Researchers sequenced the genomes of Jerdon's jumping ant and Florida carpenter ant, revealing clues to their complex social behavior and potential links to human aging. The findings highlight the importance of epigenetics in controlling gene expression, which may influence longevity and behavior.
The NYU Urothelial Biology Team has received a five-year, $8.2 million grant from the NIDDK to investigate bladder biology and diseases such as UTI. The team aims to understand how disease-causing bacteria interact with host urothelial cells, which is crucial for developing novel treatments for recurrent UTI and other urologic diseases.
Researchers found diminished cognitive performance in obese adolescents with type 2 diabetes, as well as subtle brain abnormalities detected by MRI. The study highlights the importance of addressing obesity and inactivity to prevent cognitive deficits.
A new study by NYU School of Medicine found that UVA radiation causes mutations in human melanocyte cells, leading to melanoma. Melanocytes are more vulnerable to UVA damage due to their limited DNA repair capacity.
A new study from NYU Langone Medical Center shows that carotid artery ultrasound is a valuable screening tool for diagnosing and excluding coronary artery disease. The non-invasive test can identify severe plaque buildup in the neck arteries, potentially avoiding the need for invasive angiography.
Mutations in the presenilin 1 gene disrupt cellular protein-recycling, killing nerve cells and leading to neuronal loss. Alternative pathways can be targeted for therapies aimed at repairing toxic protein elimination mechanisms.
Researchers at NYU Langone Medical Center found that Jewish communities retained their genetic influences despite migration, exhibiting common genetic threads. The study identified distinct population clusters with shared Middle Eastern ancestry and variable degrees of European and North African intermingling.
Scientists found that M. tuberculosis antigens remain unchanged and homogenous, unlike many viruses and parasites, allowing the bacteria to be transmitted from person to person.
Researchers from the NYU Cancer Institute will present studies on improved ways to diagnose melanoma in lymphatic vessels and investigate genetic differences between melanoma subtypes. Laura Hogan, a pediatric hematology and oncology fellow, is also honored for her outstanding work in pediatric oncology research.
Researchers at NYU Langone Health have discovered a micro-RNA, miR-33, that regulates key genes involved in cellular cholesterol transport. Inhibiting miR-33 may enhance cholesterol removal from tissues and raise HDL levels.
A new study found that Hispanic/Latino individuals have varying genetic makeups due to the influence of multiple ancestral populations. The research discovered a significant sex bias consistent with the disproportionate contribution of European male and Native American female ancestry.
Scientists have characterized a general mechanism that controls transcription elongation in bacteria, revealing the active ribosome's role in adjusting transcriptional yield. This finding could lead to novel ways to interfere with bacterial gene expression and develop new antimicrobial therapies.
Researchers at NYU Langone Health have developed a powerful new method to investigate the discrete steps necessary to turn on individual genes. The finding allows scientists to examine the unfolding of DNA, a process required for gene activation, which breaks down in diseases like cancer.
Scientists at NYU Langone Health discovered a potential new target for treating rheumatoid arthritis by boosting the normal activity of regulatory T cells, which counterbalance conventional T cells' hyperactivity. The study reveals how an investigational drug wards off inflammation by holding an enzyme at bay.
Researchers found a greater number of protein clumps linked to Alzheimer's, especially among children of mothers with the disease. The study suggests a genetic mechanism is involved and may help explain why family history is a significant risk factor for the brain disease.
Researchers at NYU School of Medicine have found that elevated levels of phosphorylated tau231 may predict future memory decline and loss of brain gray matter in healthy adults. High levels of P-tau231 are associated with reductions in medial temporal lobe gray matter, suggesting its potential as a diagnostic tool for Alzheimer's disease.
Researchers at NYU Langone Medical Center have discovered a new paradigm to understand the molecular principles of gene transcription in bacteria. The study reveals an allosteric mechanism by which Rho terminates transcription and shows that Rho binds tightly to RNA polymerase throughout the transcription cycle.
A study published in the Journal of Neuroscience found a link between loss of smell function and amyloid protein accumulation in the brain, potentially serving as an early diagnostic tool for Alzheimer's disease. Researchers suggest that olfactory dysfunction may be used to detect the disease prior to substantial brain degeneration.
A new study found that healthy older adults with subjective cognitive impairment (SCI) are 4.5 times more likely to progress to mild cognitive impairment (MCI) or dementia than those without SCI. Over a seven-year period, 54% of SCI individuals showed further cognitive decline, compared to 15% of non-SCI individuals.
A new study identifies βCTF, a small protein found in APP, as a novel factor contributing to Alzheimer's disease-related endosome abnormalities. Elevated levels of βCTF cause specific pattern of endosome defects similar to brain cells in Alzheimer's disease.
Scientists at NYU Langone Medical Center have discovered a new pathway that protects epithelial and endothelial cells from uncontrolled tuberculosis infection by producing an enzyme that inhibits Th17 cell production.
Researchers have developed a new method using diffusion tensor imaging (DTI) to improve the removal of benign tumors in children. By visualizing nerve fiber bundles, DTI enables surgeons to avoid damaging critical brain tissue and achieve more complete tumor removal.
Researchers discovered that the brain integrates new information by forming and eliminating neural connections, maintaining a balance between old and new memories. This dynamic process allows humans to learn and adapt without losing existing memories.
Researchers at NYU Langone Medical Center have identified hundreds of genes linked to patient survival in advanced melanoma. The study used DNA-microarray technology to find genes involved in the immune response and gene proliferation, providing a new framework for personalized medicine.
Researchers used fMRI to divide the precuneus into four distinct functional regions, finding similarities with monkey brains. This discovery confirms that higher-order association areas have complex architectures preserved across evolution.
