Researchers have developed a gene therapy approach to treat GM2 gangliosidosis, a devastating neurodegenerative disease. The treatment has shown promising results in mouse models and is now being tested in clinical trials using recombinant Adeno-associated viruses for gene transfer.
Researchers at the U.S. Army Research Laboratory developed a new technology that allows soldiers to learn 13 times faster than conventional methods, potentially saving lives. This technique uses low-cost hardware and collaborative filtering to achieve a significant speedup in training compared to state-of-the-art systems.
The Foundation for Food and Agriculture Research has awarded a $5 million grant to Texas A&M AgriLife Research to develop and adopt water and energy-efficient irrigation technologies. The grant will be matched by project partners, totaling $10 million over five years. Researchers will focus on precision application systems, weather pre...
A recent study found significant differences in nutrient levels and species composition between Devils Hole and a constructed scale replica at the Ash Meadows Fish Conservation Facility. The findings suggest that modifications to the refuge's operation could improve the prospects for continued survival of the critically endangered Devi...
Researchers at Kumamoto University developed a new catalyst that improves NH3 combustibility and suppresses NOx generation. The catalyst allows for the decomposition of NH3 into H2 with low ignition temperature and purification through oxidation.
Researchers at University of Strathclyde and Capital Normal University have developed a new source of intense terahertz radiation with unprecedented efficiency. This breakthrough could lead to new advances in science and technology, including the identification of normally hidden phenomena and unique control of matter.
Researchers at the University of Bristol have developed a method to enhance red blood cell transfusion compatibility using CRISPR-Cas9 gene editing. By altering specific blood group genes, they can prevent immune reactions in patients with rare blood types or those requiring frequent transfusions.
Researchers discovered that two amino acids in the guard cells' protein SLAC1 enable grasses to quickly close their stomata and prevent water loss. This mechanism allows grasses to adapt better to drought, making them more suitable for water-scarce regions.
Researchers used supercomputer simulations to study the behavior of mantle plumes, a key factor in volcanic formation. The study provided new insights into how plumes interact with seismic waves and could help guide future experiments on the ocean floor.
Biologist Judy Simon develops a system to observe interactions between tree roots in 3D, enabling the study of nitrogen uptake and communication. The transparent substrate allows for the observation of root activities, potentially contributing to sustainable forest management.
A UCI-led study finds that tropical forests respond to higher CO2 by reducing water vapor, leading to drought in the Amazon and increased rainfall in Indonesia. This process can have significant impacts on biodiversity, freshwater availability, and food supplies.
A new study at Boston Medical Center aims to bridge a gap in care for patients with substance use disorders by linking them with trained peer recovery coaches. The project, Project RECOVER, will provide support and sustain recovery for up to six months through interventions delivered by certified peer coaches.
A NUS-led study reveals that a beltway in Sao Paulo diverted heavy-duty diesel vehicles, reducing public health damage from diesel emissions. The intervention led to a sustained drop in nitrogen oxides levels and improved air quality.
Kyoto University scientists have developed a shape-memory effect in porous materials, which can change and retain their shapes. The new material, with a porosity of 46%, has been shown to adsorb carbon dioxide and retain its shape after multiple cycles.
Researchers at UC Davis developed a new technique using conventional digital camera technology to measure brain blood flow. The method, called interferometric diffusing wave spectroscopy, boosts the signal to detect fluctuations in blood motion, providing valuable information about blood flow.
The Texas Advanced Computing Center (TACC) is developing innovative software solutions to enhance scientific productivity. Their interactive parallelization tool, IPT, enables researchers to convert serial code into parallel code using tens of thousands of processors, achieving significant speed-ups and user productivity enhancements. ...
Researchers found that bacteria in Pseudomonas aeruginosa colonies produce dual signal responses to antibiotic tobramycin, including a localized and community-wide response. This communication may enable the bacteria to develop tolerance to some antibiotics.
Scientists have successfully engineered defects in diamonds to store and transfer quantum information, a crucial step towards quantum computing. The technique uses vibrations from a mechanical resonator to stabilize optical properties, enabling the manipulation of electron orbitals.
Platelet-rich plasma (PRP) injection has shown positive aesthetic outcomes in facial rejuvenation, hair regrowth, and acne scar treatment. However, the research evidence is limited due to inconsistent PRP preparation and injection techniques, lack of standardized assessments, and short follow-up periods.
Scientists at OIST have developed stable and efficient perovskite solar cells that could revolutionize the solar industry. The new material is made of inorganic components, making it more heat-stable than previous versions.
