A recent study by Gladstone researchers reveals that specific stretches of DNA, called human accelerated regions (HARs), control the development of uniquely human characteristics. HARs were found to be crucial in human ancestors becoming distinct from our closest primate relatives.
Researchers at the Gladstone Institutes have identified a unique change in protein structure that guides the production of RNA from DNA. The study sheds light on key aspects of transcription, including polymerase pausing and acetylation, which are crucial for precise transcription and cellular processes.
Researchers at Gladstone Institutes have discovered molecular signals that activate latent HIV, offering a potential strategy to purge viral infections and develop a cure. The study suggests using calcineurin, prostratin, and NF-κB proteins to activate the dormant virus.
Researchers at Gladstone Institutes and UCSF uncovered a molecular process causing neurons to degenerate, a hallmark of conditions like Alzheimer's disease and frontotemporal dementia. The study used human stem cells with genetic mutations, allowing for the comparison of diseased and healthy neurons.
Researchers at Gladstone Institutes develop method to reprogram human fibroblasts into beating heart cells using a cocktail of five genes. The transformation has the potential to regenerate damaged heart muscle and could revolutionize treatment for heart attacks.
Researchers developed a technique called pE-MAP to map thousands of interactions between an enzyme's molecular components, allowing them to predict its behavior. The study reveals patterns that can help understand how mutations in enzymes like RNAPII lead to specific disease states.
Researchers at Gladstone Institutes discover that individual neurons' ability to flush out toxic proteins, not the buildup itself, contributes to Huntington's disease progression. A newly developed technology allowed them to see how different types of neurons respond to mutant huntingtin protein over time.
Researchers at Gladstone Institutes have identified the molecular signals that direct blood vessel formation, revealing a precise order and timing of signals that spur artery formation. The study uncovers the role of Vegf and Dll4 in this process, shedding light on a so-called 'black box' of embryonic development.
Scientists at the Gladstone Institutes and Salk Institute have developed a novel brain-tracing technique to map neurons in the basal ganglia, revealing clues about how specific brain regions connect. The findings suggest that different brain areas preferentially transmit signals to distinct types of neurons, guiding movement and decisi...
Researchers at Gladstone Institutes discovered how one protein regulates fundamental circadian processes and maintains metabolic health, shedding light on the molecular basis for metabolic health and disease. The study found that p75NTR production oscillates in time with the body's natural circadian clock.
Gladstone scientists have mapped the process by which brain cells form long-term memories, revealing how an important protein called Arc regulates neuron activity. The discovery provides new insight into the molecular mechanisms underlying memory formation and may shed light on neurological diseases such as Alzheimer's and autism.
Researchers at Gladstone Institutes found that a certain type of DNA damage can occur during normal brain functions such as learning. The team identified two therapeutic strategies that reduce disruptions to this process, which is associated with Alzheimer's disease.
Researchers at Gladstone Institutes mapped CMV's molecular mechanism to understand its successful infection. The 'accelerator circuit' helps maintain optimal levels of toxic IE2 protein.
Researchers identify β-hydroxybutyrate as a key compound in protecting cells from oxidative stress, potentially slowing aging and age-related diseases. The discovery reveals a new avenue for treating or preventing conditions like Alzheimer's disease, Parkinson's, autism, and traumatic brain injury.
Gladstone researchers propose targeting ApoE4 as a new strategy for treating Alzheimer's disease. They suggest that drugs can correct the shape of the ApoE4 protein, slowing or stopping its progression.
Researchers at Gladstone Institutes have identified a key underlying process implicated in MS, offering new hope for therapies to treat the disease. The discovery reveals that a protein called fibrinogen sets off an immune response in the brain, leading to nerve cell damage and debilitating symptoms.
Researchers at Gladstone and Stanford Institutes develop new tactic for treating neurodegenerative conditions like ALS by hijacking gene Dbr1 to reduce toxic TDP-43 levels. This breakthrough could have far-reaching implications for treating devastating diseases.
