Researchers at Buck Institute for Research on Aging provide a framework for precision nutrigeroscience to study the need for individualized dietary interventions. Studies in fruit flies show that lifestyle and genetics impact lifespan and healthspan, leading researchers to challenge the field to adopt a more nuanced approach.
A study found that boosting a cellular response to misfolded proteins actually shortens lifespan, contradicting previous research. The discovery highlights the complexity of aging and suggests new targets for disease prevention.
Researchers discovered that yeast changes hundreds of proteins' expression patterns and subcellular localizations after adapting to a higher temperature. The proteome's plasticity allows the cells to adapt by reducing thermolabile protein load, changing protein conformation, and adopting new functions.
Researchers created an inflammatory clock of aging (iAge) using deep learning to predict multi-morbidity, frailty, and immune health. The tool identifies a modifiable chemokine associated with cardiac aging and provides a target for interventions.
Researchers have found that targeting the FK506-binding protein 51 (FKBP51) promotes autophagy and reduces toxic Huntingtin protein levels, potentially providing a new treatment option for Huntington's disease. This new mechanism avoids worrisome side effects associated with rapamycin.
Researchers at Buck Institute discover non-invasive biomarker test to measure and track performance of senolytic drugs, which target multiple age-related diseases. The biomarker detects a unique lipid metabolite released when senescent cells die.
A new predictive model helps identify individuals at risk of severe COVID-19 by analyzing data from the COVID-19 Symptom Tracker app used by 3 million people in the UK. The study found that factors such as immunosuppressant medication, mobility aid use, and shortness of breath increase the risk for severe disease.
Researchers at the Buck Institute have discovered a compound that slows bone loss in aging mice by up to 31% over the course of a year's treatment. The study provides a treasure trove of data for those studying aging and age-related diseases, including serially profiled individual mice as they aged while testing several therapeutics.
A recent study from the Buck Institute for Research on Aging reveals that tissue stiffness significantly impacts the innate immune system, contributing to the development of chronic diseases. The research suggests that cellular tension sets off an inflammatory loop, which may be targeted by new force-targeting immunotherapies.
Researchers at the Buck Institute have identified chronic inflammation as a driver of NAD+ decline, a key metabolite central to an efficient and healthy metabolism. Senescent cells activate CD38, which degrades NAD+, leading to age-related diseases. Blocking CD38 activity may offer a new target for therapeutic interventions.
A double-blind study found that middle-aged mice treated with alpha-ketaglutarate had a significantly improved healthspan, experiencing fewer diseases and disabilities before death. The study suggests that AKG may suppress chronic inflammation, which is a major driver of aging.
The GCRLE awarded $7.4 million to 22 researchers, including early career scientists and established scholars, to investigate the causes of female reproductive aging. The grants will support innovative projects addressing ovarian aging and its impact on health and longevity.
Ketone bodies, produced during fat metabolism, may have therapeutic benefits against COVID-19, seasonal flu and other respiratory infections. Researchers propose testing ketone supplementation to bolster muscle function and attenuate delirium among infected survivors.
Researchers developed ribosome tethering tools to image neural circuits with greater precision. This allows for direct visualization of neuronal activity, reducing background fluorescence and spurious signals from surrounding nerve fibers.
Research involving 160 genetically distinct strains of fruit flies found that while dietary restriction extended lifespan, its effect on healthspan was less consistent. The study suggests that healthspan, rather than just lifespan, should be the primary focus for those seeking to improve aging outcomes.
Astrocyte senescence is linked to excitotoxicity in cortical neurons involved in memory, highlighting aging as a major risk factor for neurodegeneration. The study identifies targets for drug development to slow pathology.
Scientists have developed a proteomic atlas of senescence-associated secretomes, which can be used to identify senescent cells and their inflammatory factors. This will enable the development of simple, reliable biomarkers to assess the abundance of senescent cells in human tissues.