A UAB-led study published in The Lancet Diabetes & Endocrinology found that denosumab was superior to risedronate in increasing bone density in patients with glucocorticoid-induced osteoporosis. The 12-month study enrolled 795 patients and showed promising results for the new drug.
Researchers recover intact human mitochondrial DNA from common type of plant-based artifact, providing insights into the genetic ancestry of Native Americans in the Desert Southwest. The study also sheds light on the Numic Spread event, a contentious debate among scientists.
Researchers verify anomalous amplitude apodization for non-spherical particles, boosting microscope magnifying power and peak field intensity. This technique enhances imaging capabilities for biological molecules, viruses, and living cells.
The U.S. Small Business Administration has renewed the Veterans Business Outreach Center grant at the University of Texas at Arlington for $1.375 million over five years. The grant supports education, training, and consulting services for veterans starting or growing businesses in North Texas, Oklahoma, and Arkansas.
Scientists at the University of Cambridge have identified N-acetyltransferase 10 (NAT10) as a potential therapeutic target for Hutchinson-Gilford Progeria Syndrome (HGPS), a rare condition that causes premature ageing. In a mouse model, chemical inhibition or genetic deregulation of NAT10 led to significant health and lifespan gains.
Researchers at UTHealth and Ohio State University combined virotherapy with boosting the natural immune system to fight cancer. The study found that increasing the number of externally added NK cells strengthens the ability to fight cancer.
Research identifies a mechanism by which glioma cells develop resistance to anti-angiogenic treatment, using different strategies to spread through the brain. The study reveals a potential target for combination therapies based on Wnt signaling and vessel co-option pathways.
The American Academy of Sleep Medicine has selected several individuals for its 2018 awards, including Dr. Jack D. Edinger and Naresh M. Punjabi, who received the Nathaniel Kleitman Distinguished Service Award and William C. Dement Academic Achievement Award respectively. Arianna Huffington also received the Mark O. Hatfield Public Pol...
A study published in the Journal of Advertising Research found that both Black and White teens perceive Black-oriented media as being targeted towards them, suggesting the potential for increased profitability when marketed to a broader audience. The study surveyed 1,900 adolescents ages 14-17 about their movie preferences.
The AVIATOR 2 international registry found significant discrepancies between physician-perceived risks and calculated scores for stroke, ischemic risk, and bleeding in patients with AF undergoing PCI. The study used a novel smartphone-based survey to capture physician and patient perspectives on antithrombotic therapies after PCI.
Researchers discovered that a multiple sclerosis drug can mitigate the painful side effect of cancer treatment bortezomib. Fingolimod, an approved multiple sclerosis medication, blocks the production of molecules causing nerve damage and alleviates neuropathic pain.
A study analyzed online reviews of over 1,000 plastic surgeons on Google, Yelp, and RealSelf, finding that positive reviews were more likely to mention good bedside manner and surgeon expertise. Negative reviews often cited disappointment with cosmetic results or perceived rudeness from the surgeon.
Scientists at Helmholtz Zentrum München have identified 16 virus structures that can be attacked by killer T cells, which could lead to new therapies for immunocompromised individuals and patients with autoimmune diseases. The researchers discovered these targets using an algorithm and verified them in a large group of patients.
A team of renewable energy experts at the University of Exeter has developed a new method to produce hydrogen from sunlight using a revolutionary photo-electrode. This breakthrough could create a virtually limitless energy source with zero carbon emissions and double the energy density of fossil fuels.
Swansea University's METaL scheme has received £1.4m EU funding to increase skills in the advanced manufacturing sector. The additional funding will enable the scheme to support over 400 people in gaining technical skills, with a focus on emerging sectors such as energy and smart manufacturing.
Researchers found that music activates the salience network of the brain, which remains relatively functioning in individuals with Alzheimer's disease. The study suggests that personalized music programs may be an alternative route for communicating with patients who have lost contact with their environment.
Talin and α-catenin proteins unfold through stable 3-helix intermediates, enabling recruitment of other binding partners and regulating protein function.
Scientists have engineered red blood cell lines to express fewer antigens, making them less immunogenic for patients with rare blood types. This breakthrough could lead to the development of more universal blood sources for transfusion patients.
The PERSPECTIVE trial presents a comprehensive review of the safety, efficacy, and durability of Zotarolimus-Eluting Stents in treating chronic total occlusion. Treatment with second-generation drug-eluting stents resulted in lower occurrence of adverse events compared to previous DES trials.
Researchers used stable carbon and oxygen isotope analysis to show that some individuals subsisted primarily on forest resources, while others relied on agriculture through trade. The study's findings are significant for the Wanniyalaeto people's battles to remain on their traditional hunting grounds.
