A recent study has identified a blood protein called fibrin as the root cause of developmental delays and brain damage in preterm infants. The researchers found that fibrin interferes with a cell-signaling pathway essential for neuron creation, particularly in the cerebellum.
A team of scientists at Gladstone Institutes has developed a new method that enables them to make precise edits in multiple locations within a cell—all at once. They created a tool using molecules called retrons to efficiently modify DNA in bacteria, yeast, and human cells.
Scientists at Gladstone Institutes developed two new tools for single-molecule analysis, slashing the amount of DNA needed by 90 to 95 percent. The SMRT-Tag tool allows researchers to study DNA at single-molecule resolution using as few as 10,000 cells, enabling the analysis of tumor biopsies and other clinically relevant samples.
Scientists at Gladstone Institutes used CRISPR interference to map the layered mechanisms controlling expression of key immune genes. The study provides valuable insights into immune balance, autoimmunity, and cancer immunotherapies, shedding light on genetic variants linked to disease risk and potential treatments.
The study identified over 150 genetic variants linked to disease and showcased the utility of using organoids for brain research. Machine learning was used to predict gene activity, enabling faster and more efficient research.
Researchers at Gladstone Institutes have identified a blood coagulation protein, fibrin, as the culprit behind toxic inflammation and neuron loss after a major head injury. This finding can inform new treatment strategies for traumatic brain injuries, which often lead to dementia, depression, and difficulty concentrating.
The Exploratorium's new exhibit allows visitors to sync their heartbeat with living heart cells, sparking discussion about the heart and health, as well as stem cell science. Visitors reported increased engagement with the exhibit, sharing reactions and experiences with others.
Researchers analyzed immune cells in people with long COVID, finding chronic inflammation and faulty T-cell activity. They also discovered signs of exhaustion and 'tissue-homing' T-cells, suggesting persistent infections may cause the condition.
A team of scientists used CRISPR to identify genes responsible for energy production and ROS production in mitochondria. Their findings offer a starting point for developing therapies that independently control mitochondrial energy and ROS levels, potentially treating neurodegenerative diseases like Parkinson's and Alzheimer's.
Gladstone scientists have created an intricate map of how the immune system functions, examining the detailed molecular structures governing human T cells. This study will accelerate the development of new and better therapies for cancer and autoimmune diseases.
A new study from Gladstone Institutes has greatly expanded the scientific body of knowledge about how the body responds to too much oxygen. The research highlights a particular protein, MYBBP1A, that may play a central role in regulating cells' response to hyperoxia.
Researchers at Gladstone Institutes have identified cells and molecules that go awry in the developing hearts of fetuses in women with diabetes, leading to higher levels of retinoic acid activity. The study could eventually lead to interventions to lower heart malformations risk in babies born to women with diabetes.
Researchers at Gladstone Institutes used CRISPR to destroy glioblastoma cells in an approach that could be applied to other highly mutated cancers. The technique, dubbed "cancer shredding," targets and rapidly eliminates tumor cells while sparing healthy ones.
Deepak Srivastava, president of Gladstone Institutes, has made significant original and sustained scientific contributions advancing cardiovascular science. His laboratory has deciphered new ways to generate cardiac cells that repair heart damage, translating into novel approaches for treating disease.
Researchers discovered that the Christchurch mutation blocks the detrimental effects of apolipoprotein E4 on Alzheimer's disease by reducing tau protein accumulation and neuroinflammation. This genetic variant may offer novel therapeutic interventions to mimic its protective effects.
Researchers at Gladstone Institutes found that ApoE4-producing neurons release HMGB1, triggering microglial activation and neurodegeneration. Blocking HMGB1 with experimental drugs offers strong protection against APOE4-driven neurodegeneration.
Researchers developed a technology to rapidly screen genetic edits in immune cells, identifying a new combination that improves their effectiveness against cancers. By combining multiple genes into long DNA stretches and testing thousands of combinations, scientists discovered that different CARs can be optimized by different factors.
