David Cheresh, a renowned cancer researcher, has received a $4.2 million NCI award to investigate how tumors adapt to stress and develop drug resistance. His research aims to find ways to perturb the malignant cell version of wound repair, potentially eliminating highly drug-resistant cancers.
Researchers developed a new approach to prevent malaria by targeting the parasite at an earlier stage in its lifecycle. They tested over 500,000 chemical compounds and identified 631 promising candidates that could form the basis for new drugs.
Researchers found that targeted cognitive training improved verbal learning and auditory perception scores in patients with severe schizophrenia. The treatment, which used computerized brain games to target specific neural pathways, was effective regardless of age, clinical symptoms, or medication duration.
Researchers have engineered sensors to monitor multiple signaling pathways driving tumor metastasis, enabling the prediction of a tumor cell's potential to spread. The development of Fluorescence Resonance Energy Transfer (FRET) biosensors has the potential to transform cancer cell biology and inform personalized treatment strategies.
Researchers at UC San Diego School of Medicine developed a method to turn B cells into factories that assemble and secrete vesicles containing tumor-suppressing microRNAs. In mice, breast tumors treated with this approach were significantly smaller than untreated tumors, and the treatment was long-lasting.
A randomized clinical trial found immunotherapy drug pembrolizumab more effective than standard chemotherapy in treating chemotherapy-resistant head and neck cancer. Patients receiving pembrolizumab had a higher response rate with longer-lasting responses compared to those on standard therapy.
Researchers at the University of California San Diego have developed a simple 3D bioprinting technique using natural materials to create lifelike organ tissue models. The method allows for the creation of vascularized human gut and blood vessel networks capable of keeping cancer tumor tissues alive outside the body.
Seven researchers from the University of California, San Diego have been recognized as AAAS Fellows for their groundbreaking work in various fields. Robert Continetti was honored for his novel studies on molecular reaction dynamics, while Farhat Beg received recognition for his contributions to high energy density science.
A study published in Nature Neuroscience found a large-scale association between molecular gene expression activity and neural responses to speech in toddlers with autism. The researchers identified widespread gene expression activity across the genome, which was linked to whole-brain neural response to speech.
High levels of prions were found throughout the eyes of deceased sCJD patients, suggesting the eye as a potential source for early detection and prevention of disease transmission. Researchers also discovered that prion seeds accumulate in the retina, with implications for diagnostic tests before symptoms become apparent.
A team of UC San Diego researchers has received a $1 million Stand Up To Cancer grant to test drugs that block signals driving pancreatic cancer growth. The study aims to identify new therapies that can more effectively block tumor growth and metastasis.
Researchers have found evidence of multiple environmental triggers for Kawasaki Disease, with clusters associated with distinct atmospheric patterns and warmer conditions in Southern California. Gene expression analysis revealed distinct groups of patients based on their gene expression pattern, suggesting varying causes for the disease.
Researchers discovered that breastfeeding for over six months lowers the risk of non-alcoholic fatty liver disease (NAFLD) in mothers. Women who breastfed one or more children for longer periods had a lower risk compared to those who did not breastfeed or breastfed for under one month.
Researchers developed a computer model showing how climate change affected food production in ancient Asia, leading to crop diversification, trade networks, and the development of the Silk Road. The study suggests that adapting to climate change requires investing in diversity and innovation.
A Scripps Oceanography-led study finds that small-scale fisheries in the Gulf of California are overexploited and unable to support fishermen's livelihoods. However, if fish stocks recover, total annual revenues could increase by 70%.
Researchers have discovered four new ways to 'history sniffing' attacks, which can profile a user's online activity in seconds and work across recent web browsers. The attacks can be used by hackers to learn which websites users have visited, and could also be deployed by legitimate companies for marketing and advertising purposes.
Biologists at UC San Diego have discovered a human gene that inhibits HIV and makes tumor cells sensitive to DNA-damaging agents. The researchers found that the Schlafen 11 protein blocks the synthesis of viral proteins, allowing tumor cells to survive.
A University of California San Diego School of Medicine team will investigate a novel treatment model called Regulation of Cues (ROC) to tackle binge eating disorder and obesity in military personnel. ROC targets underlying mechanisms associated with binge eating, aiming to reduce weight and obesity.
Researchers developed a machine learning approach to identify and predict antibiotic resistance genes in Mycobacterium tuberculosis. The approach identified 33 known and 24 new resistance genes, which could aid in personalized treatment for different strains of the bacteria.
A new $3.3 million grant will fund a high-resolution reference map of pancreatic cells to identify molecular changes leading to type 1 diabetes.
Researchers will work together to develop tools and methods to manage machine learning risks, including methods to defend against adversarial inputs and develop robust training methods. The center aims to foster a long-term research community in trustworthy machine learning.
Researchers found that aggressive blood pressure treatment does not damage the kidneys themselves, but rather leads to decreased blood flow. This discovery challenges previous beliefs and offers new hope for patients with hypertension.
A new technology, Sprocket, enables fast video processing by breaking down files into small pieces and processing them on thousands of servers. This reduces processing time to seconds, making it ideal for image searches within videos.
Researchers found that corals living in more productive waters consume plankton and other microorganisms for energy, suggesting some corals are less reliant on symbiotic algae. This discovery could aid predictions on coral recovery from bleaching events and inform strategies for identifying resilient reefs.
The world's largest outdoor shake table at UC San Diego will now test heavy structures with complex ground motions, enabling researchers to gather critical data on tall wooden buildings and retrofitting systems.
