Researchers developed a water-soluble phosphorescent carbon nanodot ink for high-resolution invisible printing, achieving resolutions of up to 2480×3508 dpi. The ink can accurately reproduce complex text patterns on various substrates with an accuracy of over 98.7%.
Researchers engineered human-derived transcriptional activators that surpass viral benchmarks like VPR, offering compact and efficient CRISPR tools for precise gene activation. Combinations of hTADs showed improved efficacy and reduced immunogenicity risk.
Researchers identified and characterized the RibD-enolase complex in Francisella novicida, revealing key interactions and catalytic activities. The study provides the first structural and biochemical characterization of the complex, establishing a foundation for further investigations into its functional significance.
Researchers have developed a transgene-free approach to construct mouse post-implantation embryo models, utilizing extended pluripotent stem cells. These models recapitulate key features of post-implantation development, including gastrulation and extraembryonic tissue formation.
A comprehensive single-cell atlas of endocrine aging was established, revealing both shared and organ-specific aging mechanisms. The study suggests that immune-endocrine interactions are a key node for potential interventions, and future studies may uncover the role of aged endocrine organs in systemic aging.
Research reveals that miR-378 acts as a metabolic-state-dependent switch controlling liver autophagy and lipid balance. Under short-term fasting, miR-378 promotes lipid clearance by suppressing its target gene MAFG, while during prolonged fasting or high-fat feeding, it increases bile acid synthesis leading to fat accumulation.
Researchers developed a fully coupled optical, electrical and thermal-fluid model for a parabolic-trough CPV-T collector with spectral-splitting liquid filters. The design achieved high-performance solar thermal energy generation, reaching maximum thermal efficiency of 45% and electrical efficiency of 15%.
Researchers developed a metal phthalocyanine compound to modify the magnesium metal surface, reducing charge transfer barriers and promoting uniform ion transport. This work provides new insights into interface design for other metal-based batteries.
A new modeling framework elucidates how antigen heterogeneity, immune selection, and chemotherapy jointly determine tumor evolution and therapeutic outcomes. Chemotherapy reduces antigen heterogeneity, improving the immune microenvironment and enhancing overall treatment efficacy.
This review analyzes multi-physics phenomena in metal additive manufacturing, leveraging machine learning to optimize quality attributes like defect suppression and geometric fidelity. Machine learning-driven real-time closed-loop control is also explored for full-process regulation.
The proposed 'observation-cognition-interpretation' pipeline matches or surpasses deep baselines with minimal samples per learner, providing actionable feedback and laying groundwork for open-ended problems and multimodal coursework. Expert raters deem its explanations substantially credible.
Researchers identified key dopants to improve structural stability and ion transport in Na2FeSiO4, a promising cathode material for sodium-ion batteries. The study's findings provide a roadmap for developing high-performance, low-cost sodium-ion batteries that can compete with lithium-ion technology.
This article proposes a comprehensive framework for preparing students for an AI-driven world through tiered courses, active learning, and dynamic curriculum update mechanisms. The study emphasizes institutions' need to adopt proactive measures to harness GenAI's potential for equitable education.
The UK's digital education policy has shifted from basic initiatives to AI-focused education, emphasizing integration, personalized learning, and digital literacy. The study highlights key trends, including comprehensive technology integration and bridging the digital divide.
Scientists develop AMOUR method for accurate profiling of surface RNAs and Intact-Surface-FISH for visualization and quantification of representative surface RNAs. The study reveals a rich repertoire of noncoding RNAs on human and murine blood cells, with potential contributions to autoimmunity.
Researchers are utilizing metal-organic frameworks to deliver targeted therapies with improved efficiency and precision. These 'smart' cargo systems can be designed to open up and release drugs in response to specific disease triggers.
The system integrates fine-tuned LLMs and advanced computer vision/audio synthesis to create personalized digital instructors. It improves student engagement and learning outcomes, outperforming traditional methods.