Researchers at Gladstone Institutes identified conditions that enable gamma delta T cells to recognize cancer cells by disrupting energy production and causing cellular stress. This insight suggests that therapies manipulating butyrophilin abundance on the surface of cancer cells could boost gamma delta T cell effectiveness.
Researchers at Gladstone Institutes create Gaussian Process Spatial Alignment (GPSA) to analyze 2D data from tissue slices and generate a 3D 'atlas' of the tissue. This allows for deeper understanding of biological tissue samples, enabling more precise predictions of gene expression and treatment outcomes.
A study by Gladstone Institutes researchers found that tight junctions between cells may play a critical role in gastrulation in human embryos. By suppressing tight junction formation, the team was able to create primordial germ cell-like cells, which are stem cells resembling human precursors of sperm and egg cells.
Researchers at Gladstone Institutes discovered that blood leaking into the brain triggers toxic genes in microglia, turning them into harmful cells that destroy neurons. Fibrin, a blood protein, is responsible for this process, which can lead to cognitive dysfunction and motor impairment.
Researchers developed an AI system, Geneformer, to predict how disruptions in human gene connections cause disease. The model, trained on data from thousands of genes, can identify potential drug targets for diseases like heart disease and cancer.
Large structural changes in human ancestors' genomes may have sparked smaller changes that set human brains apart from other primates. Researchers found that many enhancers, which regulate brain development, are located near these regions, suggesting a link between DNA folding and brain evolution.
Researchers at Gladstone Institutes have made a groundbreaking discovery about how neurons consume and metabolize glucose, a process crucial for maintaining normal energy levels. The study found that neurons rely on glycolysis to break down glucose, and its disruption can lead to severe learning and memory problems in mice.
Scientists at Gladstone Institutes have discovered how excess oxygen changes proteins in our cells, triggering a cascade of events that damage cells and tissues. The findings have implications for conditions such as heart attacks and sleep apnea, revealing that hyperoxia is not solely caused by reactive oxygen species.
Researchers at Gladstone Institutes discovered that chronically low oxygen levels, similar to those experienced at high elevation, rewire how mice burn sugars and fats. The study found lasting changes in metabolism, including lower blood glucose levels and body weight, which mirror what has been seen in humans who live at high altitude.
Researchers at Gladstone Institutes found that ApoE4 from neurons plays a critical role in Alzheimer's disease, contrary to previous focus on glial cells. The study shows that deleting ApoE4 from neurons reduces brain changes resembling Alzheimer's disease, offering new possibilities for treatment.
Researchers found that many changes to human DNA had opposing effects, with some variants making enhancers stronger while others made them weaker. This discovery has implications for understanding human evolution and the potential link between human DNA variations and psychiatric diseases.
Researchers developed a novel, single-dose, intranasal treatment that reduces symptoms and viral shedding of multiple SARS-CoV-2 variants. The therapeutic interfering particle (TIP) treatment effectively blocks COVID-19 transmission in animal models.
Researchers at Gladstone Institutes and UCSF have developed a new approach to introduce long DNA sequences into cells with remarkable efficiency. The technology, which uses single-stranded DNA templates, overcomes the limitations of traditional viral vectors and has the potential to make cell therapies faster, better, and less expensive.
Researchers at Gladstone Institutes developed a tool called Retro-Cascorder, which logs a cell's genetic activity for days at a time. This allows scientists to create living biosensors that can record changes to their environment.
Researchers used virus-like particles to identify mutations in Omicron that make it more infectious and escape antibodies. The study found that mutations in the nucleocapsid protein are crucial for enhancing spread, highlighting potential new vaccine targets.
Gladstone researchers discovered that BET proteins play two distinct roles in interacting with SARS-CoV-2 infected human cells: giving the virus a window into cells while helping our cells defend themselves. Blocking certain BET proteins worsens disease symptoms, highlighting the need for targeted therapeutics.
