Astronomers detect a massive black hole in the early universe that is lying dormant due to low accretion rates, sparking debate about its formation and growth. The discovery challenges standard models of black hole development and suggests that these monsters may be born big or go through periods of hyperactivity.
Researchers observed California ground squirrels hunting, eating and competing over vole prey, revealing a carnivorous summer behavior. This flexible diet suggests they can adapt to changing environments.
The new therapy significantly improves three-year disease-free survival for children with B-ALL, with 96% being disease-free for at least three years. Blinatumomab is now being used in most patients due to its practice-changing breakthrough, offering improved quality of life and reduced side effects.
Researchers at MIT have created a new magnetic state in an antiferromagnetic material using terahertz laser light, enabling controlled switching and potentially leading to more efficient memory chips. The technique provides a powerful tool for manipulating magnetism and advancing information processing technology.
A live-attenuated vaccine against Lassa virus has been developed and shown to be safe and 100% effective in protecting guinea pigs from the virus. The vaccine was created by modifying the genome of the virus to prevent it from causing disease, making it a promising candidate for future clinical trials.
The study, published in Aging, introduces a new therapy for osteoarthritis that uses extracellular vesicles derived from fat tissue to repair damage caused by aging cells. The treatment showed strong therapeutic effects in both cellular and mouse preclinical studies, reducing inflammation and DNA damage markers in human joint cells.
The COVID-19 pandemic and lockdown created space for trans and gender diverse youth to explore and resolve their gender identity, with the most prevalent theme being a 'time for identity development'. This research found largely positive impacts on gender identity development in this age group.
A new study by researchers at Brown University found that greater race-day pollution is associated with slower average marathon finish times. Runners' efforts to optimize their performance should consider the effect of air pollution.
A new study from Uppsala University shows that an app can help parents who are mourning the loss of a child, reducing symptoms of prolonged grief and post-traumatic stress. The app provides four components: learning about grief, finding support, practical exercises, and a 'grief meter' to track feelings.
The Field Museum has digitized over a quarter-million specimens and records thanks to its Collections Club, a community science program. This effort provides valuable data for researchers worldwide, with over 3,800 volunteers contributing more than 13,500 hours.
The Horizon Europe-funded PollinERA project has launched a new open-access collection in the Food and Ecological Systems Modelling Journal to tackle pollinator population declines. The collection provides ecotoxicological knowledge gaps datasets, pollinator pesticide risk indicators, and models for chemicals and pollinator populations.
A new study by University of California, Davis researchers suggests that hiring boomerang workers can bring benefits to both the organization and current employees. However, existing workers may not be as helpful to boomerangs as they are to newcomers. The study found that resentment among former colleagues can lead to reduced assistan...
People with severe depression who received vagus nerve stimulation showed significant improvement in depressive symptoms, quality of life, and ability to complete everyday tasks after a year. Despite this, the therapy remains unaffordable for many patients due to high costs.
A study published in Journal of Medical Internet Research found that open-world video games provide cognitive escapism, reducing stress levels and improving mental health. Popular titles like The Legend of Zelda: Breath of the Wild offer a sense of freedom and autonomy.
Studies activated neurons in different brain regions to make male and female mice resilient to stress, revealing distinct sex-specific mechanisms. Gene expression changes were also observed in brain regions of stressed resilient vs non-resilient mice, suggesting potential for lasting protective changes.
A recent study published in PLOS ONE found that immersive VR exercise sessions resulted in more intense and enjoyable workouts compared to traditional screen-based exercises. The research suggests that virtual reality could be an efficient way to improve physical activity and overall well-being.
Dr. Gerta Hoxhaj has been recognized with the 2025 Mary Beth Maddox Award and Lectureship for her groundbreaking work on cancer metabolism. Her research focuses on understanding the connections between signaling networks and metabolic pathways in cancer cells, revealing new mechanisms crucial for tumor growth.
Craniopharyngiomas, a type of brain tumor, can hijack hypothalamic neurons to enhance growth. Researchers identified a promising treatment option: amlodipine besylate, a calcium channel blocker commonly used for hypertension. The medication disrupts chemical synaptic transmission between neurons and tumor cells.
A large-scale study found that genetic variants associated with dyslexia were linked to differences in brain areas involved in motor coordination, vision, and language. The research also discovered associations between dyslexia-related genes and white matter density in the internal capsule, which is linked to various cognitive traits.
A study by the American Chemical Society has found elevated levels of 'forever chemicals' in several smartwatch wristbands, with one compound, PFHxA, appearing in nine out of 22 tested wristbands. The concentrations of PFHxA were found to be nearly 800 ppb on average, exceeding previous findings in cosmetics.
