A new study from Trinity College Dublin suggests that teenagers who spend a 'goldilocks amount' of time online may have better mental wellbeing. The research found that low engagement with digital media is also associated with poor mental health outcomes for adolescents, while high engagement predicts worse mental health outcomes.
Researchers found that ancient Maltese humans had limited genetic changes due to island isolation. The study suggests that seascapes played a central role in shaping the genetic structure of European populations.
Researchers have identified a potential method of preventing damaging seizure activity by restoring the integrity of blood vessels in the brain. This breakthrough could hold promise for treating patients who are currently non-responsive to anti-seizure medications.
Research from Trinity College Dublin suggests that cumulative childhood trauma is a key indicator of suicide ideation among university students. The study found that 35.2% of participants reported adverse childhood experiences, and serious levels of suicidal thoughts were common.
Researchers from Trinity College Dublin have discovered how SARS and MERS coronaviruses block the induction of antiviral proteins, preventing a strong immune response. This finding has potential implications for developing new therapeutic options to treat COVID-19 and future deadly coronaviruses.
Physicists have made a peculiar discovery in which energy moves from a colder to a hotter region, creating counterintuitive edge currents. The research, published in Physical Review Letters, shows that these currents are remarkably robust and can occur in topologically trivial systems.
Scientists have identified a new immune process that regulates inflammation in human fat, which may help manage obesity. The research found that specific immune cells can work together in fat tissue to cause weight gain and obesity.
Scientists at Trinity College Dublin have identified Itaconate as a potential therapeutic target for severe asthma. The discovery could pave the way for effective new treatments, especially in children, who are disproportionately affected by the disease.
The Precision ALS programme aims to provide new insights into Motor Neuron Disease through advanced data-driven prediction models and next-generation data analysis. The project will harness AI to analyse large amounts of data from a multimodal dataset, providing tools for clinical trials based on precision-medicine.
Researchers have identified how IL-36 cytokines instruct proinflammatory CD4+ T cells to accumulate in the inflamed intestine, worsening disease. This discovery offers fresh insights into targeting these proteins as a new therapeutic option for childhood IBD patients.
Researchers from Trinity College Dublin have pinpointed a key driver gene, SARM1, that contributes to impaired vision and blindness. Deleting this gene shows promise in preserving vision, suggesting targeted therapies may offer long-lasting preservation of sight for various ocular conditions.
A nationwide study found that Irish primary school children's engagement with remote schooling increased when they had access to digital technologies and parental support. Children who struggled with traditional schooling before the pandemic faced greater difficulties with online learning.
A study led by Yekaterina Chzhen at Trinity College Dublin found that poverty directly affects both children and parents, leading to economic pressure and psychological distress. This challenges mainstream theoretical models of poverty and calls for a more nuanced understanding of the impact of economic hardship on families.
Scientists sequenced DNA and measured Island Monarchs, revealing they settle down more readily than expected after colonizing an island. The study confirms the importance of island regions in species evolution, adding new knowledge to biogeography.
Researchers suggest forgetting memories due to environmental feedback and predictability, rather than decay. This 'natural forgetting' can be beneficial for decision-making and behavior, and may even be reversible in certain circumstances.
Predator species help mitigate against loss of biodiversity and ecosystem destabilization caused by heatwaves. Algal communities in freshwater streams were found to resemble each other more closely when predators were absent, highlighting the importance of conserving top predators.
A unique Irish study found that previous COVID-19 infection and age are associated with lower antibody levels six months after vaccination. The research highlights the importance of boosting vaccinations for vulnerable populations like nursing home residents.
Researchers at Trinity College Dublin have identified a crucial protein, myeloid cell nuclear differentiation antigen (MNDA), that regulates type I interferon production in response to viral infections. This breakthrough discovery has significant implications for the development of new therapies to boost or suppress immune responses, p...
A Trinity College study found that severe COVID-19 patients who received care outside of an ICU had a higher mortality rate compared to those in the ICU. The study highlights Ireland's shortage of ICU beds and emphasizes the need for increased critical care capacity.
Researchers at Trinity College Dublin have developed mathematical equations explaining how individual randomness can give rise to synchronisation, applicable to systems like clocks, fireflies and metronomes. The findings provide a basis for new types of computer technology using light signals.
Researchers from Trinity College Dublin investigate the epidemiology and population biology of Enteroccocus faecium, a high-priority pathogen. They found that Irish isolates have evolved independently and are diverse, with a unique genetic transposon element encoding vancomycin resistance.
Researchers have discovered four distinct patterns of brain network disruption that reflect the underlying disease process in motor neuron disease (MND). These patterns are predictive of how the disease progresses and can be identified using electroencephalography (EEG), which may lead to more effective treatments.
A new study published in Science of the Total Environment found that forests can reduce storm flows, but only when small-scale floods occur. In contrast, forests offer little to no protection against larger and more devastating flood events.
Researchers found a repeated link between volcanic eruptions and dynastic collapse in China's Imperial Era, with 62 of 68 collapses preceded by at least one eruption. The study highlights the need to prepare for future eruptions and emphasizes the importance of building resilient societies.
Researchers found that tap water contains trace elements and minerals, preventing plastics from degrading and releasing microplastics. This natural protection allows items like plastic kettles to remain microplastic-free, even after repeated use with tap water.
Researchers at Trinity College Dublin have identified a new molecule called 4-OI that can limit the production of prostaglandins from macrophages. This discovery could lead to the development of new anti-inflammatory compounds for treating diseases such as COVID-19 and sleeping sickness.
