A recent Indiana University study found that high levels of glyphosate in pregnant women were associated with lower birth weights and higher risk of neonatal intensive care unit admissions. The researchers observed a cohort of 187 pregnant women and detected glyphosate in 99% of their urine samples.
Researchers at Indiana University School of Medicine have identified the autophagy pathway in hair cells linked to permanent hearing loss caused by aminoglycosides. The study developed laboratory models with reduced RIPOR2 expression, which did not exhibit hair cell death or hearing loss when treated with antibiotics.
Researchers have identified two distinct phenotypes of inflammatory cell infiltration in severe alcoholic hepatitis, suggesting separate mechanisms driving liver injury and failure. These findings could lead to personalized treatment approaches, such as identifying patients who are more or less likely to respond to steroid therapy.
Researchers have discovered neural plastic changes that can improve functional recovery after a cervical spinal cord injury. Using an optogenetic neuromodulation strategy, they found that the intact corticospinal system in the opposite side of the brain and spinal cord can be modulated to take over control of the damaged forelimb, resu...
Researchers at Indiana University School of Medicine used tissue nanotransfection (TNT) technology to edit genes in chronic wound tissue, rescuing wound healing. The study found that gene silencing due to DNA methylation was a critical barrier to wound closure.
Scientists at Indiana University School of Medicine discovered differences in FOXP3 isoforms controlling Treg cells and their impact on the immune system. These findings may lead to new treatments for autoimmune diseases and allergies.
A new IU screening tool, Convergent Functional Information for Suicidality (CFI-S), has been validated to predict 80-90% of future suicidality. The tool identifies top risk factors such as feeling useless or unneeded, history of suicidality, and social isolation.
Researchers found that invasive therapy for non-ST segment elevation myocardial infarction in patients with CKD is associated with lower mortality and reduced risk of cardiac events. The study challenges the dominant practice of offering medical management instead of invasive therapy for this population.
Researchers at Indiana University School of Medicine have made significant progress in developing blood tests for Alzheimer's diagnosis and treatment. The latest study, published in Nature Medicine, explores the utility of phosphorylated tau (P-tau) blood biomarkers to aid in early detection and improve disease management.
A recent study published in JACC: Advances has discovered a significant correlation between the racial demographics of cardiovascular disease fellowship programs and the race of their program directors. The study, led by Indiana University researcher Ankur Kalra, found that fellows from diverse backgrounds are more likely to be accepte...
Researchers from Indiana University School of Medicine identify a key brain receptor that leads to a loss of neurons and synaptic structure in Alzheimer's disease models. The study found that targeting this receptor could prevent or delay the onset of Alzheimer's-related neuropsychiatric symptoms and cognitive deficits.
A study using the nation's largest COVID-19 data resource found that the vaccine protects most cancer patients from getting COVID, but those with certain types of cancer have a higher risk of breakthrough infections. The research also highlights the importance of continued vaccination efforts to protect cancer patients.
A new study identifies the age-dependent formation of TMEM106B amyloid filaments in human brains, which may not be linked to neurodegenerative diseases. Researchers found these protein structures in older but not younger individuals, suggesting a potential role in aging and other pathologies.
Researchers at Indiana University School of Medicine found that niacin modulates microglia response to amyloid plaques in an Alzheimer's disease animal model. The study identifies a potential novel therapeutic target for the disease, which can be modulated by FDA-approved drugs.
Researchers have identified a unique population of memory CD4 T-cells that produce IL-9, which plays a key role in allergic memory responses. Blocking this cytokine may lead to reduced lung inflammation and improved treatment options for seasonal asthma.
Researchers successfully differentiated human induced pluripotent stem cells into specific mesoderm subset for use as a novel therapy to rescue ischemic tissues and repair blood vessels. The results demonstrate significant improvement in visual acuity and electroretinograms with restoration of vascular perfusion in animal models.
The study defines the lung macrophage as a major target of IL-9, which promotes allergic lung inflammation. The researchers found a correlation between IL-9 and the diagnosis of asthma in patients, suggesting a potential therapeutic approach for treatment.
