Researchers identified potential causal mutations that differ between ancestral groups in ADHD patients, highlighting the importance of considering ethnic background in treatment approaches. Whole genome sequencing technology revealed novel structural variants that may impact how patients respond to medications.
Researchers at Children's Hospital of Philadelphia found that cardiac involvement in multisystem inflammatory syndrome in children (MIS-C) is associated with myocardial injury, differing from Kawasaki disease. Long-term effects on cardiac function and sports participation require further study.
Researchers at Children's Hospital of Philadelphia found convalescent plasma to be a safe treatment option for children with life-threatening COVID-19 cases. The study suggests that convalescent plasma may provide the greatest benefit for early-stage patients who have not yet generated endogenous antibodies.
A study published in the New England Journal of Medicine found that JAK inhibitors improved developmental milestones in patients with AGS, a rare genetic disorder. The treatment showed promise in improving neurological function, particularly in children who received higher doses.
A new study found that teen drivers and older adults are more likely to drive vehicles with fewer critical safety characteristics, putting them at higher risk of injury. Drivers from lower-income neighborhoods were also less likely to drive newer, safer cars.
A team of researchers at Children's Hospital of Philadelphia used new computational methods to link characteristic presentations of childhood epilepsies with specific genetic variants. They analyzed clinical information and large-scale genomic data, finding associations between 11 genetic causes and specific symptoms.
Researchers at Children's Hospital of Philadelphia have developed a new treatment that shows long-term remissions in 80% to 100% of mice with drug-resistant or high-risk solid tumors. The treatment is less toxic than conventional chemotherapy, with fewer side effects.
A new study by the Lifespan Brain Institute found that people are more concerned about others than themselves when reporting their COVID-19 related concerns. Respondents with higher resilience scores had lower COVID-19-related worries, as well as reduced rates of anxiety and depression.
A team of researchers linked genetic information with electronic medical records to identify the impact of genetic epilepsies on affected children's lives. They found associations between specific genes and clinical features, such as seizures and intellectual disability.
Researchers developed an algorithm that can predict DNA methylation sites throughout the genome using deep learning. This method has been successful in identifying potential therapeutic targets for human diseases and could improve conventional screening methods.
Pediatric infectious disease experts provide recommendations on return to school for SOT children, considering factors like clinical risk, community transmission, and infection prevention measures. The majority of SOT recipients are expected to outweigh the risks and benefit from attending school.
A new study by CHOP sleep experts found that sleep disturbances at any age are associated with diminished well-being in children by 10 or 11 years old. Children with persistent sleep problems have the greatest impairments, while those with mild sleep problems over time also experience psychosocial impairments.
Researchers at Children's Hospital of Philadelphia found that youth who are involved in the decision to start continuous glucose monitoring (CGM) are more likely to continue using the technology consistently. Having a role in the decision increases satisfaction and consistent use of CGM.
Researchers from Children's Hospital of Philadelphia found that patients with Multisystem Inflammatory Syndrome in Children (MIS-C) had elevated levels of IL-10 and TNF-? cytokines, distinguishing them from severe COVID-19. Simple peripheral blood smears also helped distinguish the conditions.
Surgeons from Children's Hospital of Philadelphia propose categorizing surgeries into four classes based on urgency and risk. Class-1 emergency surgeries must happen right away, while Class-4 elective surgeries should occur once the pandemic has reached its low point.
The Food Allergy Bravery Clinic at Children's Hospital of Philadelphia uses Cognitive Behavioral Therapy to help children with a phobia of anaphylaxis manage their anxiety. By gradually introducing children to safe, structured practices, the clinic aims to equip families with practical skills and confidence.
Researchers developed a computational algorithm to analyze noncoding mutations across five major pediatric cancers. The study identified 1,137 structural variants affecting over 2,000 genes, highlighting their potential as cancer-causing mutations.
Researchers from Children's Hospital of Philadelphia and University of Pennsylvania found that states with delayed social distancing measures had significantly higher COVID-19 mortality rates. The study analyzed over 55,000 deaths across 37 states between January and April 2020.
A team of researchers from Children's Hospital of Philadelphia used a new method to pinpoint potential disease-causing changes in the genome and identified two new potential therapeutic targets for lupus. The study focused on follicular helper T cells and created three-dimensional maps that match variants with genes they likely regulate.
The Center for Applied Genomics at CHOP will focus on five areas of research, including generating polygenic risk scores for common diseases and returning genomic risk assessments to children and their families. The study aims to identify disease risks faced by African American children and improve health outcomes.
A CHOP study demonstrates that remote continuous EEG monitoring can detect seizures in at-risk neonates, impacting clinical care and guiding treatment decisions. The study showed that seizures occurred in about one-quarter of the records, with CEEG impacting outcomes in three-quarters of cases.
A recent study by Children's Hospital of Philadelphia found that telemedicine is an effective way to deliver pediatric neurology care, with a 93% satisfaction rate among clinicians. The study also suggests that telemedicine may help address existing barriers to care, such as lack of access to computers or transportation needs. To impro...
Researchers at Children's Hospital of Philadelphia have developed a strategy to identify regions of the SARS-CoV-2 virus to target with a vaccine, employing cancer immunotherapies. They prioritize viral targets based on their ability to stimulate a lasting immune response, predicted to be in the vast majority of the human population.
A study by Children's Hospital of Philadelphia found that universal preoperative COVID-19 screening improved pediatric patient safety by identifying asymptomatic cases. The researchers analyzed data from three major children's hospitals and found significant variation in COVID-19 incidence rates, ranging from 0.22% to 2.65%.
A new study characterizes concussions in elementary school-age children, revealing common vision and balance issues that warrant consistent assessments at the initial healthcare visit. The findings emphasize the need for targeted interventions to improve outcomes, including school accommodations and vestibular or vision therapy.
