A Trinity scientist has won an ERC Starting Grant to investigate the role of microglia in brain disorders. The project aims to create a detailed map of how these immune cells change during brain damage, disease, or repair, with the goal of developing methods to control and rejuvenate neuropathology.
Drs Johanna Vos aims to better understand weather patterns on extrasolar worlds using the James Webb Space Telescope. Her Exo-PEA project will reveal dominant atmospheric processes governing giant world weather, expanding our understanding of planetary atmospheres.
Dr. Josephine Wu's project, OPTO-BIOPRINTING, aims to develop a novel platform for spatiotemporally guided tissue engineering using cellular self-assembly and light triggering. The goal is to create living organ replacements that can perform as well as native equivalents.
A study of 8,000 community-dwelling adults reveals that loneliness in later life is strongly associated with death ideation, but engaging in social activities, particularly religious services, can protect against this. The research highlights the critical issue of social disconnection and its link to a 'wish to die' among older adults.
Researchers have made a significant breakthrough in vasculitis research using AI-powered big data techniques, enabling more precise identification of disease patterns. The study offers new insights into the diagnosis and treatment of systemic vasculitis, a group of rare autoimmune diseases.
A new microscopy method, Tempo STEM, significantly reduces radiation required by 'shutting off' the beam at peak efficiency. This approach eliminates excess damaging irradiation and avoids sample transformation or destruction.
Researchers analyzed ancient DNA from an 8,000-year-old sheep bone and found evidence of Brucella melitensis, a pathogen causing significant harm to livestock. The study suggests that brucellosis evolved around the same time as farming development, with early farmers creating conditions for pathogen host-jumping.
Scientists discovered that Tumour Treating Fields (TTFs) improve Natural Killer cell killing by increasing degranulation, a sign of better cell function. The findings offer promising implications for treating glioblastoma and other cancers.
Scientists at Trinity College Dublin have identified a key biological pathway, the JAK/STAT pathway, that RSV suppresses and prevents immune system igniters from activating. This discovery provides a promising new target for therapeutic immune restoration and could lead to significant impact in treating RSV infections.
Physicists at Trinity College Dublin developed a new theory describing the energy landscape of collections of quantum particles. This work addresses decades-old questions and may help scientists design materials revolutionizing green technologies.
Scientists from Trinity College Dublin created a computer program that visualizes molecular structure in the style of Piet Mondrian. The program uses blocks of color to represent symmetry and shape, making it easier to understand complex molecular interactions.
A new study advances our understanding of how the brain responds to emotionally charged objects and scenes. The research identified how the brain represents different categories of emotional stimuli in a way that allows for more than a simple 'approach avoid' dichotomy when guiding behavioral responses.
Researchers at Trinity College Dublin have made a breakthrough in understanding how to improve vaccine responses against the potentially deadly MRSA bacterium. By targeting the immune-suppressive molecule IL-10, they improved the ability of vaccines to protect against infection and reduce bacterial clearance.
A clinical trial evaluated the economic impact of adding a dedicated team to existing emergency department care for older patients. The study found that this approach can significantly improve patient quality of life and save up to €2.4 billion nationally.
Researchers at Trinity College Dublin have discovered a novel method for forming bastnåsite, a crucial mineral in extracting rare earth elements. The study reveals that fluocerite can act as a 'seed' to promote the rapid formation of bastnåsite, with significant implications for efficient and cost-effective extraction methods.
Researchers have devised an algorithm to rationally engineer enzymes for improved performance, taking into account evolutionary history. The new method successfully introduced up to 84 mutations over a sequence of 280, resulting in improved activity and stability at higher temperatures.
A new study highlights the limitations of current brain health models, which may not apply to diverse populations in Latin America. The research emphasizes the need for tailored and personalized models that consider unique factors such as genetic admixture, socioeconomic inequities, and social determinants.
A new study found giant Atlantic bluefin tuna are spending more time in higher latitudes as the region experiences ocean warming events. The fish are normally seasonal visitors to Ireland, but climate change may alter their migration routes.
A Trinity College Dublin team, led by Professor David Taylor, has developed a machine to study hair splitting using biomechanics. The 'Moving Loop Fatigue machine' recreates the damage caused by combing tangled hair, revealing that split ends split more quickly and generated longer splits.
Researchers found human infants use 'helpless' period to pre-train brain, leading to rapid learning and high performance, similar to machine learning models. This study challenges classic explanation for infant helplessness and could inspire next gen AI models.
Researchers from Trinity College Dublin discover that eggshell waste can effectively absorb and separate rare earth elements from water, offering a new environmentally friendly method for their extraction. The innovative approach could help meet growing demand for rare earth elements while reducing environmental harm.
Researchers at Trinity College Dublin discovered that over 10,000 species have been described in just 83 big genera since 2000, with roughly one in four flowering plant species belonging to these groups. Understanding the success of these large genera may help predict their response to climate change and inform conservation efforts.
A study by Trinity College Dublin researchers has linked rare mast cell types to treatment response in chronic spontaneous urticaria (CSU), a common skin condition characterized by recurring hives. The findings suggest that these cells may help predict who will respond well to anti-IgE therapies.
Researchers from Trinity College Dublin unveil a deeper understanding of bastnäsite and rare earth carbonates' formation, influenced by multiple factors including temperature, time, and host grain solubility. This discovery could reshape the tech industry's reliance on rare earth elements.
Researchers have identified a promising new vaccine adjuvant called C100, derived from chitin, which stimulates key sensing and signalling molecules to regulate anti-tumour immune responses. The discovery offers hope for developing effective adjuvants for in situ vaccines in cancer immunotherapy.
