Articles tagged with Death Receptor Pathway
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Researchers find inhibiting TMEM219 signaling restores mucosal healing in inflammatory bowel diseases and protects intestinal stem cells from death. The study suggests TMEM219 overactivation induces intestinal stem cell death, preventing mucosal renewal during inflammation.
A global analysis reveals significant differences in disease rates, diagnosis, treatment, and death between males and females for three common conditions. Males are more likely to get sick and die from hypertension, diabetes, and HIV/AIDS, while also being less likely to seek medical care.
Researchers discovered TBX2 drives therapy resistance by shifting signaling from the androgen receptor to the glucocorticoid receptor. The study identified a strategy to target this switch, potentially predicting patient risk and offering new treatment approaches.
Researchers explore the role of efferocytosis in reducing inflammation and containing injury spread after an ischemic stroke. Efferocytosis may offer a promising therapeutic strategy to promote neural regeneration and minimize brain damage.
A study published in Chinese Medical Journal explores the use of artificial intelligence to identify potential medications for treating glaucoma. Researchers used AI models to predict the effectiveness of small-molecule compounds targeting RIPK3, a key signaling molecule involved in programmed cell death.
Researchers discovered a novel platinum complex that targets androgen receptor signaling, inhibiting cell growth and survival in prostate cancer cells. The complex, 5-H-Y, showed stronger cytotoxic effects than cisplatin with minimal toxicity, offering a promising approach to treating advanced prostate cancer.
Researchers comprehensively reviewed cerebellar involvement in Parkinson's disease, highlighting the pathophysiological role of the cerebellum in motor and non-motor symptoms. Studies showed abnormal α-synuclein aggregation, neurodegeneration, and altered functional connectivity between the cerebellum and other brain regions.
The researchers used advanced techniques like STED microscopy, FRET image spectroscopy, and photobleaching step analysis to measure the number and distribution of CD95 receptors on the membrane. They found that only 15% of receptors need to bind together to activate cell death.
A cohort study found no association between GLP-1 receptor agonist use and increased risk of suicide death or related disorders in patients with type 2 diabetes. The study included mostly patients with type 2 diabetes.
Researchers at MIT and Brigham and Women's Hospital have developed an implantable device that monitors vital signs and releases naloxone to reverse opioid overdoses. The device has shown success in reversing overdoses in animals, with a 96% recovery rate.
Researchers discovered a unique protective mechanism in pancreatic β-cells, relying on elevated levels of pro-survival proteins like cFLIP. This discovery challenges the dominant paradigm and offers new insights into diabetes research, potentially leading to novel strategies for preserving β-cell function.
Researchers discover that PD-1 forms dimers to function optimally, and manipulating its dimerization can enhance or inhibit T cell activity. This finding offers new insights into developing more effective cancer immunotherapies and treatments for autoimmune diseases.
Researchers discovered that the vitamin D/vitamin D receptor pathway protects enterocytes during aging, reducing ISC proliferation and centrosome amplification. This study provides insights into the molecular mechanisms underlying healthy aging in Drosophila.
Researchers identified NTRK gene fusion in 1.5% of Finnish papillary thyroid cancer patients, with notable co-occurring genetic alterations and favorable treatment outcomes. The study highlights the potential for biobank samples linked to electronic health records to describe patient characteristics and outcomes.
The aryl hydrocarbon receptor is highly correlated with various aging hallmarks, including mitochondrial abnormalities and cellular senescence. AhR signaling regulates airway inflammation in asthma, suggesting its crucial role in regulating asthma phenotypes.
Researchers identified blood proteomic markers associated with hepatocellular carcinoma (HCC) in patients with cirrhosis. The study found a set of biomarkers, including TGF-β driven mechanistic biomarkers and Myostatin and Pyruvate Kinase M2, which may stratify risk for HCC.
A new study published in the American Heart Association journal Hypertension found that tirzepatide significantly lowered systolic blood pressure levels in nearly 500 adults with obesity. The results suggest treating obesity with this weight loss medication may be an effective strategy for preventing or treating high blood pressure.
A pioneering study published in The American Journal of Pathology reveals the cytoprotective and proregenerative effects of neuropeptide α-MSH in promoting corneal healing after eye injury. The treatment has shown impressive therapeutic potential in reducing the need for corneal transplants.
Researchers have identified promising treatment candidates for morphine tolerance and cancer, as well as a biomarker for kidney injury. A monoclonal antibody targeting the mu-opioid receptor has been shown to alleviate morphine tolerance and physical dependence, while inducing excessive mitochondrial fission in tumor cells. Additionall...
Researchers at the CNIC in Madrid have discovered a connection between stress kinases and the development of ventricular fibrillation. The study found that activation of these enzymes alters the electrical properties of cardiomyocytes, triggering arrhythmias.
A research team from the University of California - Davis Health has identified a crucial epitope on the CD95 receptor that can trigger programmed cell death in cancer cells. This finding could lead to improved cancer treatments and potentially enhance CAR T-cell therapy for solid tumors like ovarian cancer.
Researchers have identified a neoplastic fusion transcript RAD51AP1-DYRK4 in luminal B breast cancer, associated with higher ki67 expression and aggressive clinical characteristics. MEK inhibitor trametinib may be effective in blocking the MEK-ERK signaling driven by this fusion.
A study of 98,000 postmenopausal women found that daily consumption of sugar-sweetened beverages was associated with a higher incidence of liver cancer. The findings suggest a potential link between these beverages and chronic liver disease mortality.
A study led by Boston Children's Hospital researchers found that COVID-19 causes severe inflammation through infected immune cells. Antibodies developed during infection may sometimes contribute to inflammation.
