Researchers developed a next-generation phototherapeutic agent, NDI-COE, which induces pyroptotic cell death in hypoxic tumor tissues. The agent's superior photochemical mechanism involves strong binding to water molecules and efficient electron transfer to oxygen.
A new study calls for tripling energy efficiency, electrification and action against extreme energy consumption by 2035. This would accelerate the spread of efficient technologies and generate revenue to expand energy access and support low-carbon investment.
A new study examined geographic patterns in autism diagnosis by primary care providers among Medicaid-enrolled children in 29 states, finding significant variation between regions. The study found that 29% of children were diagnosed with ASD by a primary care provider, with rates varying from 20.0% in the Midwest to 36.4% in the West.
Researchers at Goethe University Frankfurt are exploring modern quantum materials, which exhibit fascinating phenomena in response to external stimuli. Olena Fedchenko investigates electronic structure and properties of these materials using various photon sources.
The study found that low influenza vaccination rates among children are associated with increased healthcare visits, hospitalizations, and ICU admissions. Achieving a 70% immunization rate could prevent up to 2.2 million outpatient visits and 123 pediatric deaths during high-incidence flu seasons.
The MitraClip procedure has been shown to be safe and effective for patients with mitral annular calcification, improving symptoms and quality of life. Despite higher mortality rates, patients with MAC experienced significant reductions in mitral regurgitation and improvements in quality of life, indicating a promising treatment option.
A study uncovers the connection mechanism between ketone bodies and the mTORC1 pathway, identifying RagC as a key player. The findings suggest RagC-K349bhb as a potential therapeutic target for BHB-based CRC treatment strategies.
The INSEAD for Impact programme is a three-day immersive executive forum that helps leaders translate emerging trends into practical strategies and prioritized actions. The programme aims to move beyond analysis to execution, supporting leaders in understanding forces reshaping business and building personal and organizational resilience.
The study provides atomic-level templates of GHRHR's active and inactive states, enabling the design of highly selective agonists and potent antagonists. This breakthrough transforms our understanding of GPCR signaling from static snapshots to a dynamic framework for drug development.
Researchers have produced complete genome sequences for six peanut varieties, identifying two candidate genes linked to oil content and seed size. These findings provide a comprehensive blueprint for future peanut breeding and improvement strategies.
Researchers found that elevated Lipoprotein(a) levels are associated with a higher risk of major adverse cardiovascular events, including stroke and death. Patients with high Lp(a) levels should work closely with their healthcare provider to aggressively lower LDL cholesterol and manage other cardiovascular risk factors.
The study found that out-of-state Chicago Abortion Fund callers traveled more than 3 times the distance to Illinois after Dobbs compared to before. These callers were also more likely to have private or no insurance, be from rural areas, and receive hospital-based care during their pregnancy.
A new study reveals that over 75% of older adults have used complementary health approaches, including mindfulness, yoga, tai chi, acupuncture, and more. The study highlights the need for healthcare providers to discuss the risks and benefits of these therapies with their patients.
The CARPOOL study demonstrates radial-to-peripheral access achieves comparable procedural success rates to traditional common femoral artery access for lower extremity peripheral artery disease revascularization. However, the R2P group had higher major adverse limb events at six months due to target vessel revascularization.
A new study found that influenza D viruses can vigorously replicate in human cells and lung tissue samples, suggesting a strong potential to spill over to humans. Researchers also detected antibodies against Influenza D in people who work with cattle, but no active human infection has been discovered to date.
AI models can analyze complex data to predict disease progression and identify early signs of kidney damage. This allows for earlier detection and better treatment planning, making a significant impact on patient outcomes.
A novel study in Biological Diversity reveals the integrated physiological and symbiotic adaptation mechanism underlying P. purpuratum's ex situ conservation. The research demonstrates that ex situ conservation elevates seed-set rates but incurs trade-offs in photosynthetic capacity and oxidative stress.
This eight-year analysis showed that tenofovir alafenamide (TAF) maintained viral suppression, normalized alanine aminotransferase levels, and improved renal and bone safety in patients with CHB. The study's findings support the use of TAF as the preferred long-term treatment option for this population.
The new SCORE2-LAC model aims to improve cardiovascular risk prediction in Latin America and the Caribbean. The model applies region-specific data from 32 countries, incorporating 2.6 million individuals, and will be validated using an additional 37 million people from Brazil.
Researchers have developed SmartDJ, an AI-powered editor that allows users to reshape audio experiences with simple words. The system uses language models and diffusion models to interpret high-level requests and generate edited outputs.
