Hong Kong University of Science and Technology researchers identified a new mutation, METex14, in 14% of sGBM patients, leading to more aggressive tumor growth. A promising MET kinase inhibitor, PLB-1001, has been shown to target these tumors with remarkable potency.
A biochemical reconstitution approach demonstrated that multivalent interaction networks formed by major PSD scaffold proteins lead to formation of PSD-like assemblies via phase separation. These assemblies can cluster receptors, concentrate enzymes, and promote actin bundle formation.
Researchers have determined the atomic structure of the Origin Recognition Complex (ORC) bound to DNA, revealing its role in selecting replication origins. The study reveals that ORC selects DNA sites based on their unique structure rather than specific base sequences.
Researchers have discovered peptides that can inhibit autophagy in living animals, providing a promising treatment against various diseases. The peptides are derived from giant ankyrins and can be used to occlude autophagy spatiotemporally.
Researchers from Hong Kong University of Science and Technology identified a family of D-stereospecific peptidases (DRPs) that are involved in combating widely-distributed antibiotics. These genes are phylogenetically widespread and pose a significant threat to treating antibiotic-resistant bacteria.
Researchers created a synthetic crystal for ultracold atoms and emulated key properties of a one-dimensional topological material. The team's findings open up new possibilities for studying non-equilibrium quantum dynamics in exotic systems.
Researchers found Crepidula onyx snails unaffected by microplastics at environmentally relevant concentrations, suggesting potential threat to other marine organisms. The study highlights the species' resilience and implies a need for further investigation into its coping mechanisms.
Researchers employed computational approaches to estimate the fitness landscape of gp160, a polyprotein that comprises HIV's spike. The inferred landscape was validated through comparisons with diverse experimental measurements.
An interdisciplinary team of scientists discovered that ATM and ATR regulate each other's levels in the brain to maintain a balance between excitation and inhibition. Regular brain activity also changes the levels of these proteins, creating a dynamic 'conversation' that helps keep the appropriate E/I balance.
Researchers from Hong Kong University of Science and Technology discovered a new mechanism of action for DISC1, a protein linked to psychiatric disorders. The study found that DISC1 regulates Ndel1's kinetochore attachment during mitosis, leading to cell-cycle deficits in neuronal stem cells.
A research team led by Prof. Robert Qi uncovered a previously overlooked mechanism controlling the organization of microtubule cytoskeletons. They found that PolD1 physically associates with γTuRCs, blocking microtubule nucleation and regulating various cellular activities such as Golgi assembly and cell polarization.
Researchers achieve submilliamp threshold of 0.6 mA at near-infrared 1.3μm for micro-laser with radius of 5 μm, representing a major step towards miniaturization and low power consumption on silicon platform.
Researchers from the Hong Kong University of Science and Technology discovered a unique substrate-binding mode for OSB-CoA synthetase, a crucial enzyme in bacterial vitamin K biosynthesis. The study revealed distinct amino acid residues contributing to thioesterification half-reaction without affecting adenylation.
Researchers from HKUST and Harvard University found a connection between density distributions in the universe and the nature of smallest particles. They argue that the universe could be used as a 'collider' to explore new physics beyond the Standard Model.
Researchers from HKUST created a B12-dependent light-sensing hydrogel by covalently stitching together photoreceptor proteins, enabling rapid gel-sol transition on light exposure. This allows for controlled release of stem cells and proteins with high spatiotemporal precision.
Scientists have made a groundbreaking discovery using real-time monitoring to quantify cooperativity in hydrophobic interactions, demonstrating its critical role in stabilizing macromolecular assembly. The study's innovative microfluidic device enables precise tracking of solute molecule aggregation at sub-microsecond timescales.
Researchers at Hong Kong University of Science and Technology demonstrated a violation of Bell's inequality using frequency-bin entangled narrowband biphotons generated via spontaneous four-wave mixing. This finding suggests the possibility of encoding and decoding qubit information in the time domain.
The study reveals a left-handed coil structure of the Mcm2-7 hexamer and Cdt1-MCM heptamer, shedding light on DNA unwinding mechanisms. The open-coil structure has profound implications for understanding DNA replication initiation and elongation.
Researchers at Hong Kong University of Science and Technology have developed a method to produce subnatural-linewidth biphotons from a Doppler-broadened hot atomic vapor cell. This breakthrough simplifies the production process and enables the creation of narrowband biphotons for practical quantum applications.
Scientists at HKUST discover how PSD proteins form in living cells via phase-transition, revealing a possible answer to the long-standing question of PSD formation. The study also found that defects in these proteins can alter synaptic signaling activity and contribute to brain disorders.
Scientists at Hong Kong University of Science and Technology discover that interleukin-33 (IL-33) rescues contextual memory deficits and reduces beta-amyloid peptide deposition in AD mouse models, suggesting a new therapeutic intervention.
Marine invertebrate larvae of sea urchins demonstrate active responses to turbulence and flow conditions by adjusting their swimming speeds. This behavior has significant implications for the adult populations' transport, survival, and recruitment.
Researchers at HKUST elucidated the dynamics of backtracking in RNA polymerase II, revealing a stepwise process that detects mis-incorporated RNA and corrects errors. The study provides insight into fundamental mechanisms of transcription and may help understand human diseases and aging related to transcription infidelity.
Scientists from Hong Kong University of Science and Technology and University of Amsterdam observed a new phenomenon where 2D crystals premelt into a thin layer of liquid with constant thickness. This discovery challenges current understanding of melting behaviors and suggests that dimensionality plays a crucial role.
Researchers at Hong Kong University of Science and Technology found that enhancing neuronal activity through melanopsin and DREADD-Gq stimulates axonal regeneration in adult mice. This suggests a new approach to facilitate neural repair after CNS damage.
Scientists propose using 'primordial standard clocks' to label and reconstruct the expansion or contraction history of the primordial universe. This method enables researchers to distinguish between competing scenarios and verify the evolutionary history of our universe.
Researchers found that brush border microvilli and stereocilia share strikingly similar interaction modes, despite different functions. The study reveals a common mechanism for the formation of tip-link complexes in both structures.
Researchers at HKUST discovered a new type of superconductor, called Ising superconductors, that can withstand strong magnetic fields. These materials have potential applications in quantum computing and may lead to the creation of Majorana fermions.
Scientists from HKUST and Tsinghua University solved the structure of the MCM2-7 Complex using Cryo Electron Microscopy. The complex plays a key role in destabilizing and unwinding duplex DNA during DNA replication. The team's findings provide new insights into the mechanism and function of the MCM2-7 complex.
Researchers at HKUST found a way to stimulate axon growth without external stimulants. The deletion of the PTEN gene enhances compensatory sprouting and promotes regeneration of CST axons. This breakthrough study offers new possibilities for treating chronic SCI, including delayed treatment up to 1 year after injury.