Researchers have identified two compounds that restore chloride balance in neurons, thereby allowing GABAergic signaling to regain its inhibitory function. PCPZ and CLP-257 significantly improved KCC2 efficiency, reducing seizures and other electrical markers of epileptic activity in human brain tissue and animal models.
Researchers have discovered the protective role of LOXL2 protein in preventing cartilage damage and inflammation in temporomandibular joint osteoarthritis. The enzyme helps suppress inflammatory pathways, reducing cell death and preserving cartilage viability even under inflammatory conditions.
Researchers developed a unified detection framework to identify flex power operations in GPS and BeiDou, analyzing how these signal changes affect positioning accuracy and navigation reliability. The study introduces resilient estimation strategies and improved data-processing models to maintain stable navigation services.
PLP hosts satellite events globally to engage researchers in 2026 APS Global Physics Summit programming. Local workshops and networking opportunities ensure community-based spaces for scientists worldwide.
Researchers have developed new imaging techniques to detect hidden infections, inflammatory diseases, and cancers, while also evaluating the effectiveness of AI-powered tumor measurement and targeted radiotherapy for advanced solid tumors.
The RESPIN project has launched a new online course to provide a comprehensive understanding of IPBES and IPCC, two critical intergovernmental bodies. The course is designed for researchers, policymakers, and stakeholders and offers practical guidance on engaging with these bodies and applying scientific findings in policy and practice.
Researchers developed a method called optovolution that uses light to guide the evolution of proteins with dynamic, multi-state, and computational functions. This approach favors variants with better dynamics, allowing for the creation of new variants with improved light sensitivity and responsiveness.
Researchers develop gradient-thickness-protected microbottle resonator for large-scale optical trapping via whispering-gallery modes, enabling stable trapping over nearly 200 micrometers with ultralow optical power. The design supports high-order axial modes, generating multiple optical trapping sites along its length.
Researchers have developed a groundbreaking technology that simultaneously analyzes gene expression, epigenome, and 3D genome structure within a single cell. This innovation enables precise identification of disease genes and their dynamics, laying the foundation for developing treatment strategies for complex diseases.
UT Austin researcher Arumugam Manthiram is working to advance lithium-ion battery technology by understanding the chemistry of oxide cathodes. His research aims to develop more efficient and environmentally friendly battery materials, addressing supply chain disruptions and high costs.
IOP Publishing has launched a new annual award to recognize outstanding Editorial Board members for their contributions to guiding journal development, peer review, and community engagement. The awards celebrate the vital role Editorial Board members play in upholding rigorous standards and advancing scientific fields.
Attosecond pulses rely on ultrafast lasers, which face performance bottlenecks in pulse energy, duration, wavelength, and repetition rate. Key technological routes include increasing pulse energy and peak power through amplification architectures and combining strategies.
A new study reveals that applying an electric field to a ceramic material changes how phonons (tiny vibrations that carry heat) behave, leading to improved thermal conductivity. The material conducts heat almost three times more efficiently along the field direction than in perpendicular directions.
Researchers discover enzyme ANKIB1 crucial for innate immune signalling, driving type I and type III interferon induction. This finding solves a long-standing puzzle in innate immunity and provides opportunities for new therapies for devastating diseases.
The ACMG Foundation will present customized adaptive bicycles to children with genetic or medically complex conditions at the 2026 ACMG Annual Clinical Genetics Meeting. The bikes offer life-changing opportunities for mobility, independence, and participation in everyday activities.
A cross-sectional study documents persistent racial disparities in food insecurity over 23 years, with smaller disparities among SNAP-participating households. The study highlights the need for targeted policies to address food insecurity and its intersectional effects.
Researchers from MedUni Vienna have developed a new approach to drug discovery by targeting intracellular signalling proteins, such as β-arrestins, to control disease-relevant signalling pathways. This approach holds promise for personalized therapies, particularly for the treatment of neurological diseases.
Researchers from Weill Cornell Medicine found that state laws prohibiting private insurance from requiring prior authorization for buprenorphine did not significantly improve treatment retention. Despite a decrease in opioid overdose deaths, nearly 55,000 people still died from opioid overdose in 2024.
A machine-learning model developed by Weill Cornell Medicine predicts preeclampsia risk in late pregnancy with high accuracy. The model uses electronic health record data to continuously update risk predictions, potentially providing clinicians with timely clinical action.
Two studies have found that trust in landowners and experience with feral hogs significantly influence their willingness to manage the animals. Trust in neighbors and community was found to be associated with the likelihood of landowners taking actions to manage feral hogs, while experience with the animals was also a crucial factor.
Researchers at Boston University School of Medicine successfully remove caudate lobe tumor using robotic surgery, combining guidance tools to clearly mark boundaries and protect major vessels. The technique enables tumor removal with less pain, blood loss, and quicker recovery.