Research reveals that stunting rates among children in Tanzania's BBRs are significantly higher than non-BBRs. Despite increased food production, there is no significant improvement in child growth status, suggesting a correlation between agricultural commercialization and monotonous diets.
This study refines the external influencing factors of technology, organization, and environment on BIM adoption using the TOE framework. The findings highlight key factors such as technical compatibility, organizational culture, and mimetic pressure in promoting BIM adoption.
This study identified key challenges in government-led food supply chains during the pandemic, including transportation disruptions and production-demand mismatches. Effective recovery strategies include enhancing transportation capacity, establishing new district warehouses, and increasing production capacity.
This study aims to visualize blockchain-based data management processes in construction projects to gain trust in the system. The research identifies current patterns and challenges of DMP visualization on blockchain systems and develops guidelines for visualizing these processes according to construction project needs.
The proposed approach leverages AI to create intelligent, personalized learning platforms that facilitate the synergistic development of IP knowledge and ideological-political values. This integration improves teaching quality, cultivates students' legal awareness, innovation capacity, social responsibility, and practical skills.
Researchers discovered that docosahexaenoic acid (DHA) plays a crucial role in heart regeneration by triggering specific genes involved in the process. Injection of DHA improves cardiac function in adult mice after myocardial infarction, while also facilitating cardiomyocyte proliferation and inhibiting fibrosis and inflammation.
Researchers engineered midnolin for targeted protein degradation using cryo-EM structures and developed chimeras for non-native high-profile targets. This study provides a paradigm-shifting solution to challenges in targeted protein degradation approaches.
Students taught with virtual 3D scans showed greater confidence and comparable improvement in examination scores compared to those using physical prosections. Virtual technology proved valuable for preparation but lacked the hands-on experience of actual dissection.
A recent study reveals that loss of liver growth hormone (GH) signaling contributes to the development of lean metabolic-associated fatty liver disease. The researchers developed a mouse model with hepatic GH receptor knockout and found that CD36-mediated lipid uptake and C/EBPβ-driven lipogenesis form a central regulatory hub driving ...
Researchers developed a novel tree-like nitrogen-doped carbon support structure that boosts efficiency and lifespan of low-platinum fuel cells. The T-NC support maintains platinum dispersion at high loadings and shows exceptional corrosion resistance, making it compatible with various catalysts.
Researchers found that traditional protocols isolate platelet contaminants, whereas optimized protocol yields uniform, cell-derived microvesicles. These findings redefine long-standing assumptions and establish a new foundation for accurately interpreting microvesicle functions.
Researchers developed a vertical drawing technique to fabricate intricate micro/nano optical fibers with tailored geometric precision. The approach enables meticulous control over diameter transitions and unlocks new possibilities for manipulating light-matter interactions, including supercontinuum generation.
Researchers develop serial tissue optical clearing methods to image neuro-vasculature of whole organ in mouse, enabling study of larger animal models like pigs and non-human primates. The technique facilitates the study of organ development and disease mechanisms in models closer to humans.
A new study introduces an innovative PCML-based hybrid modeling framework for steam thermal cracking, reducing computational demand and optimizing economic benefits and CO2 emissions. The approach achieves a 28.97% profit reduction and 42.89% CO2 emission decrease, with significant implications for sustainable chemical production.
A new multi-scale graph neural network overcomes limitations of traditional methods, achieving improved prediction accuracy and reduced overfitting. The model's attention mechanism enables interpretable predictions, highlighting key features such as Zn–O bonds.
A recent review highlights the potential of particle vision analysis (PVA) to accelerate discovery and quality control in nanomanufacturing, biomanufacturing, and pharmaceuticals. PVA integrates AI-based methods for classification, detection, segmentation, tracking, and super-resolution to analyze microscopic particles, which determine...
An online monitoring system for farmland non-point source pollution uses a serial pipeline to monitor continuous cropping farmland. The system breaks through limitations of existing technologies, providing real-time data and automated sampling.