A USF Health study reveals that fibrinogen can directly interact with neurons, leading to inflammation and neurodegeneration in Alzheimer's disease and traumatic brain injury. The researchers found that blocking the binding of fibrinogen to its receptors may alleviate short-term memory problems associated with these diseases.
A Johns Hopkins study finds that newborn brain injury causes different responses in male and female brains, with females showing milder cell death and better response to certain therapies. Researchers highlight the need for gender-specific research to develop precisely targeted treatments.
Palliative care consultant Claud Regnard argues that the Liverpool Care Pathway was unfairly maligned and that its demise will not improve end-of-life care. He rejects recommendations to replace it with an 'end of life care plan', citing lack of evidence for its effectiveness.
Researchers found that melatonin delayed the onset of symptoms by 19% and reduced mortality by 18% in a mouse model of Huntington's disease. The hormone was shown to target mitochondria, reducing programmed cell death, and increasing neuroprotection when administered.
Scientists at Burnham Institute for Medical Research have determined the structure of protein interactions responsible for triggering apoptosis. The research reveals a particular arrangement of Fas receptor and FADD proteins that act as a control switch for cell death signaling.
Scientists found that inactivating Toll-like receptor 4 (TLR4) helps prevent necrotizing enterocolitis (NEC), a leading cause of death in premature babies. Blocking TLR4 signals could potentially treat NEC by regulating the intestine's immune response.
Scientists at UCSF deciphered a pattern of signals that determine the survival of T cells, the body's natural defense arsenal. The research identifies a new role for chemical messages between the immune system and a steroid hormone signal, which may control stress-induced hormone imbalance and autoimmune diseases.
University of North Carolina at Chapel Hill scientists have discovered a receptor molecule that can facilitate the introduction of corrected genes into cell nuclei, paving the way for potential gene therapy treatments. The study uses a G-protein-coupled receptor to enable weakened viruses to enter cells, carrying therapeutic payloads.
Researchers at MIT have discovered a key role for the N-methyl-D-aspartate (NMDA) receptor in fetal development of the respiratory system. The study found that abnormal activity of this receptor may lead to problems in newborns, such as Sudden Infant Death Syndrome and breathing difficulties.
A nerve protein known as the capsaicin receptor triggers pain signals when exposed to heat or noxious chemicals, contributing to pain from tissue injury and inflammation. Blocking this receptor may ease some kinds of pain, such as visceral pain conditions.
Scientists discovered how ecdysone initiates a biochemical cascade controlling genes that destroy salivary gland tissues during Drosophila metamorphosis. The study reveals key components of the 'death cascade' and suggests potential connections to mammalian cell death programs.
Scientists at Cedars-Sinai Medical Center have identified a key component of the immune system's over-aggressive response that leads to septic shock. The discovery confirms suspicions raised by recent studies and may lead to new treatment approaches for severe bacterial infections.
A study by Duke University Medical Center researchers found that highly depressed individuals have reduced autonomic regulation of blood pressure, increasing the risk of heart damage. Exercise was shown to be an effective treatment to restore this function and improve heart health.
As people age, a protein called TNF helps to destroy diseased cells but also causes the immune system to degenerate. Researchers found that older adults' immune cells became more sensitive to TNF, leading to increased cell death and weakening of the immune system.
Researchers at Allelix Biopharmaceuticals Inc. have successfully cloned the GLP-2 receptor, which plays a crucial role in intestinal growth and nutrient absorption. The discovery provides valuable information on the specificity and action of GLP-2, a potential therapy for gastrointestinal disorders such as short bowel syndrome.
Researchers found that HIV can infect cells lacking the CD4 receptor by forming a receptor complex with co-receptors like CCR5 or CXCR4. This expands the range of potential targets for drug therapies aimed at preventing HIV spread.
Researchers identify Hid protein as a key player in preventing programmed cell death, finding it relies on survival signals for regulation. The discovery has potential applications in treating neurodegenerative diseases and conditions like stroke.
Plant cells respond to fungal invasion by generating reactive oxygen intermediates, ion fluxes, and changes in gene activity. Gentle mechanical stimulation mimics this effect, suggesting physical contact is sufficient for triggering the defense response.
A team of researchers led by Dr. Joel Bennett has successfully developed a new technique to study the IIb/IIIa receptor, a key player in platelet aggregation. This breakthrough could pave the way for the creation of more potent anti-clotting drugs.
Researchers at Johns Hopkins have discovered that HIV depends on the moving parts of a cell's surface to enter the cell. The findings suggest that clustering transmits signals to the cell that could be important for HIV replication.
Researchers found a significant decrease in kainate binding to receptors in the arcuate nucleus of SIDS infants, leading to faulty communication among nerve cells. This finding may contribute to the development of a screening test for identifying infants at risk or measuring kainate receptor binding for diagnosis.
A mutated gene in the glutamate receptor family causes faulty nerve cells to die due to false detection of neurotransmitters. The discovery may help understand how to slow down or stop this process, preserving neurons.
Researchers at the University of Pennsylvania School of Medicine discovered that nerve growth factor induces cell death in some childhood brain tumor cells. The findings suggest a potential new treatment approach for these cancers, expanding scientists' understanding of NGF's role in development.
Researchers found increased enzyme activity in Alzheimer's patients, suggesting a potential factor in disease development. A peptide inhibiting ACTH synthesis and secretion was also identified as a regulator of the body's adaptive response to stress.
Research reveals that protein folding defects in the LDL receptor contribute to familial hypercholesterolemia by affecting calcium binding. This finding offers new hope for developing targeted therapies to enable proper protein folding and lower blood cholesterol levels.