AS-202 demonstrates excellent safety and potency as a potential treatment for ALS, with significant improvements in motor function and survival in an aggressive TDP-43 mouse model. The data also shows that AS-202 is a potent PIKFYVE suppressor with no significant off-target effects.
New research found that physical activity is linked to lower microglial activation, a key factor in Alzheimer's disease pathology. The study, published in JNeurosci, suggests that exercise may help reduce inflammation and improve cognitive aging in older adults with more severe AD pathology.
Researchers developed a tool to investigate cause of death when skeletonised remains are recovered, providing a breakthrough in forensic lightning pathology. The study identified unique markers of lightning damage deep within the human skeleton, allowing for recognition of lightning strikes even when only dry bone survives.
The Association for Molecular Pathology (AMP) has published new guidelines to improve the US' ability to respond to emerging infectious disease outbreaks. The recommendations focus on better collaboration between public health, clinical laboratories, and government agencies.
A new study by SFU archaeologists has developed a valid method for estimating the age of juvenile remains using crania and mandibular bones. This approach can help forensic teams identify child remains in archaeological work or criminal investigations, providing closure for families.
The SPIRIT-Path extension provides evidence-based guidance to standardize pathology content in clinical trial protocols, ensuring methodological rigor and adequate skills and resources. Pathology is integral to trial planning and delivery, and the new guidelines formalize pathology input into clinical trials.
A new study examines the use of terminology in forensic anthropology, finding that research often fails to critically address racial and social constructs. The study suggests that using alternative terms like 'ancestry' can help reduce the perpetuation of white supremacy and biomedical claims based on biological differences.
Researchers developed a colorization method via color transfer termed CFPM, significantly reducing reconstruction time by 2/3 without sacrificing precision. This technique enables high-throughput full-color imaging in digital pathology.
A machine learning algorithm can accurately sex Caucasian 2D footprints with up to 90 percent accuracy, surpassing expert analysis. This breakthrough has significant implications for forensic and anthropological applications.
Researchers at Flinders University have developed a method to recover DNA from the surface of capsules containing illicit drugs, such as MDMA. This breakthrough enables law enforcement agencies to potentially link various drug seizures around the world and identify suspects through DNA profiling.
According to Nemours Children's Health, over 21.5% of teen ER patients screened showed symptoms of severe depression, while 7.8% reported suicidal thoughts during the pandemic. This finding underscores the need for increased vigilance and support for adolescent mental health.
Forensic scientists have developed a new method using Easylift tape to collect and analyze microplastic samples, improving efficiency and accuracy. This technique enables multiple analytical techniques to be applied to the samples afterwards and preserves them for future study.
Nisha D'Silva, a University of Michigan professor, is recognized for her exemplary mentoring skills, having mentored over 60 students and post-doctoral fellows in oral pathology and cancer biology.
A new study successfully recovered DNA from folded duct tape submerged in ocean water for up to 2 weeks, providing a complete short tandem repeat profile. The researchers found that the durability and adhesive nature of duct tape protected cellular material on its surface.
A new study highlights the need to replace 'ancestry' in forensics with a more accurate approach, focusing on population affinity. Researchers found inconsistent use of terms related to ancestry and race within the field, leading to confusion and misuse.
Ecologists from HKU have developed a novel forensic tool using stable isotope techniques to determine whether birds in the pet trade are captive or wild-caught. The tool uses carbon and nitrogen values to analyze amino acid isotopes, distinguishing between diets of captive and wild birds.
A new study published in the American Journal of Pathology uses Fast IR imaging-based AI to identify tumor type in lung cancer, providing a promising diagnostic method for future testing and treatment prediction. The analysis takes only half an hour, offering a significant improvement over current methods.
A study by the American Cancer Society found a 10.2% decline in real-time electronic pathology reports from population-based cancer registries in 2020 compared to 2019. The study suggests substantial delays in diagnosis and treatment services for cancers during the pandemic.
The Association for Molecular Pathology (AMP) has published consensus recommendations for clinical CYP2D6 genotype testing, aiming to standardize testing across laboratories and improve patient care. A minimum set of variants is recommended for inclusion in all future clinical assays.
Scientists at Cincinnati Children's are developing an automated risk assessment system using natural language processing and machine learning to analyze student interviews and predict violent outcomes.
Forensic archaeologists from Cranfield University are recovering the bodies of victims executed by the Franco regime during the Spanish Civil War. The team, working with partners and social anthropologists, aims to exhume and identify the remains of 26 people buried in a civil cemetery between 1939-1940.
