Articles tagged with Mesenchymal Stem Cells
Researchers successfully engineered mesenchymal stromal cells to carry and deliver therapeutics specifically to targeted tissues, offering a precise and reliable approach for treating diseases. This novel cargo-carrier, dubbed 'Cargocytes,' retains most of its cellular functionality while greatly enhancing therapeutic capacity.
Researchers have created reconstructable uterus-derived materials (RUMs) to aid in the recovery of damaged uteruses. The materials, which can be formed into different states and shapes, prevent intrauterine adhesion and promote angiogenesis, endometrial regeneration, and muscle collagen rebuilding.
A recent review article describes a class of viruses known as oncolytic viruses, which have the remarkable ability to target and destroy cancer cells. Researchers are exploring these viruses for cancer therapy, with some showing promising results in stimulating an immune response against cancer.
A subpopulation of mesenchymal stem cells expressing CD73 has been identified as crucial for bone regeneration, displaying enhanced proliferation and differentiation capabilities. This subgroup promotes fracture healing by forming new cartilage and bone cells, contributing to the remodeling process.
A new study by University of Pennsylvania researchers uses human gingiva-derived mesenchymal stem cells to guide nerve growth and regeneration, achieving similar results as traditional autograft procedures. The approach has potential for treating larger nerve gaps, including those resulting from oral cancer surgery.
Researchers identified specific mesenchymal stromal cells within the bronchovascular bundle of lungs that play a crucial role in creating scarring through interaction with epithelial cells. These cells are thought to be triggered by immune cell attacks, leading to fibrotic scarring and rejection.
A new ex vivo drug delivery system has been shown to keep MSCs viable longer and reprogram the peripheral immune response toward organ repair. The study's results suggest that SBI-101 can impact a peripheral immune response that can be transmitted to local tissue damage in vital organs, including the kidney.
A study found that treating wounds with mesenchymal stromal cell secretions significantly reduced MRSA viability and stimulated the surrounding skin cells to build a defense. The treatment has potential as an alternative to antibiotics, reducing antibiotic resistance in both veterinary and human medicine.
A new clinical study reveals that treatment with mesenchymal stromal cells reduces inflammation in patients with chronic obstructive pulmonary disease (COPD). The study provides insights into the therapeutic potential of MSCs as a novel treatment for COPD, which is a leading cause of morbidity and mortality worldwide.
Researchers used autologous adipose micrografts to treat tendon injuries in sheep, achieving similar diameter and hardness to healthy tendons within two months. The study suggests a safe, reliable, and relatively fast way to promote tendon healing, with potential for human treatment.
A study confirmed the safety of a novel stem cell therapy for knee pain caused by osteoarthritis. The treatment, which involves transplanting patient's own mesenchymal stem cells into the affected knee, showed no serious side effects over five years.
A compassionate-use study released in STEM CELLS Translational Medicine found significant improvement in body muscles with mesenchymal stem cells derived from Wharton's jelly, a substance in the umbilical cord. The treatment resulted in improved muscle strength and function without serious side effects.
Scientists have found key trends in how proteins are localized in mesenchymal stem cells, which can be controlled by substrate stiffness. This discovery may guide the control of stem cell states for research and medical treatments.
Researchers have developed a new model of NTM lung infection and found that human mesenchymal stem cells (hMSCs) are effective in treating this condition. The study identified donor-specific hMSC potency against NTMs, which could lead to improved treatment outcomes for patients with chronic NTM lung disease.
Researchers develop a new bioprinting process using ultrashort peptides, overcoming challenges in cell survival and creating complex scaffolds that facilitate long-term cell growth. The technology enables the creation of tissue models for high-throughput drug screening and diagnosis.
Researchers successfully transformed oral epithelial cell rests of Malassez into progenitor stem-like cells, which were then directly differentiated into endothelial, mesenchymal stem, and osteogenic cells. This breakthrough could lead to the development of new periodontal regenerative therapies.
Scientists identify critical enzyme KDM4B as key factor in skeletal aging and bone loss, leading to brittle bones and fractures. The study provides promising insights into the development of strategies to reverse bone-fat imbalance and prevent osteoporosis.
Researchers at North Carolina State University found that treating mesenchymal stem cells with TGF-β2 reduces the immune response in recipients. This could lead to simplified treatment options for ligament and tendon injuries in horses, as well as potential human therapies.
Researchers found that umbilical cord-derived mesenchymal stem cell infusions safely reduce the risk of death and quicken recovery time for severe COVID-19 patients. Patient survival at one month was 91% in the treatment group versus 42% in the control group.