Researchers at Tokyo University of Science demonstrated a method for manipulating metallic chiral nanoparticles using circularly polarized light. By confining light to an evanescent field near the surface of ultra-thin optical fibers, they selectively transported left- and right-handed particles based on their chirality.
A study on elite male football players found that athletes of Black ethnicity, particularly those from West and Central African regions, exhibited more pronounced repolarisation abnormalities and structural remodelling. The findings suggest that treating athletes of Black ethnicity as a single group may oversimplify clinically meaningf...
A study published at ESC Preventive Cardiology 2026 found that climate change is driving extreme weather events, leading to increases in major cardiovascular events. Heatwaves had an immediate impact, while coldwaves produced a delayed and more sustained effect. Air pollution further amplified the effects of extreme temperatures.
A new study reveals that conspicuous markings, including 'eyespots', evolve under specific ecological conditions. Smaller skates and rays, lacking strong physical defences, are more likely to develop bold spots or eyespots in well-lit, shallow waters.
Monash University researchers have made a breakthrough in using phage therapy to treat life-threatening infectious diseases. The treatment involves injecting viruses called bacteriophages to kill bacterial infections that have not responded to other treatments.
Researchers have discovered a new vulnerability in senescent cells, which can be targeted to kill them and treat cancers. The approach could complement existing treatments, leading to improved outcomes for patients.
A new study improves gene editing efficiency by identifying key genes in human cells that drive particle assembly. By disabling a single gene, researchers boosted production of potent delivery vehicles. The discovery has broad implications for the widespread application of gene editing technologies.
Researchers mapped epigenome changes in cells that regulate blood sugar levels, finding patterns differ between people with and without type 2 diabetes. Epigenetic alterations impact insulin-producing beta cells, leading to impaired energy production and reduced insulin release.
A new study warns that by 2085, 36% of animal habitats on land may experience multiple extreme events like heatwaves, fires, or floods. However, rapidly cutting emissions to net zero could limit the areas affected to just 9%.
Researchers found that building everyday behavioral skills in early childhood can shield young brains from the detrimental effects of prenatal stress. Children with stronger adaptive skills showed comparable brain activation patterns to their unexposed peers, suggesting these skills may protect brain function.
A recent study has found a significant link between ambient air pollution and an increased burden of respiratory infections in the first year of life. The Immune Development in Early Life (IDEaL) Rome Cohort study suggests that exposure to urban pollutants during infancy may fundamentally shape immune resilience, leading to a higher ri...
A new CHOP study investigates the relationship between parenting and gaming disorder in young children with ADHD, finding that negative parenting behaviors are associated with an increased risk of problematic gaming. The study also highlights the importance of parental involvement in gaming and household limits on gaming consoles.
A new study examined measles vaccination coverage in a primary care network following a large post-elimination outbreak. The findings show that MMR coverage remained below herd immunity levels, highlighting the fragility of measles elimination.
Partial heart transplantation replaces only defective valves and related structures, eliminating need for repeat replacements. This procedure can provide thousands of additional valve transplants annually, benefiting young patients worldwide.
A new study found that US children experience higher all-cause mortality than peers in other high-income nations, with a gap of over 800,000 excess child deaths between 1975 and 2023. The mortality disadvantage is now concentrated among older adolescents, particularly males.
A recent study found that states with stricter firearm laws had significantly lower rates of youth-perpetrated firearm homicides, with a 66% lower rate compared to those in weaker law states. The study also highlighted the importance of understanding how firearm laws shape youth-perpetrated homicides in prevention efforts.
A team of scientists has developed an electrochemical system that simultaneously produces hydrogen and value-added chemicals using waste glycerol, reducing energy costs for hydrogen production. The technology enables the co-production of chemical feedstocks, enhancing the economic viability of green hydrogen.
Researchers analyzed pollen trapped in Roman shipwreck coatings to identify plant taxa present during construction and repairs. The study found evidence of four to five distinct batches of coatings, suggesting the ship was patched up successively at different locations throughout the Adriatic Sea.
A large clinical trial involving thousands of patients across the US and abroad found that balanced crystalloid fluid resuscitation was as effective as saline solution in preventing major adverse kidney events after pediatric sepsis treatment. The study also revealed biochemical differences between the two fluids, including elevated bl...
A new study uses unprecedented simulations to reveal how ultra-faint dwarf galaxies reflect the conditions of the early Universe. These tiny satellite galaxies can provide clues about the properties of dark matter and help test early-Universe physics with upcoming observations.
