A rare form of pulmonary hypertension has been discovered in dogs, with similar symptoms and potentially useful as a model for human PVOD. The study, published in Veterinary Pathology, could lead to new insights into the disease and its treatment options.
Researchers at Griffith University identified significant impairments in cellular function of CFS patients. They found dysfunctional signalling may contribute to impaired cell activity, aligning with symptoms. The study provides further evidence for the pathology of this disabling illness.
Researchers found that about 5% of patients experienced unexpected relapses of cancer after laparoscopic radical cystectomy (LRC) despite favorable pathology. The use of pneumoperitoneum during LRC may have played a role in these recurrences, according to the study published in The Journal of Urology.
A study found that nearly half of routine tests for monoclonal gammopathy are unnecessary and costly. An algorithm-driven approach can improve efficiency and reduce healthcare costs by putting more decision-making power in the hands of pathologists.
A new study from Michigan State University applies criminology theory to combat counterfeit medicines, identifying key factors in crime occurrence and the importance of field product authentication efforts. By analyzing protocols for crime scene investigation and forensic science in Nigeria, the researchers found that a country's willi...
Researchers from Regenstrief Institute and Indiana University have found that machine learning algorithms can detect cancer cases from free-text pathology reports with similar accuracy to human reviewers. The computerized approach is faster and less resource-intensive, facilitating timely health department action.
Scientists at the University of Wisconsin-Madison have created a mouse model to study Zika virus, allowing researchers to test vaccines and antivirals while understanding the virus's effects on human brains. The model, lacking key immune system defenses, shows the virus causes severe pathology in brain tissue.
A new publication by the Association for Molecular Pathology provides cost and value analysis of gene panels, including non-small cell lung cancer and hearing loss. The study demonstrates economic value in optimizing care for patients with hereditary diseases and cancer through targeted gene panels.
Researchers have developed location-specific standards for identifying human remains based on X-rays of the spine, upper leg, or skull. These standards provide a consistent approach to identification with high accuracy and reduced misclassification rates. The study's findings have significant implications for forensic experts and can h...
Scientists have developed an improved method for lifting and analyzing lipstick samples, using gas chromatography to compare crime scene lipsticks to a database of known brands. This breakthrough could help law enforcement identify suspects more efficiently.
A study in the American Journal of Pathology finds that serotonin deficiency is associated with worse rheumatoid arthritis (RA) symptoms and pathology in mice. Serotonin or its agonists can reduce RA effects, suggesting a new therapeutic target for this debilitating disease.
Medical evaluations of torture victims can significantly impact asylum-granting decisions, with success rates doubling when combined with legal support. Physicians are uniquely positioned to provide comprehensive evaluations and advocate for human rights.
Researchers identify IRF4 as the first gene associated with greying hair, revealing a genetic link to human aging. The study analyzed 6,000 people from diverse ancestry, uncovering additional genes influencing hair shape, curliness, and density.
Researchers at Sam Houston State University developed a test to individualize marijuana samples using DNA analysis, linking drugs across cases. Pine pollen has also been found to be a viable source of DNA for criminal investigations, persisting on clothing for up to two weeks and helping link suspects or victims to locations.
According to Matthew Logan, PhD, a retired police officer and psychologist, a small percentage of violent incidents involving the police dominate headlines. The article argues for greater public airing of the police perspective to provide a more balanced understanding of violence.
Researchers at Massachusetts General Hospital found that inducing the hypoxia response, the body's reaction to low oxygen levels, may relieve symptoms of mitochondrial diseases. Activation of this response alleviated mitochondrial pathology and extended survival in animal models.
A recent study from Sam Houston State University highlights the difficulties in detecting synthetic cathinones in biological samples due to their thermal degradation and instability. The researchers emphasize the need for a systematic approach to understanding the structural facets of these compounds to improve detection methods.
A new forensic footwear imaging technique using Frustrated Total Internal Reflection (FTIR) imaging has been developed to extract additional information and create detailed digital pictures of personal footprints. This technology has the potential to link individuals or their shoes to specific locations, vital for law enforcement.
The locus coeruleus is a critical brain region that releases norepinephrine, regulating heart rate, attention, memory, and cognition. It is vulnerable to toxins and infection, making it the first place affected by late-onset Alzheimer's disease.
Alicia Carriquiry's symposium aims to improve statistical and scientific study in forensics, with a focus on pattern and digital evidence. The Center for Statistics and Applications in Forensic Evidence will build a solid foundation under two branches of forensics.
