Researchers developed a method to preserve and visualize SARS-coronavirus replication complexes, revealing the dependence on modified host membranes for viral replication. The study provides insights into the interplay between viral proteins and host membranes, opening doors for new antiviral strategies.
Researchers create genetically modified mice with a switch to turn on and off disease-typical proteins in renal tissue. The model simulates the natural course of disease development and healing processes, allowing for better investigation of kidney diseases.
A study in Bangladesh found that treating children with severe pneumonia at local, first-level facilities instead of hospitals resulted in higher proportions being treated correctly. The modified guidelines allowed for local treatment with referral to hospital only for the most severe cases.
Researchers at Caltech developed a novel way to produce large quantities of drugs, including antiplaque toothpaste additives and antibiotics, using genetically modified yeast. The yeast produces reticuline, a precursor for benzylisoquinoline alkaloid molecules with various pharmacological activities.
A study by researchers at the US Department of Agriculture's Agricultural Research Service found that certain romaine and 'crisphead' lettuce cultivars can stay fresh for longer when packaged using modified-atmosphere packaging. This innovation has the potential to improve shelf life, quality, and sales of pre-cut salads and lettuce.
Researchers at Whitehead Institute develop a technique to produce genetically identical induced pluripotent stem (IPS) cells, offering new efficiencies in embryonic stem cell research. This breakthrough allows for the creation of large numbers of IPS cells without genetic variation.
Researchers deliver genetically engineered T-reg cells to the intestine to suppress inflammation and autoimmunity. The 'bystander' effect enables these cells to target diseased tissue, suppressing inflammatory cells and promoting healing.
Researchers at the University of Texas Medical Branch have created new vaccines for West Nile and Japanese encephalitis viruses, showing promise in providing immunity against these deadly diseases. The 'pseudoinfectious' vaccines use genetically modified viruses that can only infect a single cell, mimicking a viral infection without am...
A survey of college students revealed mixed opinions on the benefits and drawbacks of biotechnology in sustainable agriculture, with some supporting genetically modified crops and others expressing concerns over environmental and social impacts. The study suggests that educators should provide neutral exposure to both sustainable agric...
Researchers have developed a chemically modified protein that neutralizes inhibitor antibodies in people with Hemophilia A, offering a potential new treatment option. The modified protein, called electrophilic FVIII analog (E-FVIII), permanently inactivates these antibodies, paving the way for more effective blood clotting correction.
Planting herbicide-tolerant crop varieties can significantly reduce herbicide losses and concentrations in surface runoff, according to a USDA study. The study found that contact herbicides like glyphosate and glufosinate resulted in lower concentrations of herbicides in water compared to residual herbicides.
A tiny variation in the CHI3L1 gene increases blood levels of YKL-40, a biomarker for asthma. The genetic variation also lowers YKL-40 levels and protects against asthma. Researchers found similar connections between the CHI3L1 variations, YKL-40 levels and asthma susceptibility in three genetically diverse populations.
Scientists at Albert Einstein College of Medicine genetically engineered immune cells to target and kill HIV-infected cells. This approach, using genes from elite controllers' immune systems, could lead to a new strategy for combating AIDS. The study shows promise in both test tubes and animal models.
Scientists have created a genetically modified pig model that carries the mutated gene responsible for cystic fibrosis, mimicking lung disease in humans. This breakthrough could lead to better understanding of the disease and development of new treatments.
Farmers perceive genetically modified (GM) crops as a means to reconcile high-quality food production with environmentally sensitive farming. They are more interested in the practical applications and potential benefits of GM crops rather than any moral or ethical concerns.
Researchers are conducting trials for a new malaria vaccine using a genetically-modified chimpanzee adenovirus to stimulate an immune response. The goal is to develop a combination product targeting both liver and blood stages of the parasite to prevent infection.
A modified version of the Atkins diet has been shown to significantly reduce epileptic seizures in adults with epilepsy. The high-fat, low-carbohydrate diet can lead to the production of ketones, which may help control seizures. While side effects were mild, compliance was a challenge for some patients.
Using modified-release prednisone significantly reduces morning stiffness duration in RA patients by adapting to circadian rhythms. The new formulation has a higher mean relative change of -22.7% and reduced morning stiffness time by 44 minutes compared to standard prednisone.
Researchers at Baylor College of Medicine developed genetically modified carrots that increase the transport of calcium across plant cell membranes. The modified carrots can provide up to 41% more bioavailable calcium than regular carrots, making them a promising source for improving bone mineral density and treating osteoporosis.
The Modified MyPyramid for Older Adults prioritizes nutrient-dense foods, including whole grains, fruits, and vegetables, with a focus on fiber-rich options. Regular physical activity is also emphasized to reduce chronic disease risk and improve quality of life.
