Researchers developed a new technology that tracks thousands of cells and determines the precise moment of death for any cell in the group. The approach was shown to work in rodent and human cells as well as within live zebrafish, and can be used to follow cells over weeks to months.
Researchers developed a new kind of organoid that grows both heart and gut cells together, mirroring their cooperation in embryonic development. This breakthrough could improve understanding of tissue communication and inform research into congenital disorders.
Scientists at Gladstone Institutes discovered that non-convulsive epileptic activity drives chronic brain inflammation in Alzheimer's models, which can be reversed by eliminating protein tau or using the anti-epileptic drug levetiracetam. This link between brain networks and immune cells may hold promising treatments for Alzheimer's di...
Researchers at Gladstone Institutes found that reducing tau levels impacts both excitatory and inhibitory cells, leading to a reduction in excitation-inhibition ratios. This effect counteracts diseases that cause abnormal increases in this ratio, potentially improving the brain's ability to perform its functions.
Researchers discovered that bumetanide, a 30-year-old diuretic, reverses signs of Alzheimer's disease in mice and human brain cells. The study also found that people over 65 who took bumetanide were less likely to develop Alzheimer's disease.
Researchers found that both Pfizer and Moderna vaccines generate long-term populations of T cells that can recognize multiple variants of the SARS-CoV-2 virus. However, individuals with a prior COVID-19 infection showed improved T cell responses in the respiratory tract, suggesting better protection against breakthrough infections.
Two Gladstone scientists, Leor Weinberger and Vijay Ramani, received NIH Director's Awards to fund groundbreaking research on a single-administration antiviral for COVID-19 and a molecular strategy to fight cancer. Their work has implications for treating various diseases, including cancers.
A new study published in Science identifies a specific molecule, C1q, that plays a key role in the long-term effects of traumatic brain injury. The researchers found that an antibody treatment could prevent the development of negative outcomes such as sleep disruption and inflammation.
A new study suggests that existing drugs for multiple sclerosis may not be effective due to toxic blood leaks in the brain. Researchers have identified a promising alternative treatment option that could improve myelin repair, even in the presence of these harmful elements.
A new strategy for curing HIV targets latent viruses by blocking and excising the virus, offering hope for patients to be taken off daily treatments. The HOPE Collaboratory's approach uses genome editing technology to destroy latent HIV.
Scientists discovered a new mitochondrial recycling pathway that may help prevent Parkinson's disease. The study, published in Science Advances, reveals that genes associated with Parkinson's disease play key roles in this process and that disruptions can contribute to neurodegeneration.
Gladstone researchers have discovered a molecular mechanism that boosts the 'noise' of gene expression in stem cells, accelerating their ability to differentiate into other cell types. The DiThR pathway involves a DNA repair process that increases noise across the genome, making cells more responsive to signals guiding their fate.
Researchers discovered fundamental differences in T-cell responses between patients who recover from and die from severe COVID-19. They found that dying patients harbor more lung-homing T cells, which contribute to extensive lung deterioration, while survivors have a growing number of Th1 T cells, important fighters of viral infection.
Researchers at Gladstone Institutes have discovered a master switch for fibrosis in the heart, which they believe could be used to treat and prevent heart failure. The study suggests that blocking this gene, MEOX1, could prevent fibrosis in other organs as well.
Researchers at Gladstone Institutes develop a three-dimensional human spinal cord organoid that mimics the earliest developmental steps of the nervous system in embryos. The organoid demonstrates how human spinal cord cells become oriented in an embryo, shedding light on potential impact of environmental exposures and toxins.
Researchers analyzed COVID-19 swab samples from California counties and found the new variant was more transmissible, infecting people who already had COVID-19. Vaccines showed higher neutralization rates against the variant than antibodies from previously infected patients.
Scientists at Gladstone Institutes create an artificial intelligence system that can follow hundreds of cells in a petri dish, revealing key findings on cell behavior and leadership patterns. The AI approach provides a comprehensive view of how cells cooperate and form complex organs, with potential applications for therapeutic purposes.