A study from University of California San Diego found that patients who recorded videos of themselves taking TB medications had better adherence to treatment than those observed in-person. VDOT (video directly observed therapy) was also cost-effective and preferred over traditional DOT.
A clinical trial at UC San Diego Health is testing personalized vaccines that use a patient's unique cancer mutations to stimulate an immune response. The vaccine, combined with an FDA-approved checkpoint inhibitor, aims to unleash the full potential of T cells activated by the vaccine.
A recent study published in Cancer Prevention Research reveals that California's long-term tobacco control efforts have led to a 28% decrease in lung cancer deaths compared to the rest of the country. The state's approach has been particularly effective in discouraging young people from starting to smoke, with a 39% lower initiation ra...
A novel study suggests that people who participate in dementia prevention trials are primarily motivated by a desire to help others. The findings also highlight the importance of human interaction, with trial participants preferring staff-administered assessments over automated technologies.
Engineers at UC San Diego developed an algorithm to predict individual blood pressure based on sleep, exercise, and blood pressure data from wearable devices. The study found that personalized data was more effective than generalized information in lowering blood pressure.
Engineers at UC San Diego create a super-hydrophobic surface that produces at least 50 millivolts when salt water flows over it, enabling new power sources for lab-on-a-chip platforms and microfluidics devices.
Researchers at UC San Diego discovered human milk oligosaccharides in amniotic fluid during pregnancy, which may influence early microbiome development and prevent preterm birth. HMOs' presence in amniotic fluid also suggests potential benefits for prenatal lung and brain development.
A team of researchers has identified the genetic basis for the production of domoic acid, a potent neurotoxin produced by harmful algal blooms. The study's findings suggest that changes in oceanic conditions, such as phosphate limitation and increased carbon dioxide levels, can trigger toxin production.
A new grant from the National Institute on Aging aims to boost Latino researchers studying Alzheimer's disease and related dementias. The San Diego Resource Center for Advancing Alzheimer's Research in Minority Seniors will provide mentorship, data, and intellectual resources to support emerging scholars.
Researchers discovered that E. coli bacteria discharge damaged proteins bundled inside minicells as a survival mechanism. Minicells can help bacteria resist antibiotics by kicking out damaged proteins.
Researchers evaluated the safety of pimavanserin for treating Parkinson's disease psychosis, finding a lower mortality risk compared to quetiapine or combination therapy. The study provides reassurance for clinicians and families but highlights the need for further research on disease severity and cause of death.
Researchers discovered that tweaking pH balance and oxygen in a CF lung model can help eradicate pathogenic bacteria while minimizing antibiotic resistance. The study found two distinct communities of microbes in CF lungs: anaerobes thriving in low-oxygen and low-pH regions.
A new study estimates that the US is expected to suffer significant economic damage from climate change, with losses of around $50 per ton of carbon emissions. The study reveals that the US will pay approximately $250 billion annually due to its high level of CO2 emissions, outpacing other major economies like India and Saudi Arabia.
A recent study found that CD4+ T cell's binding partner, MHC-II, plays a significant role in emerging tumors, suggesting new avenues for improving cancer immunotherapies. The researchers also discovered no correlation between MHC-II's ability to recognize antigens and the age at which patients were diagnosed with cancer.
Researchers from UC San Diego use reinforcement learning to train gliders to navigate atmospheric thermals, achieving heights of 700 meters. The study highlights vertical wind accelerations and roll-wise torques as key cues for soaring birds, with implications for autonomous flying vehicle development.
Researchers use artificial neural networks to predict crystal stability in garnets and perovskites, achieving accuracy up to 10 times that of previous models. The team's web application allows for fast computation of material properties on various devices.
Researchers at UC San Diego School of Medicine discovered that ubiquitination influences GPCR function and promotes inflammation. Existing cancer drugs targeting enzymes involved in ubiquitination may be repurposed to treat vascular inflammation.
A study published in PLOS Pathogens identified three new molecular drug targets for the treatment of primary amebic meningoencephalitis. The researchers found that certain cancer drugs, such as tamoxifen and Prozac, are effective against the brain-eating amoeba Naegleria fowleri.
Researchers identified caspase-2 as a critical driver of non-alcoholic steatohepatitis (NASH), a chronic and aggressive liver condition. The study found that an inhibitor of caspase-2 could provide an effective way to treat or prevent NASH, possibly even reversing early symptoms.
Researchers at the University of California - San Diego have developed a wearable ultrasound patch that can monitor central blood pressure in major arteries up to four centimeters below the skin. The device provides accurate, precise readings and has potential applications in real-time monitoring of patients with heart or lung disease.
Researchers discovered that mice lacking a key gene, CMAH, can run stronger and longer with less fatigue. This gene loss may have contributed to humanity's ability to run long distances relatively tirelessly.
Researchers have developed a method to separate infected and uninfected cells, revealing how Zika virus manipulates the human immune system by suppressing gene production in macrophage cells. This approach provides a more accurate account of Zika's effect on macrophages and shows that the virus uses two methods to stop their function.
Chronic diseases are linked to disrupted healing cycles caused by cellular miscommunication, preventing the completion of the natural healing process. This blocks the cycle, leading to persistent conditions like cancer, diabetes, and neurological disorders.
UC San Diego researchers develop rapid and cost-effective method to create human cortical organoids directly from primary cells. The new protocol enables large-scale production of brain organoids, which can be used to better understand human brain function and develop treatments for neurological disorders.
Researchers at the University of California San Diego have developed nanosponges that can safely absorb and neutralize a variety of proteins involved in rheumatoid arthritis progression. These nanosponges effectively treated severe rheumatoid arthritis in two mouse models, reducing swelling and minimizing cartilage damage.