Researchers found that 57% of tested chemicals altered fruit fly larvae behavior significantly, even at non-lethal doses. Long-term survival was compromised in a dose-dependent manner, with a 60% drop in egg-laying rates observed among exposed mosquitoes and Painted Lady butterflies.
Researchers at EMBL Hamburg and CSSB have uncovered the molecular details of vitamin B1 absorption, revealing critical transporters and barriers that hinder its progress. The study sheds light on rare diseases caused by SLC19A3 mutations and potentially life-threatening hidden deficiencies triggered by certain medications.
Scientists discovered a unique way in which yeast cells adapt to starvation by coating their mitochondria with massive molecular complexes called ribosomes. This adaptation has potential implications for cancer treatment as it may help overcome the challenges faced by cancer cells when they are starved of nutrients.
Researchers discovered that certain bacteria display communal behaviors protecting sensitive species from drugs, allowing them to grow normally in a community. The study found that high drug concentrations cause microbiome communities to collapse and cross-protection strategies are replaced by cross-sensitisation.
Researchers identified key control sites regulating gene expression in cells, including those controlling ancient viral sequences. Mutating these sites caused defects in cell differentiation and survival, as well as spurious activation of genes across the genome.
Researchers have successfully visualized and tracked specific cells in deep brain tissue, including along the corpus callosum's nerve fibre highway. This advancement could potentially lead to better diagnostic tools for glioblastoma, a deadly brain cancer.
Researchers have developed novel photoacoustic probes for neuroscience applications, enabling visualization of neurons in specific brain regions. The probes use a combination of protein and synthetic dye to bind to chemicals and emit sound waves that can be detected by imaging equipment.
A new study from the Cusack group sheds light on how avian influenza virus can mutate to replicate in mammalian cells. The key enzyme polymerase must adapt to overcome two main barriers: entering and replicating within host cells, as well as acquiring human transmission capabilities.
Researchers developed a simple, cost-effective method to study ubiquitination, a critical protein modification process involved in diverse cellular functions. The Ub-POD method quickly labels targets of E3 ligase enzymes directly in human cells, allowing for the identification of new substrates and expanding therapeutic options for dis...
A study by EMBL researchers found that gut bacteria can convert carcinogenic chemicals like BBN into BCPN, leading to tumour formation. The team discovered 12 bacterial species involved in this process, with individual differences in human gut microbiome affecting the risk of cancer development.
Researchers discovered that enzyme METTL6 interacts with tRNA synthetase to recognize specific tRNAs, enabling precise modification and potential application in cancer treatment. This discovery provides new insights into the molecular machinery of protein production.
Scientists have identified a new mechanism by which cells counteract a key cancer-promoting protein using an 'invisible' protein called RAI2. In cancer cell lines and patient samples, RAI2 levels are reduced in more severe and treatment-resistant forms of prostate cancer.
Researchers have found that approximately one in 40 human bone marrow cells carry massive chromosomal alterations without causing any apparent disease or abnormality. Cell samples from people over 60 tend to have higher numbers of cells with such genomic alterations, suggesting a possible connection to ageing-related diseases.
Scientists have discovered that different modes of cell division used by animals and fungi may have evolved to support diverse life cycles. A study using Ichthyosporea as a model found that certain species use closed mitosis while others use open mitosis, shedding light on the evolutionary origins of these processes.
Researchers have developed a modular epigenome editing platform to study the impact of chromatin modifications on transcription. The system allows for precise programming of nine biologically important chromatin marks, enabling the discovery of causal relationships between chromatin marks and gene regulation.
Researchers found that altering a male mouse's gut microbiota increases the probability of low birth weight and premature death in their offspring. The study suggests a 'gut-germline axis' exists, connecting the gut microbiota to the germline and potentially influencing inherited traits.
SpatialData unifies spatial omics data from various technologies, enabling holistic analysis of cellular interactions and tissue function. The framework provides a unified representation and implements ergonomic operations for convenient processing of spatial omics data.
Scientists discovered a shift in gene regulation by enhancers during embryonic development, showing both 'instructive' and 'permissive' modes of regulation. The study found that developmental stage determines which mode is dominant, allowing for rapid gene expression changes and tissue-specific control systems.
Researchers identified a mechanism of 'copy-paste' genetics in Plasmodium falciparum that increases genetic diversity of surface proteins, potentially evading the human immune system. This discovery offers valuable insights for vaccine design and could help inform new approaches to preventing malaria.
A new study reveals that MAGE family proteins bind to RAD18 using a groove, preventing its degradation and contributing to cancer progression. The findings also suggest that blocking this interaction could lead to re-sensitization of cancer cells to chemotherapy and radiotherapy.
Sponges exhibit coordinated movements despite lacking muscles or neurons, attributed to relaxation of stress fibres triggered by an evolutionarily ancient inflammation-like mechanism. This process also regulates human blood vessel contraction, influencing blood pressure.
Scientists in Germany developed a new analytical method to precisely elucidate the size of particles, structure, and RNA molecules in pharmaceutical products. This information can help evaluate product quality, enabling improved development of new products.
The portal brings together genomic data from different biodiversity projects to aid conservation and biodiversity efforts. It allows researchers to understand genetic factors that make a species unique, including its vulnerabilities and strengths in adapting to changing environmental conditions.
A Hamburg collaboration between EMBL Hamburg and TUHH has yielded new insights into a lipid-degrading enzyme from an exotic microbe, which may contribute to the development of more sustainable industrial processes. The findings could help improve chemical processes in various branches of industry.
The Cusack group at EMBL Grenoble has provided insights into the interactions of XIAP and RIPK2 molecules involved in gut signalling pathways. This research sheds light on how these molecules interact, revealing a promising drug target for treating inflammatory bowel diseases.
