The study resolves the Hamilton-Tian conjecture, which posits that most space is perfect, while singularities can be restricted to low-dimensional spaces. This breakthrough has far-reaching implications for studies of Ricci flows, thermal expansion, and contraction.
A recent study reconstructed the geologic events leading to the 2018 Kīlauea eruption, revealing a sequence of cascading events that drove major destruction. The research team found that focusing on broader, longer history can help overcome tunnel vision and improve eruption forecasting.
Researchers used bioengineered models of patient-specific skin to study how inherited DNA defects cause skin damage and deadly squamous cell carcinoma in children with Fanconi anemia. The study identified key biological connections important to skin formation and function, leading to accelerated blistering and disease progression.
The Pneumask device uses full-face snorkel masks with 3D-printed filter-holders to create a comfortable and effective face shield. Researchers also designed filters inspired by the nasal cavities of animals like dogs and pigs, which have super-sensitive sniffers and can block micron-sized particles.
Researchers have identified a new class of glial cells in the cornea, known as Schwann cells, with unique genetic properties that could help improve wound healing and nerve regeneration after surgeries and corneal transplants. The study's findings may also provide insights into conditions like dry eye and LASIK-related side effects.
Scientists have successfully demonstrated the interaction between infrared light and molecular vibrations, leading to the formation of hybrid polaritons. The study's findings could pave the way for ultrasensitive spectroscopy devices and a deeper understanding of strong vibrational coupling on the nanoscale.
Scientists have discovered how drug-like small molecules can regulate the activity of therapeutically relevant ion channels, providing new avenues for drug discovery. The study reveals how Pico145 binds to TRPC5 channels, preventing them from opening, and highlights the importance of individual amino acid residues in this binding site.
Bioinformaticians at Friedrich Schiller University Jena developed a new method called CANOPUS that assigns structural properties to unidentified metabolites, increasing knowledge gained from examining molecules. The two-stage process uses machine learning methods to identify compound classes.
The US seafood industry experienced a significant decline in catches, imports, and exports during the pandemic. Small-scale fisheries were more affected than large-scale production systems, highlighting the need for targeted federal support to preserve local operations and promote resilience.
A team of researchers developed an AI model that estimates thoughts by evaluating behavior, then tested it on a trained artificial brain. The study found neural activity associated with those estimates, providing new insights into the brain's computations involved in complex behavior.
Researchers have identified the molecular mechanism by which tarantula venom traps voltage sensors on sodium channels, effectively immobilizing nerve signals. This finding may lead to the development of new pain therapeutics that target the Nav1.7 channel, a key player in pain transmission.
A new study published in the Journal of the American College of Surgeons suggests that Medicaid expansion under the Affordable Care Act may lead to earlier diagnoses of colon cancer. Researchers found improved access to care and enhanced surgical care for patients with colon cancer in states that implemented Medicaid expansion.
A study analyzed 250 top-grossing US movies from 1994-2018, comparing the nutritional quality of food and beverage depictions to dietary guidelines. The findings indicate that movie foods often exceed recommended levels of calories, added sugars, and saturated fats.
A study published in PNAS reports a breakthrough treatment for type 1 diabetes in mice, utilizing a combination of haploidentical mixed chimersim and administration of gastrin and epidermal growth factor. This approach successfully reversed autoimmunity, augmented beta cell regeneration, and normalized blood glucose levels by reactivat...
Sandia National Laboratories successfully completed the first flight test of the B61-12 nuclear bomb on the F-35A Lightning II fighter jet, demonstrating its compatibility and versatility. The test was part of a larger program to increase confidence in the bomb's reliability and effectiveness.
Vaccination of endangered tiger population against canine distemper virus could reduce extinction probability from 15.8% to 5.7%
The article argues for a revitalized view of history in ecology and evolution, proposing nine understandings of history to generalize findings and observe scientific laws. These 'flavors' include contingency, chance, chaos, capriciousness, approach, constraint, construction, turnover, and template.
A Canadian study found that people with frequent alcohol-related emergency department visits have a high mortality rate, especially among young adults, urban dwellers, and those from low-income neighborhoods. The risk of death doubles for those with five or more visits.
A new World Health Organization Labour Care Guide was evaluated in six countries for its usability, feasibility and acceptability among healthcare providers. The study found that the guide supported woman-centered care and precise monitoring during labor, with providers identifying design improvements.