The Association for Molecular Pathology (AMP) has updated its pathology residency curriculum recommendations, focusing on 10 major molecular pathology topics. The new report aims to equip pathologists with the latest scientific breakthroughs and technological innovations in molecular pathology.
Researchers at Sam Houston State University are developing new sample preparation methods for skeletal and decomposing remains using emerging next generation DNA technology. The goal is to improve the ability to resolve more missing person cases, as conventional methods may fail.
Biological anthropologists use skeletal remains to understand how earlier peoples lived, while forensic experts decipher skeletal evidence to solve crimes. Researchers at North Carolina State University have published guidance on analyzing child-abuse victims to shed light on past cultures' treatment of children.
Researchers at IUPUI have developed a new technique to detect illicit treatment of racing tires with volatile chemicals, finding approximately 15% of tires tested positive for banned substances. The method uses Headspace Solid Phase Microextraction (SPME) and Gas Chromatography/Mass Spectrometry (GC/MS), and has the potential to be app...
A portable version of NIST's 'headspace analysis' technique has been developed, enabling detectives to carry a convenient version of the method in a briefcase-sized kit. The kit can recover vapors from solid or liquid compounds, including environmental pollutants and forensic evidence, with collection times as fast as 3 seconds.
Forensic entomologists may uncover new information by studying tiny mites that feed on vertebrate carrion, including human remains. The discovery of these hitchhiking mites could add more time points to the timeline used for estimating postmortem intervals.
Researchers found elevated concentrations of synaptic soluble amyloid-β (Aβ) oligomers in early-stage AD patients compared to controls. The study suggests that therapies targeting synaptic Aβ oligomers may be more effective than anti-amyloid therapies in preventing or delaying AD-related dementia.
A new study found unique microbial communities associated with human cadavers exhibit predictable succession following death, providing a reliable 'clock' for forensic scientists. This method also showed promise in determining the original location of moved corpses and locating buried bodies.
Researchers at Mayo Clinic found significant evidence of chronic traumatic encephalopathy (CTE) in males who participated in amateur contact sports, including football, wrestling, and rugby. The study suggests that these sports may increase the risk of developing CTE, a progressive degenerative disease caused by repetitive brain trauma.
Dr Erica Gold's £360,000 project defines the West Yorkshire accent to assist forensic speech comparison in criminal cases. The study aims to address the scarcity of population data and variability in speech across different speaker groups.
A study by UPMC and KingMed Diagnostics researchers found that international telepathology consultations significantly improved patient care in China, altering treatment plans for over half of cases. The consultation service expanded access to pathology expertise, facilitating the diagnosis of rare malignancies.
The concentration of THC in Danish cannabis has tripled over 20 years, reaching an average of 28% per cent in recent samples. This significant increase is attributed to the growing trend of skunk farms in Denmark, which provide high-quality cannabis plants with elevated THC levels.
Researchers at Case Western Reserve University are creating a 'pathology image informatics platform' to analyze and share digital pathology imaging data, focusing on prostate and breast cancers. The project aims to unlock the potential of images in cancer prediction.
Researchers used genetically-modified mice to study hereditary deafness caused by mitochondrial dysfunction. Reducing enzyme activity in mice showed promise for preventing or delaying deafness, according to new research.
A study published in Human Pathology found that lung cancer patients without the retinoblastoma tumor suppressor protein (pRB) experience significantly improved survival rates when undergoing chemotherapy. The absence of pRB was detected in 15% of patients, with a 92% 5-year survival rate compared to 49% for those with the protein.
Scientists developed new techniques to retrieve fingerprints from ivory, overcoming its porous nature and achieving clearer prints with reduced-size powders. This breakthrough enhances forensic tool use in regions with high levels of ivory-related crime.
The program provided a rare chance for participants to experience burn scenarios with controlled variables, yielding professional research-level training results. The five-day course covered fire science, death investigations, and forensic science, culminating in controlled experiments using cadavers.
A new study found that acceptance of both male and female rape myths is associated with reduced likelihood to intervene when a friend is being sexually assaulted. However, only male rape myths had a negative relationship with the likelihood to help a stranger.
Researchers found that a humanized mouse model of gluten sensitivity showed increased immune responses and gut damage when exposed to gluten, but protection was seen in mice with a balanced microbiome. The study suggests that microbial imbalance may contribute to the development of celiac disease.
In Trinidad and Tobago, ballistic imaging technology was hindered by inefficient processes, backlogs, and delayed information transmission. The country's Integrated Ballistics Information System (IBIS) generated few hits due to database delays and insufficient evidence input.