Scientists at Tomsk Polytechnic University discovered that xenon positively affects physicochemical, mechanical and biological properties of calcium phosphate coatings used in oral and maxillofacial surgery, orthopedics, and traumatology. The coatings formed using xenon show better adhesion, which prevents peeling off too quickly.
Researchers identified two cell signals that can guide stem cells to repair eye damage, increasing their survival and function after transplantation. The study's findings offer a promising approach to restoring eyesight by modifying stem cells with enhanced chemokine receptors.
The study investigated the long-term effects of sirolimus on three different cell in vitro models, cultured in physiological conditions mimicking sirolimus-eluted stent. Sirolimus showed a cytostatic effect but had varying effects on clonogenic potential among different cell types.
A research team at Pohang University of Science & Technology has developed a technology that allows for the rapid harvesting of human bone marrow-derived mesenchymal stem cell sheets using poly(N-isopropylacrylamide) (PNIPAAm) nanotopography. This breakthrough reduces the harvest time from one week to just two days, making it possible ...
A new bioengineering technique called CardioCluster has shown promise in improving heart function after a heart attack by reducing scar tissue. The clusters of mesenchymal stem cells, endothelial progenitor cells, and cardiac interstitial cells persist in the heart walls for up to five months.
Researchers have discovered a novel cell type called PRIME cells that accumulate in the blood before rheumatoid arthritis flares, allowing for potential early prediction of disease onset. The findings could lead to better management of the condition and its symptoms.
Researchers at Texas A&M University created superior bone grafts using primitive stem cells, which help create fertile scaffolds needed for bone regeneration. These grafts could reduce inflammation, pain, and the need for revision surgeries, promoting swift and precise bone healing.
A Kazan University research team has developed a novel nanoformulation using biocompatible halloysite nanotubes and bacterial pigment prodigiosin, which selectively disrupts cancer cells without harming healthy ones.
A review assesses the potential of mesenchymal stem cells to treat preeclampsia, a pregnancy complication that can cause high blood pressure and organ damage. The study found promising results in animal models, with MSCs or their secreted cargo showing promise as novel treatment options.
A new study found that nicotinamide inhibits aggressive cell transformations and reverses the development of fibrous membranes in the retina, potentially treating fibrotic eye diseases. The compound also promotes the transition from mesenchymal to epithelial cells, helping to preserve their original identity.
Researchers at Penn State developed a novel bioprinting technique that uses aspiration-assisted printing to place tiny tissue spheroids in precise locations, enabling the creation of homogeneous and heterocellular tissues. This method has potential applications in regenerative medicine, drug screening, and microphysiological systems.
A team of researchers has begun a doctor-initiated clinical trial for a new cell spray treatment method targeting heart failure. The product, ADR-002K, uses a spraying technique to administer mesenchymal stem cells onto the heart, aiming to improve prognosis and cardiac function in patients with ischemic cardiomyopathy.
A new handheld 3D skin printer has been developed to accelerate wound healing of large, severe burns. The device deposits sheets of skin using 'bio ink' made from mesenchymal stem cells, which promotes skin regeneration and reduces scarring.
Boston researchers developed a novel approach to generate intestinal organoids in vitro using human induced pluripotent stem cells. The protocol allows for the creation of three-dimensional groups of intestinal cells, enabling disease treatment testing and uncovering novel therapies.
Scientists at Peter the Great Saint-Petersburg Polytechnic University create a method of targeted drug delivery to cancer cells using microcapsules made of polymeric compounds and gold nanorods. The technology allows for precise treatment of tumors without harming healthy tissues.
Researchers develop single-cell encapsulation technology to protect transplanted stem cells from clearance and immune attack, improving bone marrow transplant success rates in mice. The new microgels allow MSCs to persist in the body longer and resist immune rejection.
Researchers find that human iPSCs can efficiently produce highly purified extracellular vesicles for treating aging-related diseases. These vesicles contain proteins and other treatments that can help repair damaged cells, and may one day be used to treat progeria and ALS.
Scientists have successfully preserved frozen animal cells without using cryoprotectant agents (CPAs), which can be toxic and cause cell damage. The new method relies on ultrarapid cooling, achieving vitrification and cryopreservation with minimal damage to the cells.
Researchers identified nine types of cells and subtypes in the marrow microenvironment, including vascular endothelial cells and stem cells. The study revealed a critical role of subsets of cells involved in cancer chemotherapy and immune cell production.
Scientists created smart glues from human stem cells that can repair chronic wounds, protecting the cells from aggressive environments. The new technology uses natural enzymes to grow artificial extracellular matrices, paving the way for tissue engineering advancements.
Scientists identify CXCL12-expressing mesenchymal stromal cell niches as a strategy to target and eliminate treatment-resistant leukemic stem cells in chronic myelogenous leukemia. The study reveals that these niche interactions control quiescence of leukemic stem cells.