A new study by Children's Hospital of Philadelphia researchers found a nearly 2.5-fold decrease in pediatric fractures overall due to cancelled sports and playground closures, but an increase in at-home fractures, particularly bicycle and trampoline injuries.
A new study by Children's Hospital of Philadelphia researchers found that a primary care-based intervention promoting parent-teen communication led to less distress among teens and more positive emotions. The intervention, which included an eight-page booklet with discussion prompts, showed promise in improving adolescent health outcomes.
Children in rural communities face higher risk of debilitating lawnmower injuries, which can lead to amputations and lengthy hospital stays. The study found that over 80% of pediatric lawnmower injuries occur in Southern and Midwestern states due to warmer weather and ride-on mower prevalence.
Dexrazoxane has been shown to preserve cardiac function and reduce risk of severe cardiac events in pediatric patients undergoing chemotherapy for acute myeloid leukemia (AML). The study suggests dexrazoxane should be considered for cardioprotection in all pediatric patients undergoing standard chemotherapy for AML.
A study by CHOP researchers found that continuous pulse oximetry monitoring is being used in infants with bronchiolitis who do not require supplemental oxygen. The use of this practice varies widely among hospitals, with some institutions using it as a safety net despite national recommendations against it.
Researchers have characterized how the gut microbiome develops in the first hours of infancy, providing a critical baseline for understanding the impact on health and disease later in life. The study found that multiple strains of bacteria emerged early, influencing metabolite levels and protein consumption.
Researchers at Children's Hospital of Philadelphia have identified a genetic variation responsible for driving IBD development. The study found that the rs1887428 SNP alters gene expression in the JAK2 pathway, which is also targeted by immunotherapies.
Researchers developed an online tool to refine results from RNA sequencing obtained from clinically-accessible tissues. The study found that 40.2% of non-clinically-available tissues have inadequate splicing representation in at least one clinically-available tissue.
Researchers at Children's Hospital of Philadelphia develop a new tool to measure quality of life for autistic individuals across their lifespan. The tool assesses physical and mental health, relationships, and subjective well-being, providing insights into the struggles and successes of autistic people.
Researchers found that most mass shootings (71.1%) occurred more than 10 miles from a pediatric trauma center, highlighting the need for preparedness and resources in all hospitals.
Researchers used headband-mounted sensors on soccer players to collect data, which was confirmed by video analysis. The study found 60% of recorded events were false positives and highlighted the importance of video verification for reliable injury prevention strategies.
Researchers developed a novel treatment that compacts and stabilizes neutrophil extracellular traps (NETs) to enhance bacterial capture, resist degradation, and improve sepsis outcomes. The treatment improved survival in mice with sepsis by reducing severity of illness and decreasing bacteria levels.
A study published in The Journal of Allergy and Clinical Immunology: In Practice found that children with food protein-induced enterocolitis syndrome (FPIES) are at a higher risk of developing other allergic conditions. Despite this, the researchers did not find a direct causal link between FPIES and these other allergies.
Researchers developed a novel computational algorithm to track pediatric sepsis epidemiology, providing more accurate data on outcomes and incidence over time. The algorithm showed an increasing incidence of sepsis among hospital encounters and mortality rates remained stable.
Researchers at Children's Hospital of Philadelphia developed a new imaging method to visualize the enteric nervous system, a key part of the human colon, in three dimensions. This allows doctors to gain new insight into cells that control bowel function and may help understand disorders of the colon.
The Roberts Individualized Medical Genetics Center at Children's Hospital of Philadelphia has developed a centralized genetic testing model that has improved diagnosis and patient outcomes. The center's success highlights the importance of standardizing genetic testing across different clinical disciplines.
A new study identifies a strong cancer driver gene linked to alternative splicing changes in aggressive cancers. The researchers developed computational tools and biological model systems to analyze RNA sequences from nearly 900 prostate tissue samples, revealing over 13,000 alternative splicing events.
Researchers found that primary care doctors rarely discuss safe driving and monitor patients for risky sexual behavior with adolescents who have a history of ADHD. The study highlights the need for additional resources and training to provide better care for these patients as they transition from childhood to young adulthood.
Researchers found significant physical and emotional benefits a decade after prenatal surgery for myelomeningocele, including better walking ability and bladder control. School-age children who received corrective surgery in the womb demonstrated improved gross and fine motor skills and a lower need for shunts and surgeries.
A large-scale study of over 100,000 people revealed new genetic targets for a variety of diseases, including autoimmune disorders and cancer. The research also identified potential repurposing of existing drugs to target these conditions.
A new treatment protocol at Children's Hospital of Philadelphia reduced albuterol use in infants with bronchiolitis without compromising care. The protocol change prevented over 600 unnecessary treatments and did not impact patient admission rates or length of stay.
A team of CHOP researchers has discovered a genetic signature that can help diagnose adult-onset 'type 1.5' diabetes, which shares characteristics with pediatric-onset type 1 diabetes. The finding could lead to more effective diagnostic methods and improve treatment outcomes for adults.
Researchers have discovered key mechanisms and structural details of how chromosomes reorganize themselves after cell division. The study reveals a dynamic hierarchical framework of sequence by which chromosomes rebuild themselves after mitosis, shedding light on the interplay between chromatin architecture and gene transcription.
A large clinical trial found that an oral drug improved exercise capacity in adolescent patients with severe single-ventricle heart defects. The treatment showed benefits in oxygen consumption and circulatory function, which may translate to better long-term outcomes for these patients.
A new screening approach for retinopathy of prematurity (ROP) has been developed, adding slow weight gain to existing criteria. The method was tested in a large prospective study and found to correctly predict ROP cases while reducing unnecessary examinations by nearly a third.