Daniel Hook steps down as Digital Science CEO after 11 years, handing over to Stephen Leicht, who aims to build on the company's success. Leicht has been part of the Digital Science story since 2013 and is focused on growth and innovation.
A noninferiority randomized clinical trial found that an alternative first-line regimen containing doravirine, lamivudine, and tenofovir disoproxil fumarate produced less weight gain than a combination of dolutegravir, emtricitabine, and tenofovir alafenamide. The regimen was noninferior for viral suppression at 48 weeks.
Researchers found changes in tooth enamel mineralization in rats exposed to secondhand smoke, with increased carbon content and reduced phosphorus levels. This suggests a potential impact on tooth strength and hardness.
Researchers created a detailed map of breast tumour cells, identifying distinct neighbourhoods of proliferating and dormant cells. The study reveals that protective immune and connective cells surround the hibernating cancer cells, potentially shielding them from treatments.
Researchers developed Fe-doped carbon composite catalysts to regulate the thermal decomposition and combustion behavior of DAP-4. The catalysts improved decomposition and combustion reactions by accelerating hydrogen transfer and forming reactive intermediates.
US nursing homes have seen a significant increase in closures between 1985 and 2025, with changes in ownership and capacity reconfiguration being more common than permanent facility closure. The study highlights the need for policy and oversight considerations that take into account ownership transitions and capacity changes.
Researchers at Institute of Science Tokyo developed strategies to overcome xenophagocytosis, which eliminates living donor cells in interspecies organ generation. By blocking this response, they significantly improved donor cell survival and generated rat pancreas in mice.
Co-transcriptional splicing plays a critical role in regulating chromatin structure, mRNA maturation, and protein diversity. The review identifies key detection methods, regulatory mechanisms, and therapeutic applications for this process.
Researchers combined fishing regulations and trade data to explore the complex global market for shark products. Despite significant regulatory efforts, no statistically significant effect on global trade was found.
Scientists create complex solid solutions by firing five atomic elements onto a wafer from different directions, forming chemically disordered nanocrystals. The resulting epitaxial films exhibit interesting defect structures that may influence the desired properties of catalysts.
A Boston University-led study found that the solar wind strips away Mars' atmosphere by generating Kelvin-Helmholtz waves, similar to wind on Earth. The process drives atmospheric ion escape, with plasma clouds facilitating bulk escape.
Hepatic encephalopathy recurrence can be reduced through education on precipitants correction and pharmacotherapy with lactulose and rifaximin. Nutritional support with protein-rich diets improves QOL and reduces episodes.
Researchers found that no electoral system can guarantee both local votes translate directly into local seats and total seat distribution matches overall vote shares. However, they proposed an algorithm called 'geographically ranked guaranteed proportionality' which could get around the impossibility of current systems.
A likely case of soft tick-borne relapsing fever was reported in an Austin resident, who experienced recurring high fevers and symptoms before finding an infected tick. Researchers confirmed the presence of Borrelia turicatae bacteria and emphasized the need for greater awareness and surveillance of tick populations in urban areas.
Researchers developed stronger stem cell-derived extracellular vesicles to rebuild damaged microvessels and heal diabetic wounds more effectively. The treatment improved tissue remodeling, restored angiogenesis, and reduced oxidative stress in mouse and miniature pig models.
Chinese scientists have observed hafnium-153, an extremely rare isotope, using the High Intensity heavy-ion Accelerator Facility (HIAF). The discovery provides critical experimental information for testing nuclear models and advancing our understanding of nuclear structure.
Researchers found that larger departing bubbles can improve hydrogen evolution reaction efficiency by up to 30% through coalescence, a self-driven cleaning and mixing process. This design principle has broader applications in industrial electrolysis, where surface bubble removal and interfacial transport remain major limits.
The study advances solar desalination by removing over 99.99% of oil from seawater while maintaining stable performance and efficient freshwater production. The multifunctional membrane combines oil removal with solar-powered desalination, demonstrating a promising strategy for treating real-world oily seawater.
Current Science, Engineering and Technology is an international, peer-reviewed journal publishing original research across major disciplines of science, engineering, technology, and medicine. The journal fosters cross-disciplinary advancements through rigorous peer-review and open access policy.
Researchers discover soy-derived LPC70 promotes organ-specific, receptor-dependent PG signaling to counteract HS-induced cardiovascular and cognitive abnormalities. LPC70 enhances AA utilization, promoting AA-derived PG production under HSD conditions.
