Researchers discovered that arsenite destabilizes lysosomes, breaking them apart and releasing enzymes that destroy APL cells. This finding could inform further research into treating APL, a rare cancer caused by chromosome fusion.
A recent study published in The Journal of Clinical Pharmacology found that palifermin clearance and tolerability are not affected by renal function. No dose adjustment is indicated for patients with impaired kidney function, allowing the drug to be used without restrictions.
A recent study published in The Journal of Clinical Pharmacology found that varenicline was well-tolerated and effective in reducing cravings and withdrawal symptoms in elderly smokers. The researchers reported mild adverse reactions, including nausea, but no participants withdrew from the study.
Researchers at the University of Illinois College of Medicine identified a molecule that plays a critical role in lung tissue recovery following severe injury. The study found that FoxM1, a protein controlling cell proliferation, is involved in endothelial regeneration and barrier integrity restoration.
A recent study published in the Journal of Clinical Pharmacology found that short duration of depressive symptoms in teens can make it difficult to distinguish between actual treatment efficacy and placebo effects. This design issue may lead to unnecessary long-term drug therapy for some children, as those who recover quickly from depr...
Researchers found five proteins overexpressed and three underexpressed in response to chronic alcohol exposure, affecting programmed cell death, cholesterol balance, and signal transduction. The study suggests a progressive increase in behavior disruption with prolonged exposure, highlighting the potential for new therapeutic targets.
Dr. Meechan has received the IADR Pharmacology, Therapeutics, & Toxicology Research Award for his contributions to dental care management and medically compromised patients. The award recognizes his research interests in local anesthesia and pain control.
The study found that activating hedgehog signals in adult mouse hearts increased blood vessel density, offering an alternative to invasive procedures. The researchers believe a drug treatment targeting hedgehog signaling could provide substantial benefit to patients with ischemic heart disease and myocardial infarctions.
Researchers are studying salamanders and MRL mice to identify the types of cells, molecular signals, genes, and cellular scaffolding required for regenerative cell growth. They hope to develop a blueprint for regenerative growth, which could help overcome the formation of scar tissue in humans.
UC San Diego scientists chart rapid progress in developing new fluorescent probes to study proteins in living cells. These techniques enable the localization of molecular machines in situ by electron microscopy.
Researchers discovered capsaicin significantly reduces tumor size and induces apoptosis in human pancreatic cancer cells, with no harm to normal pancreatic tissue. The compound's potential use as a novel agent for prevention and treatment of pancreatic cancer is being explored.
A study found that Acanthamoeba polyphagam increases MRSA numbers 1000-fold by providing a survival environment. The released bacteria are more invasive and less susceptible to biocides.
Renowned clinicians call for collaborative effort to revive clinical pharmacology in the UK. The Lancet experts advocate for joint action by medical schools, government bodies, and industry partners to bolster this crucial field.
Researchers at UNC have identified CIB1 as a 'gatekeeper' protein that inhibits platelet-to-platelet interactions in the blood. By binding to GPIIb/IIIa, CIB1 prevents platelet activation and clot formation.
Researchers at UCLA have developed a new method to track neuronal cell death in the hippocampus, a key memory center, which may lead to early detection and treatment of Alzheimer's disease. The study found that 49% of Alzheimer's patients and 24% of mild cognitive impairment patients showed significant density decreases.
Tumor cells that border normal tissue exhibit distinct behavior, losing surface proteins and gaining the ability to dissolve matrix surrounding cells. This change signals activation of proteins allowing tumor cells to migrate, posing a risk for metastasis. The discovery highlights the importance of tumor environment in cancer progression.
Researchers at University of Pittsburgh discovered that loss of pol zeta's activity in mouse cells leads to chromosomal instability and tumor development. The study suggests that pol zeta may act as a tumor suppressor gene, preventing double-stranded breaks in chromosomes.
A review and meta-analysis of 127 trials found ACE inhibitors and ARBs no better than other drugs in preventing diabetic kidney disease. Treatment decisions for hypertension in renal disease should be based on blood-pressure-lowering effect, comparative tolerability, and cost.
A new study published in Clinical Pharmacology and Therapeutics found that a nicotine vaccine was safe and well-tolerated in helping smokers quit. The vaccine, which works by producing antibodies that bind to nicotine, showed impressive results with 38% of participants quitting for at least 30 days.
A new joint neuroscience doctoral training program will be established at New Jersey Institute of Technology, Rutgers-Newark and UMDNJ-New Jersey Medical School. The program aims to bring together interdisciplinary approaches to study nerve and brain function, with a focus on addressing complex challenges in the neurosciences.