EMBL researchers have systematically profiled over 10,000 drug combinations for their effectiveness against common multidrug-resistant bacteria. The team identified over a thousand interactions, including both synergies and antagonisms, with distinct effects on Gram-positive and Gram-negative bacteria.
Researchers at EMBL Grenoble have obtained the first structure of p38α being activated by MKK6, opening up new directions for developing drugs to stop cytokine storms. The inflammatory response is triggered by a series of kinases, and inactivating p38α could prevent inflammation from occurring.
A new study sheds light on the molecular mechanisms behind immunotherapy's lack of response in certain types of cancer. Researchers found that intratumoral heterogeneity damps the immune response, leading to diminished effectiveness.
Researchers at EMBL Heidelberg have identified a protein called Snx33 as a critical regulator of the process by which cells arrest their progress upon encountering an obstacle. This allows the cell to slowly dissolve the leading edge and make progress in a different direction.
Researchers at EMBL Heidelberg discovered that mutations in the RBM20 gene cause familial DCM by disrupting normal RNA splicing, leading to detrimental cytoplasmic granules. Targeted gene editing via CRISPR-Cas9 and restoring nuclear localisation of RBM20 could improve therapy options for patients.
A recent study by the Eustermann group at EMBL Heidelberg reveals that DNA packaging into hexasomes impacts the function of enzymes involved in gene regulation. The researchers used cryo-electron microscopy to visualize the molecular processes of how this packaging regulates genome expression and maintenance.
Researchers compared developmental time across six species, including humans and mice, to find that embryonic duration is a key factor. They also discovered correlations between evolutionary history and segmentation clock periods.
Scientists have developed a new microscopy method that allows for non-invasive observation of mechanical properties in developing embryos. The line-scanning Brillouin microscopy (LSBM) technique provides faster imaging, reduced light-induced damage, and simultaneous visualization of biomolecules.
Researchers used long-read sequencing to identify novel mutational patterns and complex genomic rearrangements in cancer genomes, including those associated with liposarcoma. This approach offers a more comprehensive understanding of DNA mutations and their impact on cell function.
Researchers used UK Biobank image and genomic data to uncover insights into rare retinal dystrophies, a leading cause of blindness in working-age adults. The study identified new genetic associations with the thickness of photoreceptor cell layers, offering new avenues for research and diagnosis.
Researchers created a network of interacting proteins to understand the function of genes and link specific biological processes to diseases. They identified groups of proteins interacting with genes linked to over 1,000 human traits, providing insights into new targets for drug discovery and potential repurposing opportunities.
Researchers used unconventional methods to study fruit fly phenotypes, finding that loss of epigenetic mark led to changes in behavior, gene expression, metabolism, and offspring production. This knowledge can aid in predicting ecological patterns of change in wild animal populations.
Researchers at EMBL Grenoble have discovered that THC inhibits the human enzyme autotaxin, which is involved in cancer, inflammation, and pulmonary fibrosis. This finding provides new molecular insights into the therapeutic effects of medical cannabis.
Researchers have developed a new approach to test the efficacy of multiple anticancer drug combinations simultaneously, rapidly, and accurately. Combi-seq overcomes limitations of conventional technologies by using microfluidics to carry out large-scale experiments with small sample volumes.
Researchers observe atomic-level structural changes in bacterial ribosomes and their response to antibiotics, shedding light on mechanisms of action and potential off-target effects. The study provides new insights into the complex interactions between ribosomes and other cellular complexes.
Researchers found that developing sea anemones use hydraulic muscles to regulate body pressure and sculpt tissue. The more active larvae are, the longer they take to develop, suggesting a trade-off between movement and growth.
A team of EMBL researchers used data from over 300 human faecal microbiota transplants to investigate the ecological understanding of what happens when two gut microbiomes clash together. The study found that species richness and how different a recipient's gut microbiome is from a donor's are key factors in determining which microorga...
Researchers have constructed the most complete single-cell map of fruit fly embryo development, enabling a continuous view of molecular changes driving embryonic development. This study provides a significant advance in understanding the complex process of embryogenesis and its relationship to gene regulation.
Scientists identified that retrons encode toxin proteins kept inactive by a small DNA fragment, unleashing them upon viral attacks. The EMBL team discovered how retrons form antitoxins and found natural switches to trigger growth inhibition complexes.
Researchers at EMBL discovered how messenger RNA molecules bind to and regulate the enzyme ENO1, which breaks down glucose. This riboregulation process can determine cell growth and differentiation, with potential implications for understanding cancer.
Researchers at the Kosinski Group used a combination of cryo-electron tomography, single particle cryo-EM, and integrative modelling to create the most complete model of the human NPC to date, covering over 90% of its core. This breakthrough enables scientists to understand the NPC's structure and function in greater detail.
A family of DNA motor proteins, condensin, has been found to create loops of DNA that form chromosomes during cell division. The protein complex achieves this feat by acting as a molecular machine, using energy from ATP to drive the process.
Inversions in the human genome are more common than previously believed, according to a recent study. The researchers found that these genetic variations can lead to genomic instability and an increased risk of certain diseases, including developmental delays and neuropsychiatric disorders.
Researchers from EMBL Barcelona have successfully recreated the formation of human spinal column precursor structures in a laboratory setting. The study reveals that the segmentation clock regulates somitogenesis and that somite size is species-specific.
The study found that a solid state of oskar RNP granules is crucial for localization and function in Drosophila embryos. Genetic engineering resulted in defects when granules were made liquid-like, highlighting the importance of biophysical properties.