Researchers found that ZEB1 forces KRAS-driven lung cancer cells to switch from stable to mobile, resistant mesenchymal cells, making them less responsive to MEK inhibitors. A combination of an HDAC inhibitor and a MEK inhibitor reversed this transition and restored vulnerability to targeted therapy.
Researchers have identified a novel transcription factor called Osteoblast Inducer-1 (ObI-1) that regulates the differentiation of mesenchymal stem cells into bone in mice. This discovery has significant implications for regenerative medicine, as MSCs offer a promising source of stem cells for therapeutic applications.
Researchers have developed an innovative treatment using uterine stem cell conditioned medium, showing antifungal activity against resistant strains of Candida albicans. This breakthrough opens up a new window of hope for treating vaginal candidiasis and its chronic carriers.
Researchers at NYSCF identified two growth media types that support effective expansion of mesenchymal progenitor cells for bone treatment and repair. MP cells have promise in treating blood, heart, and immune diseases as well as repairing damaged bone and cartilage.
Researchers compared iSCs and BM-MSCs for CNS repair capacity. iSCs exhibit potential for neuronal differentiation, making them promising candidates as therapeutic agents.
The Mek5/Erk5 pathway plays a crucial role in skeletogenesis through the regulation of mesenchymal stem cell differentiation and chondrocyte maturation. Erk5 controls early chondrogenic differentiation and chondrogenic differentiation after condensation formation. This study improves our understanding of skeletal development and paves ...
Scientists discover that as we age, a small molecule called microRNA-141-3p increases and silences key signaling molecules like SDF-1 in stem cells, leading to weaker bone formation. Restoring a youthful balance could be a novel approach to reducing age-related problems like osteoporosis.
Researchers identified adventitial CD90+ and mesenchymal stem cells in human arteries for the first time, providing a clear link to vascular diseases like coronary artery disease. These cells appear to play a key role in mediating vascular diseases.
Tissue-engineered human pancreatic islets developed a circulatory system and secreted hormones like insulin, resolving the disease in transplanted mice. The self-condensation cell culture process promotes vascularization, offering a potential curative strategy for type 1 diabetes.
Researchers used adipose-derived mesenchymal stem cells to treat spinal cord injuries in rats, resulting in improved motor function and reduced damage. The study's findings suggest a promising therapeutic approach for repairing nervous tissue after injury.
Researchers found that gingival mesenchymal stem cells release more proteins, including IL-1RA, which blocks proinflammatory cytokines, accelerating wound healing in mucosal tissues. The study suggests potential therapeutic applications for delayed wound healing in diabetic patients.
Clinical trials have produced encouraging results for mesenchymal stem cell therapy in treating feline inflammatory diseases, such as chronic gingivostomatitis and enteropathies. However, further research is needed to answer questions about logistics and optimal use of the treatment.
Researchers at The Scripps Research Institute identified the p53 gene as a master regulator of mesenchymal stem cells' ability to differentiate. The study found that a basal level of p53 is required for MSCs to act accurately in the body, and its deletion can lead to unexpected differentiation outcomes.
Diabetes impairs dead heart-muscle cell removal, increasing cardiovascular risk. Researchers study mesenchymal stem cells and their exosomes to boost dead cell removal and reduce inflammation after heart attacks.
A new stem cell method creates human arterial endothelial cells from cord blood and adult bone marrow, revealing two distinct states: healthy and compromised. The compromised state is linked to arteriosclerosis and can be used to study a major risk factor for heart disease.
Researchers develop targeted delivery vehicles for multiple sclerosis drugs using extracellular vesicles, offering a potential treatment breakthrough. The new method uses naturally occurring vesicles to deliver small molecules of RNA that boost myelin production in oligodendrocytes.
Researchers found that omega-3 polyunsaturated fats in fish oil push stem cells towards forming bone cells, rather than fat cells. This fundamental research may provide insight into the connections between dietary fats and various clinical outcomes.
Researchers at MUSC are testing whether mesenchymal stem cells can help people with treatment-resistant lupus. The study, led by Gary Gilkeson and Diane Kamen, marks a milestone in lupus research and aims to develop better treatments.
Researchers at Scripps Research Institute have discovered a compound that irreversibly stops the growth of certain aggressive, treatment-resistant tumor cells. The compound, FiVe1, blocks cell division by binding to a structural protein, vimentin, produced abundantly in mesenchymal-type cells.
Aging is associated with a decrease in Cbf-beta protein, leading to an imbalance in bone maintenance and increased fat cell creation. Maintaining Cbf-beta may be essential to preventing age-associated osteoporosis.