A recent Columbia Nursing study analyzed over 1,700 clinical notes and found stigmatizing language common against Black patients. The most frequent category was unjustified descriptions of social and behavioral risks, with 22.4% of notes containing such language.
Researchers at Columbia University Irving Medical Center have developed an AI method that can accurately predict the activity of genes within any human cell, revealing the cell's inner mechanisms. The system can also uncover hidden biology of diseased cells and explore the role of genome's 'dark matter' in cancer and other diseases.
Researchers discovered that some cells can inactivate one parent's copy of a gene, influencing disease outcomes. This phenomenon could help explain diseases with flares or those triggered by environmental factors.
A new study by Columbia University researchers has found a strong link between structural sexism and faster memory decline in women. Born in the most sexist US states, these women experience faster memory decline compared to those born in less sexist states, with an age equivalent to nine years of cognitive aging.
Researchers found that targeting antidepressants to intestinal cells reduces anxiety and depressive behaviors in mice, and may offer a better alternative to current treatments during pregnancy. The study suggests that increasing serotonin signaling in the gut can impact gut-brain communication and ultimately mood.
A pioneering study shows that DNA analysis picks up many more preventable and treatable serious health conditions than standard newborn screening, improving children's medical care. Genome sequencing detects gene variants linked to hundreds of specific diseases, far exceeding the 60 disorders detected by current methods.
Researchers have engineered probiotic bacteria to educate the immune system to destroy cancer cells, opening the door for a new class of cancer vaccines. The bacterial vaccine proved more efficacious than peptide-based therapeutic cancer vaccines in studies using mouse models of advanced colorectal and melanoma cancers.
A new Columbia University School of Nursing-led study explores how patients view the use of artificial intelligence (AI) to improve mental health care. The survey found that 49.3% of participants considered AI beneficial for mental health care, but with concerns over incorrect diagnoses and patient autonomy.
A new study published in JAMA Network Open has found that pandemic-era children do not have a higher risk of developing autism. Researchers analyzed data from nearly 2,000 children born during and before the pandemic, and found no difference in positive autism screenings between groups.
Surgical sterilization rates increased significantly among women in the US following the Dobbs v. Jackson Women's Health Supreme Court decision, with a notable rise in states where abortion access was limited or banned. Researchers found that tubal sterilization remained an irreversible method of contraception despite changing state laws.
Researchers identified two distinct cellular communities driving Alzheimer's disease, with one community promoting cognitive decline and the other contributing to the preservation of brain function. The study provides new insights into the molecular mechanisms underlying Alzheimer's, highlighting potential targets for intervention.
A recent study discovered that mitochondria frequently insert their DNA into brain cell nuclei, which may contribute to early death. The research found that participants with more mitochondrial DNA insertions in their brain cells were more likely to die earlier than those with fewer insertions.
The gift will support the expansion of the Vagelos-funded institute, construction of a new biomedical research building, and innovative collaborations in cell engineering and gene therapy. This investment aims to revolutionize treatment for various diseases, representing a new paradigm in medicine.
A study published in the Journal of the American Medical Association identified the most common long COVID symptoms in school-age children and adolescents. The researchers created indices to guide research and diagnosis, highlighting differences between boys and girls in symptom profiles.
The new center aims to build on Columbia's groundbreaking work in developing innovative diagnostics and treatments for rare kidney diseases. It will also provide expert care to patients with glomerular disease and expand education and training for medical professionals through a fellowship program.
A new study by Columbia researchers shows that bacteria can create free-floating and ephemeral genes, raising the possibility that similar genes exist outside of our own genome. These 'hidden genes' are essential for cell survival and could lead to new genome editing tools.
A new article from Columbia University's Division of Ethics presents a set of recommendations to advance racial equity, diversity, and inclusion in bioethics. The guidelines emphasize the need for anti-racist practices within academic programs and provide concrete steps for implementing these principles.
