Researchers develop novel imaging technique that maps out high-resolution map of proteins, lipids, and collagen fibers in bone tissue. The technique achieves impressive diagnostic accuracy of 93.56% for identifying T2DM-related changes in bone quality.
Researchers have developed a novel image enhancement method that effectively reduces noise and recovers critical structure in low-dose CT images. The mGCVR algorithm models the grayscale distribution of CT images using a multi-Gaussian strategy, enabling pixel-wise intensity adjustment and variance reduction.
Researchers propose active retinal projection displays (ARPDs) with simplified architecture, enabled by emerging AM microdisplay panels. A-RPDs offer smaller, more comfortable, and laser-free AR devices, resolving vergence-accommodation conflict (VAC) issues in mainstream AR displays.
Researchers used graph neural networks to identify asperuloside as a promising OA therapeutic candidate. Asperuloside improved cartilage metabolic homeostasis, mitigated subchondral bone sclerosis, and reshaped cartilage gene expression.
This study reveals Yanghe Decoction's anti-tumor effects on osteosarcoma cells by modulating the PI3K/AKT and p38 MAPK pathways, inducing ROS-mediated mitochondrial dysfunction. YHD also inhibits tumor growth and metastasis in orthotopic OS mouse models.
Researchers discovered CLCA4 suppresses CSC properties and enhances anti-PD-1 immunotherapy, halting tumor growth and immune suppression in colorectal cancer. CLCA4 overexpression also reshaped the tumor immune microenvironment, sensitizing tumors to anti-PD-1 therapy.
A new study published in Genes & Diseases journal reveals that lncRNA ROLLCSC promotes ferroptosis resistance and metastasis in lung cancer by regulating lipid metabolism. The researchers identified ROLLCSC as a therapeutic target, suggesting potential treatments for advanced lung adenocarcinoma.
Research reveals a causal link between alcohol consumption and epilepsy risk via neutrophil extracellular trap (NET) formation. MPO inhibition shows promise in reducing seizure susceptibility.
A study found that HSP90B1 upregulates in gliomas and correlates with poor prognosis and tumor malignancy. It enhances tumor cell proliferation, migration, and invasion while protecting cells from radiotherapy-induced apoptosis by modulating DNA damage repair factors.
A new study reveals that ALK mutations enhance tumor immunogenicity and predict favorable outcomes in immune checkpoint blockade. The presence of ALK mutations is an independent favorable predictor of overall survival, decreasing the risk of patient death by 31%.
Researchers found that eEF1A2 is significantly overexpressed in gallbladder cancer and correlates with advanced lymph node metastasis and poor patient survival. Targeting the EEF1AKMT4-eEF1A2 signaling axis may suppress translation-driven tumor growth and halt lymphatic spread.
Researchers found that NRG4, an adipokine secreted by white adipose tissue, suppresses breast cancer metastasis via ERBB4-YAP1 signaling. The study also showed that higher NRG4 levels correlate with improved patient survival outcomes.
A new publication proposes a polarization-guided diffusion prior model to remove eyeglass reflections. The method, PDPrior, achieves robust removal across diverse scenarios without relying on training data or ground-truth images, resulting in improved face image quality and accuracy.
Researchers develop a photoacoustic spectroscopy system using a gain-switched Er³⁺/Dy³⁺ fiber laser, achieving ppt-level monitoring of multiple key VOCs and improving overall sensing performance by over an order of magnitude. The system enables precise detection of industrial pollutants and non-invasive clinical breath diagnostics.
Researchers developed a machine learning-empowered femtosecond laser processing technology to create high-performance anti-reflective windows. The technology achieves accurate prediction of ultra-broadband transmittance spectra and enables efficient optimization, overcoming challenges in conventional numerical simulations.
The convergence of AI and metaphotonics enables the design and integration of ultra-thin, flat optical devices that can bend, focus, and filter light. This technology has the potential to solve real-world hardware limitations, including shrinking cameras and enabling autonomous systems.
Researchers from Nanchang University have created a breakthrough solution for ultra-efficient infrared imaging using smart silicon metasurfaces. The team achieves a record-high conversion efficiency for such a silicon metasurface, enabling direct upconversion imaging with high fidelity and resolving fine details.
