Researchers have discovered that processing bodies can contribute to immune defenses by responding to viral infections. Viruses alter the composition of processing bodies to enhance their replication, but PBs can limit this ability.
Stem cells use a process called nonrandom chromosome segregation to divide into different cell types, suggesting that distinct genetic information on the chromosome copies may underlie this diversification. The study used fruit fly stem cells to demonstrate this ability and sheds light on how cells develop into complex organisms.
Natasha Raikhel, a distinguished professor at UC Riverside, has been named recipient of the Adolph E. Gude, Jr. Award for outstanding service to plant biology. Susan Wessler, also from UC Riverside, is a fellow of the ASPB for her pioneering work on plant transposable elements and genomes.
Researchers at Mount Sinai identified new targets for abnormal cell division, finding that blocking CDK7 can inhibit the activity of other critical enzymes CDK4 and CDK6. This discovery suggests turning off these enzymes may be an effective therapeutic target for preventing cancer cell proliferation.
Researchers at the University of Luxembourg have developed a computer-based method to analyze biological data and identify unique factors for 166 different human cell types. These master regulators determine cell development and distinguish between cell types, paving the way for potential cell replacement therapies.
A new study shows that chemical shift techniques in MRI can accurately differentiate clear cell renal cell carcinoma from other types of kidney cancer, enabling better treatment planning. The technique achieved an 83% accuracy rate in distinguishing between tumor types.
Researchers have discovered that protein Shc acts as a tumor suppressor by binding to and blocking the activation of cancer-promoting protein Erk. This finding has significant implications for treating various types of cancer, including ovarian and prostate cancer.
New York Stem Cell Foundation researchers have developed a quantitative protocol to consistently harvest early-reprogrammed cells, resulting in standardized iPS cell lines. This method enables the derivation of 228 individual iPS cell lines, which can be compared to one another for use in drug screens and cell therapies.
The rapid development of synthetic biology presents new dialogue opportunities between conservation and synthetic biology communities to address ecological and ethical concerns. The authors highlight five emerging issues requiring discussion, including potential impacts on biodiversity and conservation strategies.
Researchers at UC Davis have discovered that whole cells and cell fragments orient and move in response to electric fields, with two distinct pathways identified. These findings could lead to new ways to heal wounds and deliver stem cell therapies.
A new model of cell fusion was created by researchers at Johns Hopkins, revealing two critical components necessary for the process. The discovery may lead to improved treatments for muscular dystrophy, as cell fusion plays a crucial role in muscle regeneration.
Researchers at the University of Manchester identified the method by which cells regulate integrin recycling, allowing precise control over cell movement. Syndecan-4 plays a critical role in regulating this process, responding to subtle changes in the cell's surroundings.
A previously poorly investigated signalling pathway is crucial for prostate cancer cell proliferation, involving the production of cAMP at multiple locations in the cell. Inhibiting the soluble adenylyl cyclase enzyme suppresses cancer cell growth, suggesting a promising new therapeutic approach.
Scientists have visualized molecular changes in a critical protein involved in cell death, providing new insights into apoptosis and its role in disease. The discovery could lead to the development of new medicines that control cell life or death.
A new study by University of Illinois researchers reveals that lipids in the cell membrane form larger domains than previously thought, with cholesterol playing a key role in their organization. The findings challenge current understanding of cell membrane structure and function.
Researchers discovered a novel class of early replicating fragile sites contributing to genome instability in B cell lymphomas. These sites, uncovered through genome-wide sequencing, overlap with mutations associated with the disease and suggest a major feature of its mutational landscape.
Researchers have developed a new technique to study cell division without a cell membrane, allowing them to uncover physical forces and constraints involved in the process. By using this method, they discovered that squeezing the 'cell' into tighter quarters does not lead to smaller spindles, contradicting previous assumptions.
Researchers created a biophysical model predicting that holes larger than 15-24 nanometers would cause bacterial cells to burst. Experiments validated this theory by measuring holes in lysed bacteria cells with diameters of 22-180 nanometers.
Researchers used advanced microscopy to track telomere movement in real-time throughout the cell cycle, finding they move to the outer edge of the nucleus after duplication. This reorganization may help maintain correct gene expression profiles and influence aging and cancer development.
The American Society for Cell Biology's Celldance awards recognized top videos showcasing cellular mechanisms in development, health, and disease. Winners included a time-lapse of fruitfly embryonic development and a cancer cell movement video.