The American College of Clinical Pharmacology (ACCP) implemented a tiered-membership fee policy to lower fees for international members based on economic need. The organization offset costs by offering electronic access to publications, aiming to strengthen clinical pharmacologists' capacity worldwide.
A study by Ohio State University researchers found that a genetic variation in the mu opioid receptor gene may make brain cells more vulnerable to addictive drugs. The A118G variation resulted in reduced protein production and altered mRNA regulation, potentially increasing an individual's susceptibility to addiction.
Researchers have found that certain anti-cancer drugs, known as FTIs, can block biochemical processes causing progeria's symptoms. The collaboration has shown a strong positive effect on progeria patients' cells.
Researchers at UNC have discovered that CIB1 inhibits cell migration in cancer cells by activating PAK1, a kinase that adds phosphate groups to other proteins. This finding suggests that CIB1 may be a potential target for developing new treatments to decrease tumor metastasis.
A recent study published in The Journal of Clinical Pharmacology found that use of over-the-counter (OTC) topical progesterone results in significant drug exposure through skin absorption, comparable to prescribed oral progesterone products. The study revealed similar rates of adverse effects among women taking both types of progesterone.
Researchers at Virginia Tech will use 'in situ click chemistry' to design a novel, species-specific insecticide for Anopheles gambiae mosquitoes, reducing toxicity and ensuring safety for humans and animals. The project aims to provide an effective solution for malaria control in communities worldwide.
The University of Pittsburgh has been awarded $9 million to develop research tools for drug discovery as part of NIH's Roadmap initiative. The Molecular Libraries Screening Centers Network aims to accelerate medical discoveries by conducting high-throughput screenings of molecules.
Researchers have discovered that specific proteins in the fruit fly eye play a crucial role in organ development, including kidney formation. These proteins, Roughest and Hibris, are also found in human kidneys and are essential for proper filtration and filtering of unwanted molecules.
Researchers discovered an antibody compound that effectively targets and destroys blood vessels within cancerous tumors, reducing tumor growth by 93% when combined with docetaxel. This promising treatment approach may offer a new solution to treating breast cancer patients with limited effectiveness from traditional therapies.
Researchers found that palmitate, a saturated fatty acid, can attach to proteins regulating bioelectricity in cells. This attachment affects the transmission of electrical impulses in nerve and heart cells, with potential health implications.
Scientists have discovered that elevated estrogen levels can reduce the severity of asthma by preventing abnormal airway constriction. Selective estrogen receptor modifiers (SERMs) also showed similar effects, suggesting a new molecular target for asthma therapy.
Researchers discovered NAADP, a natural molecule with potential as an obesity treatment, that works in cells to regulate satiety. The study found NAADP levels increased rapidly and selectively in response to cholecystokinin, a hormone controlling digestion and appetite.
Researchers found that allicin, a compound in garlic, protects against severe chronic pulmonary hypertension in rats by inducing vasorelaxation. Daily consumption of garlic may provide similar benefits for humans, particularly those with respiratory issues.
Dr. Moore's distinguished career has led to evidence-based frameworks for clinical dentistry, with notable contributions in pediatric sedation guidelines and diabetes research. His work has provided a foundation for optimal pain control and minimal adverse effects in clinical analgesics and anesthetics.
Scientists have made a breakthrough in understanding diabetic nephropathy by identifying CD36 as the probable trigger of kidney disease in diabetics. High glucose levels cause a change on the surface of cells, triggering the production of CD36, which leads to kidney cell death.
New studies suggest that blocking estrogen may be essential to slowing the spread of lung cancer. Researchers found that a combination therapy targeting both estrogen and epidermal growth factor receptors resulted in a 59% tumor volume decrease.
A natural gene mutation in rats' brains increases their tolerance to alcohol, leading to rapid intoxication. The study may help identify children and adults at higher risk of developing alcohol dependency.
Researchers found that molecular clock genes Bmal1 and Clock play a crucial role in regulating glucose levels, with suppressing these molecules eliminating diurnal variation. A mutated Clock gene also protected mice from diabetes induced by high-fat diets, suggesting altering meal timing may reduce disease risk.
Researchers found that the combination of nicotine and acetaldehyde significantly enhances addictiveness in adolescent rats, while adult rats show no significant increase. The study suggests studying interactions between nicotine and other tobacco smoke components could improve smoking cessation efforts.
The St. Petersburg/New Haven Partnership aims to develop a community-wide HIV/AIDS care program in Russia, with training and exchanges between American and Russian health professionals. Led by Yale's Krystn Wagner and Robert Heimer, the partnership seeks to improve HIV/AIDS care and treatment in Russia.