A recent study found that nearly half of cancer institutions lack adequate translation services, leading to difficulties recruiting minority patients. The study highlights the need for improved language equity in clinical trials to ensure equitable access to treatments.
A multinational research team has identified a novel way to attack measles by targeting specific proteins on the virus, paving the way for new vaccines and antiviral drugs. The study found that antibodies against the fusion protein successfully prevented the virus from completing its merger with the cell membrane.
A new study from Columbia University Irving Medical Center suggests that the brain's mitochondria play a fundamental part in translating feelings and experiences into physical changes. Researchers found that older adults with lower psychological stress had greater mitochondrial energy transformation machinery, linked to higher well-being.
Chi-Min Ho, assistant professor at Columbia University Irving Medical Center, has been awarded the Pew Biomedical Scholars Program for her innovative work on malaria parasite biology. Her team plans to use integrated structural biology approaches to deepen our understanding of malaria parasite biology.
A new study by Columbia University researchers confirms the high burden of long COVID, shedding light on who's at greatest risk. The study found that women, adults with pre-pandemic cardiovascular disease, and those with chronic conditions were more likely to experience prolonged recovery times.
Researchers developed tricks to slow down the receptor's closure and speed up freezing process, capturing critical images of kainate receptor in open configurations. These images provide information for drug developers to design more precise medicines for patients.
Two independent studies by Columbia scientists challenge long-held assumptions about gut stem cells, revealing they are descendants of true stem cells producing different proteins and responding to distinct signals. The discovery could revitalize regenerative medicine by targeting the correct stem cell populations.
A study by Columbia University researchers found that an injectable omega-3 emulsion can prevent brain damage in newborn rodents after oxygen deprivation near birth. The therapy, which enhances omega-3 fatty acids' ability to penetrate the blood-brain barrier, reduced brain damage and preserved neurologic function.
Researchers found transformed smooth muscle cells driving atherosclerosis by proliferating and resisting cell death, suggesting potential treatment with anticancer therapies. A common cancer drug reduced plaque size in mouse models, but further studies are needed for clinical translation.
A recent study suggests that removing the bursa during shoulder surgery may impair the success of rotator cuff repairs. The researchers found that the bursa protects the undamaged tendon and bone by maintaining their mechanical properties and promoting healing. Retaining the bursa may prevent or delay progression of tendon degeneration.
Researchers at Columbia University Irving Medical Center have created mice with hybrid brains, allowing them to use rat neurons to sense odors accurately. The study's findings suggest that adding replacement neurons isn't plug-and-play, highlighting the need to remove dysfunctional neurons for functional replacement in neurodegenerativ...
Researchers at Columbia University Irving Medical Center have discovered a genetic variant in the fibronectin gene that protects against Alzheimer's disease. The variant, found in APOEe4 carriers, reduces the odds of developing Alzheimer's by up to 70% and may help prevent or treat the disease.
A new class of oral medications targeting RAS proteins has shown promising results in preclinical models, potentially offering novel treatment options for nearly all pancreatic tumors. The inhibitors performed well across various models, with minimal impact on normal cells.
Columbia University has received a $15 million grant to develop tailor-made gene-based therapies for nine people with rare forms of amyotrophic lateral sclerosis (ALS). The Silence ALS program will use antisense oligonucleotide (ASO) technology to silence genes that produce toxic proteins in motor neurons. The project aims to create pe...
A new study shows that far-UVC light can virtually eliminate airborne viruses in occupied work environments, reducing infectious airborne virus levels by 99.8%. The technology has the potential to provide more protection against airborne-disease transmission than ventilation systems, making it a promising solution for indoor spaces.
A new study suggests that many cases of neonatal neutropenia may originate from suppression of fetal blood-forming stem cells by maternal interleukin 10. This immune deficiency greatly increases a newborn's susceptibility to infection, leading to serious health complications and even death.
