Researchers at MIPT have identified a promising class of antibiotics, 2-pyrazol-1-yl-thiazole derivatives, which exhibit antibacterial properties and inhibit protein synthesis. The discovery was made possible by a semi-automatic analysis method that enabled the screening of over 125,000 molecules.
A new study from Cardiff University found that teenagers are less responsive to instructions from their mothers when spoken in a controlling tone of voice. The researchers discovered that autonomy-supportive tones, on the other hand, elicit positive reactions and encourage self-expression.
A machine-learning model has been developed to predict significant weight loss and need for feeding tube placement in head and neck cancer patients undergoing radiation therapy. The model showed high accuracy in predicting these two endpoints, allowing clinicians to take preventive measures.
Researchers discovered 18 cases of severe silicosis and two fatalities among young Hispanic men working in engineered stone fabrication plants. The study suggests that hundreds or thousands of workers may be at risk due to the material's high silica content, posing significant health concerns.
Researchers have created the first cell atlas of the human kidney's immune system, charting the communities of immune cells in different zones. The atlas shows how the immune system develops during early life and strengthens after birth, with implications for tackling kidney disease and transplant rejection.
A recent study reveals significant elevations in anti-inflammatory lipid mediators in response to Toxocara roundworm infections, which contribute to the pathogenesis of neurotoxocarosis. The findings provide new understanding of host-parasite interactions during this disease.
A randomized clinical trial found that high-dose radiation therapy can generate an immune system response similar to vaccination, sparking a systemic immune reaction against cancer. Patients treated with stereotactic ablative radiotherapy lived significantly longer without disease progression.
A national register study from Lund University found that fathers who underwent assisted reproduction, such as IVF and ICSI, had a 30-60% higher risk of developing prostate cancer compared to those who conceived naturally. The study also showed that men treated for infertility had a higher risk of prostate cancer at a young age.
A recent study on the Great Barrier Reef found that living coral cover can slow future reef dissolution due to ocean acidification. The experiment used a controlled system to simulate high CO2 conditions and showed that living corals were more resilient than dead ones, which would dissolve earlier.
A research team at the University of Delaware has designed an integrated photonics platform with a one-dimensional metalens and metasurfaces, limiting information loss and enabling high signal transmission. The device demonstrates functionalities of Fourier transformation and differentiation, critical techniques in physical sciences.
Astronomers discovered a giant Jupiter-like exoplanet orbiting a small red dwarf star, defying standard planet formation theories. The exoplanet, GJ 5312b, is nearly half as massive as Jupiter and orbits the tiny star with an eccentric 204-day orbit.
A new study from the University of Washington found that employment conditions beyond wages and hours impact overall health. Workers in insecure jobs reported poor mental health and increased injury risk, while those with high empowerment experienced similar health to standard employees.
A long-term study found that a giraffe's spot color strongly relates to their social patterns, not age. Darker males may use their color to signal competitive ability and attract females.
A phase II trial found that adding radiation therapy to immunotherapy increases progression-free survival for patients with metastatic non-small-cell lung cancer. T cells played a key role in the immune response, with certain markers predicting longer disease-free periods.
Researchers have discovered a key mechanism behind pancreatic cancer's aggressive growth, which may help explain why promising drugs work and when they won't. The finding identifies a weakness in the cancer cells' metabolism that could be exploited to improve treatment outcomes.
Researchers developed a highly sensitive nanowire backward diode that can convert low-power microwaves into electricity, exceeding conventional Schottky barrier diodes by over 10 times. This technology has the potential to power sensors in areas where traditional batteries are impractical.
The NIH has awarded contracts to establish three new centers for immunology research to accelerate progress in TB vaccine development. The program aims to develop a comprehensive understanding of the immune responses required to prevent TB infection and disease.
A new study in Science demonstrates a hopeful strategy for conserving plant and animal species in fragmented habitats. By connecting small, restored patches of savanna via habitat corridors, researchers found an annual increase in plant species within fragments and a drop in species extinction rates.
Researchers at Argonne National Laboratory successfully stabilized single atoms using record-high temperatures of up to 2000 K. The method enables the creation of stable single atom catalysts, which can remain in their place for unprecedented periods of time, maximizing atom-use efficiency and improving catalytic performance.
A team of researchers has developed an implantable, self-powered spinal fusion sensor to monitor the health of the spine after surgery. The sensor will provide continuous and long-term monitoring, eliminating the need for costly imaging appointments and exposing patients to radiation.