A large data analysis reveals that primary ciliary dyskinesia (PCD) is more common than initially estimated, with a prevalence of 1 in 7,500 people globally. The study also found ethnic heterogeneity in PCD-causing gene variants, with African descent and non-Finnish European groups showing higher rates.
A new study published in Science reveals distinct filament structures in Alzheimer's disease, with Type I filaments found in sporadic cases and Type II in familial cases. The findings may lead to new prevention and treatment strategies.
A team of researchers from Indiana University School of Medicine has made significant breakthroughs in testing cancer-fighting drugs by simulating physiological oxygen levels. By exposing tumor tissues to different oxygen levels, the scientists found that drug sensitivity varies greatly, leading to more effective treatment options.
A study by Indiana University School of Medicine researchers suggests that reperfusion therapy may not be as effective in halting muscle damage during heart attacks as previously thought. The team's findings indicate that internal bleeding within the heart muscle can continue to cause damage even after the blocked coronary artery is op...
A study published in the New England Journal of Medicine found that chlorthalidone significantly lowered blood pressure by 11mmHg in patients with stage 4 chronic kidney disease. The results also showed a 50% reduction in albuminuria, suggesting potential benefits for reducing kidney failure progression and hospitalizations.
A recent study published in Science Advances found that deleting the ABI3 gene increases amyloid-beta plaque accumulation and decreases microglia function, which may contribute to Alzheimer's disease progression. The researchers also identified a link between the mutation and increased risk of late-onset Alzheimer's.
A group of researchers led by Indiana University School of Medicine's Benjamin Gaston will receive a research program project grant to fund the development of personalized therapeutic approaches for severe asthma. The grant will support three key projects focused on S-nitrosylation signaling, airway pH regulation, and androgen signaling.
The CARE Consortium has received $42.65 million in new funding to follow athletes for up to 10 years after concussive injury, examining the impacts of head injuries on brain health. The study aims to validate advanced biomarkers and identify neurobiological pathways contributing to long-term negative consequences.
A synthetic hinge concept developed by Indiana University School of Medicine Professor Michael A. Weiss and his team could lead to a breakthrough in 'smart' insulin therapy. The invention exploits a natural mechanism that allows the insulin to adjust its activity based on blood glucose levels, which could transform diabetes care.
Researchers from Indiana University School of Medicine studied anxiety behaviors in male and female rodent models to understand sex differences in biological responses related to anxiety. They found that females experience intensified anxiety when faced with specific, life-relevant conditions, which is in line with previous studies.
Researchers have developed a new, noninvasive brain stimulation technique using magnetoelectric nanoparticles to stimulate deep brain function. The method is more efficient than traditional methods without invasive procedures, showing promise for treating various neurological conditions.
The National Centralized Repository for Alzheimer's Disease and Related Dementias (NCRAD) at IU School of Medicine has been renewed with a $30 million NIA grant over five years. The repository supports research on causes, early detection, and therapeutic development for Alzheimer's and other dementias.
Researchers at IU School of Medicine have made a breakthrough in treating and preventing kidney infections by utilizing the kidneys' own internal infection-fighting capabilities. The study found that intercalated cells can consume bacteria and secrete acid, offering a potential alternative to antibiotics.
A new study suggests that inhibiting GKN1, a stomach-specific protein, can lead to significant weight loss and reduced body fat in mice. The researchers found that models without GKN1 had improved metabolism and resistance to weight gain on high-fat diets.
A study by Indiana University School of Medicine researchers has found that B cell activating factor (BAFF) plays a role in the generation and maintenance of inhibitors in hemophilia A patients. Blocking BAFF with a combination therapy may induce tolerance in these patients, offering a potential solution to treatment failure.
IU School of Medicine researchers have developed a blood test that can distinguish between severe depression and bipolar disorder, as well as predict future episodes. The test uses RNA biomarkers to inform tailored medication choices, offering a promising precision medicine approach to treatment.