A new study found that children with three or more complex chronic conditions had the highest annual prescription rates and frequent use of broad-spectrum antibiotics. This highlights the need for targeted antibiotic stewardship efforts in this vulnerable population.
Researchers developed a novel design paradigm for vectorial microlasers with designable topological charges using quasi-BIC Möbius-like correspondence in photonic-crystal slabs. This approach allows for programmable structured-light sources for integrated photonic circuits and multi-dimensional optical information encoding.
The MAMBO project developed innovative technologies to monitor biodiversity, including autonomous insect traps, camera traps, sound recognition models, and image analysis tools. These tools enable standardized data collection across multiple species groups, transforming how biodiversity is assessed in Europe.
Researchers at HKUST developed a crystal-solvate seeding strategy to reconstruct buried interfaces in perovskite solar cells, achieving higher efficiency and operational stability. The approach eliminated interfacial voids and introduced stable passivation phases, enabling scalable manufacturing.
The LHAASO discovery reveals an astonishingly efficient particle accelerator powered by PSR J1849-0001, exceeding theoretical limits and challenging current theories of particle acceleration. The system's gamma-ray luminosity is several times higher than that of the Crab Nebula.
The fossil discovery of a giant ichthyosaur with injuries in Northern Bavaria has provided new insights into the species' anatomy and behavior. The animal's modified skeleton, likely caused by injuries, suggests that it may have had to change its diet to survive.
Researchers found that a spherical-shell dynamo can exist in two stable equilibrium states, with tiny initial fluctuations determining the polarity. The study suggests that breaking this stable state is necessary to trigger magnetic reversals, possibly through mechanisms outside magnetohydrodynamic theory.
A new study by UNSW researchers shows how a neural network can detect blue whale songs with remarkable accuracy, using only one recording of a blue whale call. The model performed well on real-world recordings, even those that were not part of the training data.
Researchers have uncovered a new pathway to directly regulate glycogen levels in the body, offering potential therapeutic avenues for conditions like diabetes and heart disease. By studying ubiquitin's role in sugar storage, scientists have identified a new layer to a well-understood biochemical process.
Researchers at Tohoku University discovered a hidden mechanism in DNA damage caused by singlet oxygen generating abasic sites. This process is common and represents one of the main forms of DNA damage, alongside guanine-related types.
Researchers develop a novel surface polarization strategy that pushes device efficiency beyond 26% while dramatically enhancing operational stability. This approach utilizes intrinsic surface defects as anchoring sites for dipolar molecules, transforming flaws into functional advantages for interfacial engineering.
Researchers are developing a new wearable technology to monitor babies' movements and detect early signs of autism. The study aims to improve early identification and intervention, which is crucial for optimal developmental outcomes in autistic individuals.
A new study found that Washington's hepatitis C elimination initiative increased testing and treatment access, leading to reduced total care costs. Per-patient costs declined by over 45% as more people received treatment, suggesting a cost-effective approach to screening and treatment of healthy individuals.
A study published in Biophotonics Discovery uses spectral-focusing coherent anti-Stokes Raman spectroscopy to image human white matter microstructure. The method enables automated measurement of axon size and myelin thickness, revealing new insights into brain connectivity and behavior.
A new study from Tulane University found that extra sets of chromosomes in tumor cells make them more mobile and likely to engulf neighboring cells. This stress response triggers an abundance of proteins, reprogramming the cells for motility and phagocytosis.
A new species of hamster-sized mammal, Cimolodon desosai, has been discovered in the Upper Cretaceous El Gallo Formation of Baja California. The fossil, estimated to be 75 million years old, was found alongside dinosaur fossils and provides insights into the survival strategies of early mammals.
A new AI-based approach developed by UC Riverside professor Demetrius Lewis helps correct the misclassification of creative works due to shifting genres. The tool provides a more accurate representation of how a work was originally intended and received, reducing the risk of undervaluation for boundary-pushing projects.
Researchers developed a microfluidic platform that squeezes individual breast epithelial cells to measure their mechanical age, revealing an unexpected insight: older cells are stiffer and at higher risk of cancer. The AI-powered platform provides a non-genetic test for women with unknown genetic risks.
The European Society of Endocrinology organizes World Hormone Day to educate the public about hormone-related health issues. Global endocrine disorders affect millions worldwide, emphasizing the need for proper hormone balance.
A new study shows that while dental opioid prescription fills in the US have dropped by 27% since 2021, the rate remains higher than in other developed countries and the US territory of Puerto Rico. The study suggests that some US dentists are still overprescribing opioids.