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Study suggests antioxidant treatment may help NF1-linked behavioral issues

Researchers found that defects in the NF1/Ras molecular pathway trigger production of harmful oxidative nitric oxide molecules in glial brain cells, leading to behavioral issues. Antioxidant treatment reversed symptoms in mouse models of NF1 and Costello syndrome, suggesting a potential therapeutic approach for related human conditions.

Long-lived mice are less active

A study published in PLOS ONE found that long-lived female house mice are less active than shorter-lived counterparts, consuming less food and displaying reactive personality traits. The researchers suggest that life-history theory predicts individuals with greater life expectancy to be more cautious and energy-conserving.

SourceUniversity of Zurich·JournalPLOS ONE·DateJul 4, 2013

Higher genetic risk tied to lifetime asthma suffering

A new study found that children with higher genetic risks for asthma are not only more likely to develop the condition at a young age but also experience persistent symptoms in adulthood. Those with higher risk scores had poorer quality of life, missing work and school, and were hospitalized more often due to asthma.

SourceDuke University·JournalThe Lancet Respiratory Medicine·DateJun 27, 2013

It's all in the genes -- including the tracking device

Researchers have successfully implemented a genetic-based fish tagging method, called parentage-based tagging (PBT), in the Snake River Basin. This non-invasive approach allows for the collection of detailed information about hatchery-reared fish, enabling more effective fisheries management and conservation efforts.

SourceCanadian Science Publishing·JournalCanadian Journal of Fisheries and Aquatic Sciences·DateJun 24, 2013

Mount Sinai researchers provide 1st prospective characterization of a genetic subtype of autism

Researchers from the Seaver Autism Center at Mount Sinai identified common clinical symptoms of Phelan-McDermid Syndrome, including severe to profound intellectual disability, seizures, and low muscle tone. The study provides important guidance for developing a standardized assessment methodology for this disorder.

Evolving genes lead to evolving genes

Researchers used a method to test for evolutionary adaptation in genes regulated by FOXP2, a key factor in human development and language. The study found strong evidence for selection of FOXP2-regulated genes in European populations, highlighting their potential roles in neural cell development and immunity.

SourceWellcome Trust Sanger Institute·JournalAmerican Journal of Human Genetics·DateApr 18, 2013

New therapy for fragile X chromosome syndrome discovered

Researchers have discovered a new therapy for fragile X chromosome syndrome by modulating the cerebral endocannabinoid system. The treatment has shown promise in normalizing cognitive alterations and sensitivity to pain in genetically modified mice, suggesting a potential new strategy for treating patients with FXS.

SourceElhuyar Fundazioa·JournalNature Medicine·DateApr 10, 2013

Mice show innate ability to vocalize

Researchers found that mice do not need to learn to vocalize and can produce the same suite of ultrasonic sounds regardless of whether they are deaf or hearing. This discovery points the way to a genetic tool for studying speech and its disorders, shifting focus from learning to genetic mechanisms.

Putting the clock in 'cock-a-doodle-doo'

A study published in Current Biology found that roosters' crowing is entrained to a circadian rhythm, meaning it follows a natural daily cycle. The researchers used constant light conditions and recorders to observe the birds' behavior, confirming that predawn crowing depends on an internal clock.

SourceCell Press·JournalCurrent Biology·DateMar 18, 2013

Study maps human metabolism in health and disease

A team of international researchers has created an instruction manual for the human genome, providing a framework to understand the relationship between genetic makeup and lifestyle. The model explains how individual biological parts operate differently within each person, paving the way for tailored treatments in personalized medicine.

SourceUniversity of Manchester·JournalNature Biotechnology·DateMar 3, 2013

Epigenetics shapes fate of brain vs. brawn castes in carpenter ants

Research on the Florida carpenter ant reveals that epigenetic regulation plays a key role in distinguishing two worker castes with strikingly different behaviors and physical characteristics. Histone modifications, including those influenced by the CBP regulator, are found to correlate with gene expression levels and cognitive abilities.

Induction of mild inflammation leads to cognitive deficits related to schizophrenia

Researchers identified a mutant mouse model of schizophrenia that exhibits mild chronic brain inflammation and cognitive deficits. The study found that Shn-2 deficiency leads to an 'immature Dentate Gyrus', which produces schizophrenia-related phenotypes. Chronic administration of anti-inflammatory drugs rescued working memory deficit ...

SourceNational Institute for Physiological Sciences·JournalNeuropsychopharmacology·DateFeb 6, 2013

Research from King's College London reveals why some teenagers more prone to binge drinking

A new study by King's College London has identified the RASGRF2 gene as a key player in regulating alcohol-induced reinforcement, with individuals carrying the variation more likely to engage in binge drinking. The research also found that the absence of this gene reduces alcohol-seeking activity and impairs brain function.

SourceKing's College London·JournalProceedings of the National Academy of Sciences·DateDec 3, 2012