Scientists at the Buck Institute are exploring the genetics of mice that can regrow axons after injury to develop new treatments for human brain injuries and diseases. The researchers will use a new method to identify genetic differences between closely related species, which may hold the key to boosting lifespan or healthspan in humans.
Researchers at the Buck Institute identified 44 specific senescence-associated proteins involved in blood clotting, marking the first time cellular senescence has been associated with age-related blood clots. Senescent cells accumulate over time, spewing out inflammatory proteins that lead to chronic inflammation.
Research in flies reveals potential drug targets for gout, metabolic syndrome, diabetes, and kidney stones by manipulating insulin-like signaling pathway. Elevated uric acid levels increase risk of these diseases, emphasizing the importance of routine screenings in humans.
Researchers at the Buck Institute have identified a novel molecular mechanism that orchestrates harmful inflammatory signaling in glial cells, contributing to Parkinson's disease pathology. Blocking Furin 1, a catalytic protein, in dopaminergic neurons reduces toxic cross-talk and protects neurons from degeneration.
Researchers from the Buck Institute report that MANF regulates metabolism and immune response, and replenishing it shows promise as an anti-aging treatment. MANF deficiency has hallmarks of age-related diseases, including inflammation and liver damage.
Researchers found that dietary restriction maintains cellular fitness in intestinal cells, preventing age-related damage and leaky gut. A rich diet promotes excessive cell loss and permeability, linked to human conditions like inflammatory bowel disease.
Researchers at the Buck Institute have developed a new method to pinpoint genetic differences between closely related species, which could lead to breakthroughs in understanding human longevity, disease resistance, and regenerative abilities. The technique was tested using an ancient divergence in yeast and has wide applicability to pl...
A groundbreaking cancer genomics study reveals new molecular classifications, enabling the re-classification of 33 tumor types into 28 distinct clusters. These findings hold promise for immune-based and other novel cancer therapeutics, as well as repurposing drugs used to treat other diseases.
Researchers at the Buck Institute for Research on Aging have identified a potential therapeutic avenue for Parkinson's disease by clearing senescent astrocytes, which stop dividing and secrete deleterious factors. This approach shows promise in preventing symptoms of the incurable neurological disorder.
Researchers discovered that TOR signaling becomes activated in stem cells during regenerative responses, leading to the loss of stem cell status. Inhibiting TOR with rapamycin prevented this loss and reversed age-related decline in mouse trachea and muscle tissues.
A ketogenic diet improved memory in aging mice and increased their chances of surviving to old age. The study suggests that the health benefits of BHB may go beyond memory and could affect tissues and organ systems.
Researchers have found that women with a history of preeclampsia have a 90% decrease in breast cancer risk if they carry a specific common gene variant. The study, conducted in the California Teachers Study, confirms earlier findings and aims to develop new breast cancer prevention strategies for all women.
The Caenorhabditis Intervention Testing Program (CITP) identified Thioflavin T as the most robust pro-longevity chemical, extending lifespan in all strains tested. Six out of ten compounds significantly extended lifespan in at least one strain, with three dietary restriction mimetics showing variable responses across species.
Researchers at Buck Institute for Research on Aging found that alpha-lipoic acid prevented stone formation in a mouse model of cystinuria, a rare inherited disease. The supplement increased the solubility of cystine crystals, providing a new function for alpha-lipoic acid.
Researchers at the Buck Institute found that chemotherapy induces widespread cellular senescence, contributing to persistent inflammation and cancer recurrence. Eliminating senescent cells reduced side effects, including fatigue, bone marrow suppression, and toxicity, in mice treated with common chemotherapy drugs.
Stem cell therapies aim to restore function in degenerative conditions, but ensuring cell survival is a major hurdle. Researchers successfully restored long-term vision in blind mice by transplanting photoreceptors derived from human stem cells and suppressing the immune response that rejects transplanted cells.
