Articles tagged with Rna Methylation
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Researchers develop a new approach for treating inflammatory bowel diseases by delivering locked nucleic acids (LNAs) to the relevant organ using lipid nanoparticles. The study shows improvement in inflammation markers with no side effects, paving the way for potential treatments of rare genetic disorders and other diseases.
A recent study developed a highly accurate risk prediction framework for preterm birth using genomics, transcriptomics, and large language models. The model achieved an AUC of nearly 90%, making it the most powerful approach in predicting preterm birth.
Researchers from Tel Aviv University and the Israel Institute for Biological Research have developed an mRNA-based vaccine against pneumonic plague, a disease caused by Yersinia pestis. The vaccine showed 100% protection in animal models and offers hope for combating other lethal bacteria.
A new study reveals that DNA methylation mediates the transgenerational inheritance of acquired cold tolerance in rice, supporting Lamarck's theory. Researchers developed a novel breeding strategy to develop stress-resilient crops, offering a promising avenue to tackle agricultural challenges posed by global climate change.
Researchers developed a new tool called SigRM to analyze single-cell epitranscriptomics data, enabling the study of RNA modifications in individual cells. This can provide valuable insights into gene regulation and its impact on health and disease, particularly in complex conditions like cancer.
Scientists have developed a novel enzyme, SUPer RNA EcoGII Methyltransferase (SUPREM), which can selectively modify RNA and has high methylation activity. This tool can be used to investigate RNA modifications in various diseases, providing new insights into their role in cell health.
A groundbreaking study reveals how TRMT10A deficiency disrupts protein synthesis, synaptic structure, and function in the brain, leading to impaired cognitive abilities. Researchers found a significant decrease in specific tRNA levels, particularly those essential for initiating protein synthesis.
Key RNA methylation modifications significantly impact cancer progression by influencing metabolic reprogramming, immunity, and gene expression. Dysregulated RNA methylation contributes to cancer growth, metastasis, and therapy resistance.
Researchers highlight the role of post-transcriptional RNA modifications in AML pathogenesis, identifying m6A and m7G regulators as potential therapeutic targets. Targeted therapies, including selective inhibitors and Traditional Chinese Medicine compounds, show promise in promoting cell differentiation and reversing AML phenotypes.
Researchers have identified the first inhibitors of the cancer-related RNA-modifier METTL16, which prevent its interaction with RNA. This breakthrough lays the foundation for novel RNA-targeting therapeutics and better investigation of METTL16's role in disease and health.
Researchers at Lurie Children's Hospital of Chicago have identified a novel biological mechanism that regulates mitochondrial function through RNA methylation. This finding holds promise for developing new treatments for neurological diseases like spinal muscular atrophy and autism, as well as various cancers.
Researchers have identified a crucial biological trigger of Huntington's disease, finding that methylation converts an important protein into waste. By targeting this process, they may develop effective therapies for other neurodegenerative diseases.
Reducing mRNA methylation promotes migration of macrophages into the brain and clearance of toxic protein amyloid-beta. This pathway provides a potential new target for treatment of Alzheimer's disease.
A study found that RNA methylation plays a pivotal role in TDP-43-related neurodegeneration in ALS. The researchers observed highly abundant RNA methylation in the end-stage tissues of patients with ALS. This discovery opens up new avenues for research into the disease, which is linked to environmental exposure.
Researchers found that cells don't pick certain sites to methylate, but rather where not to, due to the joints of messenger RNA. This discovery has implications for gene therapies, disease treatment, and our understanding of biology and evolution.
Researchers at Kyoto University discovered METTL16's role in DNA repair and erythropoiesis, a process generating 200 billion new red blood cells daily. Tiny methyl groups on specific mRNAs play a pivotal role in this process, involving mechanisms mediated by RNA-binding proteins.
Researchers found that SARS-CoV-2 increases methylation of host cell RNA, which can help the virus evade the immune system. This discovery provides insights into how different variants escape immunity and offers potential avenues for novel COVID-19 treatments.
Experiments in cell cultures and mice showed that blocking the function of NSUN2 triggers a powerful innate immune response, dramatically lowering viral replication and protecting lung tissue. This finding could help change the approach to developing antiviral medications.
Researchers discovered a novel form of gene regulation altered in bladder cancer, which boosts the unfolded protein response pathway to help cancer cells survive during rapid growth. Elevated TRMT6/61A enzyme levels prevent tRF-3bs from silencing genes in this pathway.
A new mechanism has been discovered that decorates the end tails of RNA molecules in a parasite causing sleeping sickness, preventing their degradation and potentially increasing virulence. This fundamental discovery opens new avenues for treatment strategies for this disease, as well as other RNA-based infections/diseases.
Scientists have discovered that mRNA modifications play a crucial role in the brain's reward learning process and transporting mRNAs to synapses. The study found that removing these modifications impaired flies' ability to learn essential survival skills, highlighting the importance of these modifications in animal function.
A research group at Osaka University has developed a new tool for sequencing various types of RNA base modifications, including microRNA modifications. They successfully detected two types of chemical base modifications simultaneously using a single-molecule quantum sequencer.
Researchers at UNIGE discovered a new mechanism for regulating RNA maturation dependent on diet, finding that methylation of specific mRNA sequences leads to its degradation. This control mechanism ensures a fair balance of methylations and prevents aberrant reactions, which can cause diseases.
Researchers found that hypoxia upregulates RNA polymerase I activity and alters ribosomal RNA methylation patterns, leading to the creation of specialized ribosomes that can differentially regulate translation of specific messenger RNAs. The study supports a long-debated postulate that ribosomal protein factories can be reprogrammed in...
Scientists at the University of Würzburg have developed a ribozyme that can transfer methyl groups to target RNAs, shedding light on an interesting aspect of evolution. The discovery may mimic a ribozyme that could have been lost in nature, and has potential applications for understanding RNA structure and function.
Scientists at UChicago discovered a previously unknown mechanism where RNA itself affects DNA transcription using a chemical process. This breakthrough has significant implications for understanding human disease and drug design.
Researchers discovered that methylation of RNA can strengthen memory formation by reducing the brain's ability to remove methyl groups. This process may have significant implications for treating memory-related disorders such as post-traumatic stress disorder or phobia.
Researchers at the University of Chicago and Tel Aviv University have discovered a new chemical modification that can boost gene conversion to proteins. The study enriches the epitranscriptome, a critical new dimension in molecular biology, suggesting an even larger cellular control panel.
A recent study by UChicago scientists reveals how the N6-methyladenosine (m6A) modification on mRNA affects the half-life of mRNA, regulating cellular protein quantities. This discovery could provide fundamental insights into healthy functioning and disorders such as obesity, diabetes, and infertility.
Researchers at Harvard University have found that genes produce extracoding RNA to prevent silencing by DNA methylase 1. This discovery has therapeutic potential as an 'on-off switch' for gene expression.
Chuan He has been selected as an HHMI investigator to uncover the mechanisms of reversible RNA methylation. His research team will use genomics tools and expertise in various biology fields to explore this new area.
This article features protocols for investigating histone demethylase activity, including methods for detecting cytosine methylation in RNA using bisulfite sequencing. These methods enable researchers to measure histone demethylase activity in tissues and cell lysates, identify novel enzymes, and screen for inhibitors.