Articles tagged with Mesenchymal Stem Cells
Clinical evidence supports the use of mesenchymal stem cell transplantation to treat Crohn's disease-related fistulas, offering a safe and effective approach. The unique advantages of MSCs include ease of collection, low immunogenicity, and immunoregulatory activity.
Researchers discovered mesenchymal cells drive lung cell formation through molecular interactions, guiding the production of alveolar and airway cells. This finding offers new avenues for treating lung disorders like asthma and emphysema.
Researchers identify the developmental pathway of human vasculature and discover cell markers to distinguish between different types of vascular cells. This breakthrough provides a blueprint for engineering blood vessels in the lab for disease modeling, drug screening, and therapeutic purposes.
A crucial protein called Polydom is essential for developing a functioning lymphatic system. The protein promotes signaling by the Angiopoietin-2-Tie1/Tie2 pathway, which is vital for lymphatic vasculature maturation.
A new study from Michigan Medicine identifies a protein in the microenvironment of metastatic breast cancer cells that promotes their spread. The researchers found that this protein, DDR2, plays a key role in fueling the growth and migration of cancer cells, and that inhibiting it may prevent metastasis.
Researchers discovered lipocalin-2 and prolactin proteins regulate mesenchymal stem cell activity in the lab and in mice with calvarial defects. This discovery aims to improve culture conditions for growing bone cells and develop therapies for bone repair.
Scientists at Tomsk Polytechnic University have developed magnetic stem cells that can target cancer cells with precision and deliver medication directly to the tumor site. The technology uses patient's own magnet-controlled cells, which are not rejected by the immune system and cause less harm.
Researchers find that specific DNA mutations in bone cells can cause nearby blood stem cells to develop leukemia. A new class of drugs has been identified to dampen this 'neighbor cell effect', offering hope for improved treatment options for Noonan syndrome patients.
A new study reveals the cellular mechanisms that help human mesenchymal stem cells (hMSCs) retain their therapeutic properties when cultured in the lab. Mitochondria play a central role in this process.
Multiple myeloma cells communicate with healthy bone marrow cells, altering protein translation initiation to create a favorable environment for cancer growth. This crosstalk allows tumor cells to modify the surrounding microenvironment, promoting progression and disease.
Researchers discover that inflammatory signaling in bone marrow tumor environment drives malignancy and predicts leukemia development. The study reveals that mesenchymal stem cells under stress release inflammatory molecules causing DNA damage in hematopoietic stem cells, increasing leukemia risk.
Researchers found that transplantation of human placental stem cells into diabetic rats improved blood flow and reduced critical limb ischemia, a condition leading to diabetic foot and amputation. The study suggests that mesenchymal stem cells have the potential to treat diabetes-related complications.
A phase II-a randomized trial showed that intravenously administered mesenchymal stem cells resulted in improved health status and functional capacity in patients with chronic non-ischemic cardiomyopathy, but no significant cardiac structural or functional improvements were observed.
Mesenchymal stem cells exhibit significant cell-to-cell variation in their capacity to survive upon implantation. The Tulane professor's three-year project aims to gain insight into the molecular mechanisms underlying this variation, with the goal of improving survival rates and advancing regenerative therapies.
Kelly Schultz's NIH-funded project focuses on characterizing how mesenchymal stem cells interact with synthetic material to advance biomaterial design and tissue engineering. By understanding cell behavior in 3D environments, researchers hope to engineer cells to move faster, enabling quicker wound healing and tissue regeneration.
A new study published in PLOS Computational Biology suggests that using a specific sub-type of human mesenchymal stem cells can reduce potential risks associated with this therapy. This finding could lead to improved treatment outcomes for heart failure patients, providing a safer alternative to existing therapies.
A small clinical trial found injecting modified stem cells into the brains of chronic stroke patients restored motor function, with no side effects attributed to the stem cells themselves. The promising results set the stage for an expanded trial and suggest a new approach to treating brain damage.
Researchers at Carnegie Mellon University have developed a new method for preparing and labeling mesenchymal stem cells (MSCs) that allows them to be tracked using magnetic resonance imaging (MRI). This breakthrough technology uses a bio-mimicry approach to create an environment similar to the body, enabling MSCs to internalize iron-ox...
A new cancer treatment approach uses microparticles and mesenchymal stem cells to deliver chemotherapy directly to tumor cells, reducing systemic toxicity. The method successfully kills tumor cells via a strong bystander effect, offering hope for targeted treatment of prostate cancer and potentially other diseases.
Researchers have successfully printed living cartilage tissue using 3D bioprinting and human cells, paving the way for precision implants to heal damaged joints, noses and ears. The technology uses a bioink containing human cells and polysaccharides from algae or wood, allowing for precise architecture and cell production.