Scientists used worms to decipher how bacterial signals from the microbiome influence the host, shedding light on diseases such as type 2 diabetes and obesity. The study found that specific bacterial genes modify worm physiology, serving as a model to study the gut microbiome in mammals.
Researchers uncovered a molecular pathway that responds to nutrient scarcity and lowers synapse activity in fruit fly larvae. This finding suggests that fasting may be beneficial by reducing neurotransmitter release and saving energy expenditure.
Research shows vitamin D engages with genes influencing longevity, slowing aging-related protein misfolding and increasing lifespan by 33%. The study provides a link between aging and disease, offering new insights into the potential benefits of vitamin D supplementation.
Researchers at Buck Institute have found a sensor for reactive molecules linked to diabetic complications, providing a pathway to study many of the ravages of diabetes. Two natural compounds, including alpha-lipoic acid, prevented nerve damage in worms experiencing similar hypersensitivity to touch as humans with diabetic neuropathy.
Researchers have discovered molecules that prevent free radical production by cells, which are implicated in human diseases and the aging process. The findings offer a precise tool to test the free radical theory of aging and could lead to new therapeutic leads for drugs.
A Buck Institute study found a key protein involved in nutrient sensing differs between male and female mice, impacting diabetes risk. Boosting this protein reduces obesity and insulin resistance in male mice.
A Buck Institute study found that boosting a broccoli-related compound, palmitoleic acid, may be a possible treatment for age-related macular degeneration. The research identified indole-3-carbinol as a starting point and used a virtual screen to find a more potent activator of the aryl hydrocarbon receptor protein.
Researchers at the Buck Institute discover metformin reduces toxic acid levels associated with Maple Syrup Urine Disease, a disorder identified 1 in 180,000 births. Metformin treatment significantly reduced ketoacid buildup in skeletal muscle of mice and toxic acid levels in human skin cells.
Scientists at the Buck Institute used a naturally occurring anti-inflammatory factor called MANF to promote tissue repair and regenerative success in the retina of mice. The discovery holds promise for treating chronic inflammatory diseases of the eye, including macular degeneration.
A groundbreaking study shows unprecedented improvements in 10 patients with early Alzheimer's disease or precursors following treatment with a personalized, 36-point therapeutic program. Patients who were struggling with memory loss returned to work and improved their performance after just 10 months on the protocol.
Researchers at the Buck Institute identified a new target for treating sporadic Parkinson's disease, which accounts for 95% of all cases. The study showed that increasing PGC-1alpha expression restored mitochondrial function and prevented degeneration of dopaminergic neurons.
Researchers at the Buck Institute discovered a small molecule that tricks C. elegans into a state of caloric restriction, extending its lifespan by 50%. This study suggests that primary sensory pathways represent new targets for human pharmacology to mimic the positive effects of a Spartan diet.
Age-related inflammation drives metaplasia in flies, causing changes in gut tissue and gut bacteria. Inhibiting this pathway prevents abnormal changes, maintains a healthy commensal population, and extends lifespan by up to 18%.
Researchers developed a new method to study genetic differences between long-separated species of yeast, providing insights into how mutations shape growth and behavior. The discovery has implications for understanding age-related diseases and developing new treatments.
Research from the Buck Institute suggests that excess iron impairs cellular recycling in Parkinson's disease, resulting in toxic oxidative stress. The study highlights the importance of maintaining a healthy balance of iron within cells to prevent neurodegeneration.
Researchers discover ApoE4's transcriptional effects, targeting genes associated with sirtuins, aging, insulin resistance, inflammation, and amyloid plaques. This finding offers a unified theory of Alzheimer's disease and potential new screening methods for prevention.
Researchers at the Buck Institute discover that dysfunctional mitochondria induce a unique type of senescence, characterized by a distinct secretory phenotype. This finding provides an alternative explanation for the free-radical theory of aging and highlights a new role for mitochondria in affecting physiology.