Researchers at Stevens Institute of Technology are developing functional polymers modified surfaces that can prevent bacterial adhesion and sensitize formed biofilms for antibiotic treatment. This project aims to combat the fourth leading cause of death in the US, hospital-acquired infections and diseases.
Researchers at Penn State are using genetically modified mushrooms to produce vaccines and other biological drugs in record time. They aim to demonstrate the ability to produce three million doses of a drug within 12 weeks.
A study by Jason Dyck at the University of Alberta found that a protein responsible for transporting fat into heart cells may be a key to preventing age-related decline in heart function. Genetically modified mice with this protein deficiency showed no accumulated fat in their hearts and outperformed normal aged mice on a treadmill test.
Genetically obese rats showed lower dopamine D2 receptor levels than lean counterparts. However, restricting food intake increased D2 receptor numbers, partially reversing age-related decline. This finding suggests a link between brain's reward system and food availability in obesity.
A genetically engineered eggplant has been developed to resist the fruit and shoot borer, a highly destructive pest causing up to 40% of crop losses in India, Bangladesh, and the Philippines. The Bt eggplant is expected to reduce insecticide use by 30% while doubling yield, benefiting farmers and consumers in South Asia.
A recent study suggests genetically engineered corn could have unintended consequences on aquatic ecosystems. Researchers found toxins from Bt corn were washing into streams near cornfields, causing increased mortality and reduced growth in caddisflies.
The University of Georgia College of Veterinary Medicine has received a $1.18 million NIH grant to develop a less expensive and less invasive means of vaccinating humans and animals against rabies. The proposed vaccine will use a genetically modified form of the live virus, aiming to establish immunity with fewer doses and reduce costs.
The adult mammalian lymphatic vasculature is derived from embryonic lymph sacs and has been shown to originate from venous endothelial cells using genetically modified mice. Understanding this origin is crucial for preventing, diagnosing, and curing lymphatic disorders.
Researchers at the University of Bristol identified a heart protection mechanism in mice that may be exploited to improve treatments for patients with coronary disease. The study found that hearts with coronary disease became more resistant to damage after mock surgery, suggesting a potential therapeutic strategy.
A genetically modified maize variety resistant to the severe maize streak virus has been created using pathogen-derived resistance, delaying symptom development and increasing survival rates. The research aims to alleviate Africa's food shortages and famine by providing a disease-resistant crop for local farmers.
A study by UCF researchers found that insulin produced in genetically modified lettuce can restore normal blood sugar levels in diabetic mice. If successful in human trials, the method could affect millions of diabetics worldwide and reduce healthcare costs.
Researchers have developed a genetically modified mouse model using the ferritin reporter gene, enabling live cell imaging via magnetic resonance imaging (MRI) without additional substances. This breakthrough overcomes limitations in detecting signal changes in tissues, such as fetal development and the central nervous system.
A study by Cornell scientists found that genetically diverse honeybee colonies produced 30% more comb, stored 39% more food, and maintained foraging levels 27-78% higher than genetically uniform colonies. These colonies also gained weight due to sophisticated communication mechanisms like waggle dancing.
Researchers discovered a genetically engineered herpes simplex virus reduces smooth muscle cell proliferation and restores endothelial layer in arteries following angioplasty. This study provides an important step towards treating vascular disease with genetically engineered viruses.
A new study published in Science analyzed the environmental impact of genetically modified (GM) crops and found that they can have benefits for sustainable agriculture. The research used data from field experiments worldwide and found that Bt-crops, which produce an insecticide internally, can reduce the need for chemical spraying.
Researchers at Rutgers University have discovered a new approach to contain genes in genetically modified (GM) crops by implanting them into plastids, minimizing the risk of escape. This innovation has the potential to alleviate concerns about 'foreign genes' contaminating wild species and ecosystems.
Researchers discovered that an investigational cancer drug selectively kills cancer cells due to its affinity for a modified version of heat shock protein 90. The modification, called acetylation, allows the drug to target and block the activity of this protein, promoting cell survival.
Researchers are investigating a genetically modified variant of Avian Newcastle disease virus to treat human prostate cancer. The virus is designed to replicate only in the presence of prostate-specific antigen, found exclusively in cancerous cells.
Researchers found that modified bone marrow cells reduced MS symptoms, nerve damage, and increased tissue debris clearance when injected into mice with EAE at disease peak. The study opens up further research avenues for human multiple sclerosis treatment.
Researchers will present on alternative energy sources, genetically-engineered crops, and new water purification processes. The symposium aims to address the world's growing demand for clean water and explore sustainable solutions to environmental challenges.
