The EU has listed phosphorus as a critical raw material due to supply disruptions and lack of substitutes. Green chemistry methods can contribute to more efficient production and use of multifunctional phosphorus compounds, including phosphonates.
The Aging Research and Drug Discovery Meeting (ARDD2025) will feature Nobel laureates Morten Meldal and Michael Levitt. Their groundbreaking discoveries have had a lasting impact on drug development and molecular design, highlighting the conference's pivotal role in advancing healthspan and longevity science.
A new study demonstrates how fluorescent cholesterol probes can visualize cholesterol in live cells, revealing its role in amyloid plaque formation and cellular signaling. The novel probes have the potential to enhance our understanding of how cholesterol imbalances contribute to neurodegenerative disorders.
Researchers from Trinity College Dublin have developed 'Malteser-like' molecules that can be governed to produce predictable and desirable self-assembly structures. These molecules hold promise for applications in highly sensitive sensors, next-gen targeted drug delivery agents, and luminescence-based monitoring.
The 26th Nagoya Medal of Organic Chemistry will be held on January 24th, 2025, with gold medalist Professor Alois Fürstner presenting lectures on catalysis and metal-carbene chemistry. Silver medalist Professor Masayuki Inoue will discuss total synthesis of highly oxygenated natural products.
Three Nobel Prize-winners, Ben Feringa, Jennifer Doudna, and Kip Thorne, share their groundbreaking discoveries in molecular-level chemistry, genetics, and gravitational physics. Their articles inspire young readers to pursue STEM careers and explore the latest scientific advancements.
The University of California, Riverside is transforming undergraduate chemistry classes with a new mastery grading system, promising to improve outcomes for underserved students. The approach reduces high-stakes exams and emphasizes frequent assessments, resulting in a 10-point improvement in performance across all student groups.
Bentham Science journals Central Nervous System Agents in Medicinal Chemistry and CNS & Neurological Disorders – Drug Targets accepted for PsycInfo database indexing, enhancing global visibility of research. PsycInfo provides extensive coverage of behavioral and social sciences, making this move a significant step forward.
Researchers demonstrate key Darwinian evolution principles in self-replicating molecules, indicating evolution predates life. Competitive exclusion among these molecules curtails chemical diversification, shedding light on potential emergence of life from non-living materials.
Recent Nobel Prizes in physics and chemistry have recognized the convergence of AI with physics and chemistry, emphasizing the need for interdisciplinary research. Researchers advocate for nurturing AI-enabled polymaths to bridge the gap between theoretical advancements and practical applications.
A new Research Training Group at Saarland University aims to develop novel materials with specific magnetic, electrical or optical properties by manipulating covalent bonds. The group will receive €6.3M in funding from the German Research Foundation to support 20 doctoral research positions.
Junior Professor Johannes Walker at the University of Göttingen has been awarded an Exploration Grant to develop new strategies for synthesizing saturated polycyclic molecules, potentially leading to new medicines. The award will enable his team to explore new lines of research and contribute to the development of new drugs.
Chemists at Emory University and Caltech have developed a revolutionary strategy for functionalizing carbon-hydrogen bonds, transforming low-cost materials into complex building blocks of organic chemistry. The breakthrough enables the synthesis of complex natural molecules with antimicrobial properties.
Researchers at the University of Liverpool developed AI-driven mobile robots that can perform exploratory chemistry research tasks faster and more efficiently than humans. The robots use AI logic to make decisions, processing analytical datasets in real-time to determine the next steps in chemical synthesis.
A study of human skeletal remains from the Tudor warship Mary Rose reveals that handedness may influence clavicle bone chemistry as people age. The analysis found increased mineral content and decreased protein content in right clavicles compared to left, suggesting repeated stress on the right side during activities like sailing.
A research group from Osaka University has developed a novel green chemistry method to synthesize sulfonyl fluorides efficiently and with minimal environmental impact. This process uses easily accessible raw materials, thiols and disulfides, and produces only non-toxic sodium and potassium salts as byproducts.
A research team led by Magnus Wolf-Watz at Umeå University has discovered the chemistry behind the cell's energy molecule ATP. They found that a small angle change caused by magnesium can significantly speed up the chemical reaction producing ATP, linking structure and catalytic effect.
Researchers at the University of Illinois have developed a method to understand and improve light-harvesting molecules for solar energy applications. By combining AI with automated chemical synthesis and experimental validation, they were able to produce molecules four times more stable than traditional ones.
Researchers at Florida State University have developed a statistical analysis method that can detect when AI chatbot ChatGPT is used to cheat on multiple-choice chemistry exams. The study uses Rasch modeling and fit statistics to identify patterns in student responses that are different from those of ChatGPT.