A team of neuroscientists proposes a framework to address the complex challenges of brain health, environment, and sustainability. The 'brain economy' concept aims to create a stronger future by reversing brain capital loss, which affects cognitive abilities and socioemotional stability.
Researchers have identified new cellular targets for a vaccine to treat eczema in children, which may limit the severity of symptoms and reduce antibiotic use. The study uncovered specific immune signatures in children with infected flares of eczema, providing a potential blueprint for future therapies.
Researchers analyzed data from over half a million UK participants to develop individualized estimates of ambient UVB levels, revealing key predictors of vitamin D status. The study highlights the need for personalized vitamin D supplementation guidelines based on ethnicity, age, sex, and other factors.
Researchers uncover how tuberculosis infection drives excessive inflammation in the lungs by activating neutrophils. Targeting neutrophils could lead to new therapies for TB treatment, potentially reducing antibiotic-resistant cases.
A team of researchers at Trinity College Dublin has developed a new blood test that measures the immune response to Epstein Barr Virus (EBV), which is the leading risk factor for multiple sclerosis (MS). The study found that people with MS have a higher immune response to EBNA-1, a part of the EBV, compared to those without MS.
Researchers found considerable variation in human temporal resolution, with some people perceiving faster-changing visual cues than others. This discovery may impact high-speed situations such as ball sports and competitive gaming, suggesting individual differences in perception speed could be an advantage.
Researchers have recovered ancient microbiomes from 4,000-year-old teeth in Ireland, revealing major changes in oral microenvironments. The study identified bacteria linked to gum disease and provided the first high-quality ancient genome of Streptococcus mutans, a major culprit behind tooth decay.
A study published in Nature Metabolism reveals that the diabetes drug metformin and solid foods increase a hunger-reducing factor called Lac-Phe, while sugary drinks have minimal effect. This discovery could lead to new anti-obesity treatments and help explain why liquid calories drive obesity.
Scientists have uncovered a novel form of MRI scan that shows how Long-COVID affects the human brain's delicate network of blood vessels. The study found disruption to the integrity of blood vessels in patients with Long COVID and brain fog, highlighting a potential target for targeted therapies.
Researchers have created fluorescent, colour-changing dyes that can visualise multiple distinct biological environments using only one dye. These dyes enable 'time travel' within cells by allowing scientists to distinguish between cellular and delivery vessel environments in real-time. The breakthrough has significant implications for ...
A new study found that one-off experiences of poverty can have a lasting impact on children's cognitive and behavioral development. The research identified parenting stress and reduced ability to invest in healthy activities as key factors contributing to this harm.
A new European study confirms pesticides harm bumblebees, contradicting current regulations. The research, published in Nature, shows that pesticide use reduces colony production and queen numbers, highlighting the need for more effective pollinator protection.
Scientists found that oceanic deoxygenation played a significant role in the Triassic–Jurassic mass extinction, leading to widespread ecosystem disruption and species extinctions. The global extent of deoxygenation was surprisingly similar to today's levels.
Researchers found that learning occurs through continuous formation of new connections between specific engram cells in different regions of the brain. This process allows us to form and store memories, with changes in synaptic wiring connectivity between these cells being a key mechanism for memory storage.
Researchers found that a more complex climate model projects stronger and sustained carbon uptake by plants until the end of the 21st century. This could lead to a larger impact on mitigating climate change through nature-based solutions like reforestation.
Researchers at Trinity College Dublin discovered that autism-induced maternal immune response alters brain development and prevents infantile amnesia. Memories formed during infancy can be permanently reinstated through light-activated neural pathways in adults.
A new study has found that a relatively ancient shark species, the smalltooth sand tiger, exhibits anatomic features suggesting regional endothermy. This discovery suggests there may be more warm-blooded sharks than previously believed, and potentially poses significant conservation implications for these species.
Researchers found that tiny timing errors can significantly impact quantum algorithms, limiting the technology's potential. Despite promising applications in fields like pharmaceutical discovery and materials science, quantum computers' fragility hinders their scalability.
Researchers from Trinity College Dublin are searching millions of star systems for technosignatures that could support intelligent alien life. The team has already scanned 1.6 million star systems but so far, no signals have been detected.
The HY4RES project aims to develop hybrid renewable energy systems combining solar, wind, and pumped storage hydropower to provide energy self-sufficiency for communities. Researchers will conduct a life cycle sustainability assessment of the technologies' impacts on the Atlantic Area.
A study published in Trends in Cognitive Science found that infants are capable of conscious experiences from birth, which can shape their sense of self and understanding of the environment. This breakthrough has important implications for clinical, ethical, and legal aspects of infant care and development.
A new study by Trinity College Dublin found that Irish secondary schools are among the most socio-economically integrated in Europe for reading literacy. Despite varying levels of privileged and underprivileged students, Irish schools have relatively small gaps in literacy scores between these groups.
The study reveals that different bee species may be exposed to pesticides differently, complicating assessments of pesticide risk. Neonicotinoid detection increased with wild plant presence in bumble bee pollen, highlighting the need for further investigation.
Researchers from Trinity College Dublin have made significant discoveries on how lung cells respond to influenza viruses, identifying two key molecular pathways that trigger the release of cytokines and cell death. These findings hold promise for treating people affected by such viruses.
Scientists have discovered two 14ft smalltooth sand tiger sharks in Ireland's waters, a rare find suggesting the species is expanding its geographic range due to warmer sea temperatures. The discovery highlights the need for increased awareness and monitoring of these vulnerable creatures.