Researchers develop high-security information encryption metasurfaces using femtosecond lasers and refractory metals, achieving crosstalk-free hierarchical regulation of visible light and infrared information. The metasurface can endow encrypted information with a high-temperature key for enhanced security.
LRRC8A plays a multifaceted role in various diseases, including cancer, where it promotes proliferation and invasion via multiple pathways. In neurology, LRRC8A is implicated in epilepsy and ischemic stroke, while also regulating metabolic processes and immune function.
Researchers from Shandong Second Medical University and Wuhan University identified LINC00862 as a tumor suppressor that forms a triplex-mediated transcriptional activation driving tumor suppression in HCC. The study reveals a bidirectional regulatory loop between LINC00862 and RBM47, which reinforces tumor suppression.
A proof-of-concept comparison between Azure Kinect and OpenCap shows that the smartphone-based system can accurately estimate lower-limb biomechanics, with strong agreements in joint angles and contact forces. However, further studies are needed to confirm its applicability for clinical diagnosis.
A cross-sectional investigation found Listeria spp. prevalence of 12.8% in raw cow milk, with L. monocytogenes accounting for 4%, highlighting the zoonotic risks. Strengthening hygienic practices and safe milk handling measures are essential to mitigate health risks.
Targeted intense light exposure alleviates right ventricular (RV) hypertrophy and fibrosis by reducing macrophage-associated inflammation. It improves cardiac function, lowers pulmonary artery pressures, and decreases collagen deposition compared to hypoxic mice under normal light.
SKP2 functions as a signaling hub orchestrating metabolic reprogramming, DNA damage response, stem cell maintenance, and synaptic plasticity. Dysregulation contributes to human diseases, including cancer and neurodegenerative conditions.
A new study presents an interpretable artificial intelligence framework that improves the accuracy and transparency of genomic prediction, capturing complex genetic interactions and providing biological insight. Boosting algorithms outperform traditional statistical methods, particularly for traits with well-defined genetic signals.
Recent breakthroughs in terahertz imaging technology have improved resolution, stability, and reconstruction fidelity for various applications. The integration of deep learning algorithms and hardware innovation is expected to enhance real-time, high-precision, and portable applications.
Researchers have made significant progress in visible light communication technology, enabling large-capacity transmission rates of over 800 Gbps. The technology offers unique advantages in diverse application scenarios, including inter-satellite links and data center interconnects.
Research on multidimensional photodetectors leverages 2D materials and silicon photonics to decode light fields. These advancements aim to empower next-gen photodetectors with higher-dimensional, faster, and more intelligent perception capabilities.
Researchers propose a new method for dynamic polychromatic holography using polymer-stabilized chiral superstructures, achieving broadband and multichannel functions. The device can dynamically modulate light wavefronts, reconstructing high-quality full-color holographic images with reversible switching.
Researchers propose a scene-level passive high-precision polarization 3D imaging method, resolving challenges of discontinuous targets, absolute depth interpretation, and dynamic reconstruction. The approach achieves accurate true depth through integrating stereo vision and polarization, enabling scene-level high-precision 3D imaging.
Researchers created a paper-thin 'metalens' that can change how it looks at the world with just a tiny electrical nudge. The device flips between two useful views, producing two small bright spots for depth sensing and keeping fine details sharp without refocusing.
A new AI design strategy transforms semitransparent solar cells into colorful, user-defined windows without compromising energy output. The technology enables up to 20% power generation increase while maintaining visual appeal, making it suitable for real-world applications in buildings, vehicles, and wearable electronics.
Researchers propose a novel space-time-coding metasurface that integrates energy harvesting, electromagnetic wave manipulation, and information modulation. This technology enables high-capacity transmission, multi-user access, and green communication, with experimental verification demonstrating superior energy efficiency.
Researchers have developed a hybrid integrated C-band high-precision tunable semiconductor laser based on thin-film lithium niobate, achieving a wide tuning range of approximately 51.8 nm and a tuning precision of 0.03 nm while maintaining narrow-linewidth characteristics. The design integrates Sagnac loop reflectors with multiple sets...