Researchers found that high levels of pro-inflammatory factor Ang2 remain elevated in CPAP users, associated with a greater risk of cardiovascular disease. Lowering CPAP pressures may reduce inflammation and improve heart health for these patients.
A study published in JAMA Psychiatry found that positive relationships with parents and adults during childhood are associated with better mental health in adulthood. Despite adverse childhood experiences, resilient youth who have strong social connections and meaningful experiences tend to experience less depression, anxiety, and stress.
A nationwide prospective study found a sharp increase in post-traumatic stress disorder (PTSD), depression, and anxiety in Israelis following the October 2023 Hamas attack. The study nearly doubled the prevalence of these conditions, which were already higher than those reported in previous studies on terrorist events.
A new study found that a genetic variant in the APOL1 gene reduces the risk of kidney disease in high-risk individuals, particularly those with African ancestry. The discovery may lead to reclassification of patients and expansion of potential kidney donors.
A new study suggests that metastatic prostate tumors contain a rich variety of immune cells that can be roused by immunotherapy into attacking the cancer. Combining hormone therapy with immunotherapy further stimulates anti-tumor immune cells, potentially improving patient outcomes.
A study found that prenatal discrimination and acculturation stress can alter the strength of infant brain circuits, potentially leading to increased risk for mental health disorders. The research suggests a critical role in treating individuals with kindness during pregnancy.
A new study by Columbia University researchers indicates that patients with expanded methadone access during the COVID pandemic are not more likely to overdose or drop out of care. The findings suggest that more flexible policies could help improve access to this life-saving treatment and close gaps in care.
A novel pilot study combines mindfulness and exposure therapy to reduce PTSD symptoms in cardiac arrest survivors, with 80% showing significant improvement. The treatment protocol also improved cardiovascular health behaviors, including sleep quality and physical activity.
A new study found that curtailing sleep by 90 minutes for six weeks increased insulin resistance in women, particularly postmenopausal women. Insulin resistance was also linked to an increased risk of developing type 2 diabetes.
A new model reveals how a single pool of stem and progenitor cells in the pancreas can give rise to multiple types of pancreatic cancer. The study suggests that understanding the cell from which a cancer arises can help researchers develop therapies tailored to an individual's disease.
Researchers found that metformin restores mitochondrial activity and prevents cancer progression in mice and human prostate cells, particularly those with low NKX3.1 levels. The study suggests metformin could be used to prevent further progression of cancer in patients under active surveillance with low-NKX3.1 tumors.
A newly developed prediction model can estimate a patient's risk of returning to opioid use within the first three weeks of treatment. The model, which was tested on data from over 2,200 adults, suggests that patients who have not experienced any positive or missed drug tests in the first three weeks have a 13% risk of relapse.
A new study from Columbia University Irving Medical Center suggests that chemotherapy-induced cognitive impairment, or 'chemobrain', may be caused by an excess of calcium floating around inside cells. The research could lead to new treatments to restore cognition in patients experiencing symptoms.
A new study found that even a mild chronic sleep deficit can lead to inflamed and dysfunctional vascular cells, increasing the risk of cardiovascular disease. Shortened sleep duration for six weeks caused oxidative stress in these cells.
Malaria parasites have developed resistance to artemisinins, a critical treatment for non-severe cases, with devastating consequences. The study found that effectiveness declined by 2025% between 2016 and 2019, highlighting the urgent need for new treatments.
A new intrauterine device successfully controlled postpartum hemorrhage in 93% of patients who delivered vaginally and 84% of those who delivered by cesarean. The device, which uses low-level suction to promote uterine contractions, showed rapid effectiveness and can be a valuable tool for managing the condition.
Researchers at Columbia University Irving Medical Center found that a misfolded protein triggers an immune attack in the gut, leading to gastrointestinal symptoms years before brain symptoms appear. The study suggests Parkinson's disease may be an autoimmune disorder and offers hope for early detection and prevention.