Researchers propose a two-phase theory for neurodegenerative disorders, with distinct activities of protein signaling pathways in each phase. This understanding could lead to personalized treatment approaches for patients in different stages of the disease.
A systematic review found financial payments from the drug industry to US physicians are associated with increased prescribing of the paying drug company's medication. The association was consistent across all studies, suggesting a causal link between industry gifts and physician prescribing practices.
Polyimidazolium compounds exhibited effective antimicrobial activity against Gram-negative bacteria, including Pseudomonas aeruginosa. The inability of this pathogen to evolve resistance suggests potential as a new class of antibiotics for combating antibiotic-resistant bacteria.
A chemist from RUDN University synthesized analogs of two natural toxins, antofine and septicine, using a universal approach. The new method involves just two steps, the four-component Ugi reaction and cyclization reaction, and can produce compounds with antibacterial, antitumor, and anti-inflammatory properties.
Australian researchers have discovered a protein called SMCHD1 involved in the 'imprinting' process, where mother's proteins linger in her child's genes and switch off at least 10 different genes. This phenomenon could potentially have a lifelong impact on the offspring.
Researchers have found that excessive calcium triggers inflammation in ischemic strokes, leading to worse outcomes. Targeting this calcium overload may offer a new way to control inflammation and improve patient recovery.
Researchers discover that micron-sized water droplets can spontaneously form hydrogen peroxide, regardless of surface type or temperature conditions. This finding has implications for environment-friendly disinfection technology and atmospheric sciences.
Researchers discovered the precise construction of moths wings that enable extraordinary ultrasound-absorptive properties, creating a resonant absorber 100 times thinner than sound wavelength. This breakthrough inspires the design of ultra-thin sound absorbers for homes and offices.
A new common framework for increasing comparability of research findings on coral bleaching has been developed by an international consortium of scientists. The framework covers key variables such as temperature, water flow, and light, allowing researchers to anchor their studies and compare results more easily.
A team of researchers discovered that young alligators can regrow their tails up to three-quarters of a foot, or 18% of their total body length. The new tails are complex structures composed of cartilage surrounded by connective tissue with blood vessels and nerves.
The PEDSnet report analyzes over 135,000 medical records to reveal disparities in COVID-19 outcomes among children. Children from lower-income families, Black, Latinx, and Asian groups are more likely to be infected, while those with diabetes or cancer fare significantly worse than others.
Researchers found that triclosan disrupts metabolism and the gut microbiome, leading to accelerated development of fatty liver and fibrosis. The study provides new insights into risk factors for non-alcoholic fatty liver disease (NAFLD) in humans.
Research suggests that psychosis symptoms may be linked to impaired information spread in the brain, with altered white matter contributing to delusions and other symptoms. The study found increased consciousness thresholds in patients with psychosis, correlating with greater white matter connectivity.
Researchers at Kaunas University of Technology developed a non-invasive method to measure electrolyte levels, particularly potassium, through electrocardiogram. This can help prevent life-threatening conditions among people with chronic kidney disease.
A new fluorescent imaging technique allows scientists to observe up to five different molecule types at a time, enabling them to study complex signaling networks and their relationships. By identifying two populations of neurons with distinct calcium signaling dynamics, researchers hope to understand how they encode long-term memories.
Researchers at Penn State created functional membraneless 'protocells' from short polymers that can sequester RNA and maintain distinct internal microenvironments. The protocells were stable in various salt concentrations and performed certain functions of a protocell, suggesting they could be relevant models for early life on Earth.
Researchers reconstructed atmospheric carbon dioxide levels, global sea level, and ice volume for a period around 2.75 to 2.4 million years ago. The study highlights the EAIS's vulnerability to melting due to rising atmospheric CO2 levels and climate change.
The study introduces a new generation of multifunctional materials created by adding carbon nanoparticles to polymer matrices, allowing for self-sensing properties. This technology has the potential to replace sensors in weight-critical systems and manufacture electrically conductive materials for various applications.
Astronomers detected near-infrared emission 10 times brighter than predicted, challenging conventional theories of short gamma-ray bursts. The observations suggest the possibility of a massive magnetar being formed after the merger of two neutron stars.
Researchers uncovered evidence of human occupations along South Africa's eastern seaboard from 35,000 years ago to 10,000 years ago, providing insights into coastal foraging during glacial periods. The study reveals that people had access to the sea and could live near coastlines even during the Last Glacial Maximum.