Researchers have discovered a unique bacterial species that can stimulate specialized immune cells in mice, potentially providing insights into human gut-dwelling microbes. This finding could lead to new understanding of how beneficial bacteria protect against pathogenic invaders.
The center will investigate the link between schizophrenia and dysfunctional brain N-methyl-D-aspartate receptors (NMDA). Researchers aim to identify pre-symptomatic individuals in adolescence to intervene before disease effects take hold. The grant also supports a summer undergraduate research program.
A recent study published in the American Heart Journal found that more than half of randomized clinical trials for cardiovascular disease fail to report vital information about patient race or ethnicity. Only 15% of trials had sufficient diversity, highlighting the need for better representation of minority groups in RCTs.
The institution has received a total of $122M in NIH grants last year, with this latest award bringing the total to over $150M. The funding supports research in various fields including HIV/AIDS, cancer, immunology, and Alzheimer's disease.
Researchers found that patients with cavitary pulmonary tuberculosis who received anti-TB medications supplemented with nebulized interferon-gamma had fewer bacilli in the lungs and less inflammation, reducing transmissibility. This treatment approach could be critical in controlling TB spread.
Researchers at NYU Langone Health have found a mechanism that makes human pathogens like MRSA and anthrax resistant to numerous antibiotics. By eliminating the oxidative stress caused by many antibiotics, NO can be neutralized, rendering existing antibiotics more potent at lower doses.
Women are slightly more likely to die from heart attacks due to a higher risk after severe presentations, while less severe cases show lower mortality rates. The study highlights the importance of considering sex in ACS research and delivery of care.
Researchers at NYU Langone Medical Center have discovered an altered type of microbiome dominated by Gram-negative bacteria in patients with esophagitis and Barrett's esophagus. This finding may provide a new approach to understanding the pathogenesis of reflux-related disorders.
The NYU-HHC CTSI aims to leverage individual expertise, support education and training, and enhance community ties to promote evidence-based medicine and reduce healthcare disparities. With the grant, researchers will focus on discoveries in the lab that can be rapidly translated to the bedside and into communities.
A recent study published in Science found that the STAT3 protein plays a key role in converting normal cells to cancerous cells by regulating gene expression in both the cell nucleus and mitochondria. This discovery may lead to the development of targeted cancer therapies.
Two NYU Langone researchers will conduct pilot demonstration projects on microbiome and psoriasis and microbiome and esophageal cancer. The studies aim to assess the relationship between the skin or esophageal microbiome and disease progression.
A new study has identified a key protein receptor responsible for tumor cells invading the brain and spinal cord in childhood leukemia. The finding may lead to new drugs that block this receptor and reduce the risk of relapse in some leukemia patients.
Researchers have identified a key gene, eIF4G1, overexpressed in the majority of cases of IBC, leading to rapid metastasis and high mortality rates. The study's findings could lead to new approaches and therapies for treating IBC.
Researchers have found that RAG-1 mediated cleavage occurs on one allele at a time during V(D)J recombination, ensuring allelic exclusion. This process is crucial in preventing translocations, a common underlying mechanism for leukemias and lymphomas.
Researchers at NYU Langone Medical Center report early promise in animal studies for a novel antiparasitic drug as a potential treatment for metastatic melanoma. Additionally, the study found associations between specific microRNAs and patient survival in metastatic melanoma and early-stage lung cancer.
A new study published in Menopause: The Journal of the North American Menopause Society found that transdermal estrogen delivery may not increase the risk of blood clots in postmenopausal women, unlike oral delivery. The study suggests that transdermal HT delivery may be a safer alternative for some women.
Two NYU School of Medicine researchers, Iannis Aifantis and Jeremy S. Dasen, have been recognized as Early Career Scientists by the Howard Hughes Medical Institute for their groundbreaking research in cancer biology and neuroscience. They will receive a six-year appointment and funding to further explore their areas of research.
A new study found that a genetic variation increases melanoma risk in pre-menopausal women, with over 40% of those under 50 carrying the mutation. This discovery could lead to more effective surveillance and prevention strategies for this deadly skin cancer.
A nationwide study found that long-term exposure to elevated ground ozone significantly raises the risk of dying from lung disease. The risk is more than 30 percent greater in metropolitan areas with high ozone concentrations compared to those with low concentrations.
A new study has found that maintenance rituximab therapy improves progression-free survival in patients with stage III-IV indolent lymphoma. The treatment showed significant benefits, including a 22% improvement in disease response and a 68% three-year progression-free survival rate.
A new microRNA-based diagnostic test has been shown to identify squamous lung cancer with high accuracy, offering improved treatment options for patients. The test's 96% sensitivity and 90% specificity make it a promising tool in the fight against this aggressive form of cancer.
Researchers at NYU Langone Medical Center have discovered a new targeted intervention for Barth Syndrome, a genetic disorder causing heart and muscle failure in children. The study identified iPLA2-VIA as a potential target for therapeutic intervention, showing promise for treating the disease.
A NYU Langone Medical Center study shows that healthy elderly patients with severe to profound hearing loss can tolerate cochlear implant surgery without significant risk, contrary to conventional wisdom. The procedure significantly improves their hearing and quality of life.
Researchers found that microRNA 182 is over-expressed in metastatic melanoma cell lines and tissues, leading to increased invasive capacity and metastatic potential. Inhibiting miRNA 182 may be an effective therapeutic strategy for metastatic melanoma.
Dr. Vivian S. Lee, inaugural vice dean for science at NYU Langone Medical Center, has been recognized for her transformational leadership and commitment to mentoring aspiring scientists. She has overseen significant research growth and established multiple centers of excellence.