Articles tagged with Morphogenesis
A research team has identified a novel enhancer that controls the tissue-specific expression of Scleraxis, a key transcription factor for tendon, ligament, and entheses formation. The enhancer, capable of recapitulating Scx gene expression in developing limbs, is highly conserved from lobe-finned fishes to tetrapods.
A recent study found that a higher body fat percentage is linked to lower sperm counts and changes in male reproductive hormones. Men with high body fat percentages had lower semen volume, sperm concentration, and testosterone levels compared to those with normal body fat percentages.
Researchers reveal a previously unrecognized form of actin self-organization that may help explain how cells spontaneously generate shape and movement. Live-cell imaging and computational modeling show that these self-propelled treadmilling actin filaments (SpTAs) drive cellular protrusions through a process powered by treadmilling.
Researchers at Pohang University of Science & Technology discovered a way to prime skin cells for regeneration before injury, enabling rapid and effective healing. This approach, called mosaic partial reprogramming, reshapes surrounding cells and tissue microenvironment to accelerate wound healing.
Researchers at Hebrew University uncover the mathematical secret behind rose petals' unique shape, discovering MCP incompatibility causes sharp points to form. This discovery opens possibilities for designing self-shaping materials with controlled cusps, mimicking nature's elegance.
A team of scientists has created a comprehensive atlas of early mammalian morphogenesis, revealing that individual events such as cell divisions and movements are highly chaotic. However, the embryos as a whole end up looking very similar to one another, with physical laws driving them to form a specific morphology shared among mammals.
High levels of plastic pollution can kill the embryos of a wide range of ocean animals, preventing healthy development in all seven tested species. This study highlights the
A research team from Doshisha University discovered a novel phenomenon for generating self-organized characteristic patterns through phase separation of polymer solutions in glass capillary tubes. They created uniform microdroplets containing DNA and medicines, which maintained their alignment for eight hours, offering insights into bi...
Researchers analyze fertilized ascidian oocytes to understand the mechanism driving cytoplasmic reorganization and cell shape changes. Friction forces between cellular components, such as actomyosin cortex and myoplasm, are found to be pivotal in determining organismal shape.
The study reveals that hepatoblasts along the portal vein receive Notch signaling and differentiate into bile duct epithelial cells. Hematopoietic cells fail to transmit signals, resulting in the failure of differentiation. This discovery provides molecular biological support for mathematical analysis results.
A recent study reveals that CAMSAP1 plays a crucial role in regulating the structure and dynamics of manchette microtubule minus-ends, impacting male fertility during spermiogenesis. The absence of CAMSAP1 leads to abnormal sperm development, including reduced sperm quantity, decreased motility, and male infertility.
A Kyoto University team reveals the Dumpy protein as the key factor in controlling 3D tissue structures through external cues. This finding challenges traditional understanding of morphogenesis and opens up new avenues for manufacturing controllable 3D tissue folding with coordinated cell behaviors.
Researchers discovered a central regulator, DipM, controlling multiple autolysins and promoting cell constriction in Caulobacter crescentus. The study reveals DipM's role in coordinating bacterial cell wall remodeling and division processes.
A new Northwestern Medicine study has furthered the understanding of metabolic pathways underlying organ development, specifically eye development. The research found that aerobic glycolysis and production of lactate regulate critical genes required for early eye development.
A CNIC team has created a dynamic 3D atlas of the formation of the heart during embryonic and fetal development, allowing for the identification of the first appearance of left–right asymmetry in the heart. This study provides important information on the development of congenital heart malformations.
A UNIGE team discovered that cells in curved tissues swell by 50% before returning to normal, opening avenues for in vitro organ culture. This active phenomenon can be harnessed to control spontaneous growth of organoids and develop new materials with volume increase upon folding.
Researchers at the University of Illinois have developed a new type of water filtration membrane that mimics the natural process of morphogenesis. The membranes, made from soft polymers, exhibit complex 3D structures that allow them to efficiently separate pollutants from water.
Using observations, lab experiments, theory, and computation, researchers have developed a simple theory to explain the form and growth of apples' cusp-like features. The team found that mechanical instability and underlying fruit anatomy play joint roles in giving rise to multiple cusps in fruits.
Scientists have created a mathematical framework to understand how termites construct intricate mounds without a plan. By analyzing the spacing and arrangement of floors and ramps, researchers have made predictions for the spontaneous formation of linear and helical ramps, shedding light on swarm intelligence.
The discovery sheds light on how a subtle deviation in the development process can be detrimental to individual survival and reproductive success. The study reveals that Kdm7a regulates Hox gene expression, which is crucial for embryonal morphogenesis and vertebrate body plan development.
Researchers discovered a new link between arginine metabolism and plant shape formation, using the moss Physcomitrium patens as a model organism. The study identified a core pathway involving transcriptional co-activators ANGUSTIFOLIA3/GRF-INTERACTING FACTOR1 (AN3/GIF1) family signaling.
Researchers describe elegantly simple solution to complex problem of how tissues branch and grow, revealing self-organising process that generates space-filling networks. This discovery has huge implications for basic biology, offering new insights into cancer development and potential applications.
A new study reveals the existence of a non-proliferative signaling center in tooth development, which drives epithelial invagination and instructs neighboring cells to proliferate. The initiation knot is identified as a critical regulator of tooth morphogenesis and size determination.
Researchers in Japan studied Sarracenia purpurea to understand how carnivorous pitcher leaves form. They found that oriented cell division is the key factor behind pitcher leaf development, resulting in a hollow structure.
Researchers from the University of Pittsburgh and Brandeis University have provided experimental evidence validating Alan Turing's theory of morphogenesis in cell-like structures. The study confirms the prediction of six different patterns and discovers a seventh, demonstrating how identical biological cells differentiate into distinct...
Scientists from Brandeis University and the University of Pittsburgh validate Alan Turing's theory of morphogenesis, demonstrating that identical cell-like structures can differentiate into various patterns through intercellular reaction-diffusion. The research has implications for biological development, materials science, and soft ro...
Scientists at UNIST have identified a common mechanism in Fragile X and Down syndrome that regulates dendritic spine morphogenesis and synaptic efficacy. This discovery provides an important stepping stone in understanding the multiple roles of DSCR1 in neurons and identifying potential therapeutic targets for intellectual disabilities.
The 'Branching Morphogenesis' installation, made from 75,000 cable zip-ties, simulates human lung cell interactions and challenges existing notions of complex biological information display. It has won the 2010 International Science & Engineering Visualization Challenge award.
The study reveals that tissue geometry controls the morphogenesis of breasts and other organs by defining local cellular branching microenvironments. This finding may reveal mechanisms to control cancer invasion and metastasis.