A new study reveals that bisphenol analogues accumulate and magnify through Arctic food webs, with polar bears showing alarming levels of contamination. Researchers identified two major local pollution sources: a firefighting training site and landfill leachate, emphasizing the need for stricter waste management and alternative materials.
Insilico Medicine has demonstrated the potential of generative biologics to rapidly design peptides targeting GLP1R, a receptor modulated by blockbuster diabetes drugs. The company generated over 5,000 novel peptides within a 72-hour cycle and identified 14 with biological activity.
Researchers at Max Planck Institute discovered quantum coherence and interference patterns in CsV₃Sb₅, defying single-particle physics expectations. The crystal's geometry influences the collective quantum behavior of electrons, potentially leading to new materials with tunable resonance.
Researchers at South China University of Technology develop a method to solve unstable anode:electrolyte interfaces using digital light processing (DLP) 3D printing. The resulting batteries retain over 91% capacity after 8,000 cycles and achieve stable cycling over 2,000 hours.
Researchers have developed a lightweight energy-absorbing box using PEEK honeycomb, increasing average crash load by 18.1% and offering superior balance between safety and weight reduction.
SourceELSP·JournalAdvanced Manufacturing·TypeComputational simulation/modeling·DateOct 29, 2025
Researchers have developed machine learning models to accelerate the discovery and design of efficient 2D electrocatalysts, enabling faster and more reliable catalyst optimization. The study highlights the importance of high-quality data, descriptor selection, and interpretable modeling in harnessing the full potential of machine learn...
A new study reveals that dissolved organic matter in biochar enhances the metal-binding power of biochar, offering insights for safer cleanup strategies. The research found that chemical complexation is the dominant mechanism of immobilization, with carboxyl groups serving as key binding sites.
Researchers found that sunlight can transform synthetic fabrics into tiny plastic fibers, releasing thousands of microscopic fragments. The study shows that fabric color and dye chemistry significantly impact microfiber generation, highlighting the need for sustainable textile design.
A clinical trial found that antibiotics within 24 hours of an obstetric tear can significantly reduce the risk of clinically relevant wound complications. The treatment group experienced fewer complications and reported better wellbeing compared to the placebo group. This finding supports the use of prophylactic antibiotics in routine ...
Researchers from Hokkaido University developed a computational method to predict the optimal ligand for generating reactive alkyl ketone radicals. The Virtual Ligand-Assisted Screening (VLAS) method successfully identified L4 as the optimal ligand, enabling the generation of ketyl radicals with high yield.
Patients with weak heart function who receive stem cell therapy shortly after a heart attack have lower rates of heart failure and hospital stays. The technique may be a valuable add-on procedure for patients with weakened heart function after a heart attack to prevent subsequent heart failure.
Three new Cochrane reviews found GLP-1 drugs result in clinically meaningful weight loss, but evidence on longer-term outcomes and side effects is limited. The wider use of these drugs should consider social and commercial determinants to avoid deepening existing health inequities.
SourceCochrane·JournalCochrane Database of Systematic Reviews·TypeSystematic review·DateOct 29, 2025
The Lancet Countdown report reveals that the world is facing unprecedented levels of health threats due to climate change, with millions of lives lost unnecessarily. The report calls for urgent action to limit future harm by prioritizing human health in policy decisions.
Researchers find that malaria parasites use a chemical reaction powered by hydrogen peroxide decomposition to make their iron crystals spin. This motion may be crucial for the parasite's survival, helping it to eliminate excess toxic chemicals and efficiently store essential heme.
A new report warns of a severe consultant recruitment crisis in the NHS, with 1 in 3 consultant posts vacant in some parts of the UK. The shortage is costing the health service £674m on locum consultants, negatively impacting staff morale and patient care.
Researchers found that the risk from airburst-sized near-Earth objects (NEOs) might be larger than currently estimated. A concentration of larger objects in a swarm could be observable by telescopes in 2032 and 2036, increasing Earth's impact risk.
Researchers have discovered detailed visualizations of mosquito's carbon dioxide-detecting neurons, revealing anatomical adaptations designed to target human blood. The study provides key insights into the mosquito's sensing mechanisms and their unique ability to detect CO2, which contributes to their deadly status.
A new small molecule drug, RAGE406R, has been developed to disrupt a key cellular pathway responsible for chronic inflammation and associated complications in patients with diabetes. The breakthrough could offer a new therapeutic option for stopping the harmful effects of both type 1 and type 2 diabetes at the source.
A new study by USC researchers reveals that short-term 'dynamic instability' in blood pressure is linked to loss of brain tissue and nerve cell injury in older adults. This phenomenon, where blood pressure fluctuates wildly from one heartbeat to the next, may be a key risk factor for brain shrinkage and neurodegeneration.