Researchers are developing sustainable alternative cements that can bind CO₂ permanently, making concrete a climate-friendly material. By using CO₂ from industrial exhaust gases, these new cements can reduce emissions and create a carbon sink.
A new study reveals that the cockroach Blaptica dubia can efficiently biodegrade polystyrene through a tightly integrated gut microbe–host metabolic system. The insects removed nearly 55% of ingested polystyrene within 42 days, achieving a degradation rate far exceeding those reported for other plastic-feeding insects.
A nationwide cohort study found a significantly elevated incidence of out-of-hospital cardiac arrests on post-holiday weekdays, particularly among vulnerable populations after consecutive rest days. The study supports enhanced emergency preparedness and targeted public health messaging during holiday periods.
Researchers found that village habitats, such as green spaces and fallow land, support a wide variety of insects, including wild bees. Native wildflowers like Knautia and Cirsium are valuable resources for pollinators. Tips for gardeners include using pollinator-friendly plants and allowing vegetation to grow without frequent mowing.
The Ateneo Laboratory for Intelligent Visual Environments (ALIVE) is developing machine learning solutions with industry partners to improve public health, traffic systems, and more. By bridging the gap between messy reality and mathematical models, ALIVE is creating intelligent visual systems that can handle real-world conditions.
Researchers uncover a critical mechanism that enables gastric cancer to spread to distant organs by stimulating Wnt signaling in surrounding stromal fibroblasts. Hyaluronan production creates a supportive microenvironment that promotes metastasis, and degrading hyaluronan suppresses metastatic tumor formation.
The Double-Helix Logic of Curriculum proposes a structural theory redefining education in AI age, emphasizing coexistence of universality and personalization. This framework situates curriculum within a broader shift towards Human Interdependence Paradigm, structuring conditions for differentiated strengths to accumulate and reinforce ...
Researchers will investigate the role of interleukin-1 receptor type 1 (IL-1R1) in brain function, behavior, and psychiatric health. The study aims to define the physiological role of IL-1R1 in the brain and explore its influence on social behaviors.
A new paper calls for integrating meaning, purpose, and spirituality into clinical practice to promote healthier behaviors and well-being. Practical strategies and tools are outlined to support clinician adoption, including patient-led conversations and culturally sensitive approaches.
A new study by Potsdam Institute for Climate Impact Research finds global warming has accelerated by 0.35°C per decade since 2015, surpassing previous decade averages. The research team analyzed five large global temperature data sets and found an acceleration with a statistical certainty of over 98 percent.
Researchers created a novel approach for simultaneous ERG, PanCK, and H&E image generation from label-free tissue sections, enhancing vascular invasion assessment accuracy and efficiency. The virtual multiplexed immunostaining method overcomes traditional IHC limitations, such as section-to-section variability and tissue loss.
A new PET imaging study reveals that ketamine relieves treatment-resistant depression by altering AMPAR in brain regions, providing potential biomarker for personalized treatment. The study found that ketamine increased AMPAR density in several cortical regions and decreased it in reward-related areas, strongly correlating with reducti...
Researchers compared anime illustrations with actual bamboo, finding that the proportions of the muzzle differ significantly from natural patterns. The study highlights the importance of accuracy in scientific representation and suggests potential educational applications.
A recent study led by UMass-Amherst biologists found that the 2021 Great Texas Freeze killed up to 27% of purple martins' breeding population, with effects felt for decades. The study also revealed that the affected birds delayed reproduction and hatched fewer chicks, and their population is already declining in Texas and Louisiana.
A study published in Nature Communications reveals that human DNA is crowded with metabolic enzymes, which interact with DNA and play a crucial role in cancer cell growth and response to treatment. The unique pattern of enzymes differs by cancer type and tissue, providing new clues for understanding cancer biology.
Researchers at Penn State have developed microscopic thermometers that can be integrated onto a chip to track temperatures. The sensors, made from advanced 2D materials, differentiate subtle temperature changes in just 100 nanoseconds and can be placed on a single chip, offering efficient temperature monitoring.
Researchers at WashU Medicine have developed a new compound that protects the liver from damage and improves nutrient absorption after small bowel resection. The drug, WUSTL0717, was tested in mice and showed promise in preventing weight loss and fibrosis, key complications of short bowel syndrome.
Researchers at KIMS developed a novel manufacturing process and membrane material capable of precisely filtering contaminants even under low-pressure conditions. The technology improves upon conventional membranes by reducing energy consumption and surface roughness.
Researchers develop a new technique to identify individual night-flying birds for the first time, using thermal imaging optics. The method, tested in Cape May, New Jersey, allows scientists to detect and photograph birds in flight after dark, revealing new insights into nocturnal bird migration and natural history.