Researchers found PML dysfunction due to altered protein modification, specifically sumoylation, enables pancreatic tumor resistance to chemotherapeutic treatment. High PML expression and sumoylation are associated with better survival rates in patients.
Researchers found that ant-associated bacteria produce continually evolving variants of antimicrobials, making it harder for parasitic fungi to become resistant. This strategy could hold promise as a means to address antimicrobial resistance in the clinic.
Scientists have created a novel approach to analyze neuronal response to different call meanings in songbirds. The analysis shows that initial responses contain information about the call's meaning, with additional information accumulating up to 600 milliseconds. Individual neurons play a significant role in categorizing call meanings.
Researchers found that the endoplasmic reticulum stress response helps reduce brain activity during seizures, potentially leading to more effective epilepsy therapies. The study's findings may also provide insights into other neurological disorders caused by seizures.
A new operational algorithm enhances intensity prediction, particularly for rapid intensification within 24 hours. The Index to Better Estimate Tropical Cyclone Intensity Change improves error rates by 16%.
A new calculator developed by the University of Exeter will help clinicians classify patients with type 1 or type 2 diabetes, reducing complications and misdiagnosis. The calculator combines blood test results with age and BMI to provide a personalized medicine approach.
Poor oral hygiene in older adults can lead to serious health issues such as cavities, periodontitis, and heart disease. Regular dental cleanings and check-ups are crucial for preventing these complications.
The UMD CONSERVE Center develops safe, alternative irrigation strategies to sustain food production in a changing climate. Non-traditional water sources like reclaimed water, brackish water, and return flows hold promise, but require additional treatments to reduce microbial and chemical contaminants.
A new study by Barcelona Institute for Global Health found that long-term exposure to green spaces can prevent metabolic syndrome and its individual components. The study analyzed data from over 6,000 adults in the UK and found a significant association between green space exposure and lower risk of metabolic syndrome.
Researchers at Cleveland Clinic identified a metabolite associated with specific PTEN mutations, distinguishing those at high risk for neurodevelopmental disorders from cancer. The findings may help tailor treatments to individual patients with germline PTEN mutations.
Researchers at Cornell University have made a groundbreaking discovery in gallium nitride, which could transform electronics and wireless communication. The new material structure creates a high-density of mobile holes, making GaN structures almost 10 times more conductive than traditional doping methods.
A new study on hunter-gatherer children reveals that younger kids tend to play in mixed-gender groups, while older children imitate adults' gender roles. Context plays a significant role in shaping gendered behaviors, differing from Western societies.
Researchers at MIT have developed a rapid imaging method to visualize hundreds of synaptic proteins at high resolution. By analyzing protein levels in thousands of neurons, they discovered groups of proteins that tend to associate with each other more often than others, shedding light on synapse subtypes and their functions.
Researchers discovered a unique mechanism involving calcium, auxin and a calcium-binding protein that regulates plant growth. This interface determines how plants grow in response to environmental signals like light, humidity and salinity.
Scientists have identified a signaling channel in the carotid body that links obesity to high blood pressure, paving the way for potential new treatments. Blocking this molecule can effectively lower blood pressure in obese mice.
A new trial analysis found that women diagnosed with early stages of cancer who undergo lumpectomies and receive either partial or whole breast radiation have equivalent cosmetic outcomes, according to patient and physician ratings. The study's findings aim to guide women seeking breast-conserving therapy for early-stage disease.
Researchers identified a neural circuit in fruit flies that controls perseverance, with dopamine and octopamine neurotransmitters playing a key role. The finding suggests that simple organisms like fruit flies exhibit stamina and perseverance, challenging the idea that these traits are unique to humans.
Rice chemists disentangled the mysterious interactions between bovine serum albumin and gold nanorods, revealing multilevel chirality and a possible way to sense single proteins' handedness. This discovery could lead to the development of drug-sensing tools with improved accuracy.
The Blood and Immune Deficiency-Cellular Therapy Program (BID-CTP) integrates expertise from multiple medical specialties to treat rare blood and immune system diseases. Patients with hundreds of different primary immune deficiency diseases can now receive unified care through a single, multi-specialty team.
Researchers at NIST have created an optical system that can measure the flow of extremely small amounts of liquids with high accuracy. The technique relies on a laser interacting with light-sensitive molecules in a liquid flowing through a microchannel, allowing for precise control of flow rates as low as 2 nanoliters per minute.
Researchers from Michigan State University and University of Nebraska Medical Center found no evidence of negative health effects from titanium dioxide in rats. The study corrected flaws in the original French research, including inadequate testing methods and unrealistic rat exposure scenarios.