A Perspective counters the DOJ's claim that forensic analysis of visual patterns is not metrology by highlighting biological sensory systems' ability to quantify patterns. This clarifies processes underlying human sensation and perception, potentially improving forensic accuracy.
Katie's research focuses on harnessing advances in digital information and data to enhance the identification of bullets and weapons. She aims to move away from subjective visual evidence and instead use quantifiable measurements and techniques.
New research by University of Kent found that EEG-based forensic memory detection tests have limited validity in older adults due to changes in recognition-related brain activity with aging. The study tested 30 young and 30 older adults using concealed information tests, finding only strong EEG responses in the younger group.
The article examines autopsy, toxicological, and psychiatric reports of Portugal's first major forensic case. It highlights the importance of toxicological analysis and suggests potential new insights with current knowledge.
Researchers at the University of Central Florida have developed a new method to analyze tire skid marks and identify vehicles involved in crimes. By classifying the chemical profile of tires, forensic scientists can link vehicles to potential crime scenes, providing valuable evidence for investigations.
Researchers developed a fluorescent polymer that binds to blood in fingerprints without damaging DNA, creating high-contrast images on various surfaces. This technology enhances the detection of invisible bloody prints, critical for forensic evidence analysis.
Researchers from University of Illinois at Chicago and Iowa State University cracked a forensic puzzle by exploring the fluid physics involved in a 2009 murder case. They found that backward blood spatter droplets can be entrained within a turbulent vortex ring of muzzle gases, potentially leaving shooter clothing bloodstain-free.
Researchers predict and capture the reversal of blood droplet flight due to gun muzzle gases, impacting forensic analysis of bloodstain patterns. The study also reveals the breakup of blood droplets in flight, affecting the formation and size of blood droplets.
A new study reveals that intestinal worm infections can change vaginal immunity and increase the likelihood of Herpes simplex virus type 2 (HSV-2) infection. The research found that targeting eosinophils can prevent this pathology, suggesting a potential solution to reduce STI severity.
A study published in Alzheimer's & Dementia found that progressive memory loss and issues with executive function are more useful for predicting CTE pathology than mood and behavior symptoms. This breakthrough could lead to the development of new therapies and improved patient care.
A proof-of-concept study shows that animal DNA can be collected from air samples, enabling new ecological and health assessments. The technique has potential applications in forensics, anthropology, and even medicine, such as understanding airborne diseases like Covid-19.
A new study reveals nearly 30% of forensic anthropologists have worked on cases involving transgender individuals, but most are unfamiliar with gender-affirming surgeries. The research highlights the need for a bio-cultural and queer theoretical perspective in forensic sex estimation to recognize signs of gender-affirming procedures.
Researchers found that a combination of an immune receptor blocker and an antiviral agent improves survival in mice infected with lethal influenza. The treatment reduces lung pathology in swine-influenza-infected piglets, providing insights into optimal timing of treatment to prevent acute lung injury.
Artificial intelligence has already shown promise in pathology, including image classification and diagnosis of diabetic retinopathy. Future developments aim to further enhance diagnostic accuracy and improve patient outcomes through augmented intelligence. The authors emphasize the need for careful validation, performance monitoring, ...
A new paper argues that ancestry estimation, used in forensic anthropology, is rooted in racist 'race science' and perpetuates white supremacy. The practice relies on flawed methods that have been debunked for decades.
A European consortium aims to create a platform for sharing pathology data to develop artificial intelligence tools, accelerating disease diagnosis and treatment. The BIGPICTURE project collects 3 million digital slides from humans and laboratory animals to support AI development in pathology.
A paper in the European Journal of Human Genetics warns that coercive DNA collection is unethical and damaging to medical research. The authors call for a mass reassessment of literature and require further information on consent and ethical approvals.
A DNA catalogue of Indian greater one-horned rhinoceroses has been created using dung samples, allowing researchers to identify unique individuals and track their populations. This forensic tool helps pinpoint poaching hotspots and trade routes, aiding conservation efforts.
A panel of experts developed guidelines for accurate determination of death in mountain rescue situations, taking into account the challenges of remote environments. Definitive signs of death include dependent lividity, rigor mortis, and decapitation, but absence of vital signs is not definitive.
Researchers at Tokyo University of Science developed a strategy to identify criminals from a single strand of hair, leveraging the composition of hair dye products. They employed surface-enhanced Raman spectroscopy (SERS) and X-ray fluorescence (XRF) analysis to distinguish between different dyes applied to individual strands of hog hair.
