Articles tagged with Sample Preparation
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
The new AEC-MS protocol provides comprehensive analysis of highly polar and ionic metabolites, improving molecular specificity and selectivity. This innovation has led to new applications in metabolomics, including studies on gut microbiome metabolism and energy substrate utilization.
A new study suggests that offering self-collection kits during routine GP appointments can increase participation rates among women overdue for cervical screening. The approach shows promise in reducing the number of cases and saving lives.
Researchers at UCSF have discovered that human lung tissue contains hematopoietic stem cells (HSCs) capable of producing red blood cells, platelets, and immune cells. The finding suggests the lungs could be a potent source for life-saving stem cell transplants, particularly for patients with leukemia.
Researchers have created a water-soluble fluorescent spray that can visualize latent fingerprints in just ten seconds. The new dye-based technology is non-toxic, biologically compatible, and reduces the risk of damaging DNA evidence.
A new multiplex assay has been developed to assess activated p300/CBP in circulating prostate tumor cells, revealing correlations with clinical outcomes and potential therapeutic targets for castration-resistant prostate cancer. The study found that patients with upregulated p300/CBP activity had shorter response times to ARSI therapy.
A new device using dielectrophoresis selectively isolates Mycobacterium tuberculosis from sputum samples, providing a purified sample for molecular confirmation. The technology has shown promising results in detecting TB in underserved areas, with high concordance rates compared to culture diagnosis.
A team of researchers from China and the UK has developed new ways to optimise the production of solar fuels by creating novel photocatalysts. These photocatalysts, such as titanium dioxide with boron nitride, can absorb more wavelengths of light and produce more hydrogen compared to traditional methods.
A team of Brown researchers has developed a new, highly accurate method for detecting antidepressants in patients using liquid chromatography tandem mass spectrometry. The technique requires minimal biological samples and can be fully automated using liquid-handling robots.
A Brazilian research team has developed a novel method to sort specialty and standard coffee beans using multispectral imaging and machine learning. The technique, which does not require roasting or human intervention, uses images of the beans at different wavelengths to distinguish between quality levels.
A new sample preparation method called 'water droplet-in-oil' (WinO) has been developed to improve efficiency in single-cell proteomics. The technique reduces sample loss and increases throughput by up to 10-fold compared to conventional methods.
Researchers emphasize the need for monitoring drinking water for HIV medications, as they can contaminate rivers and streams through wastewater. The lack of regulation on pharmaceuticals in wastewater treatment plants poses a significant challenge in ensuring safe drinking water.
Researchers have developed a new method for preparing cryo-electron microscopy samples using liquid nitrogen, which cools at rates roughly 50 times slower than ethane. This results in sharper images with reduced beam-induced motion and simplified workflows.
Researchers at the National Eye Institute developed a new sample preparation method to detect SARS-Cov-2, simplifying purification and potentially reducing test time and cost. The method uses a chelating agent to preserve RNA in samples, allowing for direct detection and increasing sensitivity.
The new Stanford-SLAC CryoET Specimen Preparation Service Center complements existing NIH-funded facilities at SLAC, providing streamlined processes for preparing cryo-ET samples. Researchers can learn state-of-the-art techniques and access multiple instruments to visualize cellular components in 3D.
The Quantum-Si ecosystem enables sensitive and accurate research tools and diagnostics through digital proteomics, transforming the study of proteins on a large scale. The company's platform offers a complete solution for sample preparation, sequencing, and data analysis, reducing costs and increasing accessibility.
The Waters Corporation and Andrew Alliance have signed a co-marketing agreement to promote their collaboration on protein therapeutics glycosylation profiling. The partnership enables laboratories to automate large numbers of routine, high-quality released N-glycan analyses with improved accuracy and precision.
A new method for identifying illicit drugs has been developed, offering high sensitivity and fast results. This technique uses multi-dimensional chromatography combined with a micro-extraction method, allowing for rapid analysis in under 20 minutes.
Researchers at Sam Houston State University are developing new sample preparation methods for skeletal and decomposing remains using emerging next generation DNA technology. The goal is to improve the ability to resolve more missing person cases, as conventional methods may fail.
A handheld mineral analyzer has been developed for mining applications, enabling rapid analysis of minerals in the field. The device combines X-ray diffraction (XRD) and X-ray fluorescence (XRF) techniques to identify and quantify minerals within 1-2 minutes.
Researchers at RIKEN developed an automated sample preparation system for the HeliScope single molecule sequencer, reducing preparation time from 42 days to 8 days. The new system uses Cap Analysis of Gene Expression (CAGE) and yields reproducible results comparable to manual prep.
A NASA scientist has added an experiment to the Sample Analysis at Mars (SAM) instrument, enhancing its ability to analyze large carbon molecules. The experiment aims to preserve information on how organic molecules formed, shedding light on the planet's carbon cycle.
Researchers developed a lab-on-a-chip PCR test that combines sample preparation with PCR on a single chip, reducing analysis time from hours to minutes.