Researchers created a detailed map of how immune genes function together, shedding light on the basic drivers of immune cell function and immune diseases. The study found interconnected regulatory networks that can help explain why mutations in different genes lead to the same disease or how drugs impact multiple immune proteins.
Astrocytes in the thalamus play a key role in susceptibility to seizures after brain injuries. Targeting a specific protein, GAT3, in these cells may prevent long-term damage.
Researchers found that HIV prefers to infect memory CD4 T cells with large amounts of specific sugars, including fucose and sialic acid. The study also reveals that HIV boosts the production of these sugars in infected cells, highlighting a new target for potential treatments.
Researchers at Gladstone Institutes and Stanford University identified key genes linked to T cell exhaustion. They discovered how to block these genes, resulting in healthier T cells and smaller tumors in mice with cancer. This breakthrough may lead to improved immune-based treatments for cancer patients.
Izpisua Belmonte's work on cellular rejuvenation programming has the promise to improve aging and age-associated diseases, with potential therapies for new treatments. He was recognized for his innovations leading to discoveries that can reset a cell's aging clock, allowing organs to regenerate.
A new study by Gladstone Institutes and UC San Francisco found that infection with the Omicron variant provides weak immune response in unvaccinated individuals, failing to confer broad protection against other variants. In contrast, vaccinated individuals show stronger immunity against multiple COVID-19 strains.
Researchers at Gladstone Institutes have developed a novel class of therapeutics called feedback disruptors that target viral proteins' negative feedback loops. These drugs break the genetic feedback circuits, causing infected cells to self-destruct and stopping infection in its tracks.
Scientists at Gladstone Institutes have discovered that reducing protein tau levels soon after birth can prevent autism and epilepsy in an experimental model. The study pinpointed the crucial brain cells where tau levels must be reduced to avoid these problems, and showed that lowering tau is still effective when initiated after birth.
Researchers at Gladstone Institutes and UC San Francisco have developed a comprehensive rule book for designing therapeutic cells with improved specificity and safety. The new receptor system, dubbed SNIPRs, is small enough for cost-effective engineering into human cells and can detect and respond to even small amounts of its target. T...
Researchers at Gladstone Institutes create mini-livers on a chip to study the immune system's response to hepatitis C infection. The platform enables precise control over cellular interactions, allowing for detailed insights into how the liver interacts with the virus and T cells.
Researchers discovered that obesity changes molecular underpinnings of allergic inflammation in both mice and humans. The treatment in obese mice makes their skin worse instead of healing, but a specific drug can 'de-fatten' obese mice without changing body weight.
Researchers at Gladstone Institutes have developed a novel method for identifying genetic variants that are likely to play important roles in congenital heart disease. The study leverages interactions between proteins to pinpoint candidate genes, including GLYR1, which is involved in turning other genes on and off.
Researchers at Gladstone Institutes and UC San Francisco have developed a CRISPR activation method that allows them to activate genes in human immune cells, revealing key regulators of cytokine production. This breakthrough accelerates immunotherapy research and may lead to more powerful cancer treatments.
A recent study by Gladstone Institutes researchers found that mouse stem cells can spontaneously transition from heart cell precursors to brain cell precursors when a specific gene is removed. This discovery upends current understanding of how stem cells differentiate into adult cells and maintain their identity. The study's findings h...
Gladstone Institutes researchers have pioneered a new method to edit genes in human cells using retrons, which can produce abundant copies of template DNA from inside cells. The optimized system has shown improved efficiency and precision compared to current approaches.
Researchers have made significant breakthroughs in understanding the human gut microbiome by focusing on bacterial strains rather than species. By using a new computational method, scientists can analyze the strains of bacteria present in a microbiome sample more quickly and affordably.
Scientists at Gladstone Institutes developed a new class of antiviral therapy that can track the evolution of SARS-CoV-2, reducing the chance of reduced efficacy against new variants. The single-dose intranasal treatment showed significant reduction in viral load and prevented disease in animals.