A team of researchers from Charité - Universitätsmedizin Berlin have studied how SARS-CoV-2 reaches the brain and found that it enters through nerve cells in the olfactory mucosa. The virus is also transported via blood vessels to reach the brain, which may contribute to neurological symptoms such as loss of smell or taste in COVID-19 ...
Forensic experts at Flinders University developed a system to trace dust DNA for terrorist investigations, matching soil profiles from specific regions or countries. This technique complements existing forensic intelligence tools and provides evidence of travel history.
A study found that forensic anthropology is a relatively homogenous discipline, lacking diversity in terms of people of color, LGBTQ+ individuals, and those with disabilities. The field struggles to keep up with issues relevant to society due to its lack of diversity.
Researchers analyzed 1,347 nephrectomy specimens to understand kidney histopathological findings. They found that more scarring in glomerulus, tubules/interstitium, and vessels is associated with worse kidney function.
New technologies are solving cold cases using DNA sequencing, robotics, and automation. Forensic genomics has made significant progress in recent years, enabling the solution of an unprecedented number of cold cases, including homicides and other violent crimes.
Researchers analyzed ancient texts from 600 BCE, concluding that many inhabitants of the kingdom of Judah could read and write. The study suggests that literacy was not exclusive to royal scribes, but rather a widespread skill among the population.
A study using iPSC technology reveals astrocytes' role in PD pathology, including altered alpha-synuclein production and disrupted calcium homeostasis. The findings suggest LRRK2 and GBA mutant astrocytes contribute to PD progression.
A meta-analysis of NHP studies reveals that AAV gene therapy often causes DRG pathology with no clinical effects, prompting preclinical safety evaluations before clinical trials. The study's findings have the potential to streamline the development process for new vectors.
A new THC Rapid Field Test Kit developed by Purdue University and Hemp Synergistics allows law enforcement to distinguish hemp from marijuana in under five minutes, accurately measuring THC levels. This tool is expected to lower forensic laboratory submissions of suspected marijuana cases by 50%.
A new study proves that the McKee CTE staging scheme accurately represents the progression of tau pathology in CTE, correlating with clinical dementia and age at death. Researchers found five brain regions with increasing p-tau pathology that conform to CTE stage, age, and years of football play.
A new CT scanning method developed by researchers from Aarhus University and University of Leicester has shown how the chest and abdominal region of a deceased person move during simulated heart massage. This detailed information can help clarify important physiological mechanisms and improve resuscitation techniques.
A new forensic approach aims to gauge the strength of witness memory and minimize unwitting bias in police lineup processes. The technique, which uses neuroscience and psychology, assigns a probability value to witness testimony and scores responses based on paired comparisons of photos.
Researchers at the University of Bristol have identified a novel protein pathway in several human neurodegenerative diseases, including Huntington's disease. Abnormal expression of SAFB1 was found to be associated with spinocerebellar ataxias and polyglutamine expansion, offering new potential diagnostic markers and therapeutic targets.
Forensic investigators can now analyze fragile human remains without excessive handling, thanks to a new 3D printing technique. This approach allows for effective physical fit analysis and demonstrates the potential for improved evidence presentation in court.
A team of scientists from the University of Portsmouth has developed a new forensic fingerprinting technique to lift finger-marks from pangolin scales, enabling wildlife crime officers to identify poachers and bring them to justice. The method uses gelatine lifters and has been successful in producing clear finger-mark detail on 74% of...
A new study in The American Journal of Pathology reports that gene expression analysis of lung explant tissue can accurately differentiate pulmonary arterial hypertension (PAH) from pulmonary veno-occlusive disease (PVOD). This molecular approach promises to facilitate clinical diagnostics and develop novel target-specific intervention...
Researchers from WMG, University of Warwick assessed seven dashcam devices to identify artefacts that can be synthesised using tools such as native video players. The study found that digital forensics faces significant issues in managing and processing dashcam evidence.
Researchers paired hyperspectral sensors with machine learning and molecular assays to differentiate between late blight clonal lineages. They found that accuracy increased at early stages of infection before symptoms appeared, suggesting a link to pre-symptomatic effector expression differences.
A new study reveals that almost 13,000 tonnes of microfibres are released into European marine environments every year. Changing laundry habits, such as using cooler wash cycles, could save up to 3,813 tonnes of microfibres being released into marine ecosystems in Europe.