Pregnant women with MS receiving disease-modifying therapies show increased risk of low birth weight and serious infections. Exposure to S1P modulators, natalizumab, and anti-CD20 antibodies is particularly concerning.
A new report outlines best practices and standards for human body donation programs in the US, emphasizing the importance of informed consent and oversight. The guidelines aim to uphold donor dignity and maintain highest ethical standards.
Researchers uncover Achilles' heel of TMZ chemotherapy resistance, revealing critical insights into mechanisms behind glioblastoma's inactivation of DNA repair pathways. The study sheds light on potential mechanisms of aging and offers new avenues for developing more effective therapies against this devastating cancer.
A new study published in the Journal of the American Geriatrics Society found that older adults with multiple chronic conditions are at a higher risk of declining kidney function. The study followed 3,094 older individuals for 15 years and found an independent dose-response relationship between the number of chronic conditions and kidn...
Heavy-ion irradiation improves FR901379 synthesis in Coleophoma empetri, with high-yield mutants exhibiting distinct morphology and fermentation characteristics. The use of nonhomologous end-joining deficient strain increases diversity of mutagenesis libraries.
A recent study published in Journal of Dental Research examined the relationship between early childhood fluoride exposure and cognitive development. The research found that there were no significant effects of fluoride exposure on cognitive neurodevelopment, with the hypothesis of non-inferiority tests also supporting this conclusion.
A new study reports a 60% decline in global diarrheal disease mortality, but highlights regional disparities and areas for improvement, particularly in sub-Saharan Africa and South Asia. The largest decrease was among children under 5 years old, with a 79% drop in deaths, while adults 70+ still face high mortality rates.
A study from the University of Notre Dame found nine out of 22 watch bands contained high levels of perfluorohexanoic acid (PFHxA), a type of PFAS. Elevated PFAS levels were more prevalent in higher-priced watchbands, posing concerns for dermal absorption and potential health risks.
A cohort of 1,500 children found cardiovascular health scores began to decline at approximately age 10, associated with health behaviors. This study identifies modifiable health behaviors for prevention efforts to optimize CVH in early life and may contribute to disparities in adulthood.
The RECOVER-adult long COVID research index has been expanded with new data and symptoms, enhancing its ability to classify symptomatic long COVID and its subtypes. This update highlights the need for continued refinement of the index as our understanding of long COVID evolves.
A team of scientists has introduced a novel basic detonation flow field, the Axisymmetric Inward Turning Curved Detonation Wave (AIT-CDW), which boosts compression capabilities and accelerates gas ignition. The study highlights the importance of geometric parameters in maintaining stable combustion processes.
A new study by Columbia University researchers has found a strong link between structural sexism and faster memory decline in women. Born in the most sexist US states, these women experience faster memory decline compared to those born in less sexist states, with an age equivalent to nine years of cognitive aging.
Scientists suggest the Moon underwent a 'remelting' event due to tidal forces, resetting its geological clock and masking its true age with volcanic activity. This hypothesis could account for discrepancies in lunar-rock ages and impact basins, placing the Moon's formation between 4.43 and 4.53 billion years ago.
A 13,000-year history of vegetation and fire in Albany Pine Bush reveals pine-oak forest dominance with frequent fires. Pollen and charcoal samples indicate moister climates in recent millennia.
Researchers developed a miniaturized all-fiber photoacoustic spectrometer for intravascular gas detection, achieving detection limits of 9 ppb and response times as quick as 18 milliseconds. The system detects trace gases at the ppb level and analyzes nanoliter-sized samples with millisecond response times.
Scientists have developed swarms of tiny magnetic robots that can lift and transport heavy objects, thanks to their unique assembly configuration and rotating magnetic field. The microrobots can even guide small organisms through complex motions.
Researchers created human stem cell models containing notochord, a tissue guiding spine and nervous system formation. The model's chemical signals organize surrounding tissue similarly to natural development, enabling studies of developmental conditions and disorders.
A study by MIT economists suggests that industrial policy has a relatively limited impact on GDP growth, with average long-run gains of 1.08% in favorable circumstances. The research indicates that local consumer demand can curb the impact of industrial policy, putting a ceiling on directed growth.
A study by MedUni Vienna identified a promising therapeutic approach for metabolic liver diseases by targeting fat metabolism inhibition, promoting liver health and reducing liver fat, inflammation and fibrotic remodeling. The approach involves blocking ATGL, an enzyme playing a central role in lipid metabolism.
A new study from the University of Bath finds that personalized gifts can increase recipients' self-esteem and evoke a sense of vicarious pride. By including personal touches such as names or messages, gift-givers can create meaningful experiences that last beyond the initial gesture.
