Articles tagged with Gonads
A study published in Science reveals that microglia and the protein RANK are involved in regulating the hypothalamic-pituitary-gonadal axis, which controls fertility. The research found that suppressing RANK expression led to distorted reproductive function, including reduced sex hormones and hypogonadism.
The ESE and ESPE have launched a landmark Joint Clinical Practice Guidance to support structured and effective transition of young people with endocrine conditions. The Guidance provides practical, evidence-based recommendations to ensure continuity, safety and quality of care during this critical phase in a patient's life.
The European Society of Endocrinology is launching a new campaign to raise awareness about the importance of hormone health. The #BecauseHormonesMatter initiative aims to improve public understanding of hormones and promote practical steps for better hormone health, following the success of last year's campaign.
A study by the Gerald P. Murphy Cancer Foundation's Center for Exceptional Longevity Studies found that retaining gonad function can significantly impact frailty mortality risk. Male dogs with shortest testis exposure had high mortality risks, while those with longest gonad exposure showed no consequence of increasing frailty.
The European Society of Endocrinology has released the EndoCompass Research Roadmap, a major new initiative to align research efforts and improve funding strategies for hormone-related health challenges. The roadmap identifies specific research needs across eight endocrine specialties and five cross-cutting areas.
Researchers found that maternal iron deficiency can lead to male-to-female sex reversal in mouse embryos due to impaired Sry gene activation. Iron is necessary for KDM3A's enzymatic activity, which removes histone methylation allowing the Sry gene to become active.
Researchers developed tiny human ovary organoids using stem cells to understand gonad development and disease. The models replicate key aspects of ovarian follicles, offering a powerful platform for studying gene function in a controlled environment.
Researchers have identified a novel target downstream of parathyroid hormone signaling that suppresses bone formation. Gprc5a negatively regulates osteoblast proliferation and differentiation by partially suppressing BMP signaling, potentially increasing teriparatide effectiveness in non-responding patients.
Researchers from Osaka University have shed light on how certain proteins contribute to the formation of piRNAs, a type of RNA that protects the genome. Tejas plays a key role in recruiting Vas and Spn-E, facilitating nuage formation and piRNA processing.
The deletion of the Wt1 gene leads to differences in sex development in adult mice, with ambiguous genital tracts and undifferentiated gonads observed in mutant females and males. The study suggests that the Wt1 gene is necessary for activating pathways determining male and female sex development.
Researchers discovered that hydraulic instability amplifies small volume differences between germ cells, leading to their selection for growth or shrinkage. The study reveals a mechanical mechanism governing the life and death decision in the nematode germline.
In a groundbreaking study, researchers discovered that anemonefish undergo male-to-female sex changes first in their brains before gonads are affected. The transition occurs independently of the gonads and can take months or years to complete.
Scientists have discovered significant differences in gonad development between Steinernema carpocapsae and C. elegans, highlighting the diversity of neuronal anatomy across nematode species. This research has practical applications for commercializing biocontrol products and advancing our understanding of genetic processes.
A new study by Nagoya University reveals that germ cells in medaka fish can feminize the body before the sexual fate decision is made. This finding suggests that the mechanism underlying this effect is activated early in development and plays a critical role in sex determination.
A new GM mosquito sexing technique allows for the quick identification of males, paving the way for releasing sterile males to control mosquito populations. This could lead to a significant reduction in malaria cases and population growth.
Researchers discovered glycosylation enhances MIG-17 action, guiding gonad cell migration; deficiency causes abnormal gonad development. Glycosylation defects may also impact ADAM-family protein functions, leading to human diseases.