Researchers at Dartmouth College have developed a self-powered pump that uses natural light and chemistry to target and remove specific water pollutants. The pump uses synthetic molecular receptors designed to bond to negatively charged ions, which are then trapped and released in a non-reactive substrate.
Aromatic compounds, a substance class in organic chemistry, now includes a new category of metal rings made of elemental bismuth. The discovery was made possible by supramolecular stabilization, allowing researchers to isolate and characterize the ring.
Josh Smalley, a chemical biology researcher and Great British Bake Off finalist, explores the overlap between chemistry and baking. He credits his lab training for handling pressure in the tent and finding creative solutions to baking issues.
Researchers at UC Santa Barbara have developed a method using photobiocatalysis to produce non-canonical amino acids that can be used as building blocks for novel proteins, therapeutics, and natural products. The efficient process is stereoselective and eliminates the need for protecting groups.
Scientists at the Paul Scherrer Institute have precisely characterized the styrene oxide isomerase enzyme, enabling the production of valuable chemicals and drug precursors in an environmentally friendly manner. The enzyme's unique mechanism and high specificity make it a promising tool for green chemistry.
Researchers at Rice University have successfully synthesized a group of natural compounds known as fusicoccanes, exhibiting diverse biological activities. The study leverages modern organic chemistry and engineered enzymes to achieve the synthesis of complex molecules.
A University of Michigan scientist proposes that chemists and pharmacists be key players in species conservation efforts to combat mass extinction. Modern bioscience has achieved breakthroughs in treating human disease, which can also be applied in the wild to save endangered species.
Researchers from UChicago create TopicVelo, a new method using scRNA-seq data to study dynamic processes in cells. The method groups data by biological processes, such as ribosomal synthesis, differentiation, and immune response, to better understand how cells change over time.
Cold Spring Harbor Laboratory researchers developed Accelerated SuFEx Click Chemistry to create over 150 new molecular compounds, including derivatives of complex natural molecules. These compounds show promise as leads for developing antibiotics and cancer therapies.
Mark Torres' $612,930 grant aims to analyze variations in river water chemistry using machine learning approaches and bridge the gap between theory and practical application. The project will inform policy decisions and drive sustainable solutions for safeguarding our planet's waterways.
A team of researchers has developed a machine learning interatomic potential that predicts molecular energies and forces acting on atoms, reducing computational time and expense. This breakthrough enables scientists to study complex chemistry systems with greater accuracy and speed.
Researchers at Carnegie Mellon University have created a new machine learning model that can simulate reactive processes in diverse organic materials and conditions. The model, called ANI-1xnr, performs simulations with significantly less computing power and time than traditional quantum mechanics models.
Wunmi Sadik, NJIT's Distinguished Professor of Chemistry, receives the Wallace H. Coulter Lectureship for her lifetime commitment to education, practice, and research in laboratory science. She is recognized for her scientific breakthroughs in nanomaterials, green chemistry, and sustainability.
The UK's first academic-industrial institute dedicated to chemistry & AI research will bring together leading researchers and industry partners. The hub aims to develop state-of-the-art AI tools for chemistry, addressing key societal needs like net zero emissions and global health.
A Baylor University chemistry professors develop a codex using lithophane, converting images from scientific textbooks into tactile formats for students with blindness. The study found that students with blindness can accurately describe, recall and distinguish high-resolution data and imagery at an average accuracy of 88%.
The convergence of automation and AI in organic chemistry has led to a paradigm shift, enabling the development of self-evolving chemistry assistants. This integration is poised to unlock new possibilities in understanding reaction mechanisms and teaching organic chemical reactions.
The Coscientist AI system has been successfully designed, planned, and executed a chemistry experiment, demonstrating its potential to revolutionize scientific research. By leveraging large language models and cloud lab technology, Coscientist can automate the experimental process, enabling scientists to design and run experiments much...
Researchers at Politecnico di Milano have designed a hydrogel with specific characteristics using supramolecular chemistry and crystallography. The study showed that the interactions between an amino acid and bioactive molecules can be identical in both solid and aqueous states.
The convergence of automation and AI is revolutionizing organic chemistry research, introducing generative AI assistants that can learn and evolve. This shift enables new possibilities in understanding reaction mechanisms and heuristics.
Researchers at University of Jyväskylä have gained new understanding on the chemistry of electrochemical interfaces, focusing on electrolyte ion effects. This knowledge can enhance the development of improved electrochemical technologies, including fuel cells and hydrogen peroxide synthesis.
The Janelia Fluor dyes have become a staple in biology labs worldwide, and the team has now expanded their spectrum with a new set of far-red shifted dyes that can penetrate deeper into tissue. The researchers developed a novel chemistry to synthesize these dyes, enabling them to create dozens of functional versions relatively quickly.