Researchers at Scripps Florida Institute have developed a new method to predict the activity of stem cells in treating various diseases. The Clinical Indications Prediction scale uses TWIST1 levels to determine therapeutic potential, highlighting the importance of considering both angiogenesis and anti-inflammatory effects.
Researchers discovered that sepsis causes severe muscle damage, impairing muscle function and leading to debilitating long-term effects. Mesenchymal stem cell transplantation has shown promising results in restoring muscle capacity and repairing mitochondrial dysfunction.
Researchers at UNC School of Medicine found a new way to force stem cells to become bone cells by altering gene expression with cytochalasin D. This discovery could lead to therapies for people who heal slowly from bone injuries or need replacement joints.
Researchers discovered a mechanism where mesenchymal stem cells recruit and suppress macrophage activity to protect themselves from damage. This process allows macrophages to repurpose damaged mitochondria for their own survival, creating a mutually beneficial relationship between the two cell types.
Researchers discovered a statistically significant increase in osteoblast formation when human mesenchymal stem cells were treated with the compound SR2595, which targets PPARy. The findings demonstrate a new therapeutic application for drugs targeting PPARy and may have broader implications for treating metabolic and bone diseases.
A rare genetic syndrome is associated with increased blood vessel resistance, which may contribute to hypertension. The study identifies mutations in the PDE3A enzyme that alter its activity and increase blood pressure. The findings suggest new avenues for investigating hypertension causes and developing targeted therapies.
Researchers used bone marrow-derived mesenchymal stem cells to treat fractures, lung injury, and renal obstruction. The cells promoted fracture healing in rats and attenuated acute lung injury in mice. They also showed therapeutic effects in treating pulmonary and extrapulmonary acute lung injury.
Research found that umbilical cord-derived mesenchymal stromal cells from women with gestational diabetes have impaired growth, cellular senescence, and metabolic function. The study highlights the potential impact of gestational diabetes on the therapeutic potential of these stem cells.
Researchers found that stem cells derived from amniotic tissues have immunosuppressive properties, specifically inhibiting natural killer cell activity and inducing white blood cell activation. The study identified interleukin-10 and prostaglandin E2 as key factors contributing to these effects.
Researchers identify physical characteristics of mesenchymal stem cells, allowing them to distinguish MSCs from other immature cells. Isolated MSCs show promise in repairing muscle and bone injuries in mice.
Researchers found that microRNA-124 significantly increases β-III tubulin and microtubule-associated protein-2 expression in BMSCs, promoting neuronal differentiation. Transplantation of miR-124-transfected BMSCs into spinal cord injury models improves motor function.
Researchers found that adding IL-10 to transplanted smooth muscle cells improved cell survival and cardiac function after myocardial infarction. The study suggests a new approach to prevent host rejection of allogenic cells in cardiac tissue repair.
Intravenous transplantation of BMSCs has been shown to promote nerve cell regeneration in injured cerebral cortex, supplementing lost nerve cells. This study provides evidence for the potential use of BMSCs as a therapeutic option for traumatic brain injury treatment.
Researchers found that citalopram increases the efficiency of bone marrow stem cells (BMSCs) differentiating into neuronal-like cells. This improvement in cellular differentiation is associated with increased cell proliferation and survival while maintaining neuronal characteristics.
Transplantation of adipose-derived stem cells (ADSCs) into APP/PS1 transgenic AD model mice promoted neurogenesis in the subgranular and subventricular zones. This improved cognitive function and reduced oxidative stress, providing evidence for AD treatment with ADSCs.
Researchers successfully silenced the Nogo-66 receptor gene in BMSCs, blocking its inhibitory effect and promoting neuronal growth. This breakthrough enhances the therapeutic effects of BMSC transplantation for spinal cord injury repair, offering new hope for patients.
A Harvard research team found that transplanting mesenchymal stem cells with blood vessel-forming cells improves results in mice. The co-transplantation method keeps the mesenchymal stem cells alive longer, enabling them to display their full regenerative potential and generate new bone or fat tissue.
Inhibition of Rho-associated kinase (ROCK) and subsequent cofilin dephosphorylation can promote neurite outgrowth in PC12 cells, a key step towards treating neurodegenerative disorders. Additionally, mesenchymal stem cell transplantation has shown promise in repairing and protecting damaged brain tissue after traumatic injury.
A Case Western Reserve University engineer has devised a technique to reconstitute collagen into tough fibers and induce adult stem cells to grow into tendons, which could lead to regenerating bulk volume of the tendon. The technology may also be used to repair hernias or urinary incontinence.
Researchers discovered that mesenchymal stem cells can enhance hippocampal neurogenesis and neuronal differentiation by augmenting the Wnt signaling pathway, a key player in Alzheimer's disease. This finding could lead to improved treatment strategies for the disease.
