation at the fracture site. This approach may lead to a new treatment for people suffering from non-healing fractures, which can cause pain, deformities, and even death.
Researchers at Cold Spring Harbor Laboratory found that BMP signaling in dermal papilla cells is essential for hair growth. Deletion of the receptor for bone morphogenetic protein 1a (BMPR1a) in DP cells prevented hair follicle formation, while intact BMPR1a and additional BMP protein promoted hair growth.
Researchers at John Hopkins University used human embryonic stem cells to develop bone tissue that heals large skull defects in mice. The study demonstrates a potential application of hESC-derived mesenchymal cells in musculoskeletal tissue regeneration.
Researchers have discovered that hyperacidification of the TGN causes increased activity of furin, leading to tissue fibrosis in individuals with CF. Additionally, a new study on EHEC O157:H7 has identified the role of type IV pili in intestinal adherence and immune response.
Researchers in Australia identify two markers to isolate mesenchymal stem-like cells from endometrial tissue, which can differentiate into various cell types and repair prolapsed pelvic floors. The study opens up possibilities for using these stem cells for pelvic floor prolapse surgery and other gynaecological applications.
Researchers found a moderate increase in risk of coronary heart disease associated with very low estimated glomerular filtration rate, according to a new prospective study and systematic review published in PLOS Medicine. The study suggests that renal function may be an important factor in the development of cardiovascular disease.
Researchers at University at Buffalo developed a method to isolate functional smooth muscle cells from bone marrow, which can be used in regenerative medicine for cardiovascular applications. The engineered blood vessels function similarly to native tissue, demonstrating potential as an alternative to venous grafts.
Researchers have successfully engineered mesenchymal stem cells from human fat tissue into 'suicide genes' that seek out and destroy tumors. This gene therapy approach inhibits tumor growth by up to 68.5% in nude mice, showing promise as a novel cancer treatment strategy.
A $2.5M NIH grant supports research using adult stem cells to engineer soft tissue for facial reconstruction after injuries or surgery. The Columbia University team aims to develop a process that allows patients to use their own stem cells to create long-lasting implants.
Nicholas Tan Xue-Wei, an 18-year-old Singaporean student, will present his research paper on stem cells at two international conferences in the US and UK. He was nominated for a Best Paper Award at WCE 2007 for his work on growing Mesenchymal Stem Cells in a serum-free medium.
A Phase 1 trial of mesenchymal stem cells (MSCs) has shown significant improvements in heart function and reduced side effects in patients with acute myocardial infarction (MI). The study, led by Joshua Hare, M.D., found that MSC-treated patients had lower rates of cardiac arrhythmias and improved heart, lung, and global function.
Research at St. Jude Children's Research Hospital shows that leukemic cells receive a protective niche from bone marrow mesenchymal cells, which release the amino acid asparagine to help them survive treatment with asparaginase. This finding suggests new strategies for enhancing anti-leukemic drugs and reducing leukemia recurrence rates.
Researchers at UC Berkeley used mechanical stretching to guide bone marrow stem cells towards becoming smooth muscle tissue, similar to that found in blood vessels. The study suggests that a combination of chemical and mechanical factors will be needed to achieve efficient cell differentiation.
Researchers at Northwestern University have found that hematopoietic stem cells can transform into a wide variety of tissue types, not just blood cells. Additionally, the elasticity of a stem cell's environment plays a major role in determining its growth, with softer environments producing nerve-like cells and more rigid environments ...
Researchers have made breakthroughs in transforming adult stem cells into various tissue types, such as blood vessel cells, nerve-like cells, and muscle-like cells. These advancements hold promise for treating conditions like Parkinson's disease, diabetes, and spinal cord injuries.
Researchers are conducting a trial to use mesenchymal stem cells (MSCs) to repair damaged heart muscle after a heart attack. The MSCs can be grown in large numbers and stored for years, allowing a single donation to treat thousands of patients.