Researchers at Gladstone Institutes have adapted CRISPR-Cas9 technology to edit human monocytes, a type of white blood cell that plays key roles in the immune system. The study shows the potential utility of gene editing for understanding how the human immune system fights viruses and microbes.
Scientists identify apoE protein's role in regulating immune-response molecules within neurons, leading to selective neurodegeneration. High levels of apoE trigger the expression of MHC-I genes, marking neurons for destruction and contributing to Alzheimer's disease progression.
Gladstone researchers have identified specific subsets of CD4+ T cells that are most susceptible to HIV infection. The team used a technology called CyTOF/PP-SLIDE to classify these cells and found that remodeling caused infected blood cells to alter their surface, potentially helping the virus infect more cells.
A new method called XYZeq allows researchers to map variation across cells in a tissue or tumor, gaining insight into their spatial location and function. The technique enables the analysis of cellular patterns in complex environments like cancerous tumors and other organs.
Researchers successfully generate synthetic mouse embryos containing the three fundamental cell types normally found in pre-implantation embryos. The study provides strong evidence that the system is a good model for studying early embryo development, shedding light on the mechanisms of totipotency and the causes of early pregnancy loss.
Researchers found that a blood-clotting protein called fibrinogen promotes the clustering of cancerous B cells at sites where there is a leak in the blood-brain barrier, leading to tumor growth in the brain. Fibrinogen may be targeted as a potential treatment for central nervous system B-cell lymphoma.
Researchers at Gladstone Institutes and UCSF have discovered a complex network of genes and proteins that go awry in a subset of congenital heart diseases. The study sheds light on how genetic mutations contribute to the disease, offering new insights into potential prevention or treatment strategies.
Researchers found that microglial surveillance helps maintain normal neuronal activity levels by preventing overactive neurons. This discovery opens new avenues for treating neurological disorders such as Alzheimer's disease, epilepsy, and autism.
Researchers at Gladstone Institutes have identified a potential therapy for calcific aortic valve disease, which affects millions of Americans. The new drug candidate has shown promise in correcting the underlying network that leads to calcification and hardening of the valves.
Researchers at Gladstone Institutes and UCSF develop large-scale genetic approach to map protein complex structures in live cells. This breakthrough enables the collection of reliable and detailed structural data reflecting how proteins work in their normal environment.
A team of researchers identified critical molecular processes in human cells that coronaviruses use to survive. Targeting these processes with drugs may treat not only COVID-19 infections but also other existing and future coronaviruses, including common cold viruses and more severe viruses.
A new CRISPR-based test for COVID-19 can provide accurate results in under 30 minutes using a smartphone camera, enabling faster and more accessible testing. The test measures viral load, helping healthcare professionals estimate the stage of infection and predict recovery.
The NIH has awarded a 4D Nucleome grant to Gladstone researchers Benoit Bruneau and Katie Pollard to investigate DNA folding in the developing heart. They aim to identify genetic causes of congenital heart disease, which affects one in 100 live births worldwide.
Seth Shipman, a Gladstone Institutes investigator, has received the NIH Director's New Innovator Award to develop innovative technologies to edit mitochondrial DNA. His research could lead to new treatments for diseases caused by mitochondrial DNA mutations.
Researchers at Gladstone Institutes are studying how cells regulate their energy levels and exploring ways to target energy regulation processes to treat diseases such as neurodegeneration and heart failure.
Researchers at Gladstone Institutes have mapped the genetic networks that control regulatory T cells, which act as a brake to suppress immune reactions. The findings could lead to therapies that strengthen or weaken the function of these cells to treat cancer and autoimmune diseases.
Researchers have mapped out an atlas of the latent virus reservoir cells of eight individuals living with HIV, challenging previous assumptions about its makeup. The study used a new approach to backtrack reactivated reservoir cells to their original latent state, revealing distinct areas and shared markers across different tissue types.