Researchers at Princeton University's Chirik Group have developed a cobalt catalyst that enables meta-selective borylation of fluoroarenes based on their electronic properties. This method bypasses the need for steric control and directing groups, making it faster and more cost-effective than traditional approaches.
Researchers developed a weeklong high school curriculum that teaches color chemistry and AI, improving students' knowledge and motivation. The curriculum uses machine learning to analyze pH levels, showing the connection between chemistry and AI in a practical application.
Researchers developed a modular flow platform to safely execute SuFEx click chemistry, generating toxic sulfuryl fluoride in a controlled manner. The system facilitates rapid functionalization of small molecules, peptides, and proteins.
The Oxford Period Project provides free period products to all students and faculty, reducing stress and stigma around menstruation. The project aims to promote inclusivity and sustainability by offering eco-friendly alternatives.
The article explores machine learning (ML) applications in chemistry, highlighting its potential to accelerate research and provide innovative solutions. Key findings include the development of ML models for retrosynthesis, atomic simulation, and heterogeneous catalysis, as well as the need for open ML contests to nurture young talent.
A new ribozyme called SAMURI can precisely modify RNA molecules, making them accessible for click chemistry. This allows researchers to label and visualize RNA pathways in living cells, enhancing their understanding of RNA interactions and functions.
A team of researchers has improved photoclick chemistry by engineering the phenanthraquinone triplet state, increasing photoreaction quantum yield and reaction rates. The study's findings pave the way for efficient photoclick transformations with unprecedented efficiency.
Researchers at the University of Sydney have successfully slowed down a simulated chemical reaction by a factor of 100 billion times using a quantum computer. This achievement allows for direct observation of previously inaccessible processes, enabling breakthroughs in fields like materials science and drug design.
Researchers at Worcester Polytechnic Institute discovered a new redox chemistry empowered by chloride ions for the development of seawater green batteries. This technology leverages abundant elements such as iron oxides and hydroxides, potentially repurposing iron rust waste materials for modern energy storage.
The newly expanded NSF Center for the Mechanical Control of Chemistry will investigate atomic-scale mysteries of crushing chemistry, enabling new advances in chemistry. The center will provide insights necessary for scaling up mechanical chemistry research across the US.
Researchers argue that modern chemistry prioritizes novelty over sustainability, neglecting environmental concerns. They advocate for a triple focus on efficiency, safety, and circularity to combat pollution and promote green chemistry. Circular design, life-cycle thinking, and toxicology assessments are key to realising positive impact.
Researchers have successfully created nano-sized rings using sandwich complexes, which consist of two aromatic organic rings filled with a central metal atom. The new compound, called cyclocene, exhibits unique properties and is expected to expand the toolbox of organometallic chemistry.
Researchers at Insilico Medicine discovered novel inhibitors for salt-inducible kinase 2 (SIK2), a potential target for anti-inflammation and anti-cancer therapy. The findings were published in the July 13 edition of Bioorganic & Medicinal Chemistry, demonstrating the power of Insilico's Pharma.AI platform.
Researchers used ultrafast electron diffraction to image the pericyclic minimum, a critical geometry in electrocyclic reactions. The study reveals that stereospecificity arises from the change of double bonds, not the exact motion, allowing for more precise synthetic chemistry tools.
Researchers at UCL and Stanford University create a three-component anti-cancer therapy using click chemistry, improving cancer-killing efficiency with sialidase enzyme, and exploring potential for next-generation agents.
Researchers have developed a set of biocatalysts that enable precise control over free radical reactions, solving a decades-old challenge in asymmetric catalysis. The metalloenzymes can selectively convert chiral compounds into desired products, opening up new possibilities for the synthesis of bioactive molecules and everyday polymers.
The study evaluates recent research on artificial intelligence-generated molecular structures from the perspective of medicinal chemists, recommending guidelines for assessing novelty and validity. Insilico Medicine's recommendations aim to improve the process of generating and evaluating novel AI-generated drugs.
Researchers successfully synthesized isotopic atropisomers based on carbon isotope discrimination, exhibiting high rotational stability and stereochemical purity. The findings hold promise for fundamental understanding of isotopic atropisomers with implications in organic and medicinal chemistry.
Phosphorus chemistry has been simplified with a new two-step process that converts primary and secondary phosphate sources into phosphorus-containing chemicals. The method uses cost-effective raw materials and eliminates the need for toxic white phosphorus.
Researchers have successfully controlled chemical reactions by manipulating electromagnetic fields in an infrared cavity, improving understanding of reactivity and products formation. The discovery offers a new path for quantum physics to regulate chemical reactions.