New research from Murdoch University found that antenatal care can reduce the likelihood of traumatic birth experiences in Australian women. Low-cost interventions like childbirth plans and midwifery-led psychoeducation showed potential to reduce fear of childbirth and improve women's experiences.
Scientists at The University of Queensland discovered that certain species of wasps and frogs share a pain and inflammation peptide similar to one found in vertebrates. This finding contributes to a shifting view of how evolution works and highlights the role of convergent evolution in shaping life.
The study introduces a conformational isomer strategy to precisely tune nitrogen atom positions in covalent organic frameworks, enhancing photocatalytic hydrogen evolution performance. The imine-linked COF-I2 exhibits superior performance due to the synergistic effect between Pt clusters and single atoms.
Researchers have charted a transformative path toward sustainable hydrogen peroxide production through the two-electron oxygen reduction reaction. The 'generate-and-use' approach eliminates hazardous storage and long-distance transport, making it ideal for remote areas and decentralized industrial applications.
Researchers have identified tyrosine phosphatase 1B (PTP1B) as a key molecular target in immunogenic cell death (ICD), a type of regulated cell death that activates the immune system against cancer cells. Two platinum-containing compounds, Pt-NHC and PlatinER, trigger ICD by blocking PTP1B's enzymatic activity.
A team of researchers proposes a transdisciplinary approach to address antimicrobial resistance by developing integrated modelling architectures. The current mathematical modelling approaches lack translation from science to policy due to fundamental gaps in data and knowledge.
Financial incentives have shown promise in promoting pro-social and health-promoting behaviors, but challenges persist, including ensuring additionality, monitoring compliance, and addressing social equity concerns. The review highlights key findings on the effectiveness of cash rewards, non-cash incentives, and conditionality in One H...
Researchers from Dalian Institute of Chemical Physics determined the structural motifs of water undecamer cluster, including three low-energy configurations. The study provides crucial insights into the evolution of water's hydrogen-bond network and paves the way for size-dependent studies on solvation processes.
Researchers mapped out the structure of a key player, augmin, in exhaustive detail, revealing its role in plant cell division and shape regulation. The study's findings could lead to new medical treatments and strategies for breeding higher-quality rice and cotton crops.
Researchers developed a novel lab-based tick feeding system that enables controlled studies on tick physiology, microbiome dynamics, and pathogen acquisition. The platform supports the feeding and reproduction of bush ticks without animal hosts.
A new clinical study aims to improve communication between patients and families about genetic risks of colorectal cancer. The trial will compare two methods of sharing genetic test results with close relatives, with the goal of learning which approach helps more family members get necessary genetic testing.
Researchers developed a spray shield that adheres to transplant organs using mussel-derived adhesive protein, reducing immune rejection and its side effects. This innovation enables targeted delivery of immunosuppressants directly to the transplanted site, increasing success rates in xenograft transplantation.
A coalition of experts warns that carbon markets may be penalizing First Nations' long-term stewardship due to their 'additionality' requirements. The definition of 'additionality' often rewards restoration on degraded land, excluding protected ecosystems and traditional owners' custodianship.
Preclinical studies reveal that MR hinders cell proliferation, triggers cell cycle arrest, and enhances standard treatments. Early-phase clinical trials report positive results on safety and tolerability, suggesting utility of MR as a complementary treatment strategy.
Researchers have uncovered the microscopic mechanism of alkali species dissolution in water clusters using a new spectroscopy station. The study found that only three water molecules can separate Ba and OH in neutral BaOH clusters, and this process is facilitated by hydrogen bonding and electrostatic interactions.
A new report from the University of East Anglia warns that charities using AI-generated images risk breaking the fundamental bond of trust with the public. The study found that when AI images are used, the humanitarian cause disappears from the conversation, and the public engages with charity rather than the cause itself.
A new study by King's College London found that specialist palliative care can reduce NHS costs by up to £8,000 per person and improve quality of life. Home-based specialist palliative care was associated with reduced costs, while hospital-based care also showed cost savings.
A study found a significant decrease in acetaminophen use during pregnancy and a surge in leucovorin prescriptions after the September 2025 White House briefing. Leucovorin prescriptions increased approximately 71% above expected levels, mainly for children with autism diagnoses.
Researchers discovered that CBD and CBG can significantly reduce liver fat and improve metabolic health by creating a backup energy reserve and restoring cellular cleaning crews. These compounds also showed promising effects on treating metabolic diseases, including reducing body fat mass and improving insulin sensitivity.
Researchers propose a new measure for recovery from substance use, recognizing incremental progress, to reduce stigma and improve quality of life. The study found strong associations between proportion of remission and quality-of-life measures, suggesting a paradigm shift in how recovery is measured.