New research estimates total and per-case costs of newly diagnosed non-melanoma skin cancers in Canada in 2011 due to workplace sun exposure. The study found that the two most common types of non-melanoma skin cancer cost $5,760 and $10,555 per case respectively.
A global project is underway to map every type of cell in the human body as a resource for investigating health and disease. Penn bioinformatics researcher Casey Greene will use this funding to develop open, shared computational tools and algorithms to analyze large data sets without being instructed what features to look for.
A smartphone video-based app substitutes for in-person daily visits required for tuberculosis treatment, with patients showing similar adherence rates as traditional DOT. The app offers a more private and cost-effective option for monitoring medication intake, but further research is needed to assess its full impact.
A new study analyzing patients with mixed drug abuse and endocarditis found a significant increase in hospitalizations over the last decade. The study estimated substantial healthcare costs, with a total of $17.3 million billed by the hospital in 2015 alone.
A new study finds that older adults with severe hearing loss who use hearing aids are less likely to visit the hospital or emergency room, despite high costs of the devices themselves. The association is significant, even considering factors such as income and education level.
Researchers analyzed the survivability of RNA-containing viruses, discovering that inaccurate genetic copying helps them adapt to adverse conditions. The study found that viruses can repair damaged elements or evolve new properties to compensate for damage, ensuring their survival and persistence.
A study found that New York City firefighters exposed to the 9/11 World Trade Center disaster site are at an increased risk for developing myeloma precursor disease, which can lead to the blood cancer multiple myeloma. The prevalence of MGUS was nearly twice as high in firefighters compared to a non-exposed group.
A recent study published in Cell Host and Microbe found that bacteria in the small intestine play a vital role in fat digestion and absorption. The researchers discovered that high-fat Western diets stimulate the growth of beneficial microbes in the small intestine, which then produce digestive enzymes to break down dietary fat.
Researchers have developed a control algorithm that regulates electrical current to provide steady sensation in prosthetic arms. The system reduces painful shocks and improves user experience, enabling users to feel touch and pressure, even with electrodes peeling off or sweat building up.
A 2017 Mw 5.4 Pohang earthquake in South Korea is believed to have been triggered by fluid injection at a nearby Enhanced Geothermal System (EGS) site, the largest-induced quake ever recorded at an EGS location.
PARP-1 levels are linked to targeted therapy resistance in ovarian cancer. Researchers have developed a method to image and measure PARP-1 using PET scans, which may predict efficacy and resistance to PARP inhibitors.
Archaeologists discovered evidence of ancient Neolithic communities using fungi as tinder to start and transport fires at the La Draga site. Researchers analyzed a unique set of remains, finding six fungal species used for this purpose, including Daedalea quercina and Coriolopsis gallica.
The Christian Doppler Lab for the Direct-Write Fabrication of 3D Nano-Probes focuses on novel 3D printing technology. The CD lab for Location-Aware Electronic Systems explores radio-based positioning systems for applications where satellite systems are not available.
Cadm1 protein interacts with Kaposi's sarcoma viral proteins to promote inflammation and cancer growth in KSHV-infected cells. This discovery could lead to a new therapy targeting human protein CADM1 in viral-mediated cancers.
A study led by Rutgers University scientists has found that a fungus causing devastating rice disease became harmful 21 million years ago. The researchers identified key genes and proteins that promote the infection process, offering insights into developing new fungicides and quarantines to combat crop diseases.
Researchers at the University of Birmingham have discovered a unique mechanism driving the spread of Cryptococcosis, a rare and deadly fungal infection. The 'division of labour' process relies on extracellular vesicles to coordinate behavior between individual fungal cells.
The VA health care system performs similarly to or better than non-VA systems on most measures of inpatient and outpatient care quality, according to a new study. The findings suggest that the VA needs targeted quality improvement efforts to ensure uniform high-quality care at all facilities.
A Japanese research team has uncovered new molecular details and provided a model explaining how stepwise flagellar assembly occurs in bacteria. The proposed model suggests that subtle changes in the ring's shape determine which proteins are exported to the growing flagellum, enabling its construction.
Researchers have developed a system to profile every cell in developing zebrafish and frog embryos, revealing the comprehensive landscape of gene expression events that mark new cell states and types. This work provides a significant resource for studying developmental biology and disease.
A large-scale study of thyroid cancer genetics has identified specific genes driving the disease and found that certain cancers can benefit from immunotherapy. The research also found amplifications of key receptor tyrosine kinases in anaplastic thyroid cancers, suggesting a potential target for treatment with lenvatinib.