The University of Pittsburgh has received a $10 million federal grant to enhance the quality of life for head and neck cancer patients. Researchers will investigate genetic changes, intracellular signaling proteins, and new treatment strategies to reduce morbidity and mortality from head and neck cancer.
Emory researchers create three-dimensional, atomic-scale images of epothilone A binding site with key protein controlling cell division. The study's results pave the way for creating new compounds and a clinical tool for pharmacogenetic profiling.
The Oregon Health & Science University has launched a new Bioanalytical Shared Resource (BSR) lab, supported by the $500 million Oregon Opportunity initiative. The BSR provides advanced analytical services for drugs and molecules, enabling researchers to quickly move from laboratory to patient testing.
Researchers found that hormone-sensitizing compounds can boost estrogen and progestin activity eight- to 10-fold, increasing cancer risk. Exposure to these compounds may be linked to reproductive toxicity, miscarriages, and irregular ovulation.
A study found that exposure to terbutaline and chlorpyrifos in early development can lead to brain damage and increased susceptibility to pesticide injury. The combination of the two chemicals caused significant loss of brain cells and nerve cell projections, particularly in regions critical for learning and memory.
Dr. David P. Siderovski, an assistant professor at UNC School of Medicine, has been awarded the John J. Abel Award for his groundbreaking research on RGS proteins that accelerates cell signaling pathway shutdown. The award honors his contributions to drug target discovery and development.
The AACR International Scholars in Breast Cancer Research program aims to improve cancer research and clinical care worldwide. Principal Investigators will mentor talented scientists from under-resourced countries, enhancing their skills and knowledge for successful breast cancer research.
Professor Ekström received the IADR Salivary Research Award for his pioneering work on non-conventional transmitters in salivary glandular function. His research has significantly advanced our understanding of autonomic neurotransmission mechanisms and their effects on salivary secretion.
The International Association for Dental, Oral, and Craniofacial Research has awarded Dr. Haas the 2004 Pharmacology/Therapeutics/Toxicology Award for his extensive work on anxiolytic agents in dentistry. Dr. Haas has also made significant contributions to the field through his presentations and leadership roles.
A study published in the Journal of Pharmacology and Experimental Therapeutics reveals how cannabinoids produce hypothermia, a decrease in body temperature. The research suggests that nitric oxide plays a role in regulating cannabinoid-induced hypothermia.
Researchers at UT Southwestern Medical Center have established a pediatric pharmacology research center to study drug therapies in infants and children. The center aims to address the challenges of conducting pharmacological studies in pediatric patients, who process drugs differently than adults.
Researchers have discovered an imaging technique that monitors cancer cell proliferation by incorporating fluorescent proteins into cell nuclei. The technique allows for simultaneous observation of up to 100 cells and can be used to screen compound libraries for novel anti-cancer therapies.
Researchers at OHSU discovered a novel compound called STX that activates a rapid signaling pathway in nerve cells, providing an alternative to estrogen replacement therapy. The new compound shows promise in alleviating menopause symptoms and may be more effective than existing treatments.
Researchers at DMS have found that removing RIP140 allows retinoids to effectively differentiate cancer cells, slowing tumor growth and increasing the efficacy of cancer treatment. This breakthrough sheds light on the potential benefits of retinoid-based therapies for various types of cancer.
A new curriculum developed by Duke University's Pharmacology Education Partnership (PEP) has shown to significantly improve students' understanding of biology and chemistry. The approach uses real-world examples, such as nerve gas and drugs, to make science more relevant and engaging for students.
U. of Washington's Dr. Abrass receives 2003 Freeman Award from the Gerontological Society of America for his outstanding research in geriatric endocrinology and pharmacology. He is also recognized for his excellent clinical care and teaching, particularly at Harborview Medical Center.
Researchers have discovered a potential new treatment for certain types of cancer by inhibiting sphingosine kinase. The study found that targeting this enzyme can reduce tumor growth and induce apoptosis in cancer cells, offering hope for new targeted therapies.
A study published in Pharmacology, Biochemistry and Behaviour found that sage oil improved word recall test performance in healthy young adults. Sage is being investigated as a potential treatment for Alzheimer's Disease due to its ability to inhibit the enzyme acetylcholinesterase.
Researchers at the University of Wisconsin-Madison have discovered a mechanism that determines early blood cell fate by interacting with two related proteins, GATA-2 and GATA-1. This finding may help hematologists treat patients with severe cancer or blood disorders by expanding HSC numbers.
A study by Dr. Pio and colleagues found that FLT-PET imaging outperforms FDG-PET in predicting tumor response to chemotherapy in breast cancer patients. The researchers compared the two imaging modalities in 11 newly diagnosed patients, taking scans before treatment began, after the first dose, and following the final cycle.