Researchers found that an electrostatic field slows pork glycolysis during near-freezing storage by preserving glycogen and adenosine triphosphate (ATP), limiting lactate accumulation, and altering muscle protein structure. This approach could offer a new route to maintaining fresh pork quality.
A new study reveals that ketamine enhances neuroplasticity in female mice by activating the FKBP51 protein, but has no effect on male mice. This finding could lead to better treatments for depression and highlight the importance of sex differences in drug effects.
Researchers have found that the alpine plant Rheum nobile has four distinct species, each with unique characteristics. The study suggests that geographic isolation and genetic drift led to the formation of these four lineages, with historical gene flow influencing their evolutionary paths.
Researchers discovered a genetic switch in tiger lilies that allows them to survive extreme cold by rewiring pigment production. The discovery opens possibilities for breeding more resilient ornamental and food crops.
A recent study reveals that the Pimentel Barbosa Indigenous Territory, home to the Xavante ethnic group, has maintained its environmental configuration amidst agricultural expansion and deforestation. The area, dominated by Cerrado vegetation, has been preserved despite surrounding areas being converted to soybean farming and livestock...
A nonrandomized trial found that aggregate neighborhood environmental interventions, including abandoned house remediation, significantly reduced fatal opioid overdoses. Community trash pickup and vacant lot cleanup were not associated with significant reductions or increases in opioid overdose rates.
The EU project B-Cubed developed automated data pipelines to standardize biodiversity data, creating 'species occurrence cubes' that support consistent indicator reporting. These data cubes enable the derivation of meaningful measures of biodiversity status and trends, allowing for timely responses to dynamic threats.
Researchers at Kennesaw State University are using interactive visualizations to improve students' understanding of complex semiconductor concepts, bridging the gap between abstract theory and real-world behavior.
Recent studies explore the impact of digital technologies on health outcomes, highlighting innovations in maternal care and wildfire preparedness. Digital tools are being used to improve access to healthcare, particularly in rural areas, and mitigate adverse effects of wildfires on air quality.
The new position statement offers practical recommendations for the assessment, diagnosis, and management of PLO. It recommends individualized management, including pharmacological treatment where appropriate.
Researchers found that higher concentrations of a fungicide residue were associated with an earlier onset of the first period, while the presence of another compound derived from the insecticide chlorpyrifos was linked to a delayed onset. This study underscores the importance of endocrine disruptors in children's health and the need fo...
A team of scientists has identified a multi-step process where neutrophils are guided to specific tissue sites to confront infecting microbes or viruses. The study found that a signaling complex formed by TRPV2 and CB2R directs migration selectively toward sites of infection.
This collection features articles on Additive Manufacturing published in Smart Materials in Manufacturing. Key findings include biodegradability, biocompatibility, antibacterial properties, fatigue resistance, radiation shielding, and mechanical properties of various additively manufactured materials.
A new study found that road traffic kills almost a third of hedgehogs in some British populations each year, with smaller populations at risk of collapse and local extinction. The research reveals that even small amounts of roadkill can have devastating effects on already small populations.
Researchers explore the widespread occurrence of sperm conjugation across arthropods, a coordinated team effort that improves reproductive success. The study reveals how collective behavior influences fertility and opens new avenues for pest control by disrupting reproduction in harmful species.
Researchers at UC Riverside are developing new treatments for malaria and babesiosis using naturally occurring compounds, including leelamine-derived isonitriles and pyrroloiminoquinones. The goal is to create oral treatments that can interrupt transmission of the parasites.
The EU project SYNCHRONY aims to improve understanding of climate and ecosystem changes in the Southern Ocean and around Antarctica, and will establish an internationally coordinated observing system. The project will coordinate interdisciplinary activities, harmonise data streams, and create new data products.
The study highlights how school-entry vaccine requirements strengthen the connection between healthcare and education systems, ultimately improving children's health outcomes. By requiring vaccinations at school entry points, these policies create a valuable interface for public health interventions.
For the first time in Brazil, scientists have detected bacteria that cause columnaris disease, a serious disease in farmed fish. The study found that six out of eleven isolated strains were of the Flavobacterium oreochromis species, infecting native Brazilian species such as tambaqui, pacu, and Amazon spotted catfish.
A decision analytical model and microsimulation study found that expanding alcohol screening and brief interventions in primary care could reduce premature mortality from major alcohol-related causes of death in US adults. By 2030, this expanded approach is projected to decrease annual alcohol-related potential years of life lost by −5...
Scientists have discovered that TRF2, a protein previously known for protecting chromosome ends, plays a crucial role in preserving the identity of muscle stem cells and enabling their regenerative abilities. This new understanding may lead to the development of therapeutic strategies for muscular dystrophy and cancer research.