A new survey by Tel-Aviv University's Moshe Dayan Center reveals that 57.8% of Arab Israelis believe the ongoing war has fostered a sense of shared destiny between Arabs and Jews in Israel. This is a statistically significant shift from previous surveys, indicating a positive trend towards coexistence.
A new study reveals how doline topography supports diverse plant communities and act as biodiversity hotspots. Doline bottoms exhibit the highest functional and phylogenetic diversity.
A study found significant racial disparities in child abuse identification, with Black children suspected at higher rates. The findings highlight the need for further research to understand these disparities and reduce them in child abuse treatment.
A new method combining Random Forest and Compound Maximum a Posteriori algorithms reduces invalid transitions and improves LULC classification, correcting 99.92 km2 of errors. The study outperforms traditional methods, especially in detecting changes in mountainous regions.
Researchers uncovered a rare musical score in an ancient manuscript, shedding light on Scotland's musical traditions during the Reformation. The discovery provides clues to what music sounded like five centuries ago and is the only surviving piece from the northeast of Scotland.
Researchers have developed a molecule called azo-menthol that precisely controls TRPM8 channels using light, enabling spatiotemporally precise and reversible activation and deactivation. This breakthrough has great therapeutic potential for diseases such as cancer, metabolic disorders, and inflammations.
Researchers at Case Western Reserve University have discovered a potential target for treating drug-resistant malaria, PfNCR1, a cholesterol-managing protein. A compound known as MMV009108 can physically block the transporter, preventing it from doing its job and potentially killing the parasite.
Researchers have discovered that dextromethorphan, an FDA-approved ingredient found in many cough syrups, has potential to treat fibrotic lung disease. The study, published in Science Translational Medicine, showed how dextromethorphan can impede collagen formation, reducing lung scarring and stiffness.
A new study by UCL researchers found that AI systems amplify human biases, leading to a snowball effect where small initial biases increase the risk of human error. The researchers demonstrated real-world consequences, including overestimating white men's likelihood of holding high-status jobs and underestimating women's performance.
Researchers have developed a new diagnostic test that uses two markers found in the synovial fluid of patients' joints to differentiate osteoarthritis from inflammatory arthritis. The algorithm, based on the ratio of cartilage oligomeric matrix protein and interleukin-8, has been validated with high accuracy.
A new study by University of Iowa researchers has identified the first and only neurons necessary for salt appetite in mice and humans. These HSD2 neurons are triggered by aldosterone, a hormone that controls sodium levels, and play a crucial role in maintaining fluid balance in the body.
Research team at the University of Basel uncovers new mechanisms in blood vessel formation, highlighting the critical role of dynamic forces and protein regulation. The study reveals that contraction forces enable continuous vascular lumen formation, while Rasip1 plays a key role in initial steps of lumen formation.
Researchers found 11 cases of laryngeal edemas in patients after tisagenlecleucel infusion, with higher doses and CAR-positive cells linked to increased risk. Steroid administration showed promise in early management without affecting therapy effectiveness.
Researchers at Nagoya University have developed a new dropsonde that can be dropped into a typhoon without a parachute, showing high accuracy in measuring atmospheric data. The device measured temperature, humidity, and wind speed with differences less than 1K and 2m/sec from reference radiosonde data.
A review highlights a novel approach to remote sensing time series analysis, integrating multi-source data for timely environmental monitoring. The methodology offers enhanced accuracy and reliable insights into terrestrial dynamics.
A study by HKUMed researchers found that patients with poorly controlled type 2 diabetes are more susceptible to severe viral infections due to impaired immune function. Effective glycaemic control is crucial for bolstering anti-viral immunity and reducing health risks.
Researchers used drone imagery to measure calf growth and maternal body condition in Hawaiʻi and Alaska, finding larger females produced larger calves. Humpback whales lose significant weight during lactation, with mothers losing nearly 214 pounds per day.
A new study by University of California, Davis, found that the current estimate of the social cost of carbon is too low, increasing to over $280 per ton of CO2 emitted. This higher estimate reflects the impact of climate change on human welfare, including economic growth and unique natural systems.
A WVU researcher creates an augmented reality training program to enhance miners' awareness of blind spots and ability to identify hazards. The training technology uses visualizations to project blind spots directly onto the trainee operator's surroundings, reducing fatalities and injuries in the mining industry.
A new study from Ben-Gurion University found that teachers often label parents as the problem, rather than viewing them as partners in their child's education. Researchers recommend increased professional training to help teachers diagnose and address various parenting styles, increasing professionalism and school legitimacy.