Researchers at University of Wisconsin-Madison discovered a new form of cell division called klerokinesis, which helps prevent faulty cell division leading to cancer. In experiments with human cells, they observed that cells with extra chromosomes could recover normal sets through klerokinesis, potentially lowering cancer incidence.
Researchers discovered that Alzheimer's disease is caused by faulty cell cycle control in neurons, triggered by the combination of amyloid-beta and tau proteins. In normal cells, these proteins do not induce cell cycle re-entry, but in AD neurons, they do, leading to cell death.
Researchers have discovered a new type of cell division called klerokinesis, which appears to be an evolutionary failsafe mechanism that could rescue cell functions during embryonic development. By analyzing human retinal pigment epithelial cells, the team found that klerokinesis can help maintain genomic integrity and potentially prev...
A Phase 2 clinical trial of ibrutinib in relapsed or refractory mantle cell lymphoma reported a 68% overall response rate and 22% complete remission rate, with few side effects. The drug's efficacy was consistent across different patient populations, making it a promising treatment option for patients with this aggressive disease.
Women leave academia at higher rates than men in biology due to intense competition for tenure-track positions, particularly when they have children. In contrast, medicine's earlier competition period may contribute to lower attrition rates among women scientists.
The partnership enables the publication of high-quality stem cell research in an open-access venue, promoting outreach and quality in the field. Stem Cell Reports will feature various article types and allow authors to retain full copyright over their work.
Researchers at Moffitt Cancer Center studied the relationship between sunlight exposure patterns and timing to understand its contribution to basal cell carcinoma and squamous cell carcinoma. Blistering sunburns and working outdoors were found to be associated with both types of skin cancer.
Researchers developed a new method to identify proteins secreted by cells, eliminating drawbacks of traditional approaches. This technique isolates the 'secretory pathway' organelles and analyzes their contents using mass spectrometry, providing precise data on cell biology.
The Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research at Albert Einstein College of Medicine hosted its first stem cell institute symposium, showcasing the latest research on induced pluripotent stem cells and hematopoietic stem cells. The event featured four presentations by renowned speakers fr...
Researchers have successfully developed a stable population of neural crest cells from mice that can differentiate into multiple cell types. This breakthrough enables the study of stem cell biology and human development, as well as potential applications in understanding diseases.
A partnership between San Francisco State University and Bay Area community college biology instructors aims to refine their teaching through scientific research, collecting evidence from students to improve instruction. The goal is to increase student engagement in science and successful transitions to four-year colleges.
A study published in Cancer Discovery reveals PARP1 and EZH2 as potential therapeutic targets for small cell lung cancer. The discovery could lead to the development of targeted treatments for this aggressive type of cancer, which currently has limited treatment options.
The PLoS ONE Synthetic Biology Collection assembles articles on various facets of synthetic biology, a dynamically evolving research area that interconnects multiple disciplines. The collection aims to inspire further progress in the field by providing a dedicated repository for researchers.
Researchers at EMBL develop method to follow molecules under light and electron microscope, revealing crucial protein interactions in endocytosis process. They discover actin scaffolding protein forms network pulling membrane inwards.
Dr. Nihal Altan-Bonnet, a Rutgers cell biologist, has been awarded the Presidential Early Career Award for Scientists and Engineers (PECASE). Her research identifies a common lipid blueprint for viral replication, paving the way for potential panviral therapeutics.
A new strategy for treating aggressive skin cancer involves inducing cell differentiation to prevent tumor growth. Researchers identified a molecular mechanism that promotes the disappearance and inhibition of skin squamous cell carcinoma development.
Recent annual citation reports confirm Cell Press's position as a leading publisher of highly cited research and reviews. The flagship journal Cell has increased its impact factor by 9% since 2005, maintaining its status as the premier research journal in its field.
Researchers have developed chemical compounds that selectively block the attachment of sugar molecules to cells, potentially leading to new treatments for chronic inflammation, autoimmune diseases, and cancer. The new tools can help scientists understand how glycans influence cell function and behavior.
Researchers at EMBL found that 15% of human genes influence the secretory pathway, a complex network for transporting molecules to the cell membrane. This discovery suggests cells have evolved a strategy to adapt to environmental changes.
Researchers found that herpes viruses and other neurotropic pathogens sabotage cell function by hijacking neuronal internal transportation networks. Viral infection elevates neuron activity and calcium levels, stopping mitochondrial motion and allowing the virus to freely travel and reproduce within infected cells.
