Researcher Martin Blaser warns that widespread antibiotic use can cause permanent damage to the body's natural defense system. This can lead to increased susceptibility to infections and disease, as well as conditions like asthma, inflammatory bowel disease, and type 1 diabetes.
Researchers at NYU Langone Health have discovered the cellular mechanisms that generate chromosomal breaks in bacteria. They found that collisions between major gene expression lead to chromosomal breaks, which may explain stress-driven evolution in bacteria and certain human diseases.
Researchers at NYU Langone Medical Center identified a molecular mechanism that regulates blood vessel formation. The Semaphorin-PlexinD1 signaling pathway, which limits VEGF growth, shows promise as a future therapeutic target for cancer treatment.
Researchers at NYU Langone Medical Center have developed advanced MRI techniques that can detect subtle changes in joint cartilage microstructure, allowing for early diagnosis of osteoarthritis. These techniques enable physicians to shift the management of the disease from eventual joint reconstruction to long-term preservation.
A novel sensory pathway modulates Th17 cell responses, revealing a potential anti-inflammatory mechanism for PI-3K and Akt inhibitors. The study's findings have significant implications for understanding autoimmune diseases and developing new treatments.
A new study published by NYU School of Medicine researchers has found that exposure to secondhand smoke nearly doubles the risk of hearing loss among adolescents. The study found that teenagers exposed to smoke performed worse across every sound frequency tested, especially mid-to-high frequencies important for understanding speech.
Researchers from NYU Langone Medical Center presented new research at the 2011 Alzheimer's Association International Conference. The study found that retired NFL players are more likely to experience mild cognitive impairment than expected, suggesting a possible link between repetitive head trauma and late-life cognitive disorders. Add...
Researchers discovered that specific microRNAs play a crucial role in melanoma metastasis by suppressing the immune system and promoting cell invasion. The study found that these miRNAs can serve as biomarkers for more aggressive tumors, suggesting new therapeutic targets for battling the deadliest form of skin cancer.
A new study published in Archives of Internal Medicine found that cardiologists in the US are still performing late artery-opening procedures despite guideline changes. The study examined nearly 29,000 patients and showed no decline in monthly rates of late procedures from 2005 to 2008.
Researchers at NYU Langone Health discovered that Wnt signaling, a biological process controlling many processes, is essential for coordinated actions of hair follicle stem cells and melanocyte stem cells. This study suggests manipulating Wnt signaling may be a novel strategy to target graying hair.
Researchers from NYU Cancer Institute presented studies on the association between MC1R variants, ultraviolet light exposure, and melanoma risk. They also identified serum-based microRNAs as biomarkers for melanoma recurrence. These findings suggest that naturally occurring genetic variations in MC1R may increase an individual's predis...
A new study by the NYU Cancer Institute reveals that novel mutations in the Notch signaling pathway lead to the development of chronic myelomonocytic leukemia, a type of blood cancer. The study suggests potential targets for future therapies.
The new guidelines emphasize the importance of genetic counseling and comprehensive clinical evaluation in treatment decisions. The guidelines also recommend specialized centers for genetic testing and interpretation, covering 13 inherited cardiac conditions.
Researchers will test a novel antibody against TGFβ to enhance radiation therapy's effectiveness in metastatic breast cancer patients. The goal is to induce an immune response against tumor sites outside the radiation field.
Researchers at NYU School of Medicine identified three novel small molecules that block a crucial cellular communication pathway regulating cancer growth. The finding could provide the basis for innovative therapies for colorectal cancer and other diseases associated with aberrations in this pathway.
Neurosurgeons from NYU Langone present cutting-edge surgical approaches and applications of technology for lateral skull base conditions, low-grade glioma tumors, and spinal surgery. The department's expertise has been recognized as one of the top ten hospitals in the country for neurology and neurosurgery.
