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Boston University School of Medicine


Patients with COVID-19 and obesity have poor outcomes not driven by inflammation

A new study suggests that COVID-19 patients with obesity have poor outcomes, but this is not due to increased inflammation. Instead, respiratory issues and other factors may play a role. The researchers found that patients with obesity had lower inflammatory markers on hospital days, which could contribute to their poor clinical outcomes.

Researchers determine how the SARS-CoV-2 virus hijacks and rapidly causes damage to human lung cells

The study reveals that the SARS-CoV-2 virus rapidly causes damage to human lung cells by exploiting core resources and inducing abnormal changes in protein abundance and phosphorylation. The researchers also identified 18 pre-existing clinically approved drugs that can be potentially re-purposed for COVID-19 therapy.

SourceBoston University School of Medicine·JournalMolecular Cell·DateDec 2, 2020

Racial/ethnic minorities comprise small portion of patients referred with AL amyloidosis

A recent study found that racial/ethnic minorities comprise only a small percentage of patients with AL amyloidosis, despite being theoretically at higher risk. Younger age and more severe illness were observed among minority patients, who were also less likely to undergo aggressive treatment with stem cell transplantation.

SourceBoston University School of Medicine·JournalBlood Cancer Journal·DateNov 10, 2020

BU study discovers connection between contact sports, CTE and troubling sleep behaviors

Researchers found a connection between contact sports participation and chronic traumatic encephalopathy (CTE) leading to sleep dysfunction. The study revealed that tau pathology in brainstem nuclei is more strongly associated with sleep symptoms than Lewy body pathology, suggesting a new link between CTE and REM sleep behavior disorder.

SourceBoston University School of Medicine·JournalActa Neuropathologica·DateSep 16, 2020