A study found that fingerprint characteristics can identify an individual's ancestral background, with significant differences between European American and African American ancestry. Researchers analyzed right index-finger fingerprints of 243 individuals from diverse backgrounds to determine if patterns were specific to sex or ancestry.
A University of Leicester study found that high-risk and impulsive offenders require extra support to complete rehabilitation programs, with non-completers exhibiting higher levels of non-planning impulsivity. The research suggests that these offenders may benefit from additional pre-programme work or ongoing support during the program.
The new 2015 WHO Classification of Lung Tumors provides standard criteria for pathology diagnosis and clinical practice. The updated classification focuses on histologic subtyping and classification according to predominant subtype, leading to multiple new discoveries in lung adenocarcinoma.
Forensic examiners can use blood or teeth samples to estimate an individual's age with great accuracy, helping track down criminals or identify human remains. Researchers at KU Leuven developed a test based on four age-associated DNA methylation markers, achieving margins of error of 3.75 years for blood and 4.86 years for teeth.
Researchers identified a similar profile among murderers of intimate partners and family members, including severe mental illness and few previous convictions. Early intervention is crucial to prevent these murders, which are often driven by jealousy or revenge, experts warn.
Research suggests retinal changes can serve as measures of brain pathology in schizophrenia, predicting disease risk and progression. The findings may help guide future treatment adjustments.
ArroGen Group's Fingerprint Molecular Identification (FMID) technology analyzes chemical residues on fingerprints to reveal a suspect's gender, nicotine status, and exposure to explosives or drugs. This non-invasive process will empower law enforcement investigations with indisputable scientific evidence.
Researchers found that repeated exposure to stimuli can lead to recurring mast cell degranulation and long-term pathological eye changes. Inhibiting this release with substances like disodium cromoglycate may offer new ways to treat serous retinal detachment.
A study published by the American Academy of Neurology found that Alzheimer's disease causes different changes in the brain, or pathologies, in African-Americans compared to white Americans of European descent. African-Americans were more likely to have mixed pathologies and blood vessel disease in their brains.
A new study aims to understand MS pathology by activating metabolic stress in oligodendrocytes, a type of cell that produces myelin. The research seeks to determine if this nonimmune-mediated animal model can recapitulate MS pathology and find evidence for behavioral changes and cognitive decline.
A groundbreaking study published in PNAS has found that fingerprint recognition accuracy stays the same even after years of aging. Using large-scale data from the Michigan State Police, researchers Anil Jain and Soweon Yoon demonstrated that fingerprints remain stable over time, addressing a long-standing concern in forensic science.
A study of 197 patients with breast cancer found that more selective use of biomarker testing could save up to $117 million annually. Testing larger excisional biopsies instead of reflexively testing smaller core biopsies would help pick up tumors eligible for targeted therapy, reducing unnecessary costs.
Researchers at Lawrence Livermore National Laboratory simulated a nuclear explosion using new experiments and computer modeling to analyze plutonium behavior. The results will help scientists perform forensic analyses in the case of an actual detonation, providing deeper insights into the element's properties.
Researchers found that genomic mutations in the TP53, APC, and CDKN2A genes were present in 75% of progressors with Barrett's esophagus. This ability to detect mutations in non-neoplastic mucosa can improve early detection and surveillance for patients at heightened risk for esophageal cancer.
Iowa State University will establish a Forensic Science Center of Excellence, focusing on pattern and digital evidence. The center aims to build a statistically sound foundation for forensic sciences, addressing serious problems with the country's forensic science system.
The center, led by Iowa State University, aims to develop tools for evaluating pattern and digital evidence analysis methods and an education program for judges, lawyers, and forensic science investigators. This will enhance the scientific basis for forensic evidence used in the criminal justice system.
Researchers created a method to determine source characteristics of near-earth surface explosions using seismic stations in Turkey. They found the Syrian tunnel bomb blast was likely around 40 tons, contradicting initial claims of 60 tons. The technique serves as a forensic tool for investigators and governmental agencies.
Two studies analyze amyloid prevalence among adults of varying ages and its association with cognitive impairment. The findings indicate that key risk factors for Alzheimer's disease are also risk factors for amyloid positivity in cognitively normal persons.
The article examines the link between mass murder and mental illness among perpetrators, who are predominantly men. Dr. Michael Stone discusses how a paranoid personality disorder contributes to this phenomenon and highlights the role of semiautomatic weapons in increasing random mass shootings in the US.
Researchers at Michigan State University have discovered that skull fractures can create distinct fracture patterns, also known as 'fracture prints', which can aid in determining the cause of head injuries. These findings could help investigators reconstruct events and solve child abuse cases with greater accuracy.