Researchers at Gladstone Institutes discover how a protein deficiency contributes to neurodegenerative disease frontotemporal dementia (FTD). Progranulin prevents microglia from becoming hyperactive, leading to inflammation that destroys neurons and causes debilitating symptoms.
Researchers have discovered that genes 'burst' on and off at precise frequencies, regulating protein synthesis. This finding has implications for understanding cancer, drug resistance, and other diseases.
Researchers at Gladstone Institutes have mapped the precise order and timing of hundreds of genetic switches required for heart development, offering new clues into the genetic basis for congenital heart disease. The study identifies groups of genes that work together in a coordinated fashion to control heart formation.
A recent study published in Science Translational Medicine has reaffirmed the effectiveness of Truvada in preventing HIV transmission, finding that patients can reap benefits even with lower adherence to daily regimens. The research suggests that alternative dosing strategies could be explored to optimize efficacy and convenience.
Scientists at Gladstone Institutes have developed a method to precisely track the life cycle of individual cells infected with HIV, targeting 'HIV latency'. This breakthrough could help advance the discovery of a cure for AIDS by understanding and interrupting the dormant virus.
Researchers at Gladstone Institutes found that levetiracetam, an FDA-approved anti-epileptic drug, reverses memory loss and alleviates other Alzheimer's-related impairments in mice genetically modified to simulate key aspects of the disease. The study shows how levetiracetam suppresses abnormal brain activity and restores memory function.
Dr. Warner C. Greene and global AIDS experts release a locally affordable version of the world's leading AIDS medical textbook, designed specifically for resource-poor regions. The textbook features up-to-date clinical information on HIV/AIDS, including managing and treating the disease in resource-poor settings.
Researchers identified a protein called LIF as crucial for the growth of female iPS cells, which contain two copies of the X-chromosome. This discovery offers new insights into how iPS cells form and could lead to improved human models for studying disease and testing new drugs.
Researchers at Gladstone Institutes have generated a human model of Huntington's disease from patient skin cells, providing a more accurate and faithful replication of the disease. This new model will help scientists better understand the development of Huntington's and identify potential therapeutic approaches.
A team of scientists from the Gladstone Institutes has contributed to a groundbreaking study that mapped the human microbiome, revealing over 10,000 microorganisms that live on and inside humans. The researchers used advanced DNA-sequencing techniques to identify individual microbes and their roles in human health.
Researchers at Gladstone Institutes successfully transformed skin cells into brain cells using Sox2 gene, potentially leading to better models for testing drugs for devastating neurodegenerative conditions. The breakthrough could accelerate drug development and reduce risks associated with human trials.
Researchers at Gladstone Institutes have discovered a specific brain circuitry associated with addictive and depressive behaviors. The study found that an imbalance in medium spiny neurons controlling movement also contributes to psychiatric disorders.
Researchers found that low Nav1.1 levels disrupt brain cell electrical activity, leading to memory problems and cognitive decline. Restoring Nav1.1 levels improves learning, memory functions, and lifespan in AD-mice.
Gladstone scientists have made a groundbreaking medical breakthrough in mice, transforming scar-forming cardiac cells into beating heart muscle. The research may have broad human-health implications and could provide an innovative alternative to heart transplants.
Scientists at Gladstone Institutes discover apoE protein plays distinct roles in young and aging brains, suggesting new research avenues for treating Alzheimer's. Increased ApoE levels can damage brains later in life, challenging current thinking.
Researchers at Gladstone Institutes discover p75NTR's role in controlling glucose metabolism, finding that blocking this receptor enhances insulin's effectiveness. This breakthrough may lead to new therapies for Type 2 diabetes, a global health problem affecting over 20 million Americans.
Researchers at Gladstone Institutes discovered a protein called RGS4 that contributes to Parkinson's disease symptoms by disrupting brain circuits. Removing RGS4 can prevent these symptoms, offering a potential alternative to existing treatments like Levodopa.