Researchers propose a novel thin-film lithium niobate OPA design, achieving simultaneous breakthroughs in narrow beam width and low sidelobes within a compact device footprint. The proposed scheme enables high-performance electro-optic beam steering with optimized non-uniformly spaced arrays and superlattice ridge waveguide structures.
Researchers identify UBR5 as a critical tumor suppressor that modulates Snail's stability, facilitating metastasis. UBR5 maintains epithelial phenotype by targeting Snail for degradation, while its deficiency promotes Snail stabilization and metastatic cascade.
Researchers identify PAK1 as a key player in colorectal cancer progression through its ability to stabilize mRNA of oncogenic factors. Targeting PAK1 inhibits proliferation, migration, and invasion, promoting the degradation of these transcripts and sensitizing tumors to standard-of-care treatments.
Researchers identified USP30-AS1 as a key oncogenic regulator in breast cancer, promoting cell proliferation, cycle progression, and tumor growth. Silencing USP30-AS1 suppresses proliferation, induces apoptosis and senescence, and reduces tumor growth in xenograft models.
Mitochondrial dysfunction acts as a pathogenic hub linking genetic mutations, environmental toxins, and age-related decline. Aging exacerbates these defects, leading to neuronal loss and progressive disease progression. The review highlights therapeutic opportunities targeting mitochondrial quality control and neuroinflammatory signaling.
Researchers discovered potent and selective SARS-CoV-2 PLpro and RIPK1 inhibitors, SHY1643 and QY1892, that demonstrate synergistic effects in reducing viral loads and cytokine release syndromes in mice. These findings establish a proof-of-concept combination therapy strategy for treating severe COVID-19.
Researchers designed macrocyclic TRPC5 inhibitors exhibiting exceptional potency and selectivity, overcoming lipid-binding site challenges. JDIC-127 demonstrated unprecedented potency and specificity, aligning with preclinical evidence supporting its potential in treating neuropsychiatric disorders.
This study reveals that palmitoylation of Tfr1 enhances platelet ferroptosis, leading to liver injury in heat stroke. Inhibiting Tfr1-mediated ferroptosis mitigates thrombocytopenia and improves liver function.
DHL-11, a novel prieurianin-type limonoid isolated from Munronia henryi, targets IMPDH2 to inhibit triple-negative breast cancer cell proliferation and migration. It induces G2/M cell cycle arrest and apoptosis, and increases ROS levels and cellular DNA damage.
This study introduces Chinese medicine and intermittent fasting integration therapy, which synergistically enhances calcium-phosphorus homeostasis regulation and vascular repair, demonstrating significantly greater efficacy than traditional therapies. The miR21-5p/Tpm1 axis mediates the anti-calcification effect, promoting VSMC overpro...
Researchers developed a data-driven classification-generation cascade model to discover new chemotype antitumor drugs. WJ0976 and WJ0909, two tetrahydrocarbazole derivatives, displayed potent broad-spectrum antitumor activity against multidrug-resistant cancer cells.
Researchers developed a self-assembling peptide-based vaccine to create a localized immune niche, demonstrating its remarkable efficacy in inducing durable and potent immunity. The vaccine served as a reservoir for antigens and adjuvants, recruiting antigen-presenting dendritic cells to accumulate within the scaffold.
Developed by Compuscript Ltd, the innovative mRNA-LNP microneedle vaccine induces effective innate immune responses and robust systemic humoral responses in the spleen. It also elicits multifunctional cellular immunity, providing some protection against lung invasion by SARS-CoV-2 pseudovirus.
Acta Pharmaceutica Sinica B Volume 16, Issue 1 publishes original articles on various pharmaceutical sciences topics. The journal covers pharmacology, pharmaceutics, medicinal chemistry, natural products, and more. Recent studies explore the use of neg-entropy as a drug target for chronic diseases and psoriasis treatment.
The new S-PTP MN patch improves psoriasis therapy by facilitating deep drug penetration and sustained release of triamcinolone acetonide. It achieves superior therapeutic efficacy compared to conventional topical treatments, reducing epidermal thickness and inflammatory cytokine levels.
This guideline standardizes therapeutic drug monitoring of biologics in IBD to improve patient outcomes. It addresses five key questions, including the indicators to be monitored and the therapeutic drug trough concentration thresholds.