A team of researchers developed a new nanomechanical technique to fast-track the detection of COVID-19 variants. The method provides real-time insights into infection immunity and enables direct classification of variant-binding properties.
A new study reveals that higher levels of education and income are associated with better health outcomes for older adults in Ireland, England, the US, and Canada. The study found that socio-economic disparities exist across countries, with those having higher education and income experiencing lower disease burdens.
Researchers at Trinity College Dublin have discovered that lactate can influence cells in the lung environment to support immune defenses against infection while limiting collateral damage. Lactate may hold therapeutic potential as a host-directed therapy for diseases like TB and COVID-19, which cause destruction of pulmonary tissue.
New study finds that modern Japanese populations have a tripartite genetic origin, with contributions from Jomon hunter-gatherers, Yayoi farmers, and Kofun peoples. The analysis reveals a complex history of population dynamics, including assimilation rather than replacement during the agricultural transition.
Scientists from Trinity College Dublin have developed tiny, color-changing gas sensors using new materials and 3D printing techniques. These sensors can detect solvent vapors in air and have potential applications in wearable devices for health monitoring and low-cost environmental monitoring systems.
Researchers found that ambient UVB radiation before COVID-19 infection was strongly associated with reduced hospitalization and death. The study suggests that vitamin D may protect against severe COVID-19 disease and death, particularly in individuals who do not produce enough vitamin D through sun exposure.
Researchers have found compounds based on gold, silver, and copper that can store hydrogen in a stable manner. These 'metal hydride' complexes could be used to store hydrogen for use in vehicles, potentially revolutionizing the production of clean energy.
Researchers used EEGs to measure brain activity while musicians listened to or imagined Bach piano melodies, finding consistent patterns of neural activity during silent intervals. The study suggests that the brain reacts to both notes and silences of music, engaging in a continuous attempt to predict upcoming musical events.
Researchers discovered how the H3K27M mutation causes diffuse midline glioma (DMG) and successfully reversed its effects with an EZH2 inhibitor. They call for clinical trials to begin, offering hope for improved treatments in the future.
New study reveals Sulawesi Babblers have diversified rapidly over a short period of time due to their understorey lifestyle, changing genetically, physically and behaviorally. The research suggests that these birds can evolve quickly even in relatively small geographic areas.
A team of geneticists sequenced DNA from a 1,600-year-old sheep mummy from Iran's Chehrābād salt mine, revealing ancient sheep husbandry practices. The preserved DNA showed remarkable integrity, with longer fragment lengths and less damage than expected.
Researchers have produced detailed molecular blueprints of the bacterial enzyme Lit, which may enable bacteria to evade the immune response and contribute to antibiotic resistance. The study's findings could lead to the development of new antibiotics targeting this enzyme.
Researchers from Trinity College Dublin have made significant progress in developing a recipe for entirely renewable energy by splitting water to produce green hydrogen. The team has identified nine earth-abundant metal combinations as highly promising leads for experimental investigation, with chromium, manganese, and iron standing ou...
Research reveals warm-blooded fish swim approximately 1.6 times faster than their cold-blooded counterparts, but don't live in broader temperature ranges, making them susceptible to climate change impacts.
A new approach to molecular drug design has yielded a highly promising bladder cancer treatment candidate that induces rapid shedding of tumour cells and results in significant tumour size reduction. The treatment shows potent effects on patients with non-muscle invasive bladder cancer, demonstrating safety without side effects.
New research suggests subterranean estuaries play a critical role in filtering pollutants from freshwater, supporting large ecosystems. These invisible structures are estimated to supply up to 25% of continental freshwater discharged to certain coastal areas.
Researchers have uncovered a novel strategy employed by MRSA to evade the immune response, causing toxic effects on white blood cells. A mutated protein-based vaccine shows promise in preventing such toxicity, suggesting a potential cure for deadly MRSA infections.
Researchers at Trinity College Dublin and ONK Therapeutics are collaborating to optimize the metabolism of natural killer cells for enhanced anti-tumor functions. The project aims to address the immunosuppressive tumor microenvironment that impairs NK cell efficacy.
The study provides clues to how early agricultural practices shaped the evolution of these animals. Genetic analyses show that the ancient goats fell at the base of the domestic goat lineage, suggesting they were closely related to the animals first recruited during domestication.
Researchers found that secondary infections trigger a heightened brain immune response, affecting memory and cognitive function in Alzheimer's disease. This over-response leads to knock-on effects on brain rhythms and cognition, similar to acute psychiatric disturbances like delirium.
A recent study on TB outbreak in an Irish prison highlights the need for increased testing and improved care. The study found that 50% of staff may have developed latent TB as a result of occupational exposure, posing a risk of progression to active TB.
Researchers from Trinity College Dublin developed tools for designing vitamin D clinical trials that capture seasonal and population-wide differences. The study found many trials were underpowered, failing to detect a benefit of vitamin D supplementation due to individual differences and seasonal fluctuations.
A clinical trial by Trinity College Dublin researchers has shown upadacitinib to be the most effective treatment for moderate-to-severe atopic dermatitis. The study involved 1,600 patients and found that the drug provides a substantial unmet need in treating this chronic inflammatory condition.
A Trinity College study found people homeless in their 20s-40s experience high levels of physical and mobility problems, with only one-third able to climb hospital stairs. The study suggests that targeted health and accommodation services are necessary for this vulnerable group.