China has made significant technological breakthroughs in stabilized fertilizers, increasing nitrogen use efficiency by over 50% while reducing losses and greenhouse gas emissions. Field trials have verified the comprehensive benefits of these products, including increased crop yields and reduced fertilizer usage.
Sugarcane intercropping improves soil health by breaking up compacted soil, enhancing nutrient use, and promoting microbial diversity. Practical cases in southern China show expanded applications with legumes, maize, vegetables, and green manure crops, improving land use efficiency and organic matter content.
China's farmland exhibits a dual characteristic of strong emissions and weak carbon sink, but optimizing management can reduce emissions by 11.6 Tg CO2-eq per year. Implementing '4R nutrient management' and improved irrigation techniques can increase soil organic carbon content and enhance carbon sequestration capacity.
Research finds that Akkermansia muciniphila alleviates hepatic fibrosis through propionate-driven antioxidant defense, improving liver function and reducing extracellular matrix accumulation. The study suggests a potential microbiota-based therapeutic strategy to combat liver fibrosis.
The study quantified emissions of four pollutants from agricultural production and domestic sewage in the Haixi area, revealing rural domestic sewage was main contributor to NH3-N. The research suggests promoting low-pollution modes, strengthening sewage pipe networks, and using comprehensive treatment technology for livestock breeding.
Researchers developed nitrogen-responsive promoters in Bacillus licheniformis, enabling expression systems to respond to changing nitrogen conditions. The newly identified promoters were found to initiate transcription and mediate transglutaminase gene expression, improving industrial production efficiency.
Multimodal AI fuses information from various sources, such as echocardiography and genomics, to deliver patient-specific insights and improve diagnostic performance. The technology can also refine treatment selection and predict patient outcomes, enabling targeted prevention strategies.
A new open-source tool estimates lifetime costs of green-hydrogen production with 95% probability, providing decision-makers with confidence intervals for bankable projects. The tool accounts for uncertainty in material prices, BoP costs, recycling rates, labor rates, and energy tariffs.
Researchers at Peking University have created a compact WGM microprobe for high-sensitivity ultrasound detection, achieving a remarkable noise-equivalent pressure of 5.4 mPa/√Hz. The device successfully performed photoacoustic imaging on various samples, including biological and synthetic microparticles.
Researchers found a higher burden of rare variants in Chinese patients with hypertrophic cardiomyopathy, with specific mutations common to the cohort. The study suggests ethnicity-specific genetic databases and refined interpretation frameworks improve diagnostic clarity for HCM management across diverse populations.
Researchers engineered Escherichia coli to produce inosinic acid, a popular umami enhancer, with significantly increased yields. The engineered strain produced 562.0 mg/L of IMP, a 4.77-fold increase over the wild-type strain.
The study found that the reduction in grain consumption was the primary reason for the decline in zinc intake. Zinc obtained from grains decreased significantly, while meat consumption only partially offset this impact. Regional differences were also observed, with certain provinces experiencing higher rates of insufficient zinc intake.
The study identifies two distinct neuronal populations affected by Alzheimer's disease: EC-stellate neurons lost and GFAP⁺ neurons expanding with glia-like features. These findings highlight energy metabolism dysfunction and neuronal identity changes in AD progression.
Secreted proteins offer promising therapeutic avenues for metabolic dysfunction-associated steatotic liver disease (MASLD). Recent research highlights their potential as therapeutic targets, but translating preclinical findings into effective clinical treatments remains challenging.
Researchers developed a novel catalyst using ultrasmall palladium nanoparticles supported on zirconium phosphate, achieving enhanced electrochemical reduction of CO2 to ethanol. The breakthrough increases the Faradaic efficiency to 92.1% for ethanol production.
Scientists established intrahepatic cholangiocyte organoids from Syrian hamsters, which withstand cooling-rewarming stress better than mouse-derived counterparts. shICOs maintain lower ROS levels and lipid peroxidation under cold exposure through enhanced anti-ferroptosis ability.