The Kavli Institute for Theoretical Physics at UC Santa Barbara has received two new grants to advance its interdisciplinary biology initiatives. The grants, totaling $2 million, will support workshops, postdoctoral fellowships, and a new summer program aimed at the interface of physics and biology.
The San Francisco State University Department of Biology has received a $1.5 million grant to support faculty-led improvements in undergraduate science education. The Biology Faculty Explorations in Scientific Teaching (FEST) program aims to refine teaching skills and assess student learning through evidence-based methods.
Two scientists, Elaine Fuchs and Howard Green, have been awarded the March of Dimes Prize in Developmental Biology for their groundbreaking research on skin stem cells and inherited skin disorders. Their work has saved thousands of lives and holds promise for new therapies for baldness and other diseases.
Researchers at the University of Delaware have identified a protein called endoglin that regulates the creation of fat cells. By decreasing the amount of this protein on the surface of cells, it may be possible to force fat cells to transform into other cell types, potentially leading to new treatments for osteoporosis and obesity.
Scientists at the University of Liverpool have resolved the debate on the mechanisms involved in human cell shut-down during division, finding that receptors can transport nutrients but are temporarily blocked. This discovery may lead to future studies on manipulating this process to prevent harmful infections.
Researchers have developed a new type of human stem cell called endodermal progenitor cells, which can differentiate into multiple cell types, including functioning pancreatic beta cells. The cells show promise for modeling human diseases and may offer a potential source for future diabetes treatments.
Cell Press has introduced a new career network to facilitate the discovery of best jobs for life scientists. The site offers improved navigation, advanced resources, and an expanded resume option.
A symposium on TMJ stem cell biology and engineering presents novel clinical therapy approaches for TMJ disorders. Researchers discuss the origin, homeostasis, differentiation, hormonal regulation, and bioengineering of temporomandibular joint tissues.
Studies on Drosophila melanogaster have provided insights into human stem cell development, particularly in the formation of specialized cells. The research also explores the role of membrane lipids in establishing polarity in sperm cells, which may contribute to cancer progression.
BGI's single-cell sequencing technology enables researchers to analyze genetic characteristics of essential thrombocythemia and clear cell renal cell carcinoma. The method provides clearer intratumoral genetic pictures and developmental history than previous bulk tissue sequencing, opening new ways for the genetic study of tumors.
Researchers at UGA created the first blueprint of how stem cells respond to external signaling molecules. The finding reconciles years of conflicting results and enables precise control over stem cell differentiation into specific cell types.
Researchers from UT Southwestern Medical Center predicted and confirmed how E. coli bacteria hijack a cell's sense of direction by manipulating actin polymers. This study provides new insights into the regulatory mechanisms controlling disease-causing agents and normal mammalian cell behavior.
Scientists at Whitehead Institute have made a breakthrough in understanding planarian stem cells, discovering genes that regulate two main functions: differentiation and renewal. The study, published in Cell Stem Cell, provides insights into the molecular mechanisms underlying regenerative medicine.
Synthetic biology faces significant environmental risks if not addressed proactively. The authors propose four areas of focus: physiology differences, escaped organisms' impact, evolution, and genetic material exchange. Interdisciplinary research is crucial to mitigate these risks.
Researchers discovered that reduced expression of OGFr accelerates tumorigenesis in human ovarian cancer. The OGF-OGFr axis plays a fundamental role in regulating cell proliferation.
Researchers have discovered that dynein, a motor protein, plays a crucial role in spindle alignment during mitosis. A signal from the chromosomes involving the ras-related nuclear protein (Ran) blocks LGN and dynein from attaching to the cell cortex closest to the chromosomes.
Researchers developed Meta!Blast, a 3D video game that teaches cell biology to students. The game simulates a plant crisis and requires players to shrink to microscopic size to rescue lost scientists and save the world.
Cell biologists have identified key steps in how small molecules alter a cell's skeletal shape and drive cell movement. By manipulating the cell membrane, researchers created ruffles that helped pull cells across surfaces, a process previously difficult to recreate.
Ziv Bar-Joseph, a Carnegie Mellon University professor, has received the Overton Prize for his outstanding contributions to computational biology. He has made significant breakthroughs in gene regulatory networks and their applications to cancer cells.
Cell Press introduces Cell Reports, a new open-access journal publishing cutting-edge science on topics from evolutionary biology to immunology. The journal offers concise, provocative stories and rapid publication to facilitate access to research.