Researchers from NYU Cancer Institute presented several promising findings at the AACR 102nd Annual Meeting 2011. They developed a novel test to detect early-stage asbestos-related pulmonary cancer with high accuracy, and explored treatment strategies for glioblastomas. Additionally, they mapped genome-wide nickel-related cancer effect...
Researchers investigated the association between bleeding and mortality in patients on dual antiplatelet therapy (DAPT) versus aspirin alone. The study shows patients with moderate or severe bleeding had a higher incidence of all-cause, cardiovascular and cancer mortality.
NYU School of Medicine researcher Cosimo Commisso will receive a grant to investigate the role of fluid uptake in pancreatic cancer cells. The goal is to understand how this process contributes to tumor development and identify potential targeting strategies.
A new study published in Medical Care found that hospitals with robotic technology are more likely to perform radical prostatectomy surgeries. This is the first study to investigate the impact of surgical robot acquisition on surgery rates, and it concludes that technological adoption leads to increased surgical volume.
Researchers at NYU Langone Medical Center created a novel protein molecule derived from progranulin, which may offer alternative treatments for chronic inflammatory diseases like rheumatoid arthritis. The protein has been shown to have a high affinity and specificity for binding to tumor necrosis factor receptors.
A study found that a population of Hudson River fish evolved rapidly in response to PCB pollution, with a single gene responsible for their ability to withstand the toxic chemicals. The study's findings suggest that this genetic adaptation allowed the fish to survive lethal heart defects triggered by PCBs.
Researchers have developed a software application that automatically detects subtle brain lesions in MRI scans of epilepsy patients, identifying 92% of previously undetectable abnormalities. This proof-of-concept study validates the potential of non-invasive, automated detection tools for diagnosing and planning epilepsy surgery.
A new study found that calorie labeling had a minimal impact on the purchasing behavior of teenagers and their parents at fast-food restaurants. While teens noticed calorie information at the same rate as adults, they responded at a lower rate, with only 9% reporting it influenced their choices.
The NYU Langone Department of Orthopaedic Surgery has been selected to participate in the American Joint Replacement Registry (AJRR), aiming to collect key joint replacement and revision data to monitor device performance and identify best practices. The registry's participation is expected to improve long-term outcomes, cost managemen...
Researchers at NYU Child Study Center developed ParentCorps, a 13-session family series to improve parenting practices and reduce child behavior problems. The program helped parents select evidence-based strategies, leading to better classroom behavior and social-emotional competencies in children.
Researchers found that parent education programs delivered through pediatric primary care offices increased verbal interactions between parents and children, leading to improved school readiness. The Video Interaction Project (VIP) and Building Blocks interventions showed significant benefits, including reduced infant television exposure.
A school-based program helped New York City high school students with moderate to severe asthma better manage their symptoms, dramatically reducing the need for urgent care. The program participants experienced significant reductions in acute medical visits, emergency department visits, hospitalizations, and night awakenings.
A new gene, MAP3K1, has been identified as a crucial switch in determining gender development. The discovery explains the cause of intersex conditions and provides hope for patients and their families.
Researchers discover that infection with Trichuris trichiura eggs increases mucus production in the colon, providing symptomatic relief from ulcerative colitis. The study identifies a shift from pro-inflammatory to anti-inflammatory immune cells, paving the way for potential helminth therapy.
The new pilot program aims to recover organs from deceased individuals who die of cardiac arrest outside of hospitals, honoring their wishes and saving lives. The program has the potential to transform organ donation in the US, making it possible for more people to become donors regardless of where they die.
Researchers found that 25% of top-selling pediatric oral liquid medications lack dosing devices, while 99% have directions on labels and device markings that don't match. The study recommends standardizing abbreviations and ensuring matching instructions and devices to reduce parent confusion and ensure safe medication use.
A study of nearly 50,000 people has identified DNA sequence variations associated with cardiac electrical activity, which may lead to novel approaches to prevent or treat serious rhythm disorders. The findings provide new clues about the biologic pathways that influence cardiac conduction and identify genes and genetic pathways involve...
