Articles tagged with Gastric Acid
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Researchers created pea-sized mini-stomachs with three main regions, replicating human stomach function and acid secretion. The study models a rare genetic disease, paving the way for personalized treatment and accelerated clinical approval.
Researchers at PolyU have developed an acid-resistant, ultra-stable mucus-inspired hydrogel that significantly improves gastrointestinal wound healing in animals and outperforms a clinically approved mucosal protectant. The hydrogel's potential for commercialization is high due to its low cost, ease of production, and established safet...
Researchers at German Cancer Research Center discovered that PPIs can be activated by zinc-carrying proteins without gastric acid. This finding could help understand the side effects of PPIs and open new perspectives for their better use.
A new study found that changes in the gut environment influence the composition and activity of gut bacteria. The study involved swallowing a capsule with pH sensors through breakfast, revealing unique gut environments and travel times among individuals. This may help explain individual differences in digestion, nutrient uptake, and bo...
A study by researchers at the Leibniz Institute for Food Systems Biology has uncovered a molecular link between bitter taste receptors and gastric acid release. Bitter substances stimulate parietal cells to secrete protons, leading to acidic stomach conditions. The findings hold promise for innovative treatments of gastric diseases.
Scientists at Nagoya University developed a new gastric acid inhibitor with a binding affinity nearly 10 times higher than existing drugs. The AI-driven approach led to the creation of compound DQ-18, which exhibits stronger binding to the gastric proton pump.
A large-scale study from three Nordic countries shows that the majority of patients with reflux disease do not have a higher risk of cancer. Only those with changes in the oesophageal mucosa are at increased risk.
A study of 151 patients with functional dyspepsia found that turmeric's curcumin was as effective as omeprazole in reducing symptoms after 28 days. Patients who took the combination treatment showed stronger improvements after 56 days, suggesting curcumin may be a viable alternative to conventional drugs.
Researchers at Leibniz-Institut für Lebensmittel-Systembiologie an der TU München discovered that casein digestion produces peptides with a satiating effect, stimulating gastric acid secretion via bitter receptors. This mechanism may help regulate food intake and maintain a healthy body weight.
A new study found that opioids like morphine can cause gastric inflammation due to increased acid secretion and delayed gastric emptying. Treatment with naloxone or proton pump inhibitors like omeprazole may provide gastroprotection, improving pain management and reducing side effects.
Research shows that common medicines have distinct effects on gut bacteria, with some having beneficial and others detrimental impacts. The study found associations between certain medications and changes to the gut microbiome, particularly with statins and gastric acid medication.
Researchers from the University of Basel found that gastric bypass and sleeve gastrectomy surgeries result in similar weight loss outcomes, with patients losing two-thirds of excess weight. Additionally, gastric bypass showed better results in reducing symptoms of gastric acid reflux.
Researchers discovered that stomach acid suppression alters specific gut bacteria in a way that promotes liver injury and progression of three types of chronic liver disease. This association was found in both mouse models and human patients with chronic alcohol abuse, highlighting the potential risks of common acid reflux medications.
Researchers developed micromotors that swim through stomachs to deliver antibiotics, reducing need for proton pump inhibitors. The treatment was more effective than traditional methods in mice with Helicobacter pylori infections.
Researchers found a 25% increased risk of death from all causes among PPI users compared to H2 blocker users. The study also suggested that PPIs may boost oxidative stress and shorten telomeres, potentially leading to tissue damage.
Research at Mayo Clinic found that patients using gastric acid suppression medications are at a higher risk for developing recurrent C-diff infections. The study suggests these medications may increase the risk, and caution is advised when prescribing them to patients with a prior C-diff episode.
Aarhus researchers identified the mechanism behind the acid pump, which pumps acid into the stomach. Replacing a key amino acid with arginine enables the pump to function like an electroneutral pump.
Scientists developed micromotors that speed independently through the stomach, neutralizing acid and releasing drugs at precise pH levels. This approach avoids common side effects associated with traditional treatments, making it a promising method for treating stomach diseases.
Researchers have successfully powered micromotors with stomach acid in a living animal, demonstrating their potential for targeted drug delivery and diagnosis of hard-to-reach tumors. The motors achieved remarkable penetration and retention rates, outperforming traditional oral delivery methods.
Researchers identify nerve pathways in the spinal cord that transmit pain signals from gastric reflux to the brain. This breakthrough could lead to more effective treatments beyond acid reduction, correcting sensitivity of nerve endings and providing balanced relief for sufferers.
A study by Mayo Clinic researchers found that histamine 2 receptor antagonists increase the risk of Clostridium difficile infection in hospitalized patients, particularly those receiving antibiotics. The study highlights the need for judicious use of these drugs to reduce C. diff infection rates.
A new study from Nationwide Children's Hospital helps clarify the definition of gastroesophageal reflux disease (GERD) in neonates. The research finds that symptoms can occur with acid, non-acid, gas, liquid, or mixed events, making treatment strategies based on modifying gastric acidity alone ineffective.
Researchers found dilated intercellular spaces in esophageal epithelium as a nonspecific ultrastructural feature of non-erosive reflux disease (NERD). This discovery suggests DIS is an early and sensitive marker for NERD diagnosis, providing new insights into its mechanism.
Researchers found that HdeA lets go of unfolded proteins gradually, allowing them to refold instead of clumping together. This unique mechanism allows HdeA to harness energy from the environment, making it a more efficient chaperone.
Researchers at the University of Michigan discovered a tiny protein called HdeA that protects disease-causing bacteria from stomach acid. This protein unfolds and becomes more flexible in response to acid, but unlike other proteins, it activates when unfolded, allowing it to bind and adapt to damaged proteins.
Researchers at University of Cincinnati discovered a gene that helps control stomach acid production, which could lead to new therapies for overproduction. The study found that eliminating the Slc26a9 transporter gene stops acid secretion in the stomach.
A study found that long-term use of histamine2 receptor antagonists increases the risk of cognitive impairment in older African-Americans. Nearly 18% of users exhibited signs of cognitive impairment after controlling for other factors.
A clinical trial shows that Garli-Eze, a unique garlic product, can deliver large amounts of allicin directly to the upper gastrointestinal tract for easy absorption. This process eliminates degradation issues and allows for effective cardiovascular benefits.
A new study found that patients with healed erosive esophagitis had better acid control and lower heartburn symptom scores compared to those who did not heal. The study suggests that controlling gastric acid levels is key to healing erosive esophagitis.
A 12-month study showed that NEXIUM maintained normal acid production levels in most patients with Zollinger-Ellison syndrome. Most participants controlled their acid output after just 10 days, and no ulcers or erosive esophagitis were observed at the end of the year.
Researchers found that inhibiting acid production made stomachs more vulnerable to bacterial invasion and gastritis. The study suggests that antibiotics are the best way to kill bacteria causing gastritis and eliminate inflammation. Inhibiting acid production can actually trigger an inflammatory response, making gastritis worse.