Researchers at Indiana University School of Medicine have successfully reprogrammed NG2 glial cells into functional neurons, potentially leading to improved recovery after spinal cord injuries. This breakthrough discovery has the potential to be translated into a clinically relevant repair strategy.
Researchers from Indiana University have identified key genetic changes in the interstitial kidney tissue of people with diabetes, which could lead to a revolutionary new genetic approach to treating kidney disease. The study found that important genes change when a scar forms on the interstitium, a previously undercharacterized part o...
Breast cancer cells can evade immune attacks by increasing the level of protein MAL2 on their surface, leading to enhanced tumor growth. Targeting this action could improve immunotherapy for patients. Researchers identified MAL2 as a key protein and found that inhibiting it can almost completely stop tumor growth.
Researchers at Indiana University School of Medicine have discovered a promising treatment approach for preventing acute graft-versus-host disease, a common complication of blood stem cell transplantation. The study found that using the oral drug sitagliptin reduces the risk of GVHD by inhibiting immune T cell activation.
Researchers at Indiana University School of Medicine published a study using a donated tumor from Tyler Trent, a college student who died from bone cancer. The team found that a combination therapy significantly slowed tumor growth in models, leading to hopes for new treatments and improved outcomes for children with osteosarcoma.
Researchers are exploring unique biomarkers in normal breast tissue of Black women to improve treatment options for aggressive breast cancer. DNA analysis revealed a genetic mutation called duffy, which may contribute to higher breast cancer rates and aggressiveness in Black women.
A researcher at Indiana University School of Medicine has received a $2.9 million grant to develop a drug that could make radiation therapy more effective in treating lung cancer and other solid tumors.
A recent study suggests that the evolution of insulin has encountered a roadblock, rendering most people vulnerable to Type 2 diabetes. The researchers discovered that even slight variations in the insulin-sequencing process can impair insulin folding and induce cellular stress.
Researchers are collecting detailed health information from people with atypical forms of diabetes to understand their causes and differences from common types. The study aims to provide critical insight into the emerging spectrum of diabetes, potentially leading to new targets for prevention and treatment.
A multi-site study found that using prophylactic negative pressure wound therapy (NPWT) does not significantly lower the risk of infection for women with obesity who have undergone cesarean delivery. The study, which included over 1,600 participants, also found increased rates of skin irritations in the NPWT group.
Researchers at Indiana University School of Medicine are testing the use of tezampanel, a novel antagonist at glutamate receptors, to treat opioid withdrawal syndrome and other addictions. The project aims to develop breakthrough medications more rapidly than traditional mechanisms, with potential approval from NIDA and FDA.
The Alzheimer's Disease Programs Initiative (ADPI) aims to build upon existing home and community-based social supports to enable people with Alzheimer's Disease and Related Dementias to remain independent in their communities. People with ADRD and their caregivers will receive coaching, training, and support services.
A new study published in Hepatology has identified a gene, Fas Associated Factor Family Member 2 (FAF2), that may reduce the risk of developing alcoholic cirrhosis. The researchers found that this gene is involved in lipid droplet organization pathway and is linked to other genes that increase the likelihood of liver disease.
A five-year grant will follow over 2,000 testicular cancer survivors to examine the role of genetic variants in platinum toxicities and assess the impact on physical, emotional, and social functioning. The study aims to identify high-risk subgroups and provide guidelines to decrease damaging side effects.
A new study led by IU School of Medicine aims to identify a biomarker that predicts wound recurrence in patients with diabetic foot ulcers. The goal is to develop an advanced approach to manage these wounds, potentially decreasing amputation rates nationwide.
Researchers at Indiana University School of Medicine have discovered how the Toxoplasma gondii parasite hijacks host cells to spread throughout the body. The parasite triggers an alarm system that leads to the activation of a protein called IRE1, connecting it to the cytoskeleton and causing hypermigration.
Indian University researchers identify circulating tumor DNA and cells in plasma as indicators of disease recurrence and survival. The study, published in JAMA Oncology, enables stratification of patients for targeted therapies.