Scientists at Gladstone Institutes have performed a massive cellular energy audit to understand how cells regulate ATP levels. They identified genes and proteins that can be targeted to manipulate cellular energy and treat disease, including neurodegenerative disorders and cancer. The study reveals new pathways for boosting cellular en...
Researchers identified a strong and specific T cell response in COVID-19 patients who recovered from mild cases, suggesting a long-lived immunity. The study found that these patients' CD4+ T cells belonged to the Th1 category, which effectively fights viruses and stimulates antibody production.
Researchers discover that cytomegalovirus enters a dormant state by varying protein levels in viral particles, allowing the virus to survive and persist for life. This 'bet-hedging' strategy enables the virus to balance between infectiousness and latency.
Researchers at Gladstone Institutes and UCSF have developed a comprehensive region-specific atlas of regulatory regions linked to human embryonic brain development. The study identified 19,000 potential genetic variants critical to brain development, providing a valuable tool for probing underlying biology of neurodevelopmental disorders.
Researchers have identified a new potential reservoir of latent HIV, specifically CD127 cells in tissues, which harbor the virus's genetic material but silence its expression. These cells may be targeted for an HIV cure, offering hope for developing an effective treatment.
Scientists have created a comprehensive atlas of toxic immune cells that damage the brain, revealing a potential new drug target for multiple sclerosis and possibly other neurodegenerative diseases. The 'atlas' was generated using a novel method called Tox-seq, which links gene expression to function in single cells.
Researchers at the Gladstone Institutes report that reducing levels of tau protein prevents core autism symptoms, seizures, and other abnormalities in mouse models. The findings suggest promise as a potential treatment for some forms of autism.
Researchers at Gladstone Institutes have discovered new human genes controlling HIV infection, which could lead to the development of new therapies. The study used a large-scale genetic approach to uncover host proteins that facilitate infection and identify key genes involved in the process.
Researchers have developed a new small molecule that potentiates synaptic NMDA receptors, restoring brain rhythms to normal patterns and improving memory in mouse models of Alzheimer's disease and Dravet syndrome. The treatment also reduced abnormal brain activity associated with these conditions.
Scientists at Gladstone Institutes used a machine-learning approach to discover new ways of controlling the spatial organization of induced pluripotent stem cells. The model predicted patterns that could lead to the creation of functional organs for research or therapeutic purposes, and was found to be correct in simulating desired arr...
A new study by Gladstone Institutes reveals that specific patterns of brain activity can predict Alzheimer's symptoms in young mice. By analyzing sharp-wave ripples and short gamma power, researchers found that deficits in these activities at an early age can predict memory problems decades later.
Researchers at Gladstone Institutes and Xyphos Biosciences have developed convertibleCAR, a cell-based immunotherapy that reduces the latent HIV reservoir in infected patients on anti-retroviral therapy. The technology combines cytotoxic T cells with antibodies, offering a flexible approach to fighting the virus.
The study provides insight into how the Komodo dragon's DNA encodes its astounding characteristics, including its ability to detect prey from far away. The team discovered changes in genes that increase the lizard's aerobic capacity, allowing it to achieve near-mammalian metabolism.
A new study published in Nature reveals the full spectrum of cells involved in congenital heart defect formation, identifying key cell types and their functions. The research uses single-cell RNA sequencing to uncover the molecular drivers of different cell types, shedding light on genetic mutations and disease mechanisms.
A research study has identified a deadly human heart disease caused by the combination of three subtle genetic variants inherited within a family. The study uses CRISPR genome editing and human pluripotent stem cell technology to prove that the interaction between these genes leads to severe heart defects in multiple siblings.
Researchers at Gladstone Institutes reveal acetylation and phosphorylation tag-team to guide RNA polymerase through transcription steps. This regulation enables cells to efficiently coordinate gene expression and respond to external stimuli.