Dr. Blaser and his team will investigate whether changes in the human microbiome as a result of antibiotic use have fueled the obesity epidemic. The grant will assess the roles of gastric and colonic microbiota related to hormones and metabolism in both humans and mice.
Researchers followed approximately 150 patients with angiographically significant coronary lesions to investigate FFR-guided revascularization's safety and effectiveness over a decade. The study found no excess risk of adverse events, including mortality, heart attacks, or need for further revascularization.
Researchers find a crucial protein involved in immune response also plays a role in T-cell acute lymphoblastic leukemia (T-ALL) progression. Suppressing the protein's activity eliminates leukemic cells, paving the way for potential new treatments.
Researchers found a sensor in dendritic cells that recognizes HIV, sparking a more potent immune response. The ability to stimulate this protective response is critical for developing therapeutic vaccines against HIV.
Scientists at NYU Langone Medical Center have discovered a single type of gene that acts as a master organizer of motor neurons in the spinal cord. The finding, published in Neuron, could lead to new treatments for diseases such as Lou Gehrig's disease and spinal cord injury.
Researchers sequenced the genomes of Jerdon's jumping ant and Florida carpenter ant, revealing clues to their complex social behavior and potential links to human aging. The findings highlight the importance of epigenetics in controlling gene expression, which may influence longevity and behavior.
The NYU Urothelial Biology Team has received a five-year, $8.2 million grant from the NIDDK to investigate bladder biology and diseases such as UTI. The team aims to understand how disease-causing bacteria interact with host urothelial cells, which is crucial for developing novel treatments for recurrent UTI and other urologic diseases.
Researchers found diminished cognitive performance in obese adolescents with type 2 diabetes, as well as subtle brain abnormalities detected by MRI. The study highlights the importance of addressing obesity and inactivity to prevent cognitive deficits.
A new study by NYU School of Medicine found that UVA radiation causes mutations in human melanocyte cells, leading to melanoma. Melanocytes are more vulnerable to UVA damage due to their limited DNA repair capacity.
A new study from NYU Langone Medical Center shows that carotid artery ultrasound is a valuable screening tool for diagnosing and excluding coronary artery disease. The non-invasive test can identify severe plaque buildup in the neck arteries, potentially avoiding the need for invasive angiography.
Mutations in the presenilin 1 gene disrupt cellular protein-recycling, killing nerve cells and leading to neuronal loss. Alternative pathways can be targeted for therapies aimed at repairing toxic protein elimination mechanisms.
Researchers at NYU Langone Medical Center found that Jewish communities retained their genetic influences despite migration, exhibiting common genetic threads. The study identified distinct population clusters with shared Middle Eastern ancestry and variable degrees of European and North African intermingling.
Scientists found that M. tuberculosis antigens remain unchanged and homogenous, unlike many viruses and parasites, allowing the bacteria to be transmitted from person to person.
Researchers from the NYU Cancer Institute will present studies on improved ways to diagnose melanoma in lymphatic vessels and investigate genetic differences between melanoma subtypes. Laura Hogan, a pediatric hematology and oncology fellow, is also honored for her outstanding work in pediatric oncology research.
Researchers at NYU Langone Health have discovered a micro-RNA, miR-33, that regulates key genes involved in cellular cholesterol transport. Inhibiting miR-33 may enhance cholesterol removal from tissues and raise HDL levels.
A new study found that Hispanic/Latino individuals have varying genetic makeups due to the influence of multiple ancestral populations. The research discovered a significant sex bias consistent with the disproportionate contribution of European male and Native American female ancestry.
Scientists have characterized a general mechanism that controls transcription elongation in bacteria, revealing the active ribosome's role in adjusting transcriptional yield. This finding could lead to novel ways to interfere with bacterial gene expression and develop new antimicrobial therapies.