Researchers at the Gladstone Institutes have identified a key genetic mechanism linked to congenital heart disease, revealing the importance of epigenetics in fetal heart development. The study highlights the role of Ezh2 and Six1 genes in regulating healthy heart development, which can have profound health consequences later in life.
Gladstone and UCSF scientists have discovered how HIV commandeers human proteins to weaken the body's defenses and enhance virulence. The study identifies a key interaction between HIV protein Vif and the human protein CBFß, which enables the virus to infect CD4 T cells.
Scientists at Gladstone Institutes have discovered protein fragments in semen that enhance HIV's ability to infect new cells. Removing these components from semen diminishes HIV's infection potential, suggesting a new approach to preventing transmission.
Researchers at Gladstone Institutes have identified a protein called p75NTR that kick-starts the response to low levels of oxygen in cells. This discovery may lead to new therapies for conditions such as heart disease, stroke and certain types of cancer by modifying blood vessel production.
Researchers at Gladstone Institutes discovered a protein form linked to Huntington's disease that influences symptom timing and severity. The study offers new avenues for treating not only Huntington's but also similar conditions like Alzheimer's and type 1 diabetes.
Scientists at Gladstone Institutes have identified CCT enzyme as a key regulator in fat storage. The research suggests new directions for treating excess fat storage and obesity. By understanding how the body stores fat safely, researchers can explore new treatments for conditions like heart disease and type 2 diabetes.
Researchers at Gladstone Institutes have discovered how dopamine levels affect brain cells involved in movement control, offering new hope for treating Parkinson's disease. A study found that a lack of dopamine alters the interaction between two groups of brain cells, leading to difficulties controlling movement.
A breakthrough discovery identifies a key gene, SIRT3, that exacerbates the development of metabolic syndrome, a condition linked to obesity, high blood pressure, and insulin resistance. The study suggests that increasing SIRT3 activity could help alleviate symptoms and develop new treatments for this growing health concern.
Scientists at Gladstone Institutes have gained new insight into the delicate relationship between two proteins that regulate stem cells in the heart and may contribute to certain types of cancer. The study reveals an unexpected cross-talk between Notch and Beta-Catenin, which together control cell growth and fetal development.
A Gladstone scientist has discovered a genetic factor that regulates heartbeat synchronization, potentially advancing medicine and human health. The study found that abnormalities in this regulation lead to heart arrhythmias, which can be fatal, and may offer new avenues for drug therapy to target these pathways.
A scientist at the Gladstone Institutes has discovered a way to convert human skin cells into brain cells, offering new hope for regenerative medicine and personalized drug discovery. The breakthrough discovery allows for efficient and robust methods to transform adult skin cells into neurons capable of transmitting brain signals.
The Gladstone Institutes have announced a Center for Comprehensive Alzheimer's Disease Research, which aims to develop therapies for Alzheimer's. The center will focus on identifying drug targets and candidates, leveraging collaborations with other institutions and companies.
The Gladstone Institutes will explore the molecular basis of HIV latency and develop inhibitors against cellular proteins to potentially cure HIV-infected patients. The funding is part of the National Institute of Allergy and Infectious Diseases' Martin Delaney Collaboratory initiative.
Researchers have identified a compound called JM6 that diminishes the effects of both diseases in animal models, preventing memory deficits and loss of synaptic connections. The compound works by inhibiting an enzyme linked to neurodegenerative diseases, suggesting a potential therapeutic breakthrough.
A Gladstone scientist has made two significant stem-cell discoveries, creating powerful new approaches for using stem cells and stem-cell-like technology. Dr. Sheng Ding reveals novel and safer methods for transforming embryonic stem cells into large numbers of brain cells and adult skin cells into neural stem cells.
Researchers identified networks of genes crucial for healthy heart formation, shedding light on congenital heart disease. MicroRNAs regulate gene expression and dosage, and the study provides insights into the genetic mechanisms underlying fetal-heart development.