A sociocultural anthropologist found that Indian farmers' inability to test new genetically modified crops led to a breakdown in traditional farming methods. The speed of change, number of choices in the seed market, and desire for novelty resulted in fads, not testing.
Chinese scientists develop heat and irradiation treatment to decrease levels of 'Pen a 1' allergen in prawns, reducing reactive proteins that cause seafood allergies. This non-GMO method may provide an alternative to genetic manipulation, suitable for those wary of genetically modified foods.
A new study in Current Anthropology examines the effect of genetically modified crops on farmers in Warangal District, India. The research reveals a pattern of 'agricultural deskilling' and reliance on social learning, exacerbated by the spread of Bt cotton seeds.
Researchers at the University of Cincinnati have created genetically modified skin cells that produce higher levels of human beta defensin 4 (HBD4), which killed more bacteria than normal skin cells. These cells may help combat infections in burn patients and reduce dependence on topical antibiotics.
Researchers at St. Jude Children's Research Hospital and City of Hope National Medical Center developed genetically modified stem cells that seek out and destroy even tiny tumors in the nervous system, using a chemotherapy drug that selectively targets cancer cells.
Scientists have engineered a molecular complex that can split water into hydrogen and oxygen using solar energy, providing an alternative to traditional electrolysis methods. This breakthrough could pave the way for more environmentally friendly production of hydrogen gas for use as a clean fuel source.
Researchers found that genetically similar ants have peaceful relations and genetically different ants attack each other. This suggests that the lack of genetic diversity permits supercolonies to arise, allowing ants to devote more resources to breeding rather than competing for territory.
Genetically-modified bacteria Clostridium novyi-NT have shown promise in treating cancer by selectively killing tumor cells while sparing normal cells. The combination of bacterial therapy and chemotherapy has demonstrated significant tumor-killing effects, with over two-thirds of mice cured permanently.
Researchers have cloned a wild wheat gene that increases protein, zinc, and iron content in grain by 10-15%, potentially addressing nutritional deficiencies affecting millions of children worldwide. The study confirms the gene's effect on matured grains showing higher nutrient levels without sacrificing size or quality.
Nuno Bandeira's award-winning protein analysis technique allows scientists to study highly modified proteins in snake venom, potentially leading to breakthroughs in drug development and cancer research. The technique surpasses current methods by providing a completely automated approach to identify amino acid sequences and modifications.
Researchers at the University of Pennsylvania School Medicine have successfully tested a new gene therapy vector that inhibits HIV replication. The treatment, called VRX496, has shown promising results in reducing viral loads and improving immune function in patients with chronic HIV infection.
Researchers have successfully treated mice with gene therapy, reversing neurological damage and deficits caused by the genetic defect that leads to metachromatic leukodystrophy. The treatment involves using hematopoietic stem progenitor cells genetically modified to express high levels of ARSA protein.
A Montana State University researcher has made significant breakthroughs in developing a live vaccine against genital herpes. The study found that mice vaccinated with a genetically-modified herpes simplex virus type 1 showed no signs of disease after exposure to the wild-type strain.
The World Trade Organization is expected to rule on biotechnology-altered foods, with differing perceptions about the 'precautionary principle' leading to trade clashes. The Japan-based Institute for Advanced Studies of the United Nations University calls for international agreement on common approaches to risk assessment.
Researchers found that increasing protein in the diet augments the body's PYY hormone, reducing hunger and aiding weight loss. High-protein diets stimulate greater release of PYY than high-fat or high-carbohydrate meals.
Researchers found that modified versions of bisphenol A stimulate breast tumor cell growth and are absorbed by breast cancer cells. The study suggests human enzymes convert BPA into a more toxic form, increasing the risk of breast cancer. Further research is needed to confirm these findings.
Scientists have identified two genes that Wolbachia manipulates when infecting the fruit fly Drosophila simulans, shedding light on the genetic basis of Wolbachia infection. This discovery could lead to the development of genetically modified mosquitoes that can help control malaria transmission.
Scientists found that genetic diversity in foundation species, like the cottonwood tree, drives the structure of entire ecosystems. This knowledge has far-reaching implications for conservation efforts and understanding the impact of genetically modified organisms on landscapes.
Researchers genetically altered mice to resist cocaine's effects, discovering that blocking dopamine transporters is crucial for producing a high. The study aims to find drugs that prevent cocaine from binding to transporters while allowing the transporter protein to function.
A team of Canadian and American researchers has identified the role of SHP-1 in regulating blood glucose levels and insulin sensitivity. The study used genetically modified mice to demonstrate that SHP-1 inhibition can improve glucose metabolism at the liver and muscle levels, potentially leading to new treatments for type 2 diabetes.