A new study from the University of Surrey found that shower habits, such as applying shampoo or pausing water while washing, contribute significantly to household water waste. Showers account for between 25% and 45% of indoor water use, making them a major contributor to domestic water consumption.
A national study of obstetrician-gynecologists reveals that state abortion laws are linked to higher levels of clinical constraints and moral distress among OB-GYNs. The findings suggest that institution-level support is needed to address moral distress, regardless of the state's abortion policy context.
Researchers at UVA Health System have made a breakthrough in treating glioblastomas, the deadliest form of brain cancer, by using focused sound waves to deliver drugs exactly where needed. The approach has shown promise in lab mice and could potentially enhance drug delivery performance for some therapeutics.
Researchers at Rice University have discovered altermagnetism in ultrathin ruthenium dioxide films, which could enable advances in miniaturized RAM architecture. The team found that applying pressure to the film induces magnetism, with spin textures consistent with unconventional magnetism.
A new study in mice reveals that brain cells in the orbitofrontal cortex respond differently when animals expect information versus no information. The researchers identified a unique neural signature associated with the intrinsic value of knowledge, which could guide animals in pursuing knowledge.
A research team developed a method for intermolecular asymmetric dearomatizing photocycloaddition using chiral metal-organic cages, enabling precise control over regioselectivity, diastereoselectivity, and enantioselectivity. The reaction exhibited broad substrate generality and high yields.
Researchers found that smaller crumpled sheets exhibit higher load-bearing capacity than larger ones, with denser internal ridge networks playing a key role. The team identified a universal evolution pathway governing the formation of ridges and junctions under compression.
Researchers at University of São Paulo develop tool using isotopes to track origin of Amazon timber, identify regions where logging is most intense. The methodology involves analyzing ratios of different isotopes in wood cellulose to pinpoint harvesting location.
A recent study published in JAMA finds that nicotine e-cigarettes are an effective treatment for smoking cessation. The research suggests that e-cigarettes can help reduce the harms of cigarette smoking and support evidence-based pharmacologic treatment for smokers seeking to quit.
A new study reveals that the 'zombie-ant' fungus harbors a hidden stage inside forest mosses, indicating a dual lifestyle with one life stage as an insect parasite and another endophytic stage. This discovery reshapes our understanding of the life cycle of these fungi.
Researchers recovered and analyzed ancient viral DNA from a local community in northern Chile, revealing the strongest direct evidence linking European colonization to the introduction of smallpox to the Americas. The study shows that smallpox evolved in a way that allowed it to spread successfully with minimal adaptation.
Researchers at Texas A&M AgriLife are leveraging AI to streamline tuberculosis drug discovery, identifying nuisance compounds that waste time and resources. By analyzing published screening data, their CAGE-Fusion model sorts compounds into four trouble categories, informing more targeted research efforts.
Thirty high school students participated in the Global Guardians for Pandemic Preparedness program, gaining insights into virology, public health, and pandemic preparedness. The program showcased the growing partnership between GVN and USF, providing hands-on experiences at research laboratories, hospitals, and public health agencies.
Research from the University of East London suggests that digital workplace innovation can support more women in leadership roles within family firms. The study argues that flexible digital working can enable women to contribute more visibly to leadership while balancing work and family life. Digital tools like Microsoft Teams can help...
The Netherlands has joined the Cherenkov Telescope Array Observatory (CTAO) as an Observer, reinforcing its long-standing partnership with the observatory. With observer status, the Dutch delegation will participate in key activities and contribute to the development of the CTAO's critical construction phase.
A new study from the University of Surrey discovered that simply explaining how customer money is spent can make them more willing to pay higher prices. The research found that customers are often more willing to pay when they understand the value behind a service, such as expert staff or quality ingredients.
A study by University of Wisconsin-Madison and Princeton University has identified large quantities of undeclared uranium extracted, concentrated and exported from the DRC over the past 20 years. The researchers estimate that 2,000 to 5,000 metric tons of natural uranium were exported, posing significant environmental and health risks.
Scientists from the University of Osaka created an autonomous solid-state nanopore that can sense molecules, generate electrical signals, and retain memories of recent events. The device continuously changes its structure through chemical reactions, creating a dynamic sensing environment that responds to molecules passing through it.
The University of Central Florida has opened a new clinic to help pilots meet Federal Aviation Administration (FAA) medical requirements for safe aircraft operation. The clinic is led by William Powers, a certified aviation medical examiner, and offers multiple medical specialties under one roof.