Researchers found that selectively bred oysters can alter their shell biomineralisation mechanisms to promote resilience against environmental acidification. This breakthrough could be a global mitigation strategy for sustainable shellfish aquaculture in the face of climate-driven change.
A study has mapped over 65,000 supraglacial lakes on the East Antarctic Ice Sheet, revealing a more extensive presence than previously thought. The findings suggest that East Antarctica may be more susceptible to the effects of a warming climate.
A study by UTHealth School of Public Health found that an innovative strategy called Teens Against Tobacco Use is a promising model in tobacco prevention. The program, which partners teachers with youth, led to significant reductions in tobacco susceptibility scores among students who received the presentation.
Researchers propose that teenage acne is a naturally occurring, inflammatory state caused by the sudden change in skin microbiota composition and increased sebum production during adolescence. This hypothesis challenges conventional thinking and may explain special clinical characteristics of acne.
Young stroke survivors who can walk faster than 3 feet per second are more likely to return to work, with those walking almost 6 feet per second showing significant improvement. The study highlights the potential of walking speed as a reliable tool for clinicians to predict return to work and guide rehabilitation.
University of Warwick researchers introduce fluorescently labelled Tau oligomers into single brain neurons and observe significant effects on action potential dynamics and synaptic transmission. They find that Tau oligomers interfere with memory storage by mis-localising at synapses.
A cluster of interacting proteins found in Tasmanian devil facial tumours and human cancers could guide the development of new drug combinations that improve immunotherapy treatment effectiveness. Researchers suggest that a class of EZH2 inhibitors may help overcome immune evasion in cancer cells.
Researchers from Oxford, Basel, and Lancaster develop an algorithm that uses machine learning to automate the process of characterizing quantum dots. By reducing measuring time and number of measurements, this approach enables efficient characterization of large arrays of quantum devices.
Researchers found that levels of filarial antigens increase after treatment in individuals with adverse events, suggesting a host response to dying parasites. Gene expression analysis also identified elevated levels of immune molecules and 744 genes involved in immune signaling in those with adverse events.
The closure of nearly 100 women's health clinics in the US was associated with fewer cervical cancer screenings, more advanced diagnoses, and increased mortality rates. States with clinic closures saw a 2% drop in screenings, particularly among uninsured women, Hispanic women, and young adults.
A new study published in Morbidity and Mortality Weekly Report found that nearly one-third of patients with lupus use prescription opioids to manage chronic pain. The research, led by Emily Somers, aims to determine current levels of opioid prescribing for lupus patients.
Karen Giuliano, a UMass Amherst Nursing associate professor, has been selected as AACN's 2020 Distinguished Research Lecturer for her work in medical device design and innovation. She will discuss her career and research journey at the AACN National Teaching Institute & Critical Care Exposition.
Dr. Jin Liu is working on a $437,864 grant to develop more precise gene editing using CRISPR-Cas9 technology, aiming to reduce off-target effects and increase on-target effectiveness for treating life-threatening diseases such as cancer, eye diseases, and sickle cell anemia.
Researchers add archaeal DNA to mouse models' genes to assess resistance to retinal degeneration and potentially develop new methods to prevent incurable eye diseases. The goal is to understand how molecular chaperones can help avoid misfolded proteins that cause blindness.
Researchers tracked basking sharks using satellite tags, finding they spent most of summer at surface, but dove to deeper depths in winter. The sharks also performed 'yo-yo' dives towards late winter and early spring, reaching depths over 1000m.
Two studies investigated links between clinical benefit and pricing in Europe and the USA, finding that many new anti-cancer medicines had low added value. The median monthly cost of these drugs was EUR2,525 more than comparator drugs in Europe, but not associated with improved outcomes.
Researchers at Texas Biomed continue testing Ebola therapies and vaccines in human clinical trials, motivated by promising preclinical data. The goal is to positively impact human lives with effective treatments, building on previous studies involving nonhuman primates.
A new analysis finds that long-term hormone therapy increases mortality risk for men with low PSA levels after prostate surgery. The study suggests that patients with high PSAs should continue to receive hormone therapy in addition to radiation, but those with low PSAs may be better off without it.
Laanes' five-year project 'Translating Memories: The Eastern European Past in the Global Arena' investigates how literature, cinema, and art shape global perceptions of WWII and Soviet regimes. The team will analyze aesthetic and political debates around these works to break local history deadlocks.