A nationwide retrospective cohort study found that patients with frailty experience worse short- and long-term postoperative outcomes following non-cardiac surgeries. Frailty screening is recommended before major and minor procedures to identify high-risk patients, emphasizing the need for greater surgeon awareness.
Researchers at the University of São Paulo developed a low-cost, portable biosensor that can quickly identify altered levels of BDNF associated with psychiatric disorders. The device detects extremely low concentrations of BDNF in human saliva, which is crucial for growth and maintenance of neurons and development of brain functions.
A pilot program at University of Missouri-Columbia's emergency department connects rural families with community resources, improving their health and stability. Nearly half of participating families reported unmet essential needs, with food insecurity being the most common.
A study of nine large mammal species in the Greater Yellowstone Ecosystem found that their behavioral responses to summer heat were influenced more by environmental structure than biological traits. Populations living in homogeneous environments altered their behavior more dramatically, seeking shade and cooler conditions.
A new study led by Mass General Brigham researchers found that a home exercise program combined with standard or sham physical therapy improved knee pain for participants with osteoarthritis and meniscal tears. The addition of regular visits with a physical therapist resulted in slightly greater pain relief, suggesting the importance o...
Scientists discovered queuine and preQ1, produced by gut bacteria, regulate protein synthesis in human cells. These bacterial metabolites promote cell growth and halt it, respectively. The study suggests using diet or microbiome composition to balance cell growth in cancer and prevent autoimmune diseases.
Ochsner MD Anderson Cancer Center has seven locations recertified for quality cancer care, demonstrating a commitment to comprehensive holistic care. The QOPI Certification Program recognizes these locations for meeting national standards and objectives.
Lillian Hughes advances quantum science by creating two-dimensional ensembles of entangled spin qubits in diamond, enabling metrological quantum advantage and high-sensitivity sensing. This breakthrough brings quantum precision closer to reality with solid-state materials like diamond.
A study exploring options for electricity markets during the clean-energy transition highlights key challenges and proposed solutions. The researchers assessed 11 market design proposals to guide energy generation and sources, with findings focusing on forecasting demand, investing in renewable resources, and ensuring system reliability.
A new study suggests that collecting and testing cancer cells in patients' blood could help doctors choose the right breast cancer treatment. The 'labyrinth chip' technology separates cancer cells from other blood cells, allowing researchers to identify biomarkers that distinguish aggressive treatments from less invasive ones.
Scientists have developed a method to remove harmful alkaline earth metal ions from biodiesel using amino polycarboxylate chelating agents. The most efficient agent, CDTA, removed up to 98.6% of Ca2+ and 94.3% of Mg2+, improving oxidative stability.
Researchers validate GLIS model as a reliable predictor of sarcopenia and mortality risk in older patients with heart failure, outperforming existing tests. The model's accuracy enables early detection of physical decline and poor prognosis, informing treatment planning and discharge decisions.
A recent study reveals that loss of liver growth hormone (GH) signaling contributes to the development of lean metabolic-associated fatty liver disease. The researchers developed a mouse model with hepatic GH receptor knockout and found that CD36-mediated lipid uptake and C/EBPβ-driven lipogenesis form a central regulatory hub driving ...
Researchers at Mayo Clinic have found a way to enhance the body's 'first responder' cells, which can boost standard immunotherapies for cancer. By targeting these myeloid cells, it may be possible to improve treatments that interfere with immune suppressive proteins PD-1 and PD-L1.
A team of researchers at UNM used a peculiar prehistoric plant to reconstruct ancient climates. The study found that water traveling through horsetails undergoes intense natural distillation, resulting in oxygen isotope ratios similar to those found in meteorites or extraterrestrial materials.
Researchers developed biomimetic helical fibers that form a 3D entangled network providing elasticity and structural integrity. The sponge features ultralow density, high porosity and exceptional thermal and washing durability.
A new study finds that electric vehicles outperform gasoline cars in lifetime environmental impact, with a reduction in cumulative CO2 emissions after two years of use. The transportation sector accounts for 28% of US greenhouse gas emissions and adopting electric vehicles can improve climate and air quality.
SourcePLOS·JournalPLOS Climate·TypeComputational simulation/modeling·DateOct 29, 2025
Pediatric access to high-readiness emergency departments in the US declined by 3% from 70% to 67% between 2013 and 2021. However, excluding staffing-related readiness, access increased by 4% from 76% to 80%, benefiting around 2.2 million more children.
AI accelerates discovery and validation of novel therapeutic targets by integrating multi-omics data and advanced computational models, reducing the traditional decade-long research and development cycle to two to three years. AI also enhances drug efficacy, predicts resistance mechanisms and improves clinical translation.
Researchers at Purdue University have developed an optical technique to observe individual particles in a battery charging, enabling the analysis of heterogeneity in composite electrodes. This breakthrough allows for the creation of better batteries by understanding the distribution of charge within the electrode.