A new forecasting model developed by Washington University in St. Louis predicts COVID-19 cases will nearly double to 20 million by the end of January, with current levels at 11.4 million.
Researchers found that slower-moving bacteria outcompete faster-moving cells in densely packed groups, allowing them to spread across surfaces. This discovery sheds light on how bacteria spread within the body during infections.
Researchers at Kyoto University discovered a method to introduce defects into perovskite oxynitrides using strain, altering their physical properties. The approach could aid in developing photocatalysts.
Researchers have identified a population of brain cells in the amygdala linked to physiological arousal responses, which can drive symptoms of anxiety disorders. These findings suggest that targeting these neurons may lead to new treatments for psychiatric illnesses.
Recent studies published in Annals of Internal Medicine investigate the association between ABO blood groups and SARS-CoV-2 infection risk, as well as vaccine development timelines. Additionally, research highlights the potential benefits of home health care for COVID-19 survivors after hospital discharge.
This observational study describes testing and outcomes for nearly 136,000 US pediatric patients. The study found no significant association between SARS-CoV-2 infection and COVID-19 illness in this population.
The US seafood industry is experiencing a significant downturn due to the COVID-19 pandemic, with monthly fresh seafood exports declining by up to 43% and catches dropping by 40% in some months. The study suggests that American fishmongers may struggle without government aid.
Researchers developed a stable oxide scaffold for perovskite solar cells, allowing for easy removal and replacement of the material while maintaining performance. The new design achieved around 11.08% power conversion efficiency upon perovskite replacement.
Researchers found triclosan suppressed FGF21 expression and altered genes involved in amino acid and lipid metabolism. Triclosan also accelerated liver disease development in mice with type I diabetes and changed gut microbiota similar to NASH patients.
Researchers have discovered that cerebrospinal fluid (CSF) can swell immediately after an injury or stroke, leading to a more efficient clearance of toxic proteins from the brain. This breakthrough could lead to new insights into health and disease, as well as novel treatments for neurodegenerative disorders.
A prestigious $16 million European Research Council Synergy Grant has been awarded to Ben-Gurion University of the Negev and an international team of researchers. The team aims to develop novel thermodynamic measurement methods for studying quantum electronic devices.
Researchers at EMBL Heidelberg used 3D imaging techniques to visualize the replication cycle of SARS-CoV-2 in infected cells. The study reveals massive changes in cellular architecture, including the creation of mini replication compartments where viral genomes are amplified.
Researchers at Princeton University discovered how forest-dwelling bacteria cooperate to build fruiting bodies when food is scarce, using the physics behind fingerprint patterns and topological defects. The study reveals new insights into the physics-biology intersection and highlights the value of interdisciplinary collaboration.
A recent study reveals correlations between clusters, observing the development of new mutations and transmission chains. The research provides important insights for pandemic control and may help assess whether treatments influence virus mutation characteristics.
A new therapeutic PD-1 cancer vaccine has been shown to be safe and effective in an animal study, activating both B- and T-cell functions to promote tumor clearance. The vaccine is targeted to block signaling pathways crucial for tumor growth and maintenance, offering a promising approach to immunotherapy.
Researchers demonstrate the existence of exotic Bloch oscillations in crystals with intrinsic non-Abelian fields, characterized by a multiplication of the oscillation period. These phenomena are perfectly synchronized with internal states of the crystal and shed new light on topological quantum matter.
Researchers have found a closer look at the behavior of electrons in strange metals, which could allow them to understand a mechanism for superconductivity at higher temperatures. This work is crucial for designing high-temperature superconductors that can power cities and levitate cars.
Researchers have developed a contact lens that uses tiny channels to collect tears and measure biomarkers like sodium ions and glucose molecules. The lens can detect changes in tear pH and flow rates, offering a potential solution for preventing dry eye disease and monitoring diabetic patients.
A study found that Latinx, African American, and African international students experienced elevated stress arousal in response to perceived racism. Rumination on racism was associated with increased negative emotions across all groups.
A new microneedle skin patch has been developed by UConn researchers to provide immunization against infectious diseases through a single administration. The patch triggers a high immune response and offers a long-term protection similar to multiple injections.
George Mason University will lead a $111 million public-private partnership, Cybersecurity Manufacturing Innovation Institute (CyManII), to introduce cybersecure energy-ROI and drive American manufacturers. The university's well-recognized strength in cybersecurity research positions it well to support the five-year goals of CyManII.