A new study from the University of Southern California found that hydrogen sulfide is essential for mesenchymal stem cells to multiply and form bone tissue. Hydrogen sulfide deficiency can lead to conditions similar to osteoporosis, but administering small molecules that release hydrogen sulfide may provide a potential treatment.
The study found that 660 nm red light promotes the migration of bone marrow mesenchymal stem cells, enhancing their contribution to treating hypoxic-ischemic brain damage. After phototherapy and cell transplantation, rats showed a significantly increased active avoidance response rate.
A study found that electro-acupuncture at Conception and Governor vessels, combined with mesenchymal stem cell transplantation, promotes neurological function recovery and angiogenesis in rats after cerebral ischemia/reperfusion. The researchers concluded that the combination has synergistic effects on promoting angiogenesis and recove...
A new method has been developed to derive large quantities of highly potent mesenchymal stem cells from human embryonic stem cells. These cells display potent immunomodulatory and therapeutic properties, offering promise in regenerative medicine.
Researchers from Sichuan University found that glial cell line-derived neurotrophic factor (GDNF) transfection promotes the neuronal differentiation of bone marrow mesenchymal stem cells. This enhancement is associated with increased expression of GDNF, nerve growth factor, and growth-associated protein-43. The study suggests a therape...
Researchers develop a sponge-like gel that compresses and induces transplanted cells to form minerals and begin tooth development. The bioinspired material could one day help repair or replace damaged organs, such as teeth and bone.
A University of Southern California study identifies a new population of mesenchymal stem cells in nerve and artery bundles that help maintain homeostasis. The discovery reveals that these stem cells are rich in the bundles, which contain nerves and blood vessels, and are regulated by the protein Shh.
Human mesenchymal stem cells can undergo spontaneous tumorigenic transformation during cell culture expansion, a finding with significant implications for their clinical application. Researchers identified RNA molecule signatures that may serve as biomarkers to detect these aberrant cells.
Researchers have identified a protein that enables the transfer of mitochondria from stem cells to damaged epithelial cells, rejuvenating their health. This discovery could lead to more effective therapies for lung disease in humans by engineering mesenchymal stem cells to produce healthy mitochondria.
Researchers at Karolinska Institutet have successfully treated two babies in utero with mesenchymal stem cells, a type of connective tissue cell that can form and improve bone tissue. The treatment was administered to babies born with osteogenesis imperfecta, a rare congenital bone disease causing stunted growth and repeated fractures.
The UTMB project aims to develop new treatments for TBI by understanding its progressive effects and using adult circulating mesenchymal cells. Researchers hope to learn how these cells can be programmed to protect brain cells, counter inflammation or replace damaged ones.
A new study published at AHA Scientific Sessions 2013 found that a single dose of stem cell therapy during surgery may improve heart function in LVAD patients. Researchers discovered that 50% of patients who received the treatment could tolerate temporarily turning down their device, compared to 20% of placebo patients.
A study found that transendocardial stem cell injection with autologous mesenchymal stem cells and bone marrow mononuclear cells is safe for patients with ischemic cardiomyopathy. The treatment also showed promise in improving quality of life and walking distance.
A USC study has identified a cellular signaling pathway that converts healthy mesenchymal stem cells in the jaw into tumor cells, leading to benign but potentially harmful tumors. The researchers hope that this understanding can be used to develop target-specific treatments for these tumors.
Researchers at the University of Illinois Chicago identified a protein expressed by human bone marrow stem cells that guides blood vessel formation. The study found that mesenchymal stem cells support functional blood vessel growth, and their genetic signature may be used to individualize stem cell treatments for heart patients.
Cardiology researchers at Emory have developed a solution to improve the impact of stem cell therapy on heart function. By packaging mesenchymal stem cells in alginate capsules, they can increase cell retention and survival, promoting healing factors that encourage regeneration of blood vessels.
Stem cells can be engineered as targeted drug factories to deliver anti-inflammatory molecules to sites of inflammation, reducing swelling. The approach uses modified messenger RNA to stimulate cell production and secretion, overcoming previous limitations such as rapid clearance.
Researchers found that mesenchymal stem cell transplantation can promote recovery from simulated childbirth injury and reduce symptoms of stress urinary incontinence. The treatment uses multipotent cells found in connective tissues, which home to damaged pelvic organs and release trophic factors to stimulate repair.
Researchers found that basic fibroblast growth factor and heparin promote differentiation of MSCs into motor neurons, increasing acetylcholine levels. This technology may prevent and treat muscular atrophy caused by peripheral nerve injury.
Researchers found that human umbilical cord mesenchymal stem cells demonstrate excellent glioma-specific targeting capacity after intratumoral injection or contralateral ventricular administration in vivo. These findings suggest a promising therapeutic strategy for glioblastoma treatment.