Insilico Medicine has been named a 2025 BostInno Fire Awards honoree for its groundbreaking achievements in AI-driven drug discovery. The company's lead asset, Rentosertib (ISM001-055), demonstrated potential signs of lung function restoration in idiopathic pulmonary fibrosis patients.
Researchers found that dementia caregivers who interacted with friends experienced lower levels of momentary loneliness. These small social interactions can make a significant difference in their emotional well-being and provide an essential emotional lift during caregiving.
Scientists have discovered how a tungsten-containing enzyme in a microbe converts toxic waste gases into ethanol, offering a promising solution for sustainable fuel production. The breakthrough reveals the mechanism behind this process, enabling the production of valuable chemicals and fuels.
Six scientists have received AFAR Grants for Junior Faculty, totaling up to $150,000 each, to conduct research on the biology of aging. The program aims to develop careers in aging research and explores a range of topics related to healthy aging.
A new study found that selective RNA sequestration in P-bodies directs cell fate transitions by preventing translation of key cell fate-related proteins. This mechanism allows for the generation of clinically relevant cell types, such as primordial germ cells and totipotent-like cells.
Researchers developed a novel tree-like nitrogen-doped carbon support structure that boosts efficiency and lifespan of low-platinum fuel cells. The T-NC support maintains platinum dispersion at high loadings and shows exceptional corrosion resistance, making it compatible with various catalysts.
The research partnership aims to develop stronger aluminum alloys for high-performance applications. Three projects focus on reducing iron impurities through electrical or chemical approaches.
A team of researchers has developed an artificial retina model using 3D printing technology, which closely replicates the pathological microenvironment of retinal vein occlusion. The model exhibited responses similar to those observed in clinical cases, validating its potential as a preclinical drug evaluation system.
The ATP-DEC calculator provides accurate and transparent information on carbon disclosure, helping align aviation with climate targets. It captures real-world variations and life cycle emissions, making it a crucial tool for policymakers, airlines, and passengers.
The scientific program features nearly 300 sessions and thousands of presentations on various fluid dynamics topics. The conference will also include a visual arts competition, Gallery of Fluid Motion, with a traveling exhibit on display until January 2026.
Researchers developed an algorithm to optimize pacemaker function usage, reducing battery power consumption and potentially extending battery life by years. By switching off unnecessary features, doctors can reduce the number of surgeries needed and lower associated costs for the NHS.
A new study found that adolescents who start using cannabis early are more likely to need healthcare for mental and physical problems as they enter adulthood. Those who began using cannabis before age 15 were more likely to seek care for depression, anxiety, suicidal thoughts, and physical health issues.
Researchers at Cincinnati Children's discovered a specific gene mutation in 'cold' tumors that block immune checkpoint inhibitors. Rapamycin was found to make these tumors responsive again by inhibiting mTORC1 signaling.
Researchers found that vibrational motion in chiral molecules leads to the emergence of spin that depends solely on chirality. This phenomenon enables chiral molecules to exhibit magnetic properties without an applied current.
A new study reveals that land-use change was the primary cause of biodiversity loss on Mount Kilimanjaro's lower slopes over the last century. Human activities such as population growth and economic development led to a decline in plant species diversity, with up to 75% lost per square kilometer.
A new method allows for the creation of light-emitting quantum centers in nanodiamonds in just four minutes, yielding large quantities of high-quality material. The breakthrough enables industrial production of higher-quality and more affordable quantum nanodiamonds with applications in research and technology.
A new drive system with individual gearbox control on each wheel improves wheel grip and enables exact speed compensation when cornering. This allows vehicles to move safely in challenging terrains, such as steep slopes and uneven ground. The technology is suitable for emission-free drives and preserves the conventional drivetrain.
A tiny 5 cm long Neanderthal bone found in Crimea revealed ancient DNA showing genetic closest relation to Neanderthals from Siberia, over 3,000 kilometers away. Climate modelling suggests that Neanderthal groups likely migrated across vast Eurasian steppes during favourable climate periods.
Researchers from genomics and exposomics converged on a historic meeting to develop strategies for identifying disease causes. The collaboration aims to merge genetic and environmental factors using biochemical, molecular, and geospatial methods, ultimately driving prevention and treatment advancements.
Glioblastoma's unique defenses hinder CAR-T cell efficacy due to antigenic heterogeneity and immunosuppressive tumor microenvironment. Novel strategies, including multi-target and logic-gated CARs, switchable and universal CARs, and combination therapies, aim to breach these barriers and reprogram the immune system.
A recent study by researchers at University of Würzburg found that a small group of four specific neurons are sufficient to maintain the fly's basal activity rhythm. The findings challenge the prevailing model of a main pacemaker and suggest a core clock network that expands through additional modulation.