Researchers at Duke University Medical Center have developed a novel growth factor that significantly improves the ability of human fat-derived stem cells to be transformed into cartilage cells. The growth factor, BMP-6, stimulates the production of key biochemical markers of cartilage cell proliferation, suggesting potential for tissu...
Researchers have successfully induced neotendon formation in mesenchymal stem cells using the Smad8 signaling pathway. This breakthrough could lead to new cell-based therapeutic approaches for musculoskeletal injuries.
Researchers have discovered two new sources of stem cells with high cardiomyogenic potential, derived from menstrual blood and umbilical cord blood. These findings suggest that these cells may be able to repair or replace damaged cardiac muscle, offering a promising treatment option for heart dysfunctions.
Scientists discovered that some adult stem cells express characteristics of muscle and heart cells, suggesting they could be the 'footprints' of evolution. The researchers believe these cells may be incomplete or 'rudiments' of earlier embryonal differentiation processes.
Scientists from Boston Children's Hospital successfully engineered tracheas using mesenchymal stem cells from amniotic fluid, allowing fetal lambs to breathe spontaneously after birth. This breakthrough technique aims to fix life-threatening tracheal defects in utero.
Researchers at Max Planck Institute find that adult stem cells fuse with muscle cells to form functional tissue, contradicting the long-held idea of transdifferentiation. This discovery has significant implications for stem cell therapies targeting organ regeneration.
Researchers have successfully isolated and differentiated human mesenchymal stem cells from embryonic stem cells, offering a promising alternative to traditional methods. These cells can differentiate into multiple cell types, including bone, cartilage, fat, and muscle, with high purity and unlimited availability.
The Hopkins team is conducting a Phase I study to test the safety of injecting donor adult stem cells into patients who have recently suffered a heart attack. The study aims to determine if the stem cells can repair damage to the heart muscle and restore its function.
Researchers have identified a new source of mesenchymal progenitor cells in the human umbilical cord's Wharton's Jelly, which can be harvested to generate an abundant supply of stem cells. This discovery has the potential to greatly improve bone marrow transplantation success rates, currently ranging from 30-40%. The new stem cell sour...
Researchers suggest that skeletal-muscle satellite cells can differentiate into neural cell lineages, potentially repairing damaged muscle or nerve tissue. These stem cells were shown to organise skeletal-muscle fibres in rats with spinal-cord injury and differentiate into astrocytes and neurons.
Researchers found that injections of bone marrow stem cells into damaged heart muscle produced nearly full recovery after two months. The study showed no recovery in the control group, with worsened conditions leading to congestive heart failure.
Researchers uncover a novel mechanism regulating cell shape changes during somitogenesis, a process crucial for vertebrae and muscle formation. Cdc42 plays a central role in this transition, with activity levels influencing mesenchymal cells' ability to become epithelial cells.
Researchers at Johns Hopkins Medicine found that mesenchymal stem cell shape is a critical factor in determining which type of cell they will become. By using micropatterning technology, the team showed that spherical stem cells efficiently transform into fat cell precursors, while those allowed to stretch and flatten move closer to be...
Researchers found that adult bone marrow stem cells can differentiate into blood vessels, potentially treating cancer tumors, wounds, and atherosclerosis. The discovery of multipotent adult progenitor cells (MAPCs) may lead to new clinical therapies.
Researchers induced human adult stem cells to develop into various tissues, including bone, cartilage, and muscle, when transplanted into fetal sheep. The transplanted cells persisted for over a year without rejection, suggesting potential for tissue repair and regeneration.
Researchers at Osiris Therapeutics confirmed the existence and capability of human adult stem cells to form multiple normal human tissues. These cells can undergo substantial expansion and differentiation into bone, cartilage, or fat, forming healthy connective tissue.
Researchers have developed a new treatment using human mesenchymal stem cells that can regenerate tissue and reduce healing time after tendon surgery. The treatment has shown